The Mechanisms of Polysaccharides from Tonic Chinese Herbal Medicine on the Enhancement Immune Function: A Review

Molecules, Journal Year: 2023, Volume and Issue: 28(21), P. 7355 - 7355

Published: Oct. 31, 2023

Tonic Chinese herbal medicine is a type of traditional medicine, and its primary function to restore the body’s lost nutrients, improve activity levels, increase disease resistance, alleviate physical exhaustion. The immunity can be strengthened by polysaccharide components, which also have potent immune-system-protecting effect. Several studies demonstrated that tonic polysaccharides immune response tumor cells, viruses, bacteria, other harmful substances. However, regulatory mechanisms various used in enhance vary. This study examines effects different on organs, immune-related cytokines. It explores mechanism understand similarities differences lay foundation for future development products.

Language: Английский

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Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project

BMC Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 2, 2023

Abstract Background Sepsis is characterized by a dysregulated immune response and metabolic alterations, including decreased high-density lipoprotein cholesterol (HDL-C) levels. HDL exhibits beneficial properties, such as lipopolysaccharides (LPS) scavenging, exerting anti-inflammatory effects providing endothelial protection. We investigated the of CER-001, an engineered HDL-mimetic, in swine model LPS-induced acute kidney injury (AKI) Phase 2a clinical trial, aiming to better understand its molecular basis systemic inflammation renal function. Methods carried out translational approach study administration on sepsis. Sterile was induced pigs LPS infusion. Animals were randomized into ( n = 6), CER20 (single dose CER-001 20 mg/kg; × 2 (two doses 6) groups. Survival rate, dysfunction biomarkers, pro-inflammatory mediators, LPS, apolipoprotein A-I (ApoA-I) levels assessed. Renal liver histology biochemistry analyzed. Subsequently, we performed open-label, randomized, dose-ranging (Phase 2a) included patients with sepsis due intra-abdominal infection or urosepsis, Group A (conventional treatment, 5), B (CER-001 5 mg/kg BID, C 10 D 5). Primary outcomes safety efficacy preventing AKI onset severity; secondary include changes inflammatory markers. Results increased median survival, reduced complement activation, endotoxemic pigs. It enhanced elimination through bile preserved parenchyma. In study, well-tolerated no serious adverse events related treatment. Rapid ApoA-I normalization associated removal immunomodulation improvement outcomes, independently type gravity CER-001-treated had risk for progression severe (stage 3) and, subset critically ill patients, need organ support shorter ICU length stay. Conclusions shows promise therapeutic strategy management, improving mitigating damage. Trial registration The approved Agenzia Italiana del Farmaco (AIFA) Local Ethic Committee (N° EUDRACT 2020–004202-60, Protocol CER-001- SEP_AKI_01) added EU Clinical Trials Register January 13, 2021.

Language: Английский

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Caspase-3/GSDME mediated pyroptosis: A potential pathway for sepsis

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 124, P. 111022 - 111022

Published: Oct. 12, 2023

Language: Английский

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Changes in Cytokine Levels in Patients with Severe Fever with Thrombocytopenia Syndrome Virus

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 211 - 222

Published: Jan. 1, 2024

To characterize the cytokine profile of patients with severe fever thrombocytopenia syndrome (SFTS) in relation to disease severity.

Language: Английский

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The Scutellaria-Coptis herb couple and its active small-molecule ingredient wogonoside alleviate cytokine storm by regulating the CD39/NLRP3/GSDMD signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118155 - 118155

Published: April 7, 2024

Language: Английский

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