Structural and functional characterization of the locus coeruleus in young and late middle-aged individuals DOI Creative Commons
Alexandre Berger, Ekaterina Koshmanova, Elise Beckers

et al.

Frontiers in Neuroimaging, Journal Year: 2023, Volume and Issue: 2

Published: June 21, 2023

The brainstem locus coeruleus (LC) influences a broad range of brain processes, including cognition. so-called LC contrast is an accepted marker the integrity that consists local hyperintensity on specific Magnetic Resonance Imaging (MRI) structural images. small size has, however, rendered its functional characterization difficult in humans, aging. A full and characteristics healthy young late middle-aged individuals needed to determine potential roles different medical conditions. Here, we wanted whether activation mismatch negativity task changes aging response was associated contrast.We used Ultra-High Field (UHF) 7-Tesla MRI (fMRI) record during auditory oddball 53 volunteers, 34 younger (age: 22.15y ± 3.27; 29 women) 19 61.05y 5.3; 14 individuals.Whole-brain analyses confirmed responses typical cortical subcortical regions previously with negativity. When focusing brainstem, found significant rostral part probability mask generated based individual Although bilateral, more extensive left LC. Individual activity not significantly between individuals. Importantly, while higher older individuals, contrast.These findings may suggest age-related alterations be related response. results further remain stable aged 20 70.

Language: Английский

Overnight neuronal plasticity and adaptation to emotional distress DOI
Yesenia Cabrera, Karin J. Koymans, Gina R. Poe

et al.

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(4), P. 253 - 271

Published: March 5, 2024

Language: Английский

Citations

23
Anything but small: Microarousals stand at the crossroad between noradrenaline signaling and key sleep functions DOI Creative Commons
Anita Lüthi, Maiken Nedergaard

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Continuous sleep restores the brain and body, whereas fragmented harms cognition health. Microarousals (MAs), brief (3- to 15-s-long) wake intrusions into sleep, are clinical markers for various disorders. Recent rodent studies show that MAs during healthy non-rapid eye movement (NREM) driven by infraslow fluctuations of noradrenaline (NA) in coordination with electrophysiological rhythms, vasomotor activity, cerebral blood volume, glymphatic flow. hence part dynamics, raising questions about their biological roles. We propose bolster NREM sleep's benefits associated NA fluctuations, according an inverted U-shaped curve. Weakened noradrenergic as may occur neurodegenerative diseases or aids, reduce MAs, exacerbated caused stress fragment collapse signaling. suggest crucial restorative plasticity-promoting functions advance our insight normal pathological arousal dynamics from sleep.

Language: Английский

Citations

5
Noradrenergiclocus coeruleusactivity functionally partitions NREM sleep to gatekeep the NREM-REM sleep cycle DOI Creative Commons
Alejandro Osorio-Forero, Georgios Foustoukos, Romain Cardis

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 22, 2023

Abstract The noradrenergic locus coeruleus (LC) is vital for brain states underlying wakefulness, whereas its roles sleep remain uncertain. Combining mouse sleep-wake monitoring, behavioral manipulations, LC fiber photometry and closed-loop optogenetics, we found that neuronal activity partitioned non-rapid-eye-movement (NREMS) into alternating autonomic rule the NREMS-REMS cycle. High levels generated an autonomic-subcortical arousal state facilitated cortical microarousals, while low were obligatory REMS entries. Timed optogenetic inhibition revealed this functional alternation set duration of cycle by ruling entries during undisturbed when pressure was high. A stimulus-enriched, stress-promoting wakefulness increased high at expense ones in subsequent NREMS, fragmenting NREMS through microarousals delaying onset. We conclude fluctuations gatekeep NREM-REMS over recurrent infraslow intervals, but they also convey vulnerability to adverse wake experiences.

Language: Английский

Citations

33
Sleep and vigilance states: Embracing spatiotemporal dynamics DOI Creative Commons
Yuval Nir, Luı́s de Lecea

Neuron, Journal Year: 2023, Volume and Issue: 111(13), P. 1998 - 2011

Published: May 5, 2023

Language: Английский

Citations

24
Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle DOI
Alejandro Osorio-Forero, Georgios Foustoukos, Romain Cardis

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 25, 2024

Language: Английский

Citations

14
Sleepiness and the transition from wakefulness to sleep DOI
Thomas Andrillon, Jacques Taillard, Mélanie Strauss

et al.

Neurophysiologie Clinique, Journal Year: 2024, Volume and Issue: 54(2), P. 102954 - 102954

Published: March 8, 2024

Language: Английский

Citations

9
Pupil size reveals arousal level fluctuations in human sleep DOI Creative Commons
Manuel Carro‐Domínguez, Stephanie Huwiler,

Stella Oberlin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 28, 2025

Abstract Recent animal research has revealed the intricate dynamics of arousal levels that are important for maintaining proper sleep resilience and memory consolidation. In humans, changes in level believed to be a determining characteristic healthy pathological but tracking fluctuations been methodologically challenging. Here we measured pupil size, an established indicator levels, by safely taping right eye open during overnight tested whether size affects cortical response auditory stimulation. We show change as function events across different temporal scales. particular, our results inversely related occurrence spindle clusters, marker resilience. Additionally, found prior stimulation influence evoked response, most notably delta power, several restorative regenerative functions sleep. Recording provides insights into interplay between oscillations.

Language: Английский

Citations

1
REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness DOI Creative Commons

Nasrin Mortazavi,

Puneet Talwar, Ekaterina Koshmanova

et al.

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: March 11, 2025

Abstract Background Animal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to variability humans is not yet established. Here, we investigated if vivo activity of LC related quality Rapid Eye Movement (REM) sleep. Methods We assessed 34 healthy younger (~ 22y) 18 older 61y) individuals engaged bottom-up top-down cognitive tasks using 7-Tesla functional Magnetic Resonance Imaging (fMRI). further recorded their electroencephalogram (EEG) evaluate associations between fMRI measures REM EEG metrics. Results Theta oscillation energy during was positively associated with response task. In contrast, theta negatively Importantly, sigma oscillations power immediately preceding a episode Conclusions intensity transient change sleep, feature causally animal studies. The depend on task, suggesting balanced level tonic required for optimal expression findings may have implications high prevalence complaints reported aging disorders such as insomnia, Alzheimer’s, Parkinson’s disease, which play pivotal through

Language: Английский

Citations

1
BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep DOI Creative Commons
Daniela Rojo, Louisa Dal Cengio, Anna Badner

et al.

Neuron, Journal Year: 2023, Volume and Issue: 111(22), P. 3604 - 3618.e11

Published: Aug. 31, 2023

Language: Английский

Citations

22
Pupil size reveals arousal level dynamics in human sleep DOI Creative Commons
Manuel Carro‐Domínguez, Stephanie Huwiler,

Stella Oberlin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 21, 2023

Abstract Recent animal research has revealed the intricate dynamics of arousal levels that are potentially crucial for maintaining proper sleep resilience and memory consolidation. Also in humans, changes level believed to be a determining characteristic healthy pathological but tracking fluctuations been methodologically challenging. Here we measured pupil size, an established indicator levels, during overnight tested whether affects cortical response auditory stimulation. We show size change as function macrostructure microstructural events. In particular, is inversely related occurrence spindle clusters, marker resilience. Additionally, prior stimulation influences evoked response, most notably delta power, several restorative regenerative functions sleep. Recording provides novel insights into interplay between oscillations, opening new avenues future clinical applications diagnosing treating associated with abnormal levels.

Language: Английский

Citations

17