Matrix Biology, Journal Year: 2023, Volume and Issue: 125, P. 31 - 39
Published: Dec. 9, 2023
Language: Английский
Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Abstract The extracellular matrix (ECM) serves not only as a structural scaffold but also an active regulator of cancer progression, profoundly influencing tumor behaviour and the microenvironment (TME). This review focuses into pivotal role ECM alterations in facilitating metastasis explores therapeutic strategies aimed at counteracting these changes. We analyse targeted interventions against collagen, including approaches to inhibit its biosynthesis disrupt associated signalling pathways critical for architecture cell migration. Additionally, therapies addressing hyaluronan are reviewed, highlighting methods suppress synthesis enzymatic degrade it, thereby mitigating tumor‐promoting effects. discussion extends innovative modulating stiffness, focusing on roles cancer‐associated fibroblasts lysyl oxidases, which key contributors remodelling mechanical signalling. By strategically modifying components, aim enhance efficacy existing treatments, tackle resistance mechanisms, achieve more durable outcomes. Insights from recent studies clinical trials highlight promise overcoming treatment improving patient Advancing our understanding biology leads development effective therapies.
Language: Английский
Citations
4
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 166, P. 115390 - 115390
Published: Sept. 4, 2023
The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular matrix (ECM) an important TME component. Collagen a major ECM component that contributes to cell infiltration, expansion, distant metastasis during progression. Recent studies reported collagen deposited form wall along which cells can infiltrate prevent drugs from working on cells. Collagen-tumor interaction complex requires activation of multiple signaling pathways for biochemical mechanical interventions. In this review, we examine effect deposition progression discuss between This review aims illustrate functions mechanisms its role therapy. findings indicated appears be better target
Language: Английский
Citations
29
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(6), P. 3515 - 3534
Published: May 24, 2024
Breast cancer is the most common type of and second leading cause cancer-related mortality in females. There are many side effects due to chemotherapy traditional surgery, like fatigue, loss appetite, skin irritation, drug resistance cells. Immunotherapy has become a hopeful approach toward treatment, generating long-lasting immune responses malignant tumor patients. Recently, hydrogel received more attention therapy its specific characteristics, such as decreased toxicity, fewer effects, better biocompatibility delivery particular location. Researchers globally reported various investigations on research for diagnosis. The hydrogel-based multilayer platform with controlled nanostructure antitumor effect. Chitosan alginate play role formation cross-link hydrogel. Also, they help stability This review discusses properties, preparation, biocompatibility, bioavailability clinical approaches multipolymer made chitosan breast treatment. With focus cases recovery rate, there need find out
Language: Английский
Citations
9
Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(1), P. e010029 - e010029
Published: Jan. 1, 2025
To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play vital role in carcinogenesis. However, it remains unclear whether they are involved pancreatic ductal adenocarcinoma (PDAC) and how relate to clinical outcomes. This study aims investigate the biological function mechanism novel UPR sensor, CREB3L1 works PDAC further evaluate its application prospect. We tested signaling including Thapsigargin-treated cells. Subsequently, we defined expression analyzed with characteristics PDAC. Then, established gene-modified cells determine functions cell proliferation migration capacity. Besides, constructed subcutaneously orthotopically transplanted mice models verify their progrowing pulmonary metastasis prove proinvasion role. What's more, RNAseq, qPCR, Western blotting, immunohistochemistry multicolor flow cytometry experiments were used explore worked Lastly, correlation immunotherapy outcome immune signatures explored patients advanced who received PD-1 antibody therapy. first confirmed could be induced by endoplasmic reticulum stressor found aberrant activation was associated poorer overall survival indicating protumor new sensor. Functionally, contributing malignant progression growth multiple vitro vivo models. Mechanistically, upregulated COL3A1 promoted dense stroma formation for facilitating knocking down disrupted function. Furthermore, CREB3L1-induced TAM polarization toward an M2 phenotype reduced infiltration CD8+ T Clinically, correlated as well checkpoint blockade (ICB) treatment CREB3L1aberrant indicated efficacy worse prognosis than low which might empower decision. Collectively, this revealed facilitated progression, shaped exclude tumor microenvironment distinguished therapy ICB promising molecular target biomarker treatment.
Language: Английский
Citations
1
Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)
Published: Jan. 8, 2025
Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs) Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) were screened. Subsequently, 14 PCD-gene-based CDI model. Genomics, single-cell transcriptomes, bulk spatial clinical information TCGA-OV, GSE26193, GSE63885, GSE140082 collected analyzed verify prediction Results The was an independent prognostic risk factor patients with SOC. Patients SOC high had lower survival rates poorer prognoses than those low CDI. Specific parameters combined nomogram that accurately assessed patient survival. used PCD-genes observe differences between groups. results showed immunosuppression hardly benefited immunotherapy; therefore, trametinib_1372 BMS-754807 may be therapeutic agents these patients. Conclusions CDI-based model, which established genes, predicted tumor microenvironment, immunotherapy response, drug sensitivity Thus this help improve diagnostic efficacy PPPM.
Language: Английский
Citations
1
RNA Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Sorafenib (Sfb) is a multikinase inhibitor regularly used for the management of patients with advanced hepatocellular carcinoma (HCC) that has been shown to increase very modestly life expectancy. We have Sfb inhibits protein synthesis at level initiation in cancer cells. However, global snapshot mRNA translation following Sorafenib-treatment not explored so far. In this study, we performed genome-wide polysome profiling analysis Sfb-treated HCC cells and demonstrated that, despite repression, set different genes remain efficiently translated or are even translationally induced. reveal response inhibition, tuned, which strongly correlates presence established cis-acting elements corresponding factors recognize them, including DAP5 ARE-binding proteins. At biological processes, leads translational down-regulation key cellular activities, such as those related mitochondrial metabolism collagen synthesis, up-regulation pathways associated adaptation survival Sfb-induced stress. Our findings indicate induces an adaptive reprogramming provide valuable information can facilitate other drugs development novel combined treatment strategies based on therapy.
Language: Английский
Citations
1
Cancers, Journal Year: 2022, Volume and Issue: 14(19), P. 4706 - 4706
Published: Sept. 27, 2022
The tumor stroma, which comprises stromal cells and non-cellular elements, is a critical component of the microenvironment (TME). dynamic interactions between stroma may promote progression metastasis dictate resistance to established cancer therapies. Therefore, novel antitumor approaches should combine anticancer anti-stroma strategies targeting dysregulated extracellular matrix (ECM). ECM remodeling hallmark solid tumors, leading extensive biochemical biomechanical changes, affecting cell signaling tissue three-dimensional architecture. Increased deposition fibrillar collagen most distinctive alteration ECM. Consequently, several therapeutic have been developed reduce excessive deposition. Herein, we provide an overview current advances challenges main aiming at normalization, include targeted drug delivery, promotion degradation, modulation structure biosynthesis collagen, cancer-associated fibroblasts, are major producers.
Language: Английский
Citations
28
Biomaterials, Journal Year: 2024, Volume and Issue: 308, P. 122531 - 122531
Published: March 21, 2024
Radiation therapy (RT) is essential for triple negative breast cancer (TNBC) treatment. However, patients with TNBC continue to experience recurrence after RT. The role of the extracellular matrix (ECM) irradiated tissue in tumor still unknown. In this study, we evaluated structure, molecular composition, and mechanical properties murine mammary fat pads (MFPs) developed ECM hydrogels from decellularized tissues (dECM) assess effects RT-induced changes on cell behavior. Irradiated MFPs were characterized by increased deposition fiber density compared unirradiated controls, which may provide a platform invasion proliferation. component collagens I, IV, VI, fibronectin observed following irradiation both dECM hydrogels. Encapsulated proliferation invasive capacity was enhanced addition, cells co-cultured macrophages induced M2 macrophage polarization exhibited further increases Our study establishes that radiation-damaged sites promotes as well an immunosuppressive microenvironment. This work represents important step toward elucidating how RT contribute recurrence.
Language: Английский
Citations
5
Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(7)
Published: July 1, 2023
The expression of cytoplasmic poly (A) binding protein-1 (PABPC1) has been reported in multiple cancer types. This protein is known to modulate progression. However, the effects PABPC1 pancreatic adenocarcinoma (PAAD) have not investigated. Here, we investigate regulatory targets and molecular mechanisms PAAD.
Language: Английский
Citations
10
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(19)
Published: Feb. 13, 2024
Abstract Engineered biomaterial scaffolds are becoming more prominent in research laboratories to study drug efficacy for oncological applications vitro, but do they have a place pharmaceutical screening pipelines? The low of cancer drugs phase II/III clinical trials suggests that there critical mechanisms not properly accounted the pre‐clinical evaluation candidates. Immune cells associated with tumor may account some these failures given recent successes immunotherapies; however, few representative platforms immune context as traditional 2D culture is typically monocultures and humanized animal models weakened composition. Biomaterials replicate microenvironmental cues provide relevant model greater vitro complexity. In this review, authors explore pertinent drive progression system, discuss how can be incorporated into hydrogel design cells, describe progress toward precision engineered tissues.
Language: Английский
Citations
4