New insights into kidney disease after COVID-19 infection and vaccination: histopathological and clinical findings

QJM, Journal Year: 2023, Volume and Issue: 117(5), P. 317 - 337

Published: July 3, 2023

In addition to its pulmonary effects, coronavirus disease 2019 (COVID-19) has also been found cause acute kidney injury (AKI), which linked high mortality rates. this review, we collected data from 20 clinical studies on post-COVID-19-related AKI and 97 cases of associated with COVID-19 vaccination. Acute tubular was by far the most common finding in kidneys patients COVID-19-related AKI. Among hospitalized for COVID-19, 34.0% developed AKI, 59.0%, 19.1% 21.9% were Stages 1, 2 3, respectively. Though other adverse effects after vaccination overall appear rare, case reports have accumulated suggesting that may be a risk subsequent disease. post-vaccination pathologic findings include crescentic glomerulonephritis (29.9%), (23.7%), IgA nephropathy (18.6%), antineutrophil cytoplasmic autoantibody-associated vasculitis (17.5%), minimal change (17.5%) thrombotic microangiopathy (10.3%). It is important note appears more prevalent who newly diagnosed renal involvement. The proportions 3 30.9%, 22.7% 46.4%, general, new-onset recurrent positive prognosis. article, explore underlying pathophysiological mechanisms infection describing key morphological features prognostic findings.

Language: Английский

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Formononetin Alleviates Ischemic Acute Kidney Injury by Regulating Macrophage Polarization through KLF6/STAT3 Pathway

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: 52(05), P. 1487 - 1505

Published: Jan. 1, 2024

Recent research has indicated that formononetin demonstrates a potent anti-inflammatory effect in various diseases. However, its impact on sterile inflammation kidney injury, specifically acute injury (AKI), remains unclear. In this study, we utilized an ischemia/reperfusion-induced AKI (IRI-AKI) mouse model and bone marrow-derived macrophages (BMDMs) to investigate the effects of explore underlying mechanism. The administration significantly preserved function from as evidenced by lower serum creatinine blood urea nitrogen levels compared IRI-AKI mice without treatment. This was further confirmed less pathological changes renal tubules low expression tubular markers such KIM-1 NGAL formononetin-treated group. Furthermore, effectively suppressed pro-inflammatory cytokines (MCP-1, TNF-α, IL-1β) macrophage infiltration into kidneys mice.

Language: Английский

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Renal Histopathological Lesions Associated with SARS-CoV-2 Infection in Patients with no History of Kidney Disease: A Systematic Review

Journal of Advances in Medicine and Medical Research, Journal Year: 2024, Volume and Issue: 36(5), P. 224 - 244

Published: April 17, 2024

Background and Aims: Structural functional lung damage is the most documented impairment in SARS-CoV-2. Nevertheless, virus's impact extends beyond pulmonary manifestations, affecting various organs tissues, including kidneys, known for their expression of ACE2, cell entry receptor. The objective this review to provide a comprehensive summary studies investigating kidney injuries individuals lacking prior renal conditions following SARS-CoV-2 infection. Methodology: A literature search encompassed published between December 2019 September 2022, adhering PRISMA protocol. Electronic strategies were developed identify relevant across several bibliographic databases, Pubmed, Scopus, Web Knowledge, Embase, Scielo, Lilacs, Bireme, Cochrane databases. analysis was undertaken, encompassing 43 involving 128 patients selected based on stringent inclusion criteria: confirmed diagnosis SARS-COV-2 infection, observable alterations through microscopy, and/or viral presence detected kidneys. Results: included patients, primarily male (60.1%) with an average age 53, exhibited prevalent comorbidities such as hypertension, diabetes, obesity. predominant outcome death (43.7%), lesions identified, sclerosis, hyalinosis, tubular necrosis, vascular being common. Tubular combined glomerular frequently observed, regardless comorbidity status. greater predominance involvement associated comorbidities, mainly arterial hypertension. limited detection virus tissue suggests multifactorial origin lesions, not solely attributed itself. risk bias assessment revealed mostly high-quality studies, 24 assessed low risk, 15 moderate, four high risk. Conclusion: Ours results provides COVID-19 emphasizing significant role obesity contributing severity occurrence complications. Notably, hypertension emerges prominent factor. findings suggest multifaceted manifestation injury induced by SARS-CoV-2, both direct systemic response study underscores importance understanding implications guiding targeted interventions future research critical area.

Language: Английский

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Targeting complement in kidney transplantation: Therapeutic approaches based on preclinical and experimental evidence

Transplantation Reviews, Journal Year: 2024, Volume and Issue: 39(1), P. 100887 - 100887

Published: Nov. 22, 2024

Language: Английский

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