Cited by A novel lactylation-related gene signature for effectively distinguishing and predicting the prognosis of ovarian cancer

Royal jelly acid suppresses hepatocellular carcinoma tumorigenicity by inhibiting H3 histone lactylation at H3K9la and H3K14la sites DOI

Haiying Xu, Lanqing Li, Shunshun Wang

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 118, P. 154940 - 154940

Published: June 21, 2023

Language: Английский

Citations

H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP DOI

Peiwen Wang,

Daxiao Xie,

Tian Xiao

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 461, P. 132582 - 132582

Published: Sept. 19, 2023

Language: Английский

Citations

The emerging role of lactate in tumor microenvironment and its clinical relevance DOI

Sihan Chen,

Yining Xu,

Wei Zhuo

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 590, P. 216837 - 216837

Published: March 26, 2024

Language: Английский

Citations

Emerging roles of lactate in acute and chronic inflammation DOI

Yunda Fang,

Zhengjun Li, Lili Yang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 16, 2024

Abstract Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that is substance plays an indispensable role in various physiological functions and contributes to energy metabolism signal transduction during immune inflammatory responses. The discovery lactylation further revealed the regulating processes. In this review, we comprehensively summarize paradoxical characteristics microenvironment highlight pivotal roles homeostasis, shuttle, (‘lactate clock’) acute chronic responses from molecular perspective. We especially focused on receptors with either proinflammatory or anti-inflammatory effects complex biological signalling pathways investigated dynamic changes cells lactate-related microenvironment. Moreover, reviewed progress use as therapeutic target for response, which may provide new perspective treating inflammation-related diseases.

Language: Английский

Citations

Histone lactylation: from tumor lactate metabolism to epigenetic regulation DOI

Xiaoning Yu,

Jing Yang,

Jin Xu

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(5), P. 1833 - 1854

Published: Jan. 1, 2024

The Warburg Effect is one of the most well-known cancer hallmarks.This metabolic pattern centered on lactate has extremely complex effects various aspects tumor microenvironment, including remodeling, immune suppression, cell migration, and drug resistance development.Based accumulating evidence, metabolites are likely to participate in regulation biological processes microenvironment form a feedback loop.Therefore, further revealing key mechanism lactate-mediated oncological reasonable scientific idea.The discovery refinement histone lactylation recent years laid firm foundation for above idea.Histone post-translational modification that occurs at lysine sites histones.Specific enzymes, known as "writers" "erasers", catalyze addition or removal, respectively, lactacyl group target sites.An increasing number investigations have reported this multiple cellular procedures.In review, we discuss close connection between series tumorigenesis, infiltration, energy metabolism.Finally, review provides insightful perspectives, identifying promising avenues exploration potential clinical application field research.

Language: Английский

Citations

Crosstalk between metabolism and cell death in tumorigenesis DOI

Shichao Yang,

Caden Hu,

Xiaomei Chen

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 4, 2024

Abstract It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid proliferation rate, cancer constantly encounter the limits of insufficient oxygen and nutrient supplies. To satisfy their growth needs resist adverse environmental events, modify metabolic pathways produce both extra energies substances required for growth. Realizing characters special will be helpful eliminating them during therapy. Cell death a hot topic long-term study targeting cell one most effective ways repress Many studies have successfully demonstrated metabolism inextricably linked Here we summarize recently identified specifically impact on different types deaths discuss roles in tumorigenesis.

Language: Английский

Citations

Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases DOI

Weiyi Yao,

Xinting Hu,

Xin Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 16, 2024

Abstract Histone post-translational modifications (HPTMs), as one of the core mechanisms epigenetic regulation, are garnering increasing attention due to their close association with onset and progression diseases potential targeted therapeutic agents. Advances in high-throughput molecular tools abundance bioinformatics data have led discovery novel HPTMs which similarly affect gene expression, metabolism, chromatin structure. Furthermore, a growing body research has demonstrated that histone also play crucial roles development various diseases, including cancers, cardiovascular infectious psychiatric disorders, reproductive system diseases. This review defines nine modifications: lactylation, citrullination, crotonylation, succinylation, SUMOylation, propionylation, butyrylation, 2-hydroxyisobutyrylation, 2-hydroxybutyrylation. It comprehensively introduces modification processes these HPTMs, transcription, replication, DNA repair recombination, structure, well involvement promoting occurrence clinical applications targets biomarkers. Moreover, this provides detailed overview HPTM inhibitors targeting emerging strategies treatment multiple while offering insights into future prospects challenges. Additionally, we briefly introduce techniques field research.

Language: Английский

Citations

Lactate and lactylation in cancer DOI

Jie Chen, Ziyue Huang,

Ya Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 11, 2025

Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.

Language: Английский

Citations

Muscle-derived small extracellular vesicles induce liver fibrosis during overtraining DOI

Ya Liu, Rui Zhou, Yifan Guo

et al.

Cell Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

Histone lactylation-driven B7-H3 expression promotes tumor immune evasion DOI

Zhibo Ma,

Jianming Yang,

Wenlong Jia

et al.

Theranostics, Journal Year: 2025, Volume and Issue: 15(6), P. 2338 - 2359

Published: Jan. 13, 2025

Rationale: Tumor cells possess sophisticated strategies to circumvent immune detection, including the modulation of endogenous checkpoints, particularly those within B7 family. Elucidating mechanisms that govern induction family molecules is crucial for advancement immunotherapy. Lysine lactylation (Kla), a newly identified epigenetic modification, suggested may play role in reshaping tumor microenvironment and facilitating evasion. Methods: We analyzed glycolysis pathway's enrichment patients with immune-evading tumors assessed impact lactate treatment on antitumor immunity CD8+ T microenvironment. interrupted using dehydrogenase A (LDHA) knockdown sodium oxamate, evaluated its effects cell cytotoxicity. Additionally, we investigated correlation between B7-H3 expression pathway, explored molecular underlying lactate-induced expression. Results: Our findings revealed pathway was highly enriched tumors. Lactate inhibited cells, whereas interruption via LDHA or oxamate augmented cytotoxicity effectively counteracting found be closely linked pathway. Mechanistically, lactate-upregulated H3K18la directly bound promoter conjunction transcription factor Creb1 co-activator Ep300, leading increased contributing progression by compromising proportion tumor-infiltrating cells. In mouse bearing models, inhibiting suppressed growth, activated demonstrated potent anti-tumor efficacy. Furthermore, this approach enhanced efficacy anti-PD-1 treatment. Conclusions: This study uncovers novel mechanism which modulates through expression, providing new avenues metabolism-targeted

Language: Английский

Citations