The discovery of NLRP3 and its function in cryopyrin‐associated periodic syndromes and innate immunity DOI Creative Commons
Christopher D. Putnam, Lori Broderick, Hal M. Hoffman

et al.

Immunological Reviews, Journal Year: 2023, Volume and Issue: 322(1), P. 259 - 282

Published: Dec. 25, 2023

Summary From studies of individual families to global collaborative efforts, the NLRP3 inflammasome is now recognized be a key regulator innate immunity. Activated by panoply pathogen‐associated and endogenous triggers, serves as an intracellular sensor that drives carefully coordinated assembly inflammasome, downstream inflammation mediated IL‐1 IL‐18. Initially discovered cause autoinflammatory spectrum cryopyrin‐associated periodic syndrome (CAPS), also known play role in more common diseases including cardiovascular disease, gout, liver disease. We have seen cohesion results from clinical CAPS patients, ex vivo human cells murine cells, models leading our understanding pathways, cytokine secretion, cell death pathways has solidified autoinflammation pathogenesis Recent advances structure provided ways for us visualize normal mutant protein function pharmacologic inhibition. The subsequent development targeted therapies successfully used treatment patients with completes bench bedside translational loop which defined study this unique protein.

Language: Английский

Sensorineural hearing loss and cognitive impairment: three hypotheses DOI Creative Commons
He Zhao, Yan Wang,

Limei Cui

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Feb. 28, 2024

Sensorineural hearing loss (SNHL) is a category of that often leads to difficulty in understanding speech and other sounds. Auditory system dysfunction, including deafness auditory trauma, results cognitive deficits via neuroplasticity. Cognitive impairment (CI) refers an abnormality the brain’s higher intellectual processes related learning, memory, thinking judgment can lead severe learning memory deficits. Studies have established strong correlation between SNHL CI, but it remains unclear how contributes CI. The purpose this article describe three hypotheses regarding relationship, mainstream load hypothesis, co-morbidity sensory deprivation as well latest research progress each hypothesis.

Language: Английский

Citations

6
Drug Development for Alzheimer’s and Parkinson’s Disease: Where Do We Go Now? DOI Creative Commons
Lisa Sequeira, Sofia Benfeito, Carlos Fernandes

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(6), P. 708 - 708

Published: May 24, 2024

Neurodegenerative diseases (NDs) are a set of progressive, chronic, and incurable characterized by the gradual loss neurons, culminating in decline cognitive and/or motor functions. Alzheimer’s disease (AD) Parkinson’s (PD) most common NDs represent an enormous burden both terms human suffering economic cost. The available therapies for AD PD only provide symptomatic palliative relief limited period unable to modify diseases’ progression. Over last decades, research efforts have been focused on developing new pharmacological treatments these NDs. However, date, no breakthrough treatment has discovered. Hence, development disease-modifying drugs able halt or reverse progression remains unmet clinical need. This review summarizes major hallmarks treatment. It also sheds light potential directions that can be pursued develop new, treat PD, describing as representative examples some advances drug candidates targeting oxidative stress adenosine A2A receptors.

Language: Английский

Citations

6
Alterations of mRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer’s Disease DOI
Karla Aketzalli Hernández-Contreras,

Jorge Antonio Martínez-Díaz,

Marı́a Elena Hernández

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(8), P. 5826 - 5840

Published: Jan. 18, 2024

Language: Английский

Citations

5
Is Drp1 a link between mitochondrial dysfunction and inflammation in Alzheimer’s disease? DOI Creative Commons

Oualid Sbai,

Veronica Bazzani,

Shreya Tapaswi

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: May 12, 2023

Recent advances highlight that inflammation is critical to Alzheimer Disease (AD) pathogenesis. Indeed, several diseases characterized by are considered risk factors for AD, such as type 2 diabetes, obesity, hypertension, and traumatic brain injury. Moreover, allelic variations in genes involved the inflammatory cascade AD. AD also mitochondrial dysfunction, which affects energy homeostasis of brain. The role dysfunction has been mostly neuronal cells. However, recent data demonstrating occurs cells, promoting secretion pro-inflammatory cytokines, turn induce neurodegeneration. In this review, we summarize finding supporting hypothesis inflammatory-amyloid describe demonstrate link between altered cascade. We focus summarizing Drp1, fission, showing Drp1 activation leads NLRP3 inflammasome, cascade, aggravates Amyloid beta (Ab) deposition tau-induced neurodegeneration, relevance pathway an early event

Language: Английский

Citations

12
Ginsenoside Rg1 alleviates lipopolysaccharide-induced pyroptosis in human periodontal ligament cells via inhibiting Drp1-mediated mitochondrial fission DOI

Kefei Chu,

Zhenghao Zhang, Yi Chu

et al.

Archives of Oral Biology, Journal Year: 2023, Volume and Issue: 147, P. 105632 - 105632

Published: Jan. 28, 2023

Language: Английский

Citations

11
The research trends and hotspots of NLRP3 inflammasome in Alzheimer's disease: a bibliometric and visualization analysis DOI Creative Commons

Xuanwei Wen,

Huiye Yang,

Shuangxi Chen

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Background Alzheimer’s disease (AD) is the most common neurodegenerative disorder, NLRP3 inflammasome has been shown to play a pivotal role in pathogenesis of AD, and with increasing attention its involvement AD. Therefore, we applied bibliometric methods describe current research status This study aims analyze trends hotspots this field from 2013 2024, providing valuable insights for AD research. Methods We have selected on Web Science Core Collection, time range January 1, 2013, November 30, exported all publications plain text format. Visualization analysis was performed using CiteSpace 6.4.R1, VOSviewer 1.6.20, Scimago Graphica 1.0.46. Results A total 759 related were included study. The number annual showed general upward trend. top three countries terms publication volume China, United States, Italy. University Manchester institution highest publications. author Michael Heneka, while cited Eicke Latz. International Journal Molecular Sciences published articles also frequently journal. keywords disease, inflammasome, neuroinflammation, Aβ, microglia. Conclusion primary focus pathology, potential as therapeutic target, strategies modulate neuroinflammation through targeting inflammasome. Future should further investigate interactions between other molecular pathways, assess clinical potential, provide new early diagnosis treatment

Language: Английский

Citations

0
Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature DOI Creative Commons
Sandra Maria Barbalho, Beatriz Leme Boaro,

Jéssica da Silva Camarinha Oliveira

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 133 - 133

Published: Jan. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Language: Английский

Citations

0
SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer’s Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia DOI
Xiaolin Pang, Zhun Wang, Mengxue Zhang

et al.

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: March 7, 2025

Language: Английский

Citations

0
Interferon Regulatory Factors as a Potential Therapeutic Target for Neuroinflammation: A Focus on Alzheimer’s Disease DOI Open Access
Xing Fan,

Weikang Diao,

Hao Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2906 - 2906

Published: March 23, 2025

Interferon Regulatory Factors (IRFs) are critical modulators of immune and inflammatory responses, yet their roles in Alzheimer's disease (AD) other neurodegenerative disorders remain incompletely understood. While IRFs recognized for regulatory functions neuroinflammation, microglial activation, neuronal survival, dual as both drivers pathological inflammation mediators neuroprotective pathways underscore a sophisticated paradox disorders. This review aims to synthesize current evidence on IRF-mediated neuroinflammation AD related diseases, focusing the multifaceted key IRF family members, including IRF1, IRF3, IRF7. We critically evaluate divergent roles: IRF1 instance, exacerbate neuroinflammatory cascades amyloid-beta (Aβ) pathology AD, whereas IRF7 may paradoxically suppress under specific conditions. Additionally, we explore dysregulation Parkinson's disease, multiple sclerosis, amyotrophic lateral Huntington's emphasizing shared distinct mechanisms across Restoring balance through genetic manipulation, small-molecule inhibitors, or microbiome-derived could attenuate enhance Aβ clearance, protect integrity. Ultimately, this work provides framework future research harness signaling development precision therapies diseases.

Language: Английский

Citations

0
Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin DOI

Mohannad Hamid Jasim,

Rosull Saadoon Abbood,

Gaurav Sanghvi

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114537 - 114537

Published: March 1, 2025

Language: Английский

Citations

0