From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches DOI Creative Commons
Qingmei Li, Jihan Wang,

Congzhe Zhao

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2389 - 2389

Published: Oct. 18, 2024

Osteoporosis (OP) is a prevalent skeletal disorder characterized by decreased bone mineral density (BMD) and increased fracture risk. The advancements in omics technologies—genomics, transcriptomics, proteomics, metabolomics—have provided significant insights into the molecular mechanisms driving OP. These technologies offer critical perspectives on genetic predispositions, gene expression regulation, protein signatures, metabolic alterations, enabling identification of novel biomarkers for diagnosis therapeutic targets. This review underscores potential these multi-omics approaches to bridge gap between basic research clinical applications, paving way precision medicine OP management. By integrating technologies, researchers can contribute improved diagnostics, preventative strategies, treatments patients suffering from related conditions.

Language: Английский

Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk DOI Creative Commons
Mohammad Ahmad, Louis‐Bastien Weiswald, Laurent Poulain

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: July 18, 2023

Cancer is the main cause of death worldwide and metastasis a major poor prognosis cancer-associated mortality. Metastatic conversion cancer cells multiplex process, including EMT through cytoskeleton remodeling interaction with TME. Tens thousands putative lncRNAs have been identified, but biological functions most are still to be identified. However, already emerged as key regulators gene expression at transcriptional post-transcriptional level control in spatio-temporal fashion. LncRNA-dependent mechanisms can cell fates during development their perturbed associated onset progression many diseases cancer. LncRNAs involved each step different modes action. The investigation roles could possibly lead identification new biomarkers innovative therapeutic options.

Language: Английский

Citations

65
LncRNAs: the art of being influential without protein DOI Creative Commons
Lorena Ramírez Gonzales, Suze Blom, Rossana Henriques

et al.

Trends in Plant Science, Journal Year: 2024, Volume and Issue: 29(7), P. 770 - 785

Published: Feb. 16, 2024

The plant long noncoding (lnc)RNA field is on the brink of transitioning from large-scale identification lncRNAs to their functional characterization. Due cross-kingdom conservation interaction types and molecular functions, there much be learned mammalian lncRNA research. Here, we discuss different processes involving regulation chromatin splicing. Furthermore, interactome, which includes proteins, other RNAs, DNA. We explore how functionalities could reflected in similar pathways plants hypothesize that several breakthroughs research lead discovery novel functions. Expanding our knowledge biological role multiple applications paves way for future agricultural applications.

Language: Английский

Citations

18
The Role of Chronic Inflammation in Pediatric Cancer DOI Open Access

Christine Mella,

Panogiotis Tsarouhas,

Maximillian Brockwell

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(1), P. 154 - 154

Published: Jan. 6, 2025

Inflammation plays a crucial role in wound healing and the host immune response following pathogenic invasion. However, unresolved chronic inflammation can result tissue fibrosis genetic alterations that contribute to pathogenesis of human diseases such as cancer. Recent scientific advancements exploring underlying mechanisms malignant cellular transformations cancer progression have exposed significant disparities between pediatric adult-onset cancers. For instance, cancers tend lower mutational burdens arise actively developing tissues, where cell-cycle dysregulation leads gene, chromosomal, fusion gene development not seen counterparts. As such, findings adult cannot be directly applied cancers, unique mutations inherent etiologies remain poorly understood. Here, we review processes chromosomal instability, tumor microenvironment, tumorigenesis transformation explore current therapeutic interventions maintain and/or restore inflammatory homeostasis.

Language: Английский

Citations

3
Targeting high glucose-induced epigenetic modifications at cardiac level: the role of SGLT2 and SGLT2 inhibitors DOI Creative Commons
Lucia Scisciola,

Fatemeh Taktaz,

Rosaria Anna Fontanella

et al.

Cardiovascular Diabetology, Journal Year: 2023, Volume and Issue: 22(1)

Published: Feb. 2, 2023

Abstract Background Sodium-glucose co-transporters (SGLT) inhibitors (SGLT2i) showed many beneficial effects at the cardiovascular level. Several mechanisms of action have been identified. However, no data on their capability to act via epigenetic were reported. Therefore, this study aimed investigate ability SGLT2 induce protective level by acting DNA methylation. Methods To better clarify issue, empagliflozin (EMPA) hyperglycemia-induced modifications evaluated in human ventricular cardiac myoblasts AC16 exposed hyperglycemia for 7 days. EMPA methylation NF-κB, SOD2, and IL-6 genes high glucose analyzed pyrosequencing-based analysis. Modifications gene expression NF-κB SOD2 confirmed response a transient silencing same cellular model. Moreover, chromatin immunoprecipitation followed quantitative PCR was performed evaluate occupancy TET2 across investigated regions promoters. Results Seven days treatment induced significant demethylation promoter NF-kB with consequent mRNA both genes. The observed mediated increased binding CpGs island Indeed, prevented HG-induced changes reducing region counteracted altered expression. regions, thus suggesting role as potential target anti-inflammatory antioxidant effect cardiomyocytes. Conclusions In conclusion, our results demonstrated that EMPA, mainly SGLT2, provided evidence new mechanism which SGLT2i can exert cardio-beneficial effects. Graphical

Language: Английский

Citations

30
Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals DOI Creative Commons

Felix Fiehn,

Claudia Beisel,

Marco Binder

et al.

Current Opinion in Virology, Journal Year: 2024, Volume and Issue: 67, P. 101423 - 101423

Published: June 25, 2024

Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis, with risk for the development hepatocellular carcinoma (HCC). Although highly effective direct-acting antivirals (DAAs) are available, incidence, morbidity, mortality HCV-associated HCC still high. This article reviews current knowledge mechanisms HCV-induced carcinogenesis special focus on those processes that continue after clearance outlines implications patient surveillance DAA treatment.

Language: Английский

Citations

9
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases DOI Creative Commons
Andrea Stoccoro

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 98 - 98

Published: Jan. 19, 2025

Neurodegenerative diseases are characterized by profound differences between females and males in terms of incidence, clinical presentation, disease progression. Furthermore, there is evidence suggesting that sensitivity to medical treatments may exist the two sexes. Although role sex hormones chromosomes driving differential susceptibility these well-established, molecular alterations underlying remain poorly understood. Epigenetic mechanisms, including DNA methylation, histone tail modifications, activity non-coding RNAs, strongly implicated pathogenesis neurodegenerative diseases. While it known epigenetic mechanisms play a crucial sexual differentiation distinct patterns characterize males, sex-specific have been largely overlooked studies aiming identify associated with This review aims provide an overview processes central nervous system, main three diseases, Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis. Understanding sex-related essential for developing personalized interventions account unique landscapes each sex.

Language: Английский

Citations

1
Research Progress and Clinical Translation Potential of Coronary Atherosclerosis Diagnostic Markers from a Genomic Perspective DOI Open Access
Hanxiang Liu, Yuchen Zhang,

Yueyan Zhao

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 98 - 98

Published: Jan. 18, 2025

Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid deposition, chronic inflammation, and fibrous tissue proliferation, leading to wall thickening lumen narrowing. As the primary cause of coronary heart disease acute syndrome, CAD significantly impacts global health. Recent genetic studies have demonstrated CAD’s polygenic multifactorial nature, providing molecular insights for early diagnosis risk assessment. This review analyzes recent advances in CAD-related markers evaluates their diagnostic potential, focusing on applications stratification within precision medicine. Methods: We conducted a systematic genomic from PubMed Web Science databases, analyzing findings genome-wide association (GWASs), gene sequencing, transcriptomics, epigenomics research. Results: GWASs sequencing identified key variations associated with CAD, including JCAD/KIAA1462, GUCY1A3, PCSK9, SORT1, which regulate metabolism, vascular function. Transcriptomic epigenomic analyses revealed disease-specific expression patterns, DNA methylation signatures, regulatory non-coding RNAs (miRNAs lncRNAs), new approaches detection. Conclusions: While marker research has advanced significantly, clinical implementation faces challenges dynamics, lack standardization, integration conventional diagnostics. Future should prioritize developing standardized guidelines, conducting large-scale prospective studies, enhancing multi-omics data advance diagnostics ultimately improving patient outcomes through

Language: Английский

Citations

1
Therapeutic Potential of FTO Demethylase in Metabolism and Disease Pathways DOI

Chaitanya Sree Somala,

S. Sathyapriya,

Nagaraj Bharathkumar

et al.

The Protein Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Language: Английский

Citations

1
Deciphering the epigenetic role of long non‐coding RNAs in mood disorders: Focus on human brain studies DOI Creative Commons
Bhaskar Roy,

Anuj Kumar Verma,

Yu Funahashi

et al.

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(3)

Published: March 1, 2025

Language: Английский

Citations

1
Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword DOI Creative Commons

Sina Kamrani,

Reza Naseramini,

Pouria Khani

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 26, 2025

Abstract Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within bone marrow (BM). While multiple impacts bone, it not classified as primary cancer. The microenvironment significantly influences progression its treatment response. Mesenchymal stromal (MSCs) in this environment engage with other components via direct contact secretion soluble factors. This review examines established roles MSCs facets MM pathology, encompassing their pro-inflammatory functions, contributions to tumor epigenetics, effects on immune checkpoint inhibitors (ICIs), influence reprogramming, chemotherapy resistance, senescence. investigates role development MM.

Language: Английский

Citations

1