Pharmacy,
Journal Year:
2024,
Volume and Issue:
12(4), P. 100 - 100
Published: June 27, 2024
Although
preliminary
evidence
suggests
Cannabis's
efficacy
in
symptom
control
for
anxiety
and
depression-psychiatric
disorders
that
significantly
impact
mental
health-much
remains
to
be
understood
about
its
effects
on
the
central
nervous
system
(CNS)
how
optimize
treatment
these
disorders.
This
study
aims
conduct
a
narrative
review
evaluate
pharmaceutical
care
treating
symptoms
of
depression
alongside
Cannabis
use,
focusing
safety
therapeutic
optimization.
We
seek
conceptualize
disorders,
quality,
identify
knowledge
gaps.
Twelve
articles
were
identified,
revealing
significant
gap
literature
regarding
integration
with
Cannabis-based
therapies,
specifically
depression.
Despite
growing
interest
relationship
between
health,
current
research
is
insufficient
comprehensive
understanding.
The
use
requires
further,
more
targeted
investigations.
underscores
importance
future
fill
existing
gaps,
providing
informed
insights
robust
guidelines
safe
effective
as
part
It
crucial
integrates
therapies
responsibly
improve
overall
well-being
patients.
Neurotherapeutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. e00556 - e00556
Published: March 1, 2025
Intermittent
theta
burst
stimulation
(iTBS),
a
novel
protocol
within
repetitive
transcranial
magnetic
(rTMS),
has
shown
superior
therapeutic
effects
for
depression
compared
to
conventional
high-frequency
rTMS
(HF-rTMS).
However,
the
neural
mechanisms
underlying
iTBS
remain
poorly
understood.
Brain
entropy
(BEN),
measure
of
irregularity
brain
activity,
recently
emerged
as
promising
marker
regional
function
and
demonstrated
sensitivity
HF-rTMS.
Given
its
potential,
BEN
may
help
elucidate
iTBS.
In
this
study,
we
computed
using
resting-state
fMRI
data
from
sixteen
healthy
participants
obtained
OpenNeuro.
Participants
underwent
over
left
dorsolateral
prefrontal
cortex
(L-DLPFC)
at
two
different
intensities
(90
%
120
resting
motor
threshold
(rMT))
on
separate
days.
We
used
2
×
2
repeated
measures
analysis
variance
(ANOVA)
analyze
interaction
between
intensity
pre-
vs.
post-stimulation
paired
sample
t-tests
examine
specific
intensities.
Additionally,
spatial
correlation
was
conducted
determine
whether
altered
baseline
coupling
neurotransmitter
receptors/transporters,
investigate
potential
changes
induced
by
Our
results
indicate
that
subthreshold
rMT)
reduced
striatal
BEN,
while
suprathreshold
(120
increased
it.
Subthreshold
led
in
several
receptor/transporter
maps,
primarily
involving
serotonin
(5-HT),
cannabinoid
(CB),
acetylcholine
(ACh),
glutamate
(Glu).
findings
suggest
is
sensitive
iTBS,
with
having
distinct
activity.
Notably,
offer
more
effective
stimulation.
This
research
highlights
crucial
role
modulating
activity
lays
groundwork
future
clinical
studies
focused
optimizing
outcomes
through
precise
intensity.
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 25, 2023
Febrile
seizures
(FSs)
are
convulsions
caused
by
a
sudden
increase
in
body
temperature
during
fever.
FSs
one
of
the
commonest
presentations
young
children,
occurring
up
to
4%
children
between
ages
about
6
months
and
5
years
old.
not
only
endanger
children’s
health,
cause
panic
anxiety
families,
but
also
have
many
adverse
consequences.
Both
clinical
animal
studies
show
that
detrimental
effects
on
neurodevelopment,
attention
deficit
hyperactivity
disorder
(ADHD),
increased
susceptibility
epilepsy,
hippocampal
sclerosis
cognitive
decline
adulthood.
However,
mechanisms
developmental
abnormalities
disease
occurrence
adulthood
been
determined.
This
article
provides
an
overview
association
with
neurodevelopmental
outcomes,
outlining
both
underlying
possible
appropriate
biomarkers,
from
histological
changes
cellular
molecular
mechanisms.
The
hippocampus
is
brain
region
most
significantly
altered
after
FSs,
motor
cortex
subcortical
white
matter
may
be
involved
development
disorders
induced
FSs.
multiple
diseases
share
common
mechanisms,
long-term
role
inflammation
γ-aminobutyric
acid
(GABA)
system
currently
well
studied.
International Journal of Environmental Research and Public Health,
Journal Year:
2025,
Volume and Issue:
22(4), P. 540 - 540
Published: April 1, 2025
The
COVID-19
pandemic
has
intensified
depression
due
to
isolation
and
reduced
physical
activity,
highlighting
the
need
for
accessible
remote
treatments.
SONRIE
study
evaluates
effectiveness
of
a
12-week
online
intervention
combining
exercise
internet-based
cognitive–behavioral
therapy
on
depressive
symptoms
in
adults
with
mild-to-moderate
depression.
This
randomized
controlled
trial
involved
80
aged
25–65
years
diagnosed
according
ICD-10
criteria.
Participants
were
an
experimental
group
receiving
combined
or
control
standard
care.
primary
outcome
was
change
severity,
assessed
by
Beck
Depression
Inventory,
outcomes
measured
at
baseline,
immediately
post-intervention,
after
8-week
follow-up
phase.
Statistical
analyses
include
analysis
covariance
compare
changes
over
time,
effect
sizes
quantifying
intervention’s
impact.
demonstrates
promising
approach
treating
depression,
potential
implications
clinical
practice
public
health
strategies.
NeuroImage,
Journal Year:
2024,
Volume and Issue:
297, P. 120722 - 120722
Published: July 4, 2024
Previous
studies
have
shown
that
major
depressive
disorder
(MDD)
patients
exhibit
structural
and
functional
impairments,
but
few
investigated
changes
in
higher-order
coupling
between
structure
function.
Here,
we
systematically
the
effect
of
MDD
on
connectivity
(SC)
(FC).
Each
brain
region
was
mapped
into
embedding
vector
by
node2vec
algorithm.
We
used
support
machine
(SVM)
with
to
distinguish
from
health
controls
(HCs)
identify
most
discriminative
regions.
Our
study
revealed
had
decreased
connections
regions
local
rich-club
organization
increased
ventral
attentional
network
limbic
compared
HCs.
Interestingly,
transcriptome-neuroimaging
association
analysis
demonstrated
correlations
regional
rSC-FC
variations
HCs
α/β-hydrolase
domain-containing
6
(ABHD6),
β
1,3-N-acetylglucosaminyltransferase-9(β3GNT9),
transmembrane
protein
45B
(TMEM45B),
correlation
dSC-FC
retinoic
acid
early
transcript
1E
antisense
RNA
1(RAET1E-AS1),
iSC-FC
ABHD6,
β3GNT9,
katanin-like
2
(KATNAL2).
In
addition,
neurotransmitter
receptor/transporter
maps
found
were
both
correlated
neuroendocrine
transporter
(NET)
expression,
metabotropic
glutamate
receptor
5
(mGluR5).
Further
mediation
explored
relationship
genes,
related
variations.
These
findings
indicate
specific
genetic
molecular
factors
underpin
observed
disparities
SC-FC
confirmed
SC
FC
plays
an
important
role
diagnosing
MDD.
The
identification
new
biological
evidence
for
etiology
holds
promise
development
innovative
antidepressant
therapies.
