Glycated
hemoglobin
(HbA1c)
is
used
to
assess
glycemic
control
in
Type
1
diabetes
(DM1)
patients.
Apolipoproteins
play
an
essential
role
DM1
pathophysiology
and
may
be
associated
with
complications,
as
well
HbA1c.
This
cross-sectional
observational
study
consisting
of
81
children
adolescents
both
sexes
diagnosed
investigated
the
relationship
between
body
fat
distribution
lean
mass
HbA1C
apolipoprotein
values
analyzing
biochemical
composition
measurements.
Shapiro-Wilk
test
Lilliefors
correction,
non-parametric
Mann-Whitney
test,
others
were
a
significance
level
5%.
The
sample
had
diagnosis
time
4.32
years
high
blood
glucose
levels
(mean
178.19
mg/dL)
HbA1c
8.57%).
Subjects
also
moderate
adiposity,
indicated
by
arm
thigh
areas.
found
significant
differences
patients
concerning
apolipoproteins
A
B,
smaller
proportion
having
undesirable
levels.
Finally,
difference
estimated
cardiovascular
risk
based
on
ApoB/ApoA-1
ratio.
Conclusively,
visceral
increase
long-term
complications
owing
its
association
elevated
values.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
275, P. 116273 - 116273
Published: April 1, 2024
Sarcopenia
is
characterized
by
decreased
muscle
mass
and
strength,
posing
threat
to
quality
of
life.
Air
pollutants
are
increasingly
recognized
as
risk
factors
for
diseases,
while
the
relationship
between
two
remains
be
elucidated.
This
study
investigated
whether
exposure
ambient
air
pollution
contributes
development
sarcopenia.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 313 - 313
Published: Jan. 16, 2025
The
loss
of
skeletal
muscle
mass
and
strength,
known
as
sarcopenia,
is
prevalent
in
older
adults
linked
to
an
increased
risk
disability,
frailty,
early
mortality.
Muscle
health
crucial
for
the
functionality
independence
adults.
As
aging
population
continuously
grows,
finding
cost-effective
strategies
preventing
treating
sarcopenia
important
public
priority.
While
nutrition
recognized
a
key
factor
development
its
role
condition
still
under
investigation.
In
recent
decades,
nutritional
research
has
shifted
from
focus
on
individual
nutrients
or
healthy
foods
examining
combination
dietary
patterns,
along
with
their
potential
synergistic
antagonistic
effects.
A
balanced
diet
regular
participation
physical
activity
are
essential
maintaining
musculoskeletal
health.
One
eating
patterns
greatest
evidence
multiple
benefits
Mediterranean
diet,
which
also
been
positive
effects
function
observational
studies.
However,
there
lack
intervention
This
review
explores
updated
longitudinal
prospective
studies
associations
between
adherence
order
promote
preventive
aging.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 12, 2025
Abstract
The
role
of
obesity
in
contributing
to
inflammation
is
an
influential
factor
the
progression
obesity-associated
medical
issues.
Metabolic
and
bariatric
surgery
has
been
proven
as
effective
obtaining
weight
loss
associated
conditions
remission.
Systemic
Immune
Inflammation
Index
(SII)
was
developed
offer
more
comprehensive
data
on
presented
a
prognostic
indicator
regarding
many
adverse
conditions.
present
study
aimed
investigate
association
between
SII
patients
with
sarcopenic
evaluate
eventual
impact
exercise
SII.
All
participants
were
obesity,
underwent
-
RYGP
randomized
participate
structured
physical
or
control
group.
assessments
performed
following
standardized
procedures,
evaluated
during
routine
clinic
follow-up
at
preoperative
20-weeks
postoperative
after
program.
At
baseline,
before
surgery,
both
groups
had
similar
anthropometrics,
body
composition,
muscle
strength
variables
percentage
comorbidities.
also
groups.
To
better
understand
different
variables,
Pearson
correlation
test
baseline
using
There
inverse
BMC,
handgrip
ASMM
which
maintained
5
months
surgery.
end
study,
combined
results
two
showed
that
weight,
BMI,
%
fat,
mass
strength,
30s
sit-to-stand
bone
mineral
density
all
decreased
significantly
expected,
along
significantly.
intervention
group
higher
ASMM,
Sit-to-stand
400-m
walk
when
compared
However,
no
difference
(
p
>
0.05).
current
research
show
positive
negative
function.
responded
very
favorably
without
exercise,
clear
decrease
its
score.
Higher
lower
function,
this
may
be
reflex
compromise
causes
health,
case,
increasing
systemic
decreasing
management
surgical
still
not
clear.
After
program
function
(without
exercise).
there
differences
score
groups,
interpreted
lack
effect
per
se
short-term
inflammatory
condition
obesity.
World Journal of Hepatology,
Journal Year:
2025,
Volume and Issue:
17(2)
Published: Feb. 20, 2025
The
etiology,
risk
factors,
and
management
of
sarcopenia
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
are
comparable,
which
prompted
the
investigators
to
search
for
a
particular
diagnostic
or
prognostic
biomarker
that
was
involved
in
both
disorders.
Peptides
proteins
known
as
myokines,
exerkines,
produced
secreted
by
contracted
muscles.
Myokines
work
similarly
hormones
their
actions.
One
common
clinical
hallmark
MASLD
is
physical
inactivity,
associated
with
alterations
levels
myokines.
Irisin
positive
regulator
muscle
size
elevated
biological
fluids
during
exercise.
Significantly
low
were
observed
pathological
conditions
inactivity.
serum
irisin
significantly
higher
patients,
while
lower
factors
MASLD,
e.g.
,
diabetes
mellitus,
obesity,
insulin
resistance.
In
obesity
(sarcopenic
obesity)
normal
build,
than
healthy
subjects.
Therefore,
serial
determination
showed
transition
from
indicated
development
those
patients.
Bulletin of Rehabilitation Medicine,
Journal Year:
2025,
Volume and Issue:
24(1), P. 91 - 102
Published: Feb. 25, 2025
INTRODUCTION.
Regular
physical
exercise
has
a
beneficial
effect
on
health,
affecting
all
body
systems
and
reducing
morbidity.
Muscle
fiber
activity
during
helps
reduce
levels
of
inflammatory
markers
stimulate
anti-inflammatory
responses.
The
ability
to
maintain
homeostasis
while
exercising
adaptation
exercises
depend
fitness,
comorbidities
other
factors,
so
the
program
should
be
tailored
individual.
THE
MAIN
CONTENT
OF
REVIEW.
Immune
system
activation
in
response
is
mediated
by
cytokine
signaling.
main
source
cytokines
skeletal
muscles
themselves.
Cytokines
produced
myocytes
(myokines)
muscle
contraction
play
key
role
providing
communication
between
working
organs
tissues.
Numerous
studies
have
shown
positive
moderate
intensity
myokine
secretion.
People
with
chronic
infectious
or
non-infectious
diseases
often
demonstrate
low-grade
systemic
inflammation
low
circulating
myokines.
Moderate
effects
conditions
diseases.
Exercise
popular
non-pharmacological
adjunct
traditional
treatments
rehabilitation
for
many
CONCLUSION.
Understanding
relationship
modalities
optimize
treatment
recommendations
populations
different
needs,
such
as
patients
cancer,
diseases,
post-viral
infection
syndromes.
Journal of Functional Morphology and Kinesiology,
Journal Year:
2023,
Volume and Issue:
8(2), P. 67 - 67
Published: May 18, 2023
Impaired
balance
is
a
significant
risk
factor
for
falls
among
older
adults.
The
precise
impact
of
lower-extremity
muscles,
including
the
proportion
muscle
strength,
on
performance
single-leg
standing
tests
in
individuals
very
interesting.
aim
this
study
to
examine
correlation
between
knee
extensor
(KE),
ankle
plantar
flexor
(AP)
and
females.
Additionally,
it
aims
evaluate
combined
KE
AP
strength
maintaining
during
standing.
A
total
90
females
(mean
age
67.83
±
8.00
years)
were
recruited.
All
participants
underwent
maximum
voluntary
isometric
contraction
(MVIC)
testing
as
well
with
eyes
open
(SSEO)
closed
(SSEC).
To
influence
performance,
multiple
regression
analysis
was
conducted.
Low
correlations
found
SSEO
MVIC
but
moderate
percentage
body
weight
ratio
(%MVIC/BW).
best
model
included
0.99
times
%MVIC/BW
0.66
that
muscles
independent
predictor
variables
(r
=
0.682).
In
conclusion,
have
greater
compared
strength.
Life Sciences,
Journal Year:
2024,
Volume and Issue:
360, P. 123230 - 123230
Published: Nov. 10, 2024
Irisin-based
interventions
have
gained
attention
for
their
potential
to
modulate
the
adenosine
monophosphate
(AMP)-activated
protein
kinase
(AMPK)
pathway
in
various
diseases.
Physiologically,
irisin
is
a
myokine
released
during
physical
exercise
that
exerts
anti-inflammatory
effects
and
metabolic
cardiometabolic
enhancer.
On
other
hand,
AMPK
crucial
maintaining
energy
balance
homeostasis.
Therefore,
individuals
presenting
low
blood
levels
of
dysregulation
are
more
predisposed
disorders
cardiovascular
health
inflammatory
conditions
since
regulating
homeostasis
preventing
or
treating
these
disorders.
In
light
those
mentioned
above
considering
no
review
has
addressed
intricate
relationships
between
regulation
realm
disorders,
health,
conditions,
we
comprehensively
reviewed
studies
involving
irisin's
on
signaling
different
models
interventions.
Our
systematic
analysis
involved
vitro
studies,
animal
models,
relevant
clinical
implications
targeting
due
absence
trials.
The
outcomes
limitations
included
were
extensively
highlighted.
Objectively,
improved
by
enhancing
β-cell
function
insulin
secretion
diabetes,
mitigating
myocardial
injury
reducing
inflammation
oxidative
stress
AMPK.
However,
lack
trials
limits
generalizability
findings
human
subjects.
Future
research
should
focus
translating
into
applications
exploring
broader
irisin-based
health.
Cell Biochemistry and Function,
Journal Year:
2024,
Volume and Issue:
42(1)
Published: Jan. 1, 2024
Abstract
Three
types
of
adipocytes,
white,
brown,
and
beige,
regulate
the
systemic
energy
balance
through
storage
expenditure
chemical
energy.
In
addition,
adipocytes
produce
various
bioactive
molecules
known
as
adipokines.
contrast
to
white
adipocyte‐derived
molecules,
less
information
is
available
on
adipokines
produced
by
brown
(batokine).
This
study
explored
regulatory
expression
interleukin
(IL)‐6
in
cell
culture
studies.
Norepinephrine
or
a
nonselective
β‐adrenergic
receptor
agonist
increased
IL‐6
primary
HB2
adipocytes.
Treatment
with
forskolin
(Fsk),
an
activator
cAMP‐dependent
protein
kinase
(PKA)
pathway
(downstream
signaling
receptor),
efficiently
stimulated
myotubes.
Phosphorylated
CREB
phosphorylated
p38
MAP
levels
were
Fsk‐treated
within
5
min.
contrast,
long‐term
(∼60
min
∼4
h)
treatment
Fsk
was
required
for
increase
STAT3
phosphorylation
C/EBPβ
expression,
respectively.
The
PKA,
kinase,
STAT3,
pathways
are
maximal
induced
Fsk,
which
verified
use
inhibitors
these
signal
pathways.
Vitamin
C
enhanced
Fsk‐induced
extracellular
signal‐regulated
activity.
present
provides
basic
activated
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 29, 2024
Abstract
The
objective
of
this
research
is
to
analyze
the
influence
various
factors
on
glycemic
control
in
pediatrics
with
type
1
diabetes
mellitus
(T1DM).
study,
a
cross-sectional
analysis,
involved
221
T1DM
patients
below
18
years
old
who
visited
our
clinic
between
2011
and
2020,
predating
COVID-19
outbreak.
Out
initial
pool,
204
participants
were
chosen
based
specific
criteria.
By
computing
odds
ratios
95%
confidence
intervals,
we
determined
correlation
these
achieving
optimal
(HbA1c
<
7.5%).
Of
individuals,
55.9%
(113
patients)
female.
average
age
at
diagnosis
was
6.93
±
3.9
years.
Mean
HbA1c
(A1C)
level
suboptimal
groups
6.97,
CI
6.84
7.1
8.86,
8.68
9.03,
respectively
(p-value
0.001).
Fifty
had
154
people
experienced
during
follow-up
that
prevalence
each
them
24.51,
18.7
31
75.49,
68.99
81.22,
respectively.
In
assessment
risk
associated
control,
aged
10–14
highest
likelihood
experiencing
(crude
ratio
[COR]
3.12,
1.04
9.3),
followed
by
duration
(COR
2.85,
1.2
6.8),
which
both
significant.
utilizing
multivariable
logistic
regression
noteworthy
finding
emerged.
It
revealed
exhibited
significant
association
[adjusted
(AOR)
4.85,
1.32
17.7].
Additionally,
statistically
identified
individuals
body
mass
index
(BMI)
falling
within
≥
95th
percentile
category
Cramer’s
V
=
0.21,
p-value
0.01.
Our
has
obese
(BMI
95th)
control.
crucial
consider
as
they
can
offer
valuable
insights
diagnosis,
highlighting
increased
long-term
