Molecular docking analysis of Salvia sclarea flower extracts evaluated for protein target affinity based on different extraction methods DOI Creative Commons
Emine İncilay Torunoğlu, Erdi Can Aytar, Alper Durmaz

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 8990 - 9006

Published: Sept. 15, 2024

Abstract This study evaluates the antioxidant activity and total phenolic, flavonoid, flavonol, tannin contents of extracts obtained from flower parts Salvia sclarea using different extraction methods, such as maceration rotavapor (RE). The results indicate that method yields with higher compared to (DPPH IC 50 : 260.70 ± 65.41 mg/mL vs. 345.48 27.91 mg/mL). Additionally, produces values in terms phenolic (26.4 7.78 mg GAE/g extract), flavonoid (10.44 0.21 QE/g flavonol (9.20 0.84 (8.36 0.39 whereas RE shows lower (phenolics: 19.8 3.31 extract, flavonoids: 10.35 0.35 flavanol's: 5.45 0.01 tannins: 7.72 0.10 extract). gas chromatography–mass spectrometry (GC–MS) analysis identified various bioactive compounds. Molecular docking studies revealed Terpinen‐4‐ol through exhibits a strong binding affinity specific protein target, indicating potential biological activity. predicted pharmacokinetic (ADME (absorption, distribution, metabolism, excretion)) parameters for suggest favorable absorption central nervous system (CNS) penetration, while Squalene properties. S. highlights significant provides insight into compounds methods. To further investigate interactions arising these differences, molecular were conducted.

Language: Английский

Biologically active secondary metabolites from white-rot fungi DOI Creative Commons
Orkun Pinar, Susana Rodríguez‐Couto

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

In recent years, there has been a considerable rise in the production of novel metabolites derived from fungi compared to ones originating bacteria. These organic substances are utilized various sectors such as farming, healthcare, and pharmaceutical. Since all dividing living cells contain primary metabolites, secondary synthesized by utilizing intermediate compounds or by-products generated metabolic pathways. Secondary not critical for growth development an organism; however, they exhibit variety distinct biological characteristics. White-rot only microorganisms able decompose wood components. Hence, play important role both carbon nitrogen cycles decomposing non-living substrates. They ubiquitous nature, particularly hardwood (e.g., birch aspen) forests. fungi, besides ligninolytic enzymes, produce different bioactive during their metabolism including some with antimicrobial anticancer properties. Such properties could be potential interest pharmaceutical industries. Considering importance untapped biologically active white-rot present paper reviews produced interesting bioactivities.

Language: Английский

Citations

13

Eco-Friendly Mycogenic Synthesis of Iron Oxide Nanoparticles Using Volvariella volvacea and Unveiling its Potential as Antibiofilm and Anticancer Agents DOI Creative Commons
Debasis Nayak, Awdhesh Kumar Mishra,

Sasmita Malla

et al.

ECS Journal of Solid State Science and Technology, Journal Year: 2024, Volume and Issue: 13(8), P. 087003 - 087003

Published: July 22, 2024

This research explores the eco-friendly creation of functional, biocompatible nanomaterials through green chemistry, utilizing natural extracts over chemicals to produce metal and oxide nanoparticles. The study focuses on iron nanoparticles synthesized with Volvariella volvacea (GIONP) evaluates their physical, chemical, biological traits, including anticancer capabilities, against traditionally made IONPs (CIONP). GIONPs, confirmed by UV-visible spectroscopy dynamic light scattering, showed enhanced stability consistent size distribution. They also demonstrated smaller sizes via -Field Emission scanning electron microscopy analysis, X-ray diffraction Fourier transform infrared studies verified crystalline structure organic functional groups. Notably, GIONPs exhibited strong antioxidant properties, low toxicity blood cells, promising for intravenous use, greater antimicrobial antibiofilm activities various bacterial strains than CIONPs. revealed that both CIONPs exhibit a similar degree towards MDA-MB 231 cancer cells. internalization within these cells was Prussian blue assay further supported concentration-dependent increase in intracellular levels post-treatment. These findings underscore successful formulation are not only but capped bioactive compounds, highlighting applications field biomedicine.

Language: Английский

Citations

4

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds DOI Creative Commons
Gebreselema Gebreyohannes, Desta Berhe Sbhatu

International Journal of Analytical Chemistry, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 20

Published: Sept. 22, 2023

Secondary metabolites are hidden gems in mushrooms. Understanding these secondary metabolites' biological and pharmacological effects can be aided by identifying them. The purpose of this work was to profile the mycochemical components extracts Auricularia auricula judae, Microporus xanthopus, Termitomyces umkowaani, Trametes elegans, versicolor comprehend their capabilities. Mushroom samples were collected from Kenya's Arabuko-Sokoke Kakamega National Reserved Forests identified using morphological molecular techniques. Chloroform, 70% ethanol, hot water solvents used extract components. Gas chromatography mass spectrometry (GC-MS) analyze chloroform, all species examined. A total 51 compounds isolated classified as carboxylic acids, esters, phenols, fatty alcohol, epoxides, aldehydes, isoprenoid lipids, steroids. Tetracosamethyl-cyclododecasiloxane (18.90%), oleic acid (72.90%), phenol, 2, 6-bis (1, 1-dimethylethyl)-4-methyl-, methylcarbamate (26.56%) found high concentrations A. auricular M. T. versicolor, respectively. Fatty acids make up majority elegans chloroform umkowaani ethanol extract, Particularly, play crucial roles anti-inflammatory, hypocholesterolemic, anticancer, antibiofilm formation activities. These bioactive elements indicate that five wild mushrooms may reliable sources for therapeutic development. Therefore, additional research is required usefulness chemicals many functional areas improve present understanding macrofungi.

Language: Английский

Citations

11

Metabolomics Profiling of Edible Mushrooms: Challenges, Applications, and Future DOI

Aruwa E. Christiana,

S’thebe W. Nosipho,

Dweba Yamkela

et al.

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 38

Published: Jan. 1, 2025

Language: Английский

Citations

0

Therapeutic applications, nutritional composition, and their future perspectives of wild mushrooms DOI Open Access

Gaurav Kothiyal,

Keerti Singh,

Mahesh Ramalingam

et al.

International Journal of Life Sciences, Journal Year: 2025, Volume and Issue: 9(1), P. 1 - 15

Published: April 15, 2025

Considering the current situation, relatively little research has been conducted on wild mushrooms to date. Many species of are found in nature. Discovering new these hidden mushrooms, properly identifying them, exploring compounds and writing literature would be novel future. In this way, properties diversity can further explored. Wild a valuable source pharmacologically active substances, nutraceuticals, cosmeceuticals, which could exploited for diverse medical applications future, particularly those requiring accurate pharmacogenetic fingerprints. The purpose present review study is compile information discovered by our scientists researchers from different places discuss their medicinal nutraceutical properties. So data guidance obtained future work.

Language: Английский

Citations

0

Exploring the Biopesticidal Potential of Edible Mushrooms DOI
Sara Taha Abdelkhalek,

Samta Zia,

Doaa R. Abdel‐Haleem

et al.

Reference series in phytochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: Jan. 1, 2025

Language: Английский

Citations

0

Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders DOI Open Access
N. V. Anil Kumar, Cristina Quispe, Jesús Herrera‐Bravo

et al.

Journal of Food Biochemistry, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 26

Published: Dec. 12, 2023

Mushrooms have long been revered not only as a staple food source but also for their potential medicinal properties. Their role natural repository of bioactive compounds positions them uniquely in the pharmaceutical domain, with particular relevance to cosmeceuticals and nutricosmetics. The global ethnobotanical ethnopharmacological chronicles highlight traditional application mushrooms against many diseases, even finding way into cosmetic formulations. This review aims consolidate existing knowledge regarding efficaciousness mushroom-derived bioactives realm skin disorders diseases. In addition, it sheds light on instances where certain mushroom species implicated causing dermatological reactions, underscoring dual nature these fungal entities. A comprehensive assessment was undertaken involving databases relevant scientific literature identify used traditionally treating conditions. contemporary research elucidating biological activities mushrooms, specifically antioxidant, anti-inflammatory, antimicrobial, wound-healing capabilities, scrutinized. Special attention accorded contact dermatitis induced by notably shiitake fungus. Preliminary findings reinforce therapeutic managing ailments, attributed primarily antimicrobial Conversely, some species, prominently shiitake, emerged potent triggers. undeniably harbor an array that can be instrumental various conditions, thereby applications. However, understanding nature, acting both remedy trigger is essential judicious care. Further mandated unravel pharmacological spectrum treasures.

Language: Английский

Citations

4

Antimicrobial activity of herbal biomass derived metabolites fabricated wound dressing material against microbial strains causing skin infection DOI
A.L. Francis, S. Karthick Raja Namasivayam,

S. Priyanka

et al.

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 175, P. 142 - 157

Published: Oct. 16, 2024

Language: Английский

Citations

1

Phosphatidylcholine and ceramide derivatives from white rot fungus Microporus xanthropus PP17-20 DOI
Phongphan Jantaharn, Audomsak Churat,

Sirirat Juanan

et al.

Journal of Asian Natural Products Research, Journal Year: 2024, Volume and Issue: 26(12), P. 1551 - 1556

Published: June 28, 2024

The undescribed phosphatidylcholine (1), along with twelve known compounds, was isolated from the cultures of white rot fungus Microporus xanthropus PP17-20. In this work cultivated in Yeast-Malt extract medium to explore active compound production. chemical structures were elucidated on basis spectroscopic and HRESIMS data. Several compounds evaluated for anti-proliferative activity against A549 MCF-7 cancer cell lines.

Language: Английский

Citations

0

Fomes fomentarius: an underexplored mushroom as source of bioactive compounds DOI
Diego Morales

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104781 - 104781

Published: July 27, 2024

Language: Английский

Citations

0