Deleted Journal,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Nov. 13, 2023
A
new
micell-mediated
phase
separation
technique
has
been
created
to
preconcentrate
levels
of
iron
before
measuring
it
using
a
UV-Vis
spectrophotometer.
The
method
is
based
on
the
extraction
from
1-Nitroso-2-
naphthol
reagent
Triton
X-114
in
cloud
point
procedure,
where
method's
ideal
conditions
were
attained.
0.2
mL
X-114,
2.887
mmol.
L-1
1-Nitroso-2-naphthol
reagent,
pH
=
8,
60
ºC.
Iron
detection
limit
for
0.05
µg.
mL-1,
and
RSD%
4.728
mL-1.
Linearity
was
maintained
concentration
range
0.25
16
Furthermore,
interference
impact
certain
cations
assessed.
proposed
successfully
applied
determine
ion
wastewater
ten
different
stations.
eight
lifting
stations
two
treatment
center
district
Al-Hurr
Karbala
city.
In
addition,
element
study
sites
also
directly
evaluated
inductively-coupled
plasma
mass
technology.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
75, P. 103211 - 103211
Published: May 30, 2024
Ferroptosis
is
a
pervasive
non-apoptotic
form
of
cell
death
highly
relevant
in
various
degenerative
diseases
and
malignancies.
The
hallmark
ferroptosis
uncontrolled
overwhelming
peroxidation
polyunsaturated
fatty
acids
contained
membrane
phospholipids,
which
eventually
leads
to
rupture
the
plasma
membrane.
unique
that
it
essentially
spontaneous,
uncatalyzed
chemical
process
based
on
perturbed
iron
redox
homeostasis
contributing
process,
but
nonetheless
modulated
by
many
metabolic
nodes
impinge
cells'
susceptibility
ferroptosis.
Among
affecting
sensitivity,
several
have
emerged
as
promising
candidates
for
pharmacological
intervention,
rendering
ferroptosis-related
proteins
attractive
targets
treatment
numerous
currently
incurable
diseases.
Herein,
current
members
Germany-wide
research
consortium
focusing
research,
well
key
external
experts
who
made
seminal
contributions
this
rapidly
growing
exciting
field
gathered
provide
comprehensive,
state-of-the-art
review
Specific
topics
include:
basic
mechanisms,
vivo
relevance,
specialized
methodologies,
tools,
potential
contribution
disease
etiopathology
progression.
We
hope
article
will
not
only
established
scientists
newcomers
with
an
overview
multiple
facets
ferroptosis,
also
encourage
additional
efforts
characterize
further
molecular
pathways
modulating
ultimate
goal
develop
novel
pharmacotherapies
tackle
associated
-
or
caused
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 883 - 894
Published: Jan. 1, 2025
Chronic
liver
disease
ranks
as
the
11th
leading
cause
of
death
worldwide,
while
hepatocellular
carcinoma
(HCC)
is
fourth
cancer-related
mortality,
representing
a
substantial
risk
to
public
health.
Over
past
few
decades,
global
landscape
chronic
diseases,
including
hepatitis,
metabolic
dysfunction-associated
steatotic
(MASLD),
fibrosis,
and
HCC,
has
undergone
changes.
Copper,
vital
trace
element
for
human
health,
predominantly
regulated
by
liver.
Both
copper
deficiency
excess
can
lead
cellular
damage
dysfunction.
Copper
deposition
genetic
process
copper-dependent
cell
associated
with
mitochondrial
respiration,
which
cardiovascular
IBD.
However,
roles
overload
cuproptosis
in
remain
largely
underexplored.
This
article
examines
recent
studies
on
metabolism
disease,
investigating
potential
targeting
ions
therapeutic
approach.
The
objective
offer
insights
guidance
future
investigations
this
developing
field
study.
World Journal of Diabetes,
Journal Year:
2023,
Volume and Issue:
14(3), P. 147 - 158
Published: March 15, 2023
Selenium
is
a
trace
mineral
essential
for
life
that
acts
physiologically
through
selenoproteins.
Among
other
actions,
the
endogenous
antioxidant
selenoprotein
glutathione
peroxidase
and
selenium
transporter
in
blood,
P,
seem
to
play
an
important
role
type
2
diabetes
mellitus
insulin
resistance
by
weakening
signaling
cascade
different
mechanisms.
Recent
findings
also
suggest
selenoproteins
affect
biosynthesis
secretion.
This
review
discussed
of
complex
interplay
between
pathways.
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(26), P. 6082 - 6094
Published: Jan. 1, 2023
Adenosine
triphosphate
(ATP)
and
Fe3+
are
important
"signaling
molecules"
in
living
organisms,
their
abnormal
concentrations
can
be
used
for
the
early
diagnosis
of
degenerative
diseases.
Therefore,
development
a
sensitive
accurate
fluorescent
sensor
is
essential
detecting
these
signaling
molecules
biological
matrices.
Herein,
nitrogen-doped
graphene
quantum
dots
(N-GQDs)
with
cyan
fluorescence
emission
were
prepared
by
thermal
cleavage
oxide
(GO)
N,N-dimethylformamide
(DMF)
as
solvent.
The
synergistic
effect
static
quenching
internal
filtration
enabled
selective
N-GQD
Fe3+.
With
introduction
ATP,
N-GQDs-Fe3+
system
formed
more
stable
complex
ATP
via
Fe-O-P
bond,
thus
restoring
N-GQDs.
detected
linear
ranges
0-34
μM
0-10
limits
detection
(LOD)
2.38
nM
1.16
nM,
respectively.
In
addition
to
monitoring
mouse
serum
urine,
proposed
method
was
also
successfully
applied
cytoplasmic
imaging
4T1
cells
vivo
freshwater
shrimps.
Moreover,
solution
color
change-based
"AND"
logic
gate
demonstrated
matrix.
Importantly,
complete
sensing
constructed
combining
N-GQDs
hydrogel
kits
flexible
films.
Thus,
expected
serve
valuable
analytical
tool
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(1), P. 104 - 104
Published: Jan. 13, 2024
Interactions
between
proteins
and
metal
ions
their
complexes
are
important
in
many
areas
of
the
life
sciences,
including
physiology,
medicine,
toxicology.
Despite
involvement
essential
elements
all
major
processes
necessary
for
sustaining
life,
metalloproteomes
remain
ill-defined.
This
is
not
only
owing
to
complexity
metalloproteomes,
but
also
non-covalent
character
that
most
metals
form,
which
complicates
analysis.
Similar
issues
may
be
encountered
some
toxic
metals.
The
review
discusses
recently
developed
approaches
current
challenges
study
interactions
involving
entire
(sub-)proteomes
with
such
labile
ions.
In
second
part,
transition
from
fourth
fifth
periods
examined,
xenobiotic
tend
form
more
stable
and/or
inert
complexes.
A
large
research
area
this
respect
concerns
metallodrug–protein
interactions.
Particular
attention
paid
separation
approaches,
as
these
need
adapted
reactivity
under
consideration.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 2, 2024
Metal
ions
exert
pivotal
functions
within
the
human
body,
encompassing
essential
roles
in
upholding
cell
structure,
gene
expression
regulation,
and
catalytic
enzyme
activity.
Additionally,
they
significantly
influence
various
pathways
implicated
divergent
mechanisms
of
death.
Among
prevailing
malignant
tumors
digestive
tract
worldwide,
gastric
cancer
stands
prominent,
exhibiting
persistent
high
mortality
rates.
A
compelling
body
evidence
reveals
conspicuous
ion
irregularities
tumor
tissues,
cancer.
Notably,
metal
have
been
observed
to
elicit
distinct
contributions
progression,
drug
resistance,
biological
attributes
This
review
consolidates
pertinent
literature
on
involvement
etiology
advancement
Particular
attention
is
directed
towards
ions,
namely,
Na,
K,
Mg,
Ca,
Fe,
Cu,
Zn,
Mn,
elucidating
their
initiation
progression
cancer,
cellular
demise
processes,
resistance
phenomena,
therapeutic
approaches.
Nanotechnology,
Journal Year:
2024,
Volume and Issue:
35(21), P. 212001 - 212001
Published: Feb. 22, 2024
As
the
second
leading
cause
of
death
worldwide,
neoplastic
diseases
are
one
biggest
challenges
for
public
health
care.
Contemporary
medicine
seeks
potential
tools
fighting
cancer
within
nanomedicine,
as
various
nanomaterials
can
be
used
both
diagnostics
and
therapies.
Among
those
particular
interest
superparamagnetic
iron
oxide
nanoparticles
(SPIONs),
due
to
their
unique
magnetic
properties,.
However,
while
number
new
SPIONs,
suitably
modified
functionalized,
designed
medical
purposes,
has
been
gradually
increasing,
it
not
yet
translated
into
approved
clinical
solutions.
The
presented
review
covers
issues
related
SPIONs
theranostic
applications.
It
refers
structural
considerations
(the
nanoparticle
core,
most
often
modifications
functionalizations)
ways
characterizing
newly
nanoparticles.
discussion
about
phenomenon
protein
corona
formation
leads
conclusion
that
scarcity
proper
investigate
interactions
between
human
serum
proteins
is
reason
difficulties
in
introducing
them
emphasizes
importance
understanding
mechanism
behind
formation,
a
crucial
impact
on
effectiveness
physiological
environment.
