Recent Advancements in Metallic Drug-Eluting Implants DOI Creative Commons

Sadeq Alshimaysawee,

Rasha Fadhel Obaid, Moaed E. Al‐Gazally

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 223 - 223

Published: Jan. 9, 2023

Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically preventing infection associated with implants. Recent studies showed that loaded drugs were substituted conventional bare metal to achieve sustained resulting a desired local therapeutic concentration. A number of secondary features can be provided by incorporated active molecules, including promotion osteoconduction angiogenesis, inhibition bacterial invasion, modulation host body reaction. This paper reviews recent trends development various delivery systems three years. There are types been developed meet this purpose, depending on or agents them. These include anti-inflammatory drugs, antibiotics agents, growth factors, anti-resorptive drugs.

Language: Английский

Investigation of Soft Matter Nanomechanics by Atomic Force Microscopy and Optical Tweezers: A Comprehensive Review DOI Creative Commons
Alessandro Magazzù, Carlos Marcuello

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(6), P. 963 - 963

Published: March 7, 2023

Soft matter exhibits a multitude of intrinsic physico-chemical attributes. Their mechanical properties are crucial characteristics to define their performance. In this context, the rigidity these systems under exerted load forces is covered by field biomechanics. Moreover, cellular transduction processes which involved in health and disease conditions significantly affected exogenous biomechanical actions. framework, atomic force microscopy (AFM) optical tweezers (OT) can play an important role determine parameters investigated at single-molecule level. This review aims fully comprehend interplay between soft systems. particular, we outline capabilities AFM OT compared other classical bulk techniques nanomechanical such as Young’s modulus. We also provide some recent examples measurements performed using hydrogels, biopolymers systems, among others. expect present manuscript will aid potential readers stakeholders understand applications

Language: Английский

Citations

110
Recent advances in long-acting drug delivery systems for anticancer drug DOI Creative Commons
Catarina Pacheco, Ana Baião, Tao Ding

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 194, P. 114724 - 114724

Published: Feb. 4, 2023

The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after administration, doses fail to reach effective intratumoral concentrations, while high significant tumor inhibition effects may also drive the death healthy cells, endangering patients. Therefore, strategies based on drug delivery systems (DDSs) for avoiding toxicity have been designed. Due their ability protect drugs from early elimination and control release, DDSs can foster exposure therapeutics extending circulation time steadily releasing into sites. However, approval tailored clinical minimal as safety in vivo activity still need be ameliorated manipulating physicochemical characteristics. During last few years, several described improve safety, stability, fine-tune pharmaceuticals release kinetics. Herein, we reviewed main DDSs, namely polymeric conjugates, nano microparticles, hydrogels, microneedles, explored long-acting treatments, highlighting recently proposed modifications potential advantages different therapies. Additionally, important limitations therapies future technology directions were covered.

Language: Английский

Citations

97
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions DOI Creative Commons

Peilin Lu,

Dongxue Ruan,

Meiqi Huang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Language: Английский

Citations

78
Light responsive hydrogels for controlled drug delivery DOI Creative Commons

Yanghui Xing,

Buhui Zeng,

Yang Wang

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 16, 2022

Light is an easy acquired, effective and non-invasive external stimulus with great flexibility focusability. Thus, light responsive hydrogels are of particular interests to researchers in developing accurate controlled drug delivery systems. obtained by incorporating photosensitive moieties into their polymeric structures. Drug release can be realized through three major mechanisms: photoisomerization, photochemical reaction photothermal reaction. Recent advances material science have resulted development photosensitizers, such as rare metal nanostructures black phosphorus nanoparticles, order respond a variety sources. Hydrogels incorporated photosensitizers crucial for clinical applications, the use ultraviolet near-infrared well up-conversion nanoparticles has greatly increased therapeutic effects. Existing systems been utilized delivering drugs, proteins genes chemotherapy, immunotherapy, photodynamic therapy, gene wound healing other applications. Principles associated site-specific targeting, metabolism, toxicity used optimize efficacy safety, improve patient compliance convenience. In view importance this field, we review current development, challenges future perspectives delivery.

Language: Английский

Citations

74
Novel strategies to reverse chemoresistance in colorectal cancer DOI Creative Commons

Shu‐Chang Ma,

Jiaqi Zhang, Tianhua Yan

et al.

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(10), P. 11073 - 11096

Published: Jan. 16, 2023

Abstract Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect greatly improved the survival of CRC patients. Nevertheless, chemoresistance one major problems during chemotherapy significantly limits efficacy treatment influences prognosis To overcome in many strategies are being investigated. Here, we review novel measures to combat resistance, including drug repurposing (nonsteroidal anti‐inflammatory drugs, metformin, dichloroacetate, enalapril, ivermectin, bazedoxifene, melatonin, S‐adenosylmethionine), gene (ribozymes, RNAi, CRISPR/Cas9, epigenetic therapy, antisense oligonucleotides, noncoding RNAs), protein inhibitor (EFGR inhibitor, S1PR2 DNA methyltransferase inhibitor), natural herbal compounds (polyphenols, terpenoids, quinones, alkaloids, sterols), new delivery system (nanocarriers, liposomes, exosomes, hydrogels), combination therapy. These or reversal promise improve CRC.

Language: Английский

Citations

60
Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow DOI Creative Commons
Myriam Neumann,

Greta Di Marco,

Dmitrii Iudin

et al.

Macromolecules, Journal Year: 2023, Volume and Issue: 56(21), P. 8377 - 8392

Published: Oct. 18, 2023

In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart can not only replicate physicochemical properties of extracellular matrix but also mimic dynamic processes that crucial regulation cell behavior. Dynamic changes be influenced by hydrogel itself (isotropic vs anisotropic) or guided applying localized triggers. The resulting swelling–shrinking, shape-morphing, well patterns have been shown to influence function in a spatiotemporally controlled manner. Furthermore, use bioinks 4D bioprinting is very promising they allow biofabrication complex microstructures. This perspective discusses recent cutting-edge advances current challenges field smart engineering. Additionally, emerging trends potential future directions addressed.

Language: Английский

Citations

52
Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products DOI Creative Commons

Katrin Zöller,

Dennis To,

Andreas Bernkop‐Schnürch

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122718 - 122718

Published: July 27, 2024

Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them based on synthetic or natural polymers forming a three-dimensional network that contains aqueous media. Among polymers, poly(meth)acrylates, polyethyleneglycols, poly(vinylalcohols), poly(vinylpyrrolidones), PLGA poly(urethanes) high relevance, whereas mainly polysaccharides hyaluronic acid, alginate chitosan proteins albumin, collagen elastin. In contrast to most biodegradable. Both often chemically modified in order improve induce favorable properties functions like mechanical strength, stiffness, elasticity, porosity, adhesive properties, situ gelling water binding capacity release controlling properties. Within this review we provide an overview about the broad spectrum functional hydrogels, summarize innovative approaches, discuss concept relevant clinical trials highlight products examples successful developments.

Language: Английский

Citations

34
A Comprehensive Review of Hydrogel-Based Drug Delivery Systems: Classification, Properties, Recent Trends, and Applications DOI
Huma Hameed, Saleha Faheem, Ana Cláudia Paiva‐Santos

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(4)

Published: March 21, 2024

Language: Английский

Citations

32
A review of electro-active shape memory polymer composites: Materials engineering strategies for shape memory enhancement DOI

Hytham Hassan,

Hans Hallez, Wim Thielemans

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 208, P. 112861 - 112861

Published: Feb. 18, 2024

Language: Английский

Citations

22
Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems DOI Creative Commons
Ernesto J. Delgado-Pujol, Guillermo Martínez,

David Casado-Jurado

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 215 - 215

Published: Feb. 7, 2025

Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.

Language: Английский

Citations

5