The implication of ADRA2A and AVPRIB gene variants in the aetiology of stress-related bipolar disorder DOI Creative Commons

Ovinuchi Ejiohuo,

Karolina Bilska, Beata Narożna

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Microbial signatures and therapeutic strategies in neurodegenerative diseases DOI Open Access

Mlaak Rob,

Mahmoud Yousef, Arun Prasath Lakshmanan

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117905 - 117905

Published: Feb. 10, 2025

Language: Английский

Citations

3
Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review DOI Creative Commons
Benjamin R. Underwood, Ilianna Lourida, Jessica Gong

et al.

Alzheimer s & Dementia Translational Research & Clinical Interventions, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 1, 2025

Language: Английский

Citations

2
The roles of intrinsically disordered proteins in neurodegeneration DOI Creative Commons
Kagistia Hana Utami, Satoru Morimoto, Yasue Mitsukura

et al.

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2025, Volume and Issue: unknown, P. 130772 - 130772

Published: Feb. 1, 2025

Language: Английский

Citations

2
Proteostasis disruption and senescence in Alzheimer’s disease pathways to neurodegeneration DOI
Riya Thapa, Asif Ahmad Bhat, Moyad Shahwan

et al.

Brain Research, Journal Year: 2024, Volume and Issue: 1845, P. 149202 - 149202

Published: Aug. 30, 2024

Language: Английский

Citations

9
Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease DOI
Anand Thirupathi, Luis Felipe Marqueze, Tiago F. Outeiro

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(7), P. 1643 - 1654

Published: May 24, 2024

Language: Английский

Citations

7
Chiral nanomaterial-based approaches for diagnosis and treatment of protein-aggregated neurodiseases: current status and future opportunities DOI

Pranav Tiwari,

Abhishek Bajpai,

Prabhat K. Dwivedi

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(8), P. 1991 - 2005

Published: Jan. 1, 2024

Stereo-specific effects of chiral nanomaterials on protein-aggregated diseases.

Language: Английский

Citations

6
Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders DOI
Mayur B. Kale, Nitu L. Wankhede, Ashok Kumar Bishoyi

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 565, P. 63 - 79

Published: Nov. 26, 2024

Language: Английский

Citations

6
Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder DOI Creative Commons
Arsen Arakelyan, Susanna Avagyan,

Aleksey Kurnosov

et al.

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 17, 2024

Abstract The molecular events underlying the development, manifestation, and course of schizophrenia, bipolar disorder, major depressive disorder span from embryonic life to advanced age. However, little is known about early dynamics gene expression in these disorders due their relatively late manifestation. To address this, we conducted a secondary analysis post-mortem prefrontal cortex datasets using bioinformatics machine learning techniques identify differentially expressed modules associated with aging diseases, determine time-perturbation points, assess enrichment quantitative trait loci (eQTL) genes. Our findings revealed early, mid, deregulation functional involved neurodevelopment, plasticity, homeostasis, immune response. This supports hypothesis that multiple hits throughout contribute disease manifestation rather than single early-life event. Moreover, time-perturbed were genetic affecting expression, highlighting role factors development phenotypes. emphasize importance investigating time-dependent perturbations before age onset elucidating mechanisms psychiatric disorders.

Language: Английский

Citations

4
Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis DOI
Chenjiarui Qin, Wenqiang Zhang,

Changfeng Xiao

et al.

Journal of Bone and Mineral Research, Journal Year: 2024, Volume and Issue: 39(7), P. 918 - 928

Published: June 6, 2024

Although the negative association of tobacco smoking with osteoporosis is well-documented, little known regarding shared genetic basis underlying these conditions. In this study, we aim to investigate a architecture between and heel estimated bone mineral density (eBMD), reliable proxy for osteoporosis. We conducted comprehensive genome-wide cross-trait analysis identify correlation, pleiotropic loci causal relationship eBMD, leveraging summary statistics hitherto largest studies in European ancestry initiation (Nsmoker = 1 175 108, Nnonsmoker 493 921), heaviness (cigarettes per day, N 618 489), cessation (Ncurrent smoker 304 244, Nformer 843 028), eBMD (N 426 824). A significant global correlation was found (${r}_g$ -0.051, P 0.01), while failed or eBMD. Partitioning whole genome into independent blocks, observed 6 local signals 22q13.1 showing strongest regional correlation. Such overlap further supported by 71 identified meta-analysis. Mendelian randomization no effect (beta -0.003 g/cm2, 95% CI -0.033 0.027) -0.017 -0.072 0.038) on but putative predisposition being current associated lower compared former smokers -0.100 -0.181 -0.018). Our study demonstrates pronounced biological pleiotropy as well link status providing novel insights primary prevention modifiable intervention advocating individuals avoid, reduce quit early possible.

Language: Английский

Citations

4
Strategies for inhibiting amyloid fibrillation: Current status and future prospects DOI
Md Nadir Hassan, Murtaza Shabbir Hussain, Rizwan Hasan Khan

et al.

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown, P. 145 - 168

Published: Jan. 1, 2025

Language: Английский

Citations

0