A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 155035 - 155035

Published: Aug. 16, 2023

Experimental studies emphasize the therapeutic potential of plant-derived photosensitizers used in photodynamic therapy. Moreover, several vitro and vivo research present promising roles less-known anthraquinones that can selectively target cancer cells eliminate them after light irradiation. This literature review summarizes current knowledge chosen plant-based-photosensitizers PDT to show results emodin, aloe-emodin, parietin, rubiadin, hypericin, soranjidiol therapy treatment describe comprehensive perspective their role as natural photosensitizers.Literature searches were conducted on PubMed.gov with keywords: "emodin", "aloe-emodin", "hypericin", "parietin", "rubiadin", "soranjidiol" "cancer" "photodynamic therapy".According data, this concentrated all existing emphasizing effectiveness detailed mechanism action anticancer preclinical clinical hypericin reveal above-described substances may be included phototoxic different cancers.Overall, presented molecular mechanisms action. It is expected future they PSs well hypericin.

Language: Английский

---

Emodin‐Based Nanoarchitectonics with Giant Two‐Photon Absorption for Enhanced Photodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(33)

Published: June 26, 2023

Abstract Two‐photon‐excited photodynamic therapy (TPE‐PDT) has significant advantages over conventional (PDT). However, obtaining easily accessible TPE photosensitizers (PSs) with high efficiency remains a challenge. Herein, we demonstrate that emodin (Emo), natural anthraquinone (NA) derivative, is promising PS large two‐photon absorption cross‐section (TPAC: 380.9 GM) and singlet oxygen ( 1 O 2 ) quantum yield (31.9 %). When co‐assembled human serum albumin (HSA), the formed Emo/HSA nanoparticles (E/H NPs) possess giant TPAC (4.02×10 7 desirable generation capability, thus showing outstanding TPE‐PDT properties against cancer cells. In vivo experiments reveal E/H NPs exhibit improved retention time in tumors can ablate at an ultra‐low dosage (0.2 mg/kg) under 800 nm femtosecond pulsed laser irradiation. This work beneficial for use of extracts NAs high‐efficiency TPE‐PDT.

Language: Английский

---

Aloe vera―An Extensive Review Focused on Recent Studies

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2155 - 2155

Published: July 8, 2024

Since ancient times,

Language: Английский

---

Exploring Aloe vera: A comprehensive review on extraction, chemical composition, biological effects, and its utilization in the synthesis of metallic nanoparticles

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 57, P. 103052 - 103052

Published: Feb. 6, 2024

Language: Английский

---

Photoactive Herbal Compounds: A Green Approach to Photodynamic Therapy

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5084 - 5084

Published: Aug. 10, 2022

Photodynamic therapy (PDT) is a minimally invasive, alternative, and promising treatment for various diseases, including cancer, actinic keratosis, Bowen’s disease, macular degeneration, atherosclerotic plaques. PDT involves three different components, photosensitizers (PS), molecular oxygen, light. The photoactivation of administered PSs using specific wavelength light in the presence oxygen leads to generation reactive species that tumour cell death. Photosensitizing potentials many commercially available compounds have been reported earlier. However, possibilities herbal medicines, which contain photosensitizing phytochemicals, are not much explored. Medicinal plants with complex phytochemical compound mixtures benefit over single or molecules diseases low reduced toxic side effects. This review emphasizes role medicines either alone combination enhance therapeutic outcome photodynamic therapy.

Language: Английский

---

Hypericin-Based Photodynamic Therapy Displays Higher Selectivity and Phototoxicity towards Melanoma and Squamous Cell Cancer Compared to Normal Keratinocytes In Vitro

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16897 - 16897

Published: Nov. 29, 2023

The aim of this study was to explore the potential hypericin, a naturally occurring photosensi-tizer, for photodynamic therapy (PDT) in skin cancer, investigating its phototoxic effects and mechanisms action cancer cells compared normal keratinocytes, squamous cell (SCC-25) melanoma (MUG-Mel2) cells. Hypericin applied at concentrations ranging from 0.1–40 μM HaCaT, SCC-25, MUG-Mel2 After 24 h incubation, were exposed orange light 3.6 J/cm2 or 7.2 J/cm2. Phototoxicity assessed using MTT SRB tests. Cellular uptake measured by flow cytometry. Apoptosis-positive estimated through TUNEL apoptotic bodies’ visualization. exhibited higher reaction keratinocytes after irradiation. Cancer demonstrated increased selective hypericin. Apoptosis observed SCC-25 following PDT. Our findings suggest that hypericin-based PDT is promising less invasive approach treating cancer. reaction, cells, proapoptotic properties support role treatment.

Language: Английский

---

Isolation and Identification of Endophytic Fungi from Aloe vera Leaves and Chemical Analysis of the Alcoholic Extract of the Leaves Using HPLC, GC, and GC-Mass Devices

Ibn AL- Haitham Journal For Pure and Applied Science, Journal Year: 2024, Volume and Issue: 37(1), P. 101 - 117

Published: Jan. 20, 2024

The study's goals were to separate and identify endophytic fungi from Aloe vera leaves by looking at their morphology molecules, as well find the chemical compounds in leaf extract using HPLC, GC, GC-Mass instruments. results showed that 53 isolated a total of 120 pieces A. leaves, with colonization rate 44.16%. fungus Aspergillus terreus had 14.16%; niger 13.33%; Penicillium chermesinum demonstrated 6.66%; Paecilomyces variotii 2.5%; Talaromyces radicus; flavus achieved 1.66%. Finally, quadrilineatus, verruculosus, Neoscytalidium dimidiatum, Alternaria solani, niveus 0.83%. examining alcoholic HPLC device presence aloin concentration 125.39 ppm aloe emodin 66.59 ppm. We looked GC machine found group fatty acids. These included linoleic, oleic, palmitic, stearic. GC-MS test revealed active compounds, including Heptane, 1-(ethenylthio), Ethanedicarboxamide, N-allyl-N'-(2,5-dimethylphenyl), 2H-Pyran, 2-(3-butynyloxy) tetrahydro, 1,2-Cyclobutanedicarboxylic acid, 3-methyl-dimethyl ester 4 (1H)-Pyrimidinone, 2-(propylthio). which effective enzymes or can be could probably have an important role future medical therapeutic uses. Also, plant medicinal uses for many diseases.

Language: Английский

---

Aloe-emodin: Progress in Pharmacological Activity, Safety, and Pharmaceutical Formulation Applications

Mini-Reviews in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(19), P. 1784 - 1798

Published: April 19, 2024

Abstract: Aloe-emodin (AE) is an anthraquinone derivative and a biologically active component sourced from various plants, including Rheum palmatum L. Aloe vera. Known chemically as 1,8-dihydroxy-3-hydroxymethyl-anthraquinone, AE has rich history in traditional medicine esteemed for its accessibility, safety, affordability, effectiveness. boasts multiple biochemical pharmacological properties, such strong antibacterial, antioxidant, antitumor effects. Despite array of benefits, AE's identity raises concerns about potential liver kidney toxicity. Nevertheless, considered promising drug candidate due to significant bioactivities cost efficiency. Recent research highlighted that nanoformulated may enhance delivery, biocompatibility, offering novel approach design. This review delves into impacts, mechanisms, pharmacokinetics, safety profile, incorporating insights studies on nanoformulations. The goal outline the burgeoning this area support ongoing development utilization AE-based therapies.

Language: Английский

---

Natural Photosensitizers

Springer eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: Jan. 1, 2025

Language: Английский

---

Emodin exhibits anti-acne potential by inhibiting cell growth, lipogenesis, and inflammation in human SZ95 sebocytes

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 7, 2023

Emodin, a natural anthraquinone derivative, possesses anti-proliferative and anti-inflammatory properties in skin diseases. However, little information is available on the efficacy of emodin treating acne vulgaris (acne). This study aims to investigate protective effects potential mechanisms as an anti-acne agent. In vitro, SZ95 sebocytes was chose establish acneigenic cellular model. We found that effectively inhibited proliferation, induced cell cycle arrest apoptosis dose-dependent manner. To evaluate lipid-lowering emodin, we examined levels lipid contents lipogenic transcription factors, both production protein expression PPARγ, LXR α/β, SREBP-1 were decreased after treatment with emodin. Furthermore, our results revealed sebaceous lipogenesis by insulin-like growth factor 1 (IGF-1), which accompanied potent inhibition phosphoinositide-3-kinase (PI3K)/Akt/forkhead box O1 (FoxO1) pathway. detail, augmented inhibitory effect isotretinoin PI3K inhibitor LY294002, while attenuating activation IGF-1 PI3K/Akt/FoxO1 addition, could decrease secretion pro-inflammatory cytokines IL-6 IL-8, suppress NLRP3, capase-1, IL-1β, IL-18 exposed Cutibacterium acnes. Overall, provides preliminary evidence supporting anti-growth, anti-lipogenic indicating therapeutic application for treatment.

Language: Английский

---