Effects of Dietary Supplementation with Mulberry Leaf Powder on the Growth Performance, Lipid Metabolism Parameters, Immunity Indicators, and Gut Microbiota of Dogs DOI Creative Commons
Aiying Yu,

Cuiming Tang,

Sutian Wang

et al.

Metabolites, Journal Year: 2023, Volume and Issue: 13(8), P. 918 - 918

Published: Aug. 4, 2023

Overfeeding and a lack of exercise are increasingly causing obesity in dogs, which has become big problem threatening the health dogs. Therefore, it is necessary to investigate how dietary regulations can help improve dogs’ body conditions minimize obesity. This study was carried out effects mulberry leaf powder (MLP) supplementation on growth performance, lipid metabolism parameters, gut microbiota Chinese indigenous Fifteen dogs (6.34 ± 0.56 kg) were randomly assigned three treatment groups received either control diet (CON), high-fat (HF), or containing 6% Mulberry for four weeks. The CON group basal diet, HF supplemented with 10% lard, MLP lard MLP. trial lasted immune globulins, cytokines, fecal measured. Results showed that there no significant difference performance. appeared have decreased (p < 0.05) serum level low-density lipoprotein cholesterol (LDL-C) apoliprotein-A1(APO-A1) serum. higher globulin A (IgA) levels. UPGMA results closer than group. LEfSe analysis contributed an alteration genus Alloprevotella, Sarcina, species belonging Bacteroides Lactobacillus genus. Overall, immunity high-fat-diet-fed alter microbial composition

Language: Английский

Flavonoids as Antidiabetic and Anti-Inflammatory Agents: A Review on Structural Activity Relationship-Based Studies and Meta-Analysis DOI Open Access
Nur Farisya Shamsudin, Qamar Uddin Ahmed, Syed Mahmood

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12605 - 12605

Published: Oct. 20, 2022

Flavonoids are a group of naturally occurring polyphenolic secondary metabolites which have been reported to demonstrate wide range pharmacological properties, most importantly, antidiabetic and anti-inflammatory effects. The relationship between hyperglycaemia inflammation vascular complications in diabetes is now well established. possessing properties may alleviate by reducing through different mechanisms action. It has suggested that the flavonoids’ biochemical structure-dependent; however, they yet be thoroughly grasped. Hence, main aim this review understand various structurally diverse flavonoids identify key positions responsible for effects, their correlation, effect substitutions on both properties. general requirement exerting effects found presence C2–C3 double bond (C-ring) hydroxyl groups at C3’, C4’, C5, C7 rings A B flavonoid skeleton. Furthermore, it demonstrated substitution C3 position C-ring decreases action while enhancing activity. Correlation discussed length support essential pharmacophores equipotent consideration these structural features play an important role synthesizing better flavonoid-based drugs dual meta-analysis further established as agents.

Language: Английский

Citations

105
Antioxidant and Anti-Inflammatory Activity on LPS-Stimulated RAW 264.7 Macrophage Cells of White Mulberry (Morus alba L.) Leaf Extracts DOI Creative Commons

Sureeporn Suriyaprom,

Pitchayuth Srisai,

Varachaya Intachaisri

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(11), P. 4395 - 4395

Published: May 28, 2023

The white mulberry (Morus alba L.) is widely used as a medicinal plant in Asia. In this study, the bioactive compounds of ethanolic extracts leaves from Sakon Nakhon and Buriram cultivars were evaluated. cultivar showed highest total phenolic content 49.68 mg GAE/g extract antioxidant activities 4.38 extract, 4.53 TEAC/g 92.78 FeSO4/g using 2,2 diphenyl-1-picrylhydrazyl (DPPH), 2,20-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid) (ABTS), ferric reducing power (FRAP) assays, respectively. resveratrol oxyresveratrol also investigated by high-performance liquid chromatography (HPLC). leaf contents 1.20 ± 0.04 mg/g 0.39 0.02 respectively, whereas was not detected. It found that potent anti-inflammatory properties its compounds, oxyresveratrol, suppressed LPS-stimulated inflammatory responses RAW 264.7 macrophage cells significantly nitric oxide production concentration-dependent manner. These further inhibited interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) mRNA protein expression inducible synthase (iNOS) cyclooxygenase-2 (COX-2) cells. Therefore, it established contribute to activity.

Language: Английский

Citations

31
Mulberry leaf and its effects against obesity: A systematic review of phytochemistry, molecular mechanisms and applications DOI
Ruilin Li, Jia Wang, Junyu Liu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155528 - 155528

Published: March 11, 2024

Language: Английский

Citations

9
Biosynthesis and Pharmacological Activities of the Bioactive Compounds of White Mulberry (Morus alba): Current Paradigms and Future Challenges DOI Creative Commons

Maryam Fatima,

Mudasir A. Dar, Maruti J. Dhanavade

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(7), P. 506 - 506

Published: July 7, 2024

Traditional natural products have been the focus of research to explore their medicinal properties. One such medicinally important plant is white mulberry,

Language: Английский

Citations

8
Enhancing the antioxidant and anti-inflammatory potentials of mulberry-derived postbiotics through submerged fermentation with B. subtilis H4 and B. amyloliquefaciens LFB112 DOI Creative Commons
Zaheer Abbas,

Yucui Tong,

Jing Zhang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 60, P. 104252 - 104252

Published: May 5, 2024

Mulberry-derived postbiotics (MDP) have been scientifically proven to possess beneficial properties for human health, making them potential nutraceuticals. This study aims enhance the antioxidant and anti-inflammatory effect of MDP via submerged fermentation with Bacillus subtilis H4 (H4) amyloliquefaciens LFB112 (LFB112) bacterial strains. Our results demonstrated compelling evidence that combination two strains optimized time (24 hours), inoculum size (8%), substrate (10%) significantly increased 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activities. When compared non-fermented mulberry (NFM), above-optimized conditions showed substantially higher activities such as DPPH, 2,2'-Azino-bis (3-ethylebenzothiazoline-6-sulfonic acid) (ABTS), hydroxyl activities, reducing power capabilities. Moreover, a significant decrease in lipopolysaccharides (LPS)-induced reactive oxygen species (ROS) generated RAW264.7 cells. The antibacterial assays minimum inhibitory concentrations (MICs) bactericidal (MBCs) possesses activity against various pathogenic lowest MIC recorded 32.5 mg/ml S. pullorum CVCC519, while highest observed was 40 P. aeruginosa. MBCs were 55 aureus ATCC43300 CVCC519 respectively. Furthermore, good ant-inflammatory by nitric oxide (NO) concentration (p<0.0001) mRNA expression proinflammatory cytokines response LPS-induced inflammation macrophage cell line. To sum up, our findings indicate novel can be utilized both functional food safe feed additive, possibly benefiting gut metabolic health.

Language: Английский

Citations

5
Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo DOI Open Access
Kun Shi,

Yangxin Xiao,

Yan Dong

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 16134 - 16134

Published: Dec. 17, 2022

Acute lung injury (ALI) is a syndrome caused by an excessive inflammatory response characterized intractable hypoxemia both inside and outside the lung, for which effective therapeutic drugs are lacking. Atractylodis rhizoma, traditional Chinese medicine, has excellent anti-inflammatory antiviral properties in addition to protecting integrity of cellular barrier. However, few studies rhizoma treatment ALI have been published, its mechanism action remains unclear. In present study, chemical composition ethanolic extract (EEAR) was initially clarified high performance liquid chromatography (HPLC), after it studied vivo using lipopolysaccharide (LPS)-induced rat model. Treatment with EEAR significantly reduced wet/dry (W/D) ratio, neutrophil infiltration, malondialdehyde (MDA) myeloperoxidase (MPO) formation, enhanced superoxide dismutase (SOD) glutathione (GSH) depletion rats ALI, thereby improving barrier function effectively reducing injury. addition, histopathological changes, decreased expression factors (such as tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), inducible nitric oxide synthase (INOS), cyclooxygenase-2 (COX-2)), inhibited activation NF-κB signaling pathway, thus inflammation. found also reduce oxidative stress upregulating nuclear factor erythroid 2-related 2 (Nrf2) downstream proteins heme oxygenase-1 (HO-1) NADPH quinone acceptor oxidoreductase 1 (NQO-1). LPS-induced THP-1 cells vitro inhibition damage from promoting Nrf2 targets HO-1 NQO-1, molecular consistent observations. Therefore, we conclude that attenuates responses via TLR4/NF-κB Keap1/Nrf2 pathways alleviate suggesting potential drug candidate ALI.

Language: Английский

Citations

20
Impact of fermentation through synergistic effect of different lactic acid bacteria (mono and co-cultures) on metabolic and sensorial profile of mulberry juice DOI
Sanabil Yaqoob,

Aysha Imtiaz,

Kanza Aziz Awan

et al.

Journal of Food Measurement & Characterization, Journal Year: 2024, Volume and Issue: 18(11), P. 9364 - 9384

Published: Oct. 8, 2024

Language: Английский

Citations

4
Efficacy analysis and research progress of complementary and alternative medicines in the adjuvant treatment of COVID-19 DOI Creative Commons
Jaung‐Geng Lin, Guan‐Jhong Huang, Yi‐Chang Su

et al.

Journal of Biomedical Science, Journal Year: 2023, Volume and Issue: 30(1)

Published: May 3, 2023

Abstract The coronavirus disease 2019 (COVID-19) pandemic has impacted human lifestyles around the world, causing huge distress in terms of public health systems, emergency response capacity and economic development. causative agent COVID-19, severe acute respiratory syndrome 2 (SARS-CoV-2), is associated with involvement, cardiovascular-related diseases, ultimately causes multiple organ failure death severely affected individuals. Thus, effective prevention or early treatment COVID-19 critical. An vaccine offers a way out for governments, scientific community people worldwide, but we still lack drug therapies, including treatments COVID-19. This had led to high global demand many complementary alternative medicines (CAMs). Moreover, healthcare providers are now requesting information about CAMs that prevent, relieve, treat symptoms even alleviate vaccine-related side effects. Experts scholars must therefore become familiar use current research directions effectiveness narrative review updates status worldwide on provides reliable evidence theoretical viewpoints therapeutic efficacies CAM combinations, support strategy Taiwan Chingguan Erhau (NRICM102) against moderate-to-severe novel infectious Taiwan.

Language: Английский

Citations

10
Innovative antifungal Therapy: In vivo evaluation of 3-Ethyl-6,7-Dihydroxy-2-Phenyl-Chromen-4-One purified from Alpinia officinarum on Cryptococcus neoformans DOI

Basma Amin,

Sobhy E. Elsilk,

S. E. Nasr

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 149, P. 114163 - 114163

Published: Feb. 4, 2025

Language: Английский

Citations

0
Integrated Macrogenomics and Metabolomics Analysis of the Effect of Sea Cucumber Ovum Hydrolysates on Dextran Sodium Sulfate-Induced Colitis DOI Creative Commons

Shunmin Gong,

Liqin Sun,

Yongjun Sun

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 73 - 73

Published: Feb. 7, 2025

Inflammatory bowel disease remains a significant challenge in clinical settings. This study investigated the therapeutic potential of sea cucumber ovum hydrolysates (SCH) dextran sulfate sodium (DSS)-induced colitis mouse model. SCH, defined by its elevated stability and solubility, with molecular weight below 1000 Da, significantly alleviated DSS-induced colitis, as evidenced enhanced splenic index, reduced colonic damage, diminished serum pro-inflammatory cytokines. Furthermore, macrogenomic analysis demonstrated that SCH increased beneficial gut microbes decreased bacteria. metabolomic tissues identified levels anti-inflammatory metabolites, such Phenyllactate, 2-Hydroxyglutarate, L-Aspartic acid, mice after oral administration SCH. In conclusion, represents promising candidate for treatment colitis.

Language: Английский

Citations

0