Effect of tea polyphenols on the prevention of neurodegenerative diseases through gut microbiota DOI Creative Commons
Lei Xu, Rui Wang, Yanan Liu

et al.

Journal of Functional Foods, Journal Year: 2023, Volume and Issue: 107, P. 105669 - 105669

Published: July 5, 2023

Tea polyphenols (TPs) have shown several memory-enhancing activities. The gut microbiota is essential in developing neurodegenerative diseases as a critical regulator of brain-gut axis function. the modulates neuronal activity and activates microglia through immune system, amino acid metabolism, visceral nerves, thereby exerting regulatory effect on brain TPs advantage multi-targeting, high safety profiles compared to drugs great potential preventing treating diseases. In addition, they can effectively modulate composition microbiota. Studies been undertaken into mechanisms related preventative mediated by This review discussed preventive mechanism modulating host microbiota, may be regarded neuroprotective substances with efficiency.

Language: Английский

The Importance of Dietary Antioxidants on Oxidative Stress, Meat and Milk Production, and Their Preservative Aspects in Farm Animals: Antioxidant Action, Animal Health, and Product Quality—Invited Review DOI Creative Commons
Eric N. Ponnampalam, Ali Kiani, Sarusha Santhiravel

et al.

Animals, Journal Year: 2022, Volume and Issue: 12(23), P. 3279 - 3279

Published: Nov. 24, 2022

The biological effects of oxidative stress and associated free radicals on farm animal performance, productivity, product quality may be managed via dietary interventions—specifically, the provision feeds, supplements, forages rich in antioxidants. To optimize this approach, it is important first to understand development their contributions tissue systems animals or human body. interactions between prooxidants antioxidants will impact redox homeostasis and, therefore, well-being animals. radical formation oxidation lipids, proteins, DNA, biologically macromolecules likewise meat milk quality, nutritional value, longevity. Dietary antioxidants, endogenous metal-binding proteins contribute ‘antioxidant defenses’ that control within systems. Different bioactive compounds varying antioxidant potential bio-accessibility sourced from tailored feeding Informed successful can help alleviate stress. However, knowledge pertaining animals, unique systems, applications novel specialized forages, compounds, etc., must established. This review summarized current research direct future studies towards more effective controls for formation/oxidative so productivity optimized.

Language: Английский

Citations

139
Modulation of gut‐microbiota through probiotics and dietary interventions to improve host health DOI Creative Commons
Vaishali Dasriya, Mrinal Samtiya, Soniya Ranveer

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: 104(11), P. 6359 - 6375

Published: Feb. 9, 2024

Dietary patterns play an important role in regards to the modulation and control of gut microbiome composition function. The interaction between diet microbiota plays order maintain intestinal homeostasis, which ultimately affect host's health. Diet directly impacts microbes that inhabit gastrointestinal tract (GIT), then contributes production secondary metabolites, such as short-chain fatty acids, neurotransmitters, antimicrobial peptides. consumption with genetically modified probiotics can be best vaccine delivery vector protect cells from various illnesses. A holistic approach disease prevention, treatment, management takes these intrinsically linked diet-microbes, microbe-microbe interactions, microbe-host interactions into account. components, fiber modulate beneficial microbiota, they have resulting ameliorative effects against metabolic disorders. Medical interventions, antibiotic drugs conversely detrimental on by disputing balance Bacteroides firmicute, contribute continuing states. We summarize known dietary fibers, carbohydrates, vitamins, minerals, proteins, phenolic antibiotics this article addition effect consequentially their shaping human © 2024 Authors. Journal Science Food Agriculture published John Wiley & Sons Ltd behalf Society Chemical Industry.

Language: Английский

Citations

34
Ecological and environmental determinants of phytochemical variability in forest trees DOI Creative Commons
Matthew Chidozie Ogwu, Sylvester Chibueze Izah, Marcella Tari Joshua

et al.

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

5
Flavonoids as promising molecules in the cancer therapy: An insight DOI Creative Commons
Suhail Ahmad Mir, Ashraf Dar, Laraibah Hamid

et al.

Current Research in Pharmacology and Drug Discovery, Journal Year: 2023, Volume and Issue: 6, P. 100167 - 100167

Published: Dec. 8, 2023

Cancer continues to increase global morbidity and mortality rates. Despite substantial progress in the development of various chemically synthesized anti-cancer drugs, poor prognosis disease still remains a big challenge. The most common drawback conventional cancer therapies is emergence drug resistance eventually leading discontinuation chemotherapy. Moreover, advanced target-specific including immunotherapy stem cell therapy are expensive enough unaffordable for patients poorer nations. Therefore, alternative cheaper therapeutic strategies needed complement current treatment approaches. Phytochemicals bioactive compounds produced naturally by plants have great potential human health disease. These possess antiproliferative, anti-oxidant, immunomodulatory properties. Among phytochemicals, flavonoids very effective treating wide range diseases from cardiovascular immunological disorders cancer. They scavenge reactive oxygen species (ROS), inhibit metastasis, modulate immune system induce apoptotic or autophagic death cancers. This review will discuss phytochemicals particularly attempts target

Language: Английский

Citations

36
Antiaging effects of dietary supplements and natural products DOI Creative Commons

Lulu Gao,

Xudong Liu, Xiaoyan Luo

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social economic development in recent decades, proportion of elderly has increased rapidly worldwide, many aging-related diseases have shown upward trend, including nervous system diseases, cardiovascular metabolic cancer. The rising burden become urgent global health challenge requires immediate attention solutions. Natural products been used for a long time to treat various human diseases. primary cellular pathways that mediate longevity-extending effects natural involve nutrient-sensing pathways. Among them, sirtuin, AMP-activated protein kinase, mammalian target rapamycin, p53, insulin/insulin-like growth factor-1 signaling are most widely studied. Several studies reviewed individual compounds on aging along with underlying mechanisms. from food sources, such as polyphenols, saponins, alkaloids, polysaccharides, classified antiaging promote prolong life via In this article, we several recently identified potential properties highlighted their molecular discovery use dietary supplements can prevent multiple humans will be beneficial. Thus, review provides theoretical background existing agents.

Language: Английский

Citations

32
Impact of nanotechnology on the oral delivery of phyto-bioactive compounds DOI Open Access
Hamdi Nsairat, Zainab Lafi, Mazen Al-Sulaibi

et al.

Food Chemistry, Journal Year: 2023, Volume and Issue: 424, P. 136438 - 136438

Published: May 22, 2023

Language: Английский

Citations

30
Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate DOI Open Access
Hosam M. Habib, Hamada El‐Gendi, Esmail M. El‐Fakharany

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2709 - 2709

Published: June 11, 2023

Pomegranate juice concentrate (PJC) is a rich source of polyphenols, which exhibit significant antioxidant activity and potential health benefits for disease prevention therapy. In this study, the polyphenolic profile PJC was investigated first time, it found that can inhibit oxidative damage to bovine serum albumin (BSA) deoxyribonucleic acid (DNA), as well acetylcholinesterase, α-amylase, tyrosinase activities. The primary polyphenols identified in were 4-Hydroxy-3-Methoxybenzoate, epicatechin, catechin, rutin, ferulic acid, P-coumaric cinnamic acid. Additionally, demonstrated potent antibacterial effects against human pathogens such Streptococcus mutans Aeromonas hydrophila dose-dependently reduced proliferation colorectal, breast, hepatic cancer cells via apoptosis. Furthermore, blocked B-cell lymphoma 2 (BCl-2) expression cyclin-dependent kinase inhibitor (P21) enhanced tumor protein (P53) expression, compared both untreated treated with fluoropyrimidine 5-fluorouracil (5-FU). As result, may be beneficial ingredient formulation emerging natural-compound-based chemotherapy functional foods could utilized by food, nutraceutical, pharmaceutical industries.

Language: Английский

Citations

26
Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives DOI
Sonal Datta, Diwakar Aggarwal, Nirmala Sehrawat

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 121, P. 155100 - 155100

Published: Sept. 18, 2023

Language: Английский

Citations

26
Microbial Secondary Metabolites via Fermentation Approaches for Dietary Supplementation Formulations DOI Creative Commons
Alexandru Rusu, Monica Trif, João Miguel Rocha

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(16), P. 6020 - 6020

Published: Aug. 11, 2023

Food supplementation formulations refer to products that are designed provide additional nutrients the diet. Vitamins, dietary fibers, minerals and other functional compounds (such as antioxidants) concentrated in supplements. Specific amounts of given body through food supplements, these include well so-called non-essential such secondary plant bioactive components or microbial natural addition narrower sense. A significant social challenge represents how moderately use resources light growing world population. In terms economic production (especially natural) molecules, ways white biotechnology with various microorganisms have recently been intensively explored. current review relevant supplements substances (e.g., vitamins, amino acids, used their via fermentative biotechnological approaches briefly reviewed. Biotechnology plays a crucial role optimizing fermentation conditions maximize yield quality target compounds. Advantages ability renewable feedstocks, high yields, potential for cost-effective large-scale production. Additionally, it can be more environmentally friendly compared chemical synthesis, reduces reliance on petrochemicals minimizes waste generation. Educating consumers about benefits, safety, methods general is crucial. Providing clear accurate information science behind help address any concerns misconceptions may have.

Language: Английский

Citations

24
A Review of the Therapeutic Potential of Sulfur Compounds in Allium sativum DOI Creative Commons
Agatha Ngukuran Jikah, Great Iruoghene Edo,

Raghda Makia

et al.

Measurement Food, Journal Year: 2024, Volume and Issue: 15, P. 100195 - 100195

Published: Aug. 28, 2024

Language: Английский

Citations

13