Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(13), P. 1450 - 1450
Published: July 7, 2024
The
dysfunction
of
several
types
regulators,
including
miRNAs,
has
recently
attracted
scientific
attention
for
their
role
in
cancer-associated
changes
gene
expression.
MiRNAs
are
small
RNAs
~22
nt
length
that
do
not
encode
protein
information
but
play
an
important
post-transcriptional
mRNA
regulation.
Studies
have
shown
miRNAs
involved
tumour
progression,
cell
proliferation,
cycle,
apoptosis,
and
angiogenesis
invasion,
a
complex
the
regulation
tumourigenesis.
detection
selected
may
help
early
cancer
cells,
monitoring
expression
profile
serve
as
prognostic
factor
course
disease
or
its
treatment.
diagnostic
biomarkers,
well
potential
therapeutic
targets
colorectal
cancer.
In
recent
years,
there
been
increasing
evidence
epigenetic
interaction
between
DNA
methylation
miRNA
tumours.
This
article
provides
overview
which
more
frequently
expressed
suggesting
oncogenic
nature.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7400 - 7400
Published: July 5, 2024
Colorectal
cancer
(CRC)
is
the
third
most
commonly
diagnosed
worldwide,
with
20%
of
patients
presenting
metastatic
disease
at
diagnosis.
TGF-β
signaling
plays
a
crucial
role
in
various
cellular
processes,
including
growth,
differentiation,
apoptosis,
epithelial-mesenchymal
transition
(EMT),
regulation
extracellular
matrix,
angiogenesis,
and
immune
responses.
signals
through
SMAD
proteins,
which
are
intracellular
molecules
that
transmit
from
cell
membrane
to
nucleus.
Alterations
pathway
mutations
proteins
common
CRC
(mCRC),
making
them
critical
factors
tumorigenesis.
This
review
first
analyzes
normal
then
investigates
its
pathogenesis,
highlighting
mechanisms
influences
metastasis
development.
promotes
neoangiogenesis
via
VEGF
overexpression,
pericyte
other
mechanisms.
Additionally,
affects
elements
tumor
microenvironment,
T
cells,
fibroblasts,
macrophages,
promoting
immunosuppression
metastasis.
Given
strategic
multiple
we
explored
different
strategies
target
mCRC
patients,
aiming
identify
new
therapeutic
options.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 11, 2025
Colorectal
cancer
(CRC)
presents
significant
treatment
challenges
due
to
its
high
heterogeneity
and
complex
intercellular
interactions.
Further
exploration
of
CRC
subtypes
interactions
among
tumor-specific
clusters
will
facilitate
the
development
personalized
strategies.
Single-cell
RNA
sequencing
bulk
datasets
were
integrated
determine
metabolic
by
hierarchical
clustering.
The
analysis
was
further
extended
cellchat,
pseudotime,
immune
infiltration,
clinicopathological
relevance
explore
characteristics
secreted
frizzled
related
protein
2
(SFRP2)
+
cancer-associated
fibroblast
(CAF)
clusters,
validated
spatial
transcriptomics
(ST),
in
vivo
experiments,
multiple
immunohistochemistry
(mIHC).
samples
stably
classified
into
three
heterogeneous
subtypes,
each
exhibiting
different
microenvironment
CAF
heterogeneity,
particularly
distribution
SFRP2
CAF,
which
aligned
with
activity.
exhibits
extracellular
matrix
(ECM)
activity
is
closely
involved
cellular
communication,
not
only
promoting
malignant
progression
cells
but
also
inducing
differentiation
Tregs.
Compared
responders
chemotherapy,
proportion
CAFs
significantly
increased
non-responders.
Importantly,
mIHC
ST
analyses
confirm
that
low
expression
agmatinase
(AGMAT)
can
recruit
CAFs,
Treg
infiltration
surrounding
observed.
AGMAT
combined
oxaliplatin
showed
best
efficacy
vivo,
may
be
associated
inhibition
infiltration.
Our
study
identified
described
potential
protumor
biological
properties
a
valuable
target
for
disrupting
their
properties.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5600 - 5600
Published: March 15, 2023
The
study
of
the
tumor
microenvironment
(TME)
has
become
an
important
part
colorectal
cancer
(CRC)
research.
Indeed,
it
is
now
accepted
that
invasive
character
a
primary
CRC
determined
not
only
by
genotype
cells,
but
also
their
interactions
with
extracellular
environment,
which
thereby
orchestrates
development
tumor.
In
fact,
TME
cells
are
double-edged
sword
as
they
play
both
pro-
and
anti-tumor
roles.
interaction
tumor-infiltrating
(TIC)
induces
polarization
TIC,
exhibiting
antagonist
phenotype.
This
controlled
plethora
interconnected
anti-oncogenic
signaling
pathways.
complexity
this
dual
function
these
different
actors
contribute
to
failure
control.
Thus,
better
understanding
such
mechanisms
great
interest
provides
new
opportunities
for
personalized
efficient
therapies
CRC.
review,
we
summarize
pathways
linked
implication
in
or
inhibition
initiation
progression.
second
part,
enlist
major
components
discuss
functions.
Molecular Carcinogenesis,
Journal Year:
2024,
Volume and Issue:
63(6), P. 1092 - 1105
Published: Feb. 28, 2024
Abstract
Colorectal
cancer
(CRC)
is
a
common
digestive
tract
tumor
with
the
third
incidence
and
death
in
world.
There
still
an
urgent
need
for
effective
therapeutic
targets
prognostic
markers
CRC.
Herein,
we
report
novel
potential
target
marker,
Chordin
like‐1
(CHRDL1).
The
function
of
CHRDL1
has
been
reported
gastric
cancer,
breast
oral
squamous
cell
carcinoma.
However,
biological
effect
CRC
remains
unrevealed.
Transwell
tube
formation
experiments
were
used
to
determine
CHRDL1.
Western
blot
rescue
specific
mechanisms
Results
showed
significantly
downregulated
lines
tissues.
In
vitro,
confirmed
that
can
inhibit
growth,
migration,
invasion,
angiogenesis
reverse
epithelial‐mesenchymal
transformation.
vivo,
proved
it
growth
metastasis.
Mechanistically,
newly
find
exerts
functions
through
transforming
factor‐beta
(TGF‐β)/vascular
endothelial
factor
signaling
axis
vitro
vivo.
Therefore,
concluded
reduces
cells
by
downregulating
TGF‐β
signaling.
Our
new
findings
on
may
provide
basis
clinical
antiangiogenesis
therapy
prognosis
Molecular Biomedicine,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: June 7, 2024
Abstract
Colorectal
carcinoma
(CRC)
stands
as
a
pressing
global
health
issue,
marked
by
the
unbridled
proliferation
of
immature
cells
influenced
multifaceted
internal
and
external
factors.
Numerous
studies
have
explored
intricate
mechanisms
tumorigenesis
in
CRC,
with
primary
emphasis
on
signaling
pathways,
particularly
those
associated
growth
factors
chemokines.
However,
sheer
diversity
molecular
targets
introduces
complexity
into
selection
targeted
therapies,
posing
significant
challenge
achieving
treatment
precision.
The
quest
for
an
effective
CRC
is
further
complicated
absence
pathological
insights
mutations
or
alterations
occurring
tumor
cells.
This
study
reveals
transfer
from
cell
membrane
to
nucleus,
unveiling
recent
advancements
this
crucial
cellular
process.
By
shedding
light
novel
dimension,
research
enhances
our
understanding
intricacies
underlying
providing
potential
avenue
breakthroughs
therapeutic
strategies.
In
addition,
comprehensively
outlines
immune
responses
incited
aberrant
activation
specific
focus
cells,
cytokines,
their
collective
impact
dynamic
landscape
drug
development.
not
only
contributes
significantly
advancing
medicine
but
also
lays
groundwork
future
clinical
trials,
fostering
optimism
improved
outcomes
refined
approaches
combating
colorectal
carcinoma.
