A Comprehensive Review of Estradiol, Progesterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in the Context of Laboratory Medicine to Support Women's Health DOI
Dina N. Greene, Sofia B. Ahmed,

Sarah Daccarett

et al.

Clinical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Background There have been conflicting messages about the influence of female sex hormones on women's health, with historical messaging indicating that use estrogen and/or progesterone in peri- or postmenopause poses a significant clinical risk to cisgender women. More recent guidance indicates benefit hormone therapy (HT) outweighs risks for symptomatic Exogenous is also indicated contraception and gender-affirming care. Despite potential broad applications, robust reference intervals estradiol, progesterone, luteinizing (LH) follicle-stimulating (FSH) are lacking, guidelines indicate measurement 17-β-estradiol (E2), LH, FSH does not facilitate care women who may be experiencing menopausal symptoms taking exogenous HT. Content Here we review physiological roles estrogen, FSH. We examine modes administration clarify nomenclature related use, comprehensively literature studies evaluating normal concentrations these gonadal axis during menstrual cycle. The content primarily focuses women, but some aspects transgender will discussed. Summary Currently, E2, FSH, remain incomplete. Although there variety indications using HT, shared decision-making should guide Collaborative efforts between clinicians laboratory professionals better define therapeutic can advance health globally.

Language: Английский

Adipose Tissue Sex Steroids in Postmenopausal Women with and without Menopausal Hormone Therapy DOI Creative Commons
Natalia Hetemäki,

Alexandra Robciuc,

Veera Vihma

et al.

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Context The decrease in serum estrogens after menopause is associated with a shift from gynoid to an android adipose tissue (AT) distribution. Menopausal hormone therapy (HT) mitigates this change and accompanying metabolic dysfunction, but its effects on AT sex steroid metabolism have not been characterized. Objective We studied of HT subcutaneous visceral estrogen androgen concentrations postmenopausal women. Design, setting, patients, interventions Serum 63 women (n = 50) without 13) per oral were analyzed for estrone, estradiol, progesterone, testosterone, androstenedione, dehydroepiandrosterone, estrone sulfate using liquid chromatography-tandem mass spectrometry. Steroid sulfatase activity was measured radiolabeled precursors. mRNA expression genes encoding steroid-metabolizing enzymes receptors performed real-time reverse transcription quantitative polymerase chain reaction. Results users had 4- 7-fold higher estradiol AT, 30% lower testosterone compared nonusers. Estrogen-to-androgen ratios 12-fold nonusers HT. In estrogen-to-androgen increased dose. remained high users. Conclusion Higher local suggest that may significantly influence intracrine AT; these changes could be involved the preventive effect menopause-associated abdominal adiposity.

Language: Английский

Citations

7
S-doped ZnO photoelectrode modified with silver and platinum nanoparticles and their photocatalytic activity for progesterone degradation DOI

Jailson S. Luis,

Samuel S. Eduardo,

Maria Joseíta dos Santos Costa

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1305, P. 137764 - 137764

Published: Feb. 9, 2024

Language: Английский

Citations

6
Nocturia in Menopausal Women: The Link Between Two Common Problems of the Middle Age DOI
Kim Pauwaert,

An‐Sofie Goessaert,

Dudley Robinson

et al.

International Urogynecology Journal, Journal Year: 2024, Volume and Issue: 35(5), P. 935 - 946

Published: March 4, 2024

Language: Английский

Citations

6
Exploring a Possible Interplay between Schizophrenia, Oxytocin, and Estrogens: A Narrative Review DOI Creative Commons
Danae Papadea, Christina Dalla, Despina Α. Tata

et al.

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(3), P. 461 - 461

Published: March 8, 2023

Schizophrenia is characterized by symptoms of psychosis and sociocognitive deficits. Considering oxytocin’s antipsychotic prosocial properties, numerous clinical, preclinical studies have explored the neuropeptide’s therapeutic efficacy. Sex differences in clinical course schizophrenia, as well oxytocin-mediated behaviors, indicate involvement gonadal steroid hormones. The current narrative review aimed to explore empirical evidence on interplay between schizophrenia psychopathology potential consideration female interactions, with a focus estrogens. was conducted using PubMed PsychINFO databases conforms Scale for Assessment Narrative Review Articles (SANRA) guidelines. results suggest synergistic effect combined oxytocin neuroprotective estrogen schizophrenia. Consideration typical menstrual cycle-related hormonal changes warranted further research needed confirm this assumption.

Language: Английский

Citations

11
The impact of 17β-estradiol on the estrogen-deficient female brain: from mechanisms to therapy with hot flushes as target symptoms DOI Creative Commons
Katalin Prókai‐Tátrai, László Prókai

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Sex steroids are essential for whole body development and functions. Among these steroids, 17β-estradiol (E2) has been known as the principal "female" hormone. However, E2's actions not restricted to reproduction, it plays a myriad of important roles throughout including brain. In fact, this hormone also profound effects on female brain life span. The receives gonadal from circulation, local formation E2 testosterone

Language: Английский

Citations

4
Effect of ambient lead on progesterone and pregnancy-associated glycoprotein 1 and their relationship with abortion in Zaraibi goats: a field study DOI Creative Commons

Abrar F. Mosaad,

Sayed M. El-Nakhla,

Ferial H. Abd El-Rasoul

et al.

Tropical Animal Health and Production, Journal Year: 2024, Volume and Issue: 56(1)

Published: Jan. 1, 2024

This study aimed to investigate the impact of ambient lead (Pb) exposure on progesterone (P

Language: Английский

Citations

4
Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality DOI Creative Commons
Yiqiu Wei, Zhourui Zhang, Yaoyao Zhang

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: May 30, 2023

Endometriosis is a common, estrogen-dependent chronic gynecological disease that endangers the reproductive system and systemic metabolism of patients. We aimed to investigate differences in metabolic profiles follicular fluid between infertile patients with endometriosis controls. A total 25 controls who were similar age, BMI, fertilization method ovulation induction treatment recruited this study. Metabolomics analysis was performed by two methods high-performance liquid chromatography tandem mass spectrometry. There 36 upregulated 17 downregulated metabolites group. KEGG pathway revealed these enriched phenylalanine, tyrosine tryptophan biosynthesis, aminoacyl-tRNA phenylalanine pyrimidine pathways. biomarker panel consisting 20 constructed random forest, an accuracy 0.946 AUC 0.988. This study characterizes associated endometriosis. These findings can provide better comprehensive understanding new direction for oocyte quality, as well potential markers prognosis

Language: Английский

Citations

10
Effect-based analysis of endocrine effects in surface and ground water with focus on progestagenicity using Arxula yeast-based reporter gene assays DOI Creative Commons
Michelle Klein,

Melissa Reibold,

Petra Reinders

et al.

Environmental Toxicology and Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The use of effect-based methods in water monitoring for identifying risks to aquatic organisms and human health is important aiding regulatory decisions. In the past decades, database on monitoring, especially surface waters, has grown as this environment openly exposed various contamination sources. With regard endocrine disruption, estrogenic androgenic effects have been primarily investigated. Here, yeast-based bioassays emerged potent tools, offering sensitivity environmentally relevant concentrations high robustness. objectives study were investigate further endpoints extend ground waters. inclusion progestagenic crucial due their multifaceted roles functions organisms. Hence, three different Arxula-yeast hormone screens (estrogen, androgen, progesterone receptors) applied, revealing simultaneous exposure diverse matrices. Although effect profiles waters showed mainly activation receptors, in-ground samples inhibitory clearly predominate. toxicological thresholds are not yet legally binding, they essential effective measures risk management ensure good ecological status ecosystems. results compared with trigger values well assessment depending sample matrix, none which exceeded.

Language: Английский

Citations

0
Treatment of threatened pregnancy loss DOI Creative Commons

Anna Maria Kastner,

Christoph Lindner,

Ida Behrendt-Møller

et al.

Ugeskrift for Læger, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Jan. 6, 2025

Vaginal bleeding in the first trimester indicates threatened pregnancy loss and may be due to progesterone insufficiency. micronised (400 mg vaginal tablets twice a day) can increase live birth rates is recommended for women with history of three or more losses (number needed treat = 8). It should considered one 20) two losses. Insufficient data exist recommend other treatments such as tranexamic acid bed rest.

Language: Английский

Citations

0
Weight Management for Fertility-Preservation Therapy in Endometrial Cancer: Opportunities and Challenges DOI
Xiaodan Li,

YiQian Chen,

Xiaowei Li

et al.

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

0