Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 31, 2024
Viruses,
despite
their
simple
structural
composition,
engage
in
intricate
and
complex
interactions
with
hosts
due
to
parasitic
nature.
A
notable
demonstration
of
viral
behavior
lies
exploitation
lysosomes,
specialized
organelles
responsible
for
the
breakdown
biomolecules
clearance
foreign
substances,
bolster
own
replication.
The
man-nose-6-phosphate
(M6P)
pathway,
crucial
facilitating
proper
transport
hydrolases
into
lysosomes
promoting
lysosome
maturation,
is
frequently
exploited
manipulation
support
Recently,
discovery
lysosomal
enzyme
trafficking
factor
(LYSET)
as
a
pivotal
regulator
within
M6P
pathway
has
introduced
fresh
perspective
on
interplay
between
entry
host
factors.
This
groundbreaking
revelation
illuminates
unexplored
dimensions
these
interactions.
In
this
review,
we
endeavor
provide
thorough
overview
its
factors
during
infection.
By
consolidating
current
understanding
field,
our
objective
establish
valuable
reference
development
antiviral
drugs
that
selectively
target
pathway.
BioMetals,
Journal Year:
2024,
Volume and Issue:
37(4), P. 983 - 1022
Published: April 5, 2024
Abstract
Independent
trials
indicate
that
either
oral
Zn
2+
or
metformin
can
separately
improve
COVID-19
outcomes
by
approximately
40%.
Coordination
chemistry
predicts
a
mechanistic
relationship
and
therapeutic
synergy.
deficit
is
known
risk
factor
for
both
non-infectious
inflammation.
Most
dietary
not
absorbed.
Metformin
naked
ligand
presumably
increases
intestinal
bioavailability
active
absorption
cation
transporters
to
transport
metformin.
Intracellular
provides
natural
buffer
of
many
protease
reactions;
the
variable
“set
point”
determined
regulation
availability.
A
-interactive
network
suggested
here.
The
two
viral
cysteine
proteases
are
targets
against
COVID-19.
Viral
host
submaximally
inhibited
exchangeable
cell
.
Inhibition
reportedly
enhances
moderating
effect
on
bioassayed
proteome
degradation.
Firstly,
dissociable
metformin–Zn
complex
could
be
actively
transported
transporters;
thereby
creating
artificial
pathways
increased
body
content.
Secondly,
coordination
create
non-natural
inhibitor
independent
Moderation
peptidolytic
reactions
mechanisms
slow
(a)
multiplication
(b)
invasion
(c)
pathogenic
inflammatory
response.
These
combined
actions
allow
development
acquired
immunity
clear
infection
before
life-threatening
Nirmatrelvir
(Paxlovid®)
opposes
selective
inhibition
main
-independent
mechanism.
Pending
safety
evaluation,
predictable
synergistic
benefits
,
perhaps
metformin/Zn
/Paxlovid®
co-administration
should
investigated.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(6), P. 984 - 984
Published: June 19, 2024
Viral
tropism
is
most
commonly
linked
to
receptor
use,
but
host
cell
protease
use
can
be
a
notable
factor
in
susceptibility
infection.
Here
we
review
the
of
proteases
by
human
viruses,
focusing
on
those
with
primarily
respiratory
tropism,
particularly
SARS-CoV-2.
We
first
describe
various
classes
present
tract,
as
well
elsewhere
body,
and
incorporate
targeting
these
therapeutic
drugs
for
humans.
Host
are
also
systemic
spread
viruses
play
important
roles
outside
tract;
therefore,
address
how
affect
across
spectrum
infections
that
occur
humans,
intending
understand
extrapulmonary
Frontiers in Veterinary Science,
Journal Year:
2024,
Volume and Issue:
11
Published: Aug. 28, 2024
Cotton
leaf
curl
Multan
virus
(CLCuMuV),
a
serious
viral
disease
causative
agent
in
cotton
plants
South
Asia,
is
transmitted
by
the
Bemisia
tabaci
cryptic
species
complex
persistent
circulative
manner.
A
previous
study
indicated
that
Asia
II-7
whiteflies
could
transmit
CLCuMuV,
while
Mediterranean
(MED)
failed
to
CLCuMuV.
However,
little
known
about
genes
involved
this
process.
In
study,
and
MED
B.
were
utilized
determine
transcriptomic
responses
after
48
h
of
acquisition
access
periods
(AAPs).
Result
Illumina
sequencing
revealed
that,
14,213
8,986
differentially
expressed
(DEGs)
identified.
Furthermore,
DEGs
related
immune
system
metabolism
response
CLCuMuV-infected
identified
analyzed
using
Gene
Ontologies
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG),
number
was
lower
than
II-7.
The
most
abundant
groups
between
both
viruliferous
aviruliferous
whitefly
zf-C2H2
family
transcription
factors
(TFs).
Notably,
comparison
MED,
exhibited
more
cathepsin
biosynthesis.
Overall,
provides
basic
information
for
investigating
molecular
mechanism
how
begomoviruses
affect
either
as
vector
or
non-vector
species.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 31, 2024
Viruses,
despite
their
simple
structural
composition,
engage
in
intricate
and
complex
interactions
with
hosts
due
to
parasitic
nature.
A
notable
demonstration
of
viral
behavior
lies
exploitation
lysosomes,
specialized
organelles
responsible
for
the
breakdown
biomolecules
clearance
foreign
substances,
bolster
own
replication.
The
man-nose-6-phosphate
(M6P)
pathway,
crucial
facilitating
proper
transport
hydrolases
into
lysosomes
promoting
lysosome
maturation,
is
frequently
exploited
manipulation
support
Recently,
discovery
lysosomal
enzyme
trafficking
factor
(LYSET)
as
a
pivotal
regulator
within
M6P
pathway
has
introduced
fresh
perspective
on
interplay
between
entry
host
factors.
This
groundbreaking
revelation
illuminates
unexplored
dimensions
these
interactions.
In
this
review,
we
endeavor
provide
thorough
overview
its
factors
during
infection.
By
consolidating
current
understanding
field,
our
objective
establish
valuable
reference
development
antiviral
drugs
that
selectively
target
pathway.
