Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1829 - 1829

Published: June 26, 2023

Nanofiber scaffolds have emerged as a revolutionary drug delivery platform for promoting wound healing, due to their unique properties, including high surface area, interconnected porosity, excellent breathability, and moisture absorption, well spatial structure which mimics the extracellular matrix. However, use of nanofibers achieve controlled loading release still presents many challenges, with ongoing research exploring how load drugs onto nanofiber without loss activity control in specific spatiotemporal manner. This comprehensive study systematically reviews applications recent advances related drug-laden skin-wound management. First, we introduce commonly used methods preparation, electrostatic spinning, sol-gel, molecular self-assembly, thermally induced phase separation, 3D-printing techniques. Next, summarize polymers preparation utilizing scaffolds. We then review application drug-loaded considering different stages healing acts. Finally, briefly describe stimulus-responsive schemes scaffolds, other exciting systems.

Language: Английский

---

Natural polymers used in the dressing materials for wound healing: Past, present and future

Journal of Polymer Science, Journal Year: 2023, Volume and Issue: 61(14), P. 1389 - 1414

Published: March 27, 2023

Abstract Wound healing is a complicated system that necessitates an appropriate environment to aid healing. dressing among the most important external variables in wound repair. Technology advancements have led creation of variety dressings treat various types by focusing on four stages Simplicity application, sterility, antibacterial, non‐adherent, gaseous exchange, non‐toxicity, and other qualities are necessary for dressings. In order fully regenerate restore structure functionality skin, ideal should address demands wound. So, kind used based type injury. This review focuses different natural polymers such as κ‐carrageenan, chitosan, cellulose, gelatin, collagen, alginate, hyaluronic acid, silk fibroin development materials hydrogels, nanofibers, sponges, films, scaffolds owing their features, example, biocompatibility, biodegradability, similarity human extracellular matrix (ECM) which aids process. The commercially available products these also discussed review. However, majority polymer‐based still exhibit number problems like adherence, opaque, fast degradability, lack multifunctionality, thus need be addressed. A naturally inspired smart hour individual monitoring multiple pH, temperature, electrical potentials eases incorporated drug biological molecules per progress with delivery systems.

Language: Английский

---

Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537

Published: Nov. 2, 2023

Language: Английский

---

Polysaccharides from red seaweeds: Effect of extraction methods on physicochemical characteristics and antioxidant activities

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 147, P. 109307 - 109307

Published: Oct. 1, 2023

Language: Английский

---

Recent advances in exploiting carrageenans as a versatile functional material for promising biomedical applications

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 235, P. 123787 - 123787

Published: Feb. 27, 2023

Language: Английский

---

Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 216 - 216

Published: March 22, 2024

Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.

Language: Английский

---

Immunomodulation by xylan and carrageenan-type polysaccharides from red seaweeds: Anti-inflammatory, wound healing, cytoprotective, and anticoagulant activities

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129433 - 129433

Published: Jan. 17, 2024

Language: Английский

---

Sustainable dressings for wound healing

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 2, 2025

Abstract The field of chronic wound care has been rapidly evolving. With a market size for wounds in billions USD, this is not an insignificant area to encourage more sustainable practices and processes. sourcing starting materials dressings from renewable resources the first crucial step ensuring that environmental impact minimized. Next important choice select methodologies accordance with principles green chemistry. This involves utilizing solvents as reaction media chemical processes preparing dressing materials. In many cases, like production hydrogels, crosslinking reagents are often employed. These can be, general, easily replaced by enzymes peroxidases, tyrosinases sortases. Process intensification strategies have emerged powerful approach ensure economy sustainability at large scale. Use microwave radiations ultrasonication instead heat accelerate rates helps cases inject wounds. review attempts highlight ongoing efforts future possibilities development cost-effective methods. Graphical

Language: Английский

---

Marine-Derived Polysaccharide Hydrogels as Delivery Platforms for Natural Bioactive Compounds

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 764 - 764

Published: Jan. 17, 2025

Marine polysaccharide hydrogels have emerged as an innovative platform for regulating the in vivo release of natural bioactive compounds medical purposes. These hydrogels, which exceptional biocompatibility, biodegradability, and high water absorption capacity, create effective matrices encapsulating different molecules. In addition, by modifying physical chemical properties marine including cross-linking density, swelling behavior, response to external stimuli like pH, temperature, or ionic strength, profile encapsulated is strictly regulated, thus maximizing therapeutic efficacy minimizing side effects. Finally, using naturally sourced polysaccharides hydrogel formulations, sustainability promoted reducing dependence on synthetic polymers, meeting growing demand eco-friendly materials. This review analyzes interaction between offers examples how molecules can be encapsulated, released, stabilized.

Language: Английский

---

Structure-activity relationships of bioactive polysaccharides extracted from macroalgae towards biomedical application: A review

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121533 - 121533

Published: Oct. 26, 2023

Language: Английский

---