Exploring the Significance of Pharmaceutical Care in Mental Health: A Spotlight on Cannabis DOI Creative Commons
Claudete da Costa-Oliveira, Michele Lafayette Pereira,

Nicole Ferrari de Carvalho

et al.

Pharmacy, Journal Year: 2024, Volume and Issue: 12(4), P. 100 - 100

Published: June 27, 2024

Although preliminary evidence suggests Cannabis's efficacy in symptom control for anxiety and depression-psychiatric disorders that significantly impact mental health-much remains to be understood about its effects on the central nervous system (CNS) how optimize treatment these disorders. This study aims conduct a narrative review evaluate pharmaceutical care treating symptoms of depression alongside Cannabis use, focusing safety therapeutic optimization. We seek conceptualize disorders, quality, identify knowledge gaps. Twelve articles were identified, revealing significant gap literature regarding integration with Cannabis-based therapies, specifically depression. Despite growing interest relationship between health, current research is insufficient comprehensive understanding. The use requires further, more targeted investigations. underscores importance future fill existing gaps, providing informed insights robust guidelines safe effective as part It crucial integrates therapies responsibly improve overall well-being patients.

Language: Английский

Escitalopram reverses anxiety-like and despair behavior and affects endocannabinoid-related genes expression in the brain of adolescent male rats subjected to early life stress DOI Creative Commons

Jonasz Dragon,

Miłosz Gołyszny, Michał Zieliński

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 567, P. 96 - 108

Published: Jan. 5, 2025

Language: Английский

Citations

1

The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN) DOI Creative Commons

P. Liu,

Donghui Song, Xin‐Ping Deng

et al.

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00556 - e00556

Published: March 1, 2025

Intermittent theta burst stimulation (iTBS), a novel protocol within repetitive transcranial magnetic (rTMS), has shown superior therapeutic effects for depression compared to conventional high-frequency rTMS (HF-rTMS). However, the neural mechanisms underlying iTBS remain poorly understood. Brain entropy (BEN), measure of irregularity brain activity, recently emerged as promising marker regional function and demonstrated sensitivity HF-rTMS. Given its potential, BEN may help elucidate iTBS. In this study, we computed using resting-state fMRI data from sixteen healthy participants obtained OpenNeuro. Participants underwent over left dorsolateral prefrontal cortex (L-DLPFC) at two different intensities (90 ​% 120 resting motor threshold (rMT)) on separate days. We used 2 ​× ​2 repeated measures analysis variance (ANOVA) analyze interaction between intensity pre- vs. post-stimulation paired sample t-tests examine specific intensities. Additionally, spatial correlation was conducted determine whether altered baseline coupling neurotransmitter receptors/transporters, investigate potential changes induced by Our results indicate that subthreshold rMT) reduced striatal BEN, while suprathreshold (120 increased it. Subthreshold led in several receptor/transporter maps, primarily involving serotonin (5-HT), cannabinoid (CB), acetylcholine (ACh), glutamate (Glu). findings suggest is sensitive iTBS, with having distinct activity. Notably, offer more effective stimulation. This research highlights crucial role modulating activity lays groundwork future clinical studies focused optimizing outcomes through precise intensity.

Language: Английский

Citations

1

The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms DOI Creative Commons

You Yi,

Zhong Chen, Weiwei Hu

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: May 25, 2023

Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during fever. FSs one of the commonest presentations young children, occurring up to 4% children between ages about 6 months and 5 years old. not only endanger children’s health, cause panic anxiety families, but also have many adverse consequences. Both clinical animal studies show that detrimental effects on neurodevelopment, attention deficit hyperactivity disorder (ADHD), increased susceptibility epilepsy, hippocampal sclerosis cognitive decline adulthood. However, mechanisms developmental abnormalities disease occurrence adulthood been determined. This article provides an overview association with neurodevelopmental outcomes, outlining both underlying possible appropriate biomarkers, from histological changes cellular molecular mechanisms. The hippocampus is brain region most significantly altered after FSs, motor cortex subcortical white matter may be involved development disorders induced FSs. multiple diseases share common mechanisms, long-term role inflammation γ-aminobutyric acid (GABA) system currently well studied.

Language: Английский

Citations

11

The role of cannabinoid-mediated signaling pathways and mechanisms in brain disorders DOI
Shunfeng Liu, Zegang Ma

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111653 - 111653

Published: Feb. 1, 2025

Language: Английский

Citations

0

Internet-Based Psycho-Physical Exercise Intervention Program in Mild-to-Moderate Depression: The Study Protocol of the SONRIE Randomized Controlled Trial DOI Open Access

Juan Manuel Escudier-Vázquez,

M Ruiz-Munoz, Inmaculada Garrido-Palomino

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 540 - 540

Published: April 1, 2025

The COVID-19 pandemic has intensified depression due to isolation and reduced physical activity, highlighting the need for accessible remote treatments. SONRIE study evaluates effectiveness of a 12-week online intervention combining exercise internet-based cognitive–behavioral therapy on depressive symptoms in adults with mild-to-moderate depression. This randomized controlled trial involved 80 aged 25–65 years diagnosed according ICD-10 criteria. Participants were an experimental group receiving combined or control standard care. primary outcome was change severity, assessed by Beck Depression Inventory, outcomes measured at baseline, immediately post-intervention, after 8-week follow-up phase. Statistical analyses include analysis covariance compare changes over time, effect sizes quantifying intervention’s impact. demonstrates promising approach treating depression, potential implications clinical practice public health strategies.

Language: Английский

Citations

0

Deletion of Fgf14 confers resilience to basal and stress-induced depressive-like behavior and reduces anxiety in mice DOI Creative Commons
Francesca Montarolo, Anita Maria Rominto, L. Berrino

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 9, 2025

Language: Английский

Citations

0

Epigenetic changes caused by early life stress in the pathogenesis of depression DOI
Hongsheng Bi,

Jingyan Jin,

Mingyuan Sun

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177671 - 177671

Published: April 1, 2025

Language: Английский

Citations

0

Gastrodin Ameliorates Post-Stroke Depressive-Like Behaviors Through Cannabinoid-1 Receptor-Dependent PKA/RhoA Signaling Pathway DOI
Shiquan Wang, Liang Yu,

Haiyun Guo

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

Language: Английский

Citations

3

Elucidating genetic and molecular basis of altered higher-order brain structure-function coupling in major depressive disorder DOI Creative Commons
Haixia Long, Zihao Chen,

Xinli Xu

et al.

NeuroImage, Journal Year: 2024, Volume and Issue: 297, P. 120722 - 120722

Published: July 4, 2024

Previous studies have shown that major depressive disorder (MDD) patients exhibit structural and functional impairments, but few investigated changes in higher-order coupling between structure function. Here, we systematically the effect of MDD on connectivity (SC) (FC). Each brain region was mapped into embedding vector by node2vec algorithm. We used support machine (SVM) with to distinguish from health controls (HCs) identify most discriminative regions. Our study revealed had decreased connections regions local rich-club organization increased ventral attentional network limbic compared HCs. Interestingly, transcriptome-neuroimaging association analysis demonstrated correlations regional rSC-FC variations HCs α/β-hydrolase domain-containing 6 (ABHD6), β 1,3-N-acetylglucosaminyltransferase-9(β3GNT9), transmembrane protein 45B (TMEM45B), correlation dSC-FC retinoic acid early transcript 1E antisense RNA 1(RAET1E-AS1), iSC-FC ABHD6, β3GNT9, katanin-like 2 (KATNAL2). In addition, neurotransmitter receptor/transporter maps found were both correlated neuroendocrine transporter (NET) expression, metabotropic glutamate receptor 5 (mGluR5). Further mediation explored relationship genes, related variations. These findings indicate specific genetic molecular factors underpin observed disparities SC-FC confirmed SC FC plays an important role diagnosing MDD. The identification new biological evidence for etiology holds promise development innovative antidepressant therapies.

Language: Английский

Citations

3

Microglial morphological/inflammatory phenotypes and endocannabinoid signaling in a preclinical model of periodontitis and depression DOI Creative Commons
Javier Robledo‐Montaña, César Díaz-García, María Martínez

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Sept. 8, 2024

Language: Английский

Citations

3