International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10316 - 10316
Published: June 19, 2023
Vitamin D, often referred to as the "sunshine nutrient", has gained considerable attention in recent years due its multifaceted impact on health and disease [...].
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 19, 2025
Abstract Eupolyphaga sinensis Walker (ESW), a medicinal insect used in traditional Chinese medicine, is renowned for its effects on blood circulation, stasis resolution, and bone tendon healing. The underlying reasons the clinical preference female ESW remain unclear. Previous investigations were limited scope, focusing narrowly specimens, large-molecule compounds, single pharmacological effect. This study systematically compared male terms of composition therapeutic efficacy. Metabolomics identified 31 compound types both ESW, including lipids, amino acids, fatty acids. Female exhibited significantly higher levels 8 bioactive 15 small peptides, 13 prostaglandins to which contribute immunity enhancement, antithrombotic effects, improved metabolism. These differences may underlie superior efficacy ESW. In thrombosis model, can cause vasodilation, reduce cell aggregation rate mice tails. It also t-PA levels, prolonged APTT, enhanced hepatic SOD activity, with showing stronger MDA D2D indicating ability protect cells from damage fibrinolytic osteoporosis increased femur length, liver, thymus indices while regulating serum BALP Mg levels. notably reduced TRACP-5b, OT/BGP, P, Cu normal metabolism, corrected disturbances calcium-phosphorus regulated inorganic elements. Overall, greater abundance components demonstrated anti-thrombotic anti-osteoporotic effects. findings highlight due enriched components, supporting underscoring potential uilization resource.
Language: Английский
Citations
0
Russian Pediatric Journal, Journal Year: 2025, Volume and Issue: 28(1), P. 41 - 46
Published: Feb. 28, 2025
Introduction. The chronic course of autoimmune hepatitis requires long-term immunosuppressive therapy, which can lead to side effects such as impairement bone mineral density (BMD). Currently, there are no data assessing mineralization in children with hepatitis. Aim. To determine the by densitometry and remodelling biochemical markers Materials methods. study included 41 child 18 patients were diagnosed for first time received treatment before admission, 15 took glucocorticosteroids up 6 months 8 them or more. required clinical: age sex patients, duration both disease treatment, body mass index, laboratory (ALT, AST, total immunoglobulin G, osteocalcin, procollagen type 1 N-terminal propeptide (P1NP), βCrossLaps, calcium, phosphorus, parathormone, vitamin D), instrumental examination (lumbar radiodensitometry, liver elastography). Results. Children at 16 years older had lower Z-score (p = 0.015). There was statistically significant difference between duration. BMD established correlate P1NP blood serum 0.035) osteocalcin 0.026). Conclusion. Autoimmune is a disease, associated risk disorders, including children. This timely assessment one state, well calcium D prescription concomitant treatment.
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)
Published: March 27, 2025
Language: Английский
Citations
0
Pharmacognosy Magazine, Journal Year: 2025, Volume and Issue: unknown
Published: April 3, 2025
Background Anorexia–cachexia syndrome in head and neck cancer (ACSHNC) seriously affects the patient’s quality of life prognosis. Curcumin inhibits anorexic cachexia syndrome. S100A9 is related to tumors, but its role ACSHNC requires further study. Purpose This study intends investigate ACSHNC. Methods In this study, subjects were randomly divided into negative control (NC) group, low-, medium-, high-dose curcumin groups, cell proliferation was detected; flow cytometry detected apoptosis; Western blot CyclinB1, P21, DR5, DR4, cleaved caspase-9, poly (ADP-ribose) polymerase (PARP), glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein expression along with analysis serum albumin prealbumin levels. Results Before treatment, patient had obvious symptoms such as loss appetite, weight loss, fatigue, levels lipid mobilization factors plasma significantly increased. After improved considerably, reduced. addition, urinary excretion also Conclusion can improve prognosis patients by regulating levels, indicating that it might be utilized a new possibility for treatment.
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 1002 - 1002
Published: April 21, 2025
Vitamin D and its metabolites are essential in various physiological processes, including muscle strength, metabolism, antifibrotic activity, immune regulation. Researchers focusing on developing vitamin derivatives with optimized receptor selectivity reduced systemic toxicity, enhancing their therapeutic efficacy against cancer, autoimmune disorders, inflammatory diseases. Several analogues, such as alfacalcidol, paricalcitol, falecalcitriol, used for managing CKD-related bone while eldecalcitol is effective osteoporosis, calcipotriol psoriasis. Recent studies have explored impact metabolic pathways, parathyroid hormone secretion, asthma, liver fibrosis, revealing broad clinical potential. Despite enormous efforts the past decades, translations of D-drugs disproportionately limited, mainly due to toxicity calcemic effects undesirable profile. This review discusses structural modifications D3, influence VDR binding, transcriptional calcium homeostasis, along role targeting pathways like EGFR, KRAS, Hedgehog cancers. Advanced analytical techniques LC/ESI-MS/MS facilitate precise detection metabolites, further improving pharmacokinetic profiling. Future research may enable approval novel D-based therapeutics minimal disruption calcium–phosphorus balance.
Language: Английский
Citations
0
Nutrients, Journal Year: 2023, Volume and Issue: 15(8), P. 1990 - 1990
Published: April 20, 2023
HIV infection and nonalcoholic fatty liver disease (NAFLD) are two major epidemics affecting millions of people worldwide. As with (PWH) age, there is an increased prevalence metabolic comorbidities, along unique factors, such as chronic inflammation life-long exposure to antiretroviral therapy, which leads a high NAFLD. An unhealthy lifestyle, dietary intake refined carbohydrates, saturated acids, fructose added beverages, processed red meat, well physical inactivity, known trigger promote the progression NAFLD steatohepatitis, fibrosis, hepatocellular carcinoma. Furthermore, no currently approved pharmacotherapy lack clinical trials that inclusive HIV, nutritional lifestyle approaches still represent most recommended treatments for PWH While sharing common features general population, in displays its own peculiarities may also reflect different impacts nutrition exercise on onset treatment. Therefore, this narrative review, we aimed explore role nutrients development PWH. In addition, discussed managing setting insights into gut microbiota lean
Language: Английский
Citations
10
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9976 - 9976
Published: June 9, 2023
In recent years, the terms sarcopenia, sarcopenic obesity, and osteosarcopenic obesity (OSO) were coined to define a situation in elderly people strongly associated with frailty increased mortality. Possibly, complex interplay of several hormones cytokines are involved its development. Ongoing research detected that OSO may occur at any age conditions. The prevalence alcoholism was poorly analyzed. aim this study analyze relationship proinflammatory and/or common complications alcoholism, such as cirrhosis, cancer, or vascular disease. We included 115 patients alcoholic use disorder. Body composition analysis performed by double X-ray absorptiometry. Handgrip strength recorded using dynamometer. assessed liver function according Child’s classification, determined serum levels (TNF-α, IL-6, IL-8), routine laboratory variables, vitamin D. People disorder showed high OSO, especially regarding (60%), osteopenia (55.65%), lean mass (60.17%). handgrip closely, independently, related presence calcification (χ2 = 17.00; p < 0.001). Vitamin D deficiency kept close correlation (rho −0.54, Therefore, among alcohol disorder, high. is cytokine supporting possible pathogenetic role these on suggesting involvement sarcopenia association between clinically relevant suggests constitute prognostic tool patients.
Language: Английский
Citations
9
Acta Clinica Belgica, Journal Year: 2024, Volume and Issue: 79(2), P. 130 - 142
Published: Jan. 3, 2024
Chronic kidney disease (CKD) is a growing health concern with complex etiological landscape. Among the numerous factors implicated, vitamin D binding protein (VDBP) has emerged as focal point of scientific studies because its critical role in metabolism and immune modulation. The relationship between VDBP CKD reveals web molecular biochemical details that have great potential for improving diagnostic understanding treatment strategies CKD. This review summarizes multifaceted roles VDBP, including dynamics, interactions D, subsequent implications function. main focus discussion how affects bone mineral homeostasis, highlighted by dysregulation calcium phosphorus metabolism, which part pathophysiology also touches on immunomodulatory scope it may reduce chronic inflammatory environment accompanies biomarker been rigorously examined, highlighting capacity to improve early detection prognostic assessment. Modification activity slow course patient outcomes. Furthermore, detailed examination genetic polymorphisms their susceptibility responsiveness provides perspective personalized medical methods. Prospects future depend expansion try understand mechanisms underlying VDBP-CKD interaction, addition clinical trials evaluate effectiveness VDBP-focused approaches.
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 10, 2024
Cardiovascular health is a hot topic around the world, and as incidence of cardiovascular disease increases each year, people are increasingly focusing on management their heart health. Dietary lifestyle changes non-pharmacological treatments have been recognized important in prevention reducing risk accidents. Awareness different nutrients effects for establishing good dietary pattern. This review summarizes five major daily diet, namely carbohydrates, proteins, fats, vitamins, minerals, health, aims to provide more comprehensive understanding healthy pattern
Language: Английский
Citations
3
Life, Journal Year: 2024, Volume and Issue: 14(2), P. 274 - 274
Published: Feb. 18, 2024
Vitamin D, a steroid hormone synthesized primarily in the skin upon exposure to ultraviolet light, is widely deficient across global populations. This study aimed fill data gap Western Romania by measuring 25-hydroxy-vitamin D levels cohort of 7141 from Arad County. It was observed that women, younger adults (18–29 years), and older (70–79 years) had notably lower vitamin compared average population. Additionally, there rise over four-year span 2018–2022, coinciding with COVID-19 pandemic. Our research provides fresh on those most susceptible deficiency lays groundwork for educational campaigns supplementation benefits.
Language: Английский
Citations
2