Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(2), P. 105 - 116
Published: Oct. 16, 2024
Background:
Lipids
encompass
a
diverse
group
of
biomolecules
that
are
crucial
for
maintaining
the
body’s
internal
equilibrium
and
range
functions,
including
energy
storage,
maintenance
cellular
membranes,
signalling.
Their
synthesis
metabolism
intricately
linked
to
hormonal
regulation,
particularly
by
thyroid
hormones,
which
influence
lipid
modulating
gene
expression,
enzyme
activity,
mitochondrial
function.
Thyroid
hormones
enhance
metabolic
rate,
clearance,
cholesterol
conversion
bile
acids,
regulated
through
feedback
mechanisms
involving
hypothalamic–pituitary–thyroid
axis.
Subclinical
hypothyroidism
(SCH)
presents
complex
challenge
in
understanding
metabolism.
Methods:
Research
on
SCH’s
impact
profiles
has
yielded
conflicting
results.
Some
studies
indicate
SCH
is
associated
with
increased
levels
triglycerides,
while
others
report
no
significant
changes.
These
discrepancies
underline
necessity
more
comprehensive
clarify
how
affects
its
potential
cardiovascular
implications.
Conclusions:
This
review
aims
consolidate
existing
knowledge,
exploring
biochemical
pathways
clinical
evidence
link
dysfunction
abnormalities
health
risks.
It
emphasizes
critical
need
further
research
elucidate
full
broader
effects
health,
guiding
future
interventions
treatment
strategies.
International Journal of Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 20
Published: Sept. 22, 2023
Secondary
metabolites
are
hidden
gems
in
mushrooms.
Understanding
these
secondary
metabolites'
biological
and
pharmacological
effects
can
be
aided
by
identifying
them.
The
purpose
of
this
work
was
to
profile
the
mycochemical
components
extracts
Auricularia
auricula
judae,
Microporus
xanthopus,
Termitomyces
umkowaani,
Trametes
elegans,
versicolor
comprehend
their
capabilities.
Mushroom
samples
were
collected
from
Kenya's
Arabuko-Sokoke
Kakamega
National
Reserved
Forests
identified
using
morphological
molecular
techniques.
Chloroform,
70%
ethanol,
hot
water
solvents
used
extract
components.
Gas
chromatography
mass
spectrometry
(GC-MS)
analyze
chloroform,
all
species
examined.
A
total
51
compounds
isolated
classified
as
carboxylic
acids,
esters,
phenols,
fatty
alcohol,
epoxides,
aldehydes,
isoprenoid
lipids,
steroids.
Tetracosamethyl-cyclododecasiloxane
(18.90%),
oleic
acid
(72.90%),
phenol,
2,
6-bis
(1,
1-dimethylethyl)-4-methyl-,
methylcarbamate
(26.56%)
found
high
concentrations
A.
auricular
M.
T.
versicolor,
respectively.
Fatty
acids
make
up
majority
elegans
chloroform
umkowaani
ethanol
extract,
Particularly,
play
crucial
roles
anti-inflammatory,
hypocholesterolemic,
anticancer,
antibiofilm
formation
activities.
These
bioactive
elements
indicate
that
five
wild
mushrooms
may
reliable
sources
for
therapeutic
development.
Therefore,
additional
research
is
required
usefulness
chemicals
many
functional
areas
improve
present
understanding
macrofungi.
Scope
Consuming
goat
milk
is
known
to
benefit
high‐fat
diet‐fed
and
streptozocin
(STZ)‐induced
diabetic
rats,
but
the
underlying
mechanisms
are
unknown.
This
study
conducted
investigate
metabolic
effects
of
a
diet
(a
form
powder)
on
glucose
homeostasis
pancreatic
conditions
in
mouse
model
Type
2
diabetes
mellitus
(T2DM)
induced
by
STZ.
Methods
results
T2DM
mice
fed
with
goat‐milk‐based
containing
10.3%
w/w
powder
for
10
weeks
investigating
vivo
effects;
β‐cell
line
MIN6
cells
used
test
vitro
digested
(DGM).
Goat
improves
deleterious
STZ
fasting
levels
tolerance,
accelerates
structure
recovery,
alters
blood
metabolites
mice.
Based
significant
differences
observed
metabolites,
key
pathways,
metabolite
regulatory
enzymes,
molecular
modules,
biochemical
reactions
identified
as
critical
integrated
pathways.
DGM
promotes
cell
activity,
transportation,
AKT
activation
cultured
STZ‐treated
vitro.
Conclusions
mice,
association
improved
profiles
pathway.
ECS Journal of Solid State Science and Technology,
Journal Year:
2024,
Volume and Issue:
13(7), P. 077005 - 077005
Published: July 1, 2024
This
study
presents
an
analytical
model
of
a
strontium
titanate
(SrTiO
3
)-based
biological
field-effect
transistor
(BioFET)
for
cholesterol
detection.
Known
its
high
dielectric
permittivity,
surface
charge
regulation,
and
superior
ionic
thermal
conductivity,
SrTiO
enhances
the
functionality
biosensors.
The
BioFET
employs
gate
functionalized
with
cholesterol-specific
enzyme,
which
facilitates
potentiometric
measurements
concentrations.
establishes
quantitative
relationship
between
concentration
voltage
in
enzyme-immobilized
,
demonstrating
selectivity
-based
BioFETs
indicates
their
potential
developing
diagnostic
tools
cholesterol-related
conditions
monitoring
food
quality.
Additionally,
effectively
predicts
behavior
detection
mechanism
electrochemical
biosensors,
underscoring
innovative
application
fields
such
as
microelectronics,
sensors,
catalysis.
