Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

Human Genomics, Journal Year: 2023, Volume and Issue: 17(1)

Published: March 7, 2023

Abstract Background Polymorphisms in the interleukin-10 ( IL10 ) gene have been linked to severity of patients infected with viral infections. This study aimed assess if polymorphisms rs1800871, rs1800872, and rs1800896 were coronavirus disease 19 (COVID-19) mortality different severe acute respiratory syndrome 2 (SARS-CoV-2) variants Iranian population. Methods For genotyping rs1800896, this used polymerase chain reaction-restriction fragment length polymorphism method 1,734 recovered 1,450 deceased patients. Results The obtained finding indicated rs1800871 CC genotype Alpha variant CT Delta had a relationship COVID-19 mortality; however, there was no association between Omicron BA.5 variant. rate associated rs1800872 TT GT variants. GG AG genotypes BA.5; nevertheless, According data, GTA haplotype most common SARS-CoV-2 TCG related Alpha, Conclusion an impact on infection, these effects various To verify results, further studies should be conducted ethnic groups.

Language: Английский

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Comparative Study of Cytokine Profiles in SARS-CoV-2 Delta and Omicron Variants

Bratislavské lekárske listy/Bratislava medical journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Background The coronavirus disease 2019 (COVID-19) has highly impacted everyday lives and healthcare systems since its spread across the globe. As a result of numerous mutations in viral genome, several genetic variants sub-variants have evolved, they differ various characteristics, such as infectivity, transmissibility, immune response human body. aim this study was to compare cytokine levels plasma samples from patients with acute COVID-19, infected either Delta or Omicron variants. Methods This retrospective included 80 hospitalized PCR-confirmed SARS-CoV-2. Blood well control subjects were collected, multiplex assay performed determining 48 cytokines plasma. Results 50 Delta, 30 variant, 18 subjects. Severe critical course led 27 significantly modified both COVID-19 compared However, 12 (GRO-α, IFN-α2, IL-1α, IL-4, IL-9, IL-16, MIF, MIP-1β, SDF-1α, TNF-α, TNF-β, TRAIL) elevated versus variant discrimination equal AUC = 0.876. Moreover, vaccination decreased GM-CSF, IL-7, IL-8 variant. Conclusions suggests that SARS-CoV-2 affect differently.

Language: Английский

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In Silico Analyses Indicate a Lower Potency for Dimerization of TLR4/MD-2 as the Reason for the Lower Pathogenicity of Omicron Compared to Wild-Type Virus and Earlier SARS-CoV-2 Variants

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5451 - 5451

Published: May 17, 2024

The SARS-CoV-2 Omicron variants have replaced all earlier variants, due to increased infectivity and effective evasion from infection- vaccination-induced neutralizing antibodies. Compared of concern (VoCs), the show high TMPRSS2-independent replication in upper airway organs, but lower lungs mortality rates. shift cellular tropism towards pathogenicity was hypothesized correlate with a toll-like receptor (TLR) activation, although underlying molecular mechanisms remained undefined. In silico analyses presented here indicate that spike protein has potency induce dimerization TLR4/MD-2 compared wild type virus despite comparable binding activity TLR4. A model illustrating consequences different potencies vs. wild-type for TLR4 activation is presented. Further clear tendency decreasing potential during evolution via Alpha Gamma Delta variants.

Language: Английский

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The Important Role of Interleukin-2 in COVID-19

Journal of Immunology Research, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 13

Published: Aug. 22, 2023

There is controversial literature about the effects of interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify potential role IL-2 COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, Web Science. The deadline up December 2022. We applied no time limits for searching strategy. After retrieving articles from authors summarized data into two extraction tables. first table described changes second therapeutic interventions targeting cytokines. results on do not show a singular rule. can change during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some studies suggest that rise infection cause inflammatory response storm. These cytokines are shown be increased immunocompromised patients worsen their prognosis. In individuals without underlying disease, upregulation shows clinical outcome disease rises with severity. However, some other these significantly change. mostly upregulated healthy who had vaccination, but did significant after single dose vaccines, which need booster doses efficient also used as immunotherapy agents

Language: Английский

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Multiplex array analysis of circulating cytokines and chemokines in COVID-19 patients during the first wave of the SARS-CoV-2 pandemic in Milan, Italy

BMC Immunology, Journal Year: 2024, Volume and Issue: 25(1)

Published: July 26, 2024

Abstract Background The systemic inflammatory syndrome called “cytokine storm” has been described in COVID-19 pathogenesis, contributing to disease severity. analysis of cytokine and chemokine levels the blood 21 SARS-CoV-2 positive patients throughout phases pandemic studied understand immune response dysregulation identify potential biomarkers for new treatments. present work reports sera from a small cohort individuals primarily infected with during first wave Milan (Italy). Results Among 27 cytokines chemokines investigated, significant higher expression Interleukin-9 (IL-9), IP-10 (CXCL10), MCP-1 (CCL2) RANTES (CCL-5) compared uninfected subjects was observed. When change cytokine/chemokine monitored over time, hospitalization day discharge, only IL-6 showed decrease. Consistent these findings, negative correlation observed between anti-Spike IgG antibodies individuals. In contrast, IL-17 positively correlated production against SARS-CoV-2. Conclusions storm modulation by infection are hallmarks COVID-19. current global immunity profile largely stems widespread vaccination campaigns previous exposures. Consequently, immunological features dynamic profiles non-vaccinated primarily-infected reported here provide novel insights into landscape context infection, offer valuable knowledge addressing future viral infections development

Language: Английский

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Unique signatures of airway and systemic immunity in severe COVID-19 patients infected with alpha to Omicron SARS-CoV-2 variants of concern

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: March 28, 2025

Language: Английский

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Possible involvement of neuropeptide Y sub-receptor 1 (NPY-Y1) in the anti-viral response of SARS-CoV-2 infection in Syrian hamster

Biomedical Research, Journal Year: 2025, Volume and Issue: 46(2), P. 37 - 50

Published: April 4, 2025

Co-administration of Molnupiravir and Remdesivir, treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), inhibits viral replication infectivity. Previous studies indicate that the neuropeptide Y sub-receptor 1 (NPY-Y1) is involved in influenza virus aggravation mouse pulmonary phagocytes, but exact mechanisms remain unclear. Understanding NPY-Y1 receptor's involvement SARS-CoV-2 both mice hamsters may help explore its potential as an indicator infections support development preventive care. This study examined effects Remdesivir on infected Syrian NPY pathway during infection. infection increased mRNA expression NPY, receptors, inflammatory cytokines chemokines hamster lungs. drugs significantly reduced these expressions. Changes receptor were correlated with IL-10, IL-12, IFN-γ, implying a role antiviral response pathway. These findings highlight changes levels are influenced by impact NPY-NPY-Y1 cascade. implies pathway's responses therapeutic target.

Language: Английский

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Differential responses of lung and intestinal microbiota to SARS-CoV-2 infection: a comparative study of the Wuhan and Omicron strains in K18-hACE2 Tg mice

Laboratory Animal Research, Journal Year: 2025, Volume and Issue: 41(1)

Published: April 23, 2025

Abstract Background The COVID-19 pandemic, caused by SARS-CoV-2, has led to the emergence of viral variants with distinct characteristics. Understanding differential impacts SARS-CoV-2 is crucial for effective public health response and treatment development. We investigated effects original Wuhan strain emergent Omicron variant using a K18-hACE2 transgenic mouse model. compared mortality rates, loads, histopathological changes in lung tracheal tissues, as well alterations intestinal microbiota following infection. Results Our findings revealed significant differences between variants, causing higher severe pathology, elevated loads variant. Microbiome analyses uncovered novel shifts associated each variant, providing evidence variant-specific microbiome alterations. These suggest microbiome-related mechanisms that might modulate disease severity host responses Conclusions This study highlights critical terms mortality, changes, emphasizing role influencing outcomes. Novel include identification shifts, which underscore potential underlying severity. insights pave way future research exploring microbiome-targeted interventions mitigate other infections.

Language: Английский

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Environmental exposures and familial background alter the induction of neuropathology and inflammation after SARS-CoV-2 infection

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 23, 2025

Language: Английский

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Earlier vs. later time period of COVID-19 infection and emergent autoimmune signs, symptoms, and serologies

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 148, P. 103299 - 103299

Published: Aug. 2, 2024

Language: Английский

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