BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 28, 2024
Language: Английский
Antioxidants, Journal Year: 2024, Volume and Issue: 13(5), P. 602 - 602
Published: May 14, 2024
Reactive oxygen species (ROS) are highly reactive derivatives that include free radicals such as superoxide anion radical (O2•−) and hydroxyl (HO•), well non-radical molecules hydrogen peroxide (H2O2), peroxynitrite (ONOO−), hypochlorous acid (HOCl) [...]
Language: Английский
Citations
54
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 845 - 845
Published: Jan. 20, 2025
Alcohol is the second-most misused substance after tobacco. It has been identified as a causal factor in more than 200 diseases and 5.3% of all deaths associated with significant behavioral, social, economic difficulties. As alcohol consumption may modulate immune system’s regulatory mechanisms to avoid attacking body’s tissues, it proven play dichotomic role autoimmune (ADs) based on quantity consumption. In this review, we report updated evidence ADs, focus addiction human biological system relationship between them, risk or protective factor. Then, narrative main most studied ADs where represents key modulator, including thyroiditis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, diabetes, allergic rhinitis, primary biliary cholangitis. at low–moderate dosages seems mostly have these diseases, while higher dosages, collateral risks surpass possible benefits. The specific by which low-to-moderate intake relieves AD symptoms are not yet fully understood; however, emerging studies suggest that immunomodulatory effect, potentially altering balance anti-inflammatory innate adaptive cells, well cytokines (via NF-κB NLRP3 pathways). might influence composition gut microbiome (increasing amounts beneficial microbes) production their fatty acid metabolites, such short-chain acids (SCFAs) polyunsaturated (PUFAs), elevated concentrations acetate, high-density lipoprotein (HDL), nitric oxide (NO). Unfortunately, definite acceptable daily (ADI) ethanol complicated establish because many despite interesting content findings, there limit applicability should be weighed cases alcoholic drinking recommendations. aim future those pathways involved alcohol-protective various strategies intake.
Language: Английский
Citations
2
Nutrients, Journal Year: 2023, Volume and Issue: 15(7), P. 1774 - 1774
Published: April 5, 2023
Inflammaging refers to a chronic, systemic, low-grade inflammation, driven by immune (mainly macrophages) and non-immune cells stimulated endogenous/self, misplaced or altered molecules, belonging physiological aging. This age-related inflammatory status is characterized increased inflammation decreased macroautophagy/autophagy (a degradation process that removes unnecessary dysfunctional cell components). predisposes diseases, including obesity, type-2 diabetes, cancer, cardiovascular neurodegenerative disorders, as well vulnerability infectious diseases vaccine failure, representing thus major target for anti-aging strategies. Phenolic compounds—found in extra-virgin olive oil (EVOO)—are known their beneficial effect on longevity. Among them, hydroxytyrosol (HTyr) appears greatly contribute healthy aging its documented potent antioxidant activity. In addition, HTyr can modulate autophagy, possibly counteracting reducing inflammaging. this review, we reference the literature pure modulatory agent of order highlight possible interference with HTyr-mediated activity might delay development progression related
Language: Английский
Citations
25
Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(4), P. 2240 - 2258
Published: Jan. 28, 2024
Abstract Resveratrol, a natural polyphenol in various plants, has gained significant attention for its potential health‐promoting properties. It been demonstrated, after reviewing clinical and vitro studies, that resveratrol possesses potent antioxidant potential. Resveratrol demonstrates cellular component protection by directly neutralizing free radicals (FRs) enhancing the expression of enzymes, thereby mitigating oxidative damage to proteins, lipids, nucleic acids. Clinical trials have shown promising results, indicating supplementation can enhance defenses reduce markers populations. In addition effects, exhibits anti‐inflammatory modulate key inflammatory pathways, such as nuclear factor‐kappa B (NF‐κB) mitogen‐activated protein kinases (MAPKs), suppressing production pro‐inflammatory cytokines chemokines. Furthermore, resveratrol's multimodal effects extend beyond discovered exert regulatory on processes, including apoptosis, cell cycle progression, angiogenesis, immunological responses. The primary aim this review paper is provide thorough overview current knowledge resveratrol, chemical composition, bioaccessibility, effectiveness, utilization nanotechnology bioavailability. From future perspectives, revising administration methods certain contexts understanding underlying systems responsible will require further inquiry. For highest health advanced trial‐based research necessary combinational nano‐delivery resveratrol.
Language: Английский
Citations
15
Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 221 - 221
Published: Jan. 18, 2023
In mammals during aging, reactive oxygen species (ROS), produced by the mitochondrial respiratory chain, cause oxidative damage of macromolecules leading to chain dysfunction, which in turn increases ROS production. Many efforts have been made understand role stress aging and age-related diseases. The complex I is major source production its dysfunctions associated with several forms neurodegeneration, other common human diseases aging. Complex I-ROS content proposed as determinants for longevity. cAMP signal has a regulation activity decrease last years, an increasing number studies attempted activate signaling treat This idea comes from long-line showing main memory consolidation mechanism functions. Here, we discuss evidences on possible connection between pathway process.
Language: Английский
Citations
14
npj Aging, Journal Year: 2024, Volume and Issue: 10(1)
Published: May 21, 2024
The emerging field of Nutritional Cognitive Neuroscience aims to uncover specific foods and nutrients that promote healthy brain aging. Central this effort is the discovery nutrient profiles can be targeted in nutritional interventions designed health with respect multimodal neuroimaging measures structure, function, metabolism. present study therefore conducted one largest most comprehensive biomarker studies examining within a sample 100 older adults. To assess health, battery well-established cognitive imaging was administered, along 13 blood-based biomarkers diet nutrition. findings revealed distinct patterns aging, categorized into two phenotypes based on hierarchical clustering. One phenotype demonstrated an accelerated rate while other exhibited slower-than-expected A t-test analysis dietary distinguished these profile higher concentrations fatty acids, antioxidants, vitamins. Study participants better scores delayed as determined by means. Notably, participant characteristics such demographics, fitness levels, anthropometrics did not account for observed differences Therefore, pattern identified motivates design neuroscience-guided
Language: Английский
Citations
6
Neuropharmacology, Journal Year: 2024, Volume and Issue: 250, P. 109906 - 109906
Published: March 16, 2024
Language: Английский
Citations
5
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1504 - 1504
Published: Nov. 22, 2024
Inflammation and apoptosis are interrelated biological processes that have a significant impact on the advancement growth of certain chronic diseases, such as cardiovascular problems, neurological conditions, osteoarthritis. Recent research has emphasized focusing these mechanisms could result in novel therapeutic approaches aim to decrease severity diseases enhance patient outcomes. Hydroxytyrosol (HT), which is well-known for its ability prevent oxidation, been identified possible candidate regulating both inflammation apoptosis. In this review, we will highlight multifaceted benefits HT agent mitigating inflammation, apoptosis, associated conditions. This review provides comprehensive overview latest vitro vivo anti-inflammatory antiapoptotic effects by it works. Based studies, strongly advised use bioactive ingredient pharmaceutical products intended well those with applications.
Language: Английский
Citations
4
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140776 - 140776
Published: Feb. 7, 2025
Language: Английский
Citations
0
Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 25, 2025
Clear cell renal carcinoma (ccRCC), the most prevalent cancer subtype, is frequently associated with poor prognosis. RHO-GTPase signaling genes have been implicated in tumor aggressiveness and unfavorable survival, but their potential risk stratification therapeutic guidance for ccRCC patients remains unexplored. Univariate regression identified prognostically relevant genes, followed by consensus clustering subtype classification. LASSO selected key to construct a six-gene model. The model was evaluated prognostic stratification, immune status, immunotherapy response, chemotherapy sensitivity. Key were analyzed at genomic, single-cell, protein levels explore underlying mechanisms. Among 62 six (ARHGAP11B, NUF2, PLK1, CYFIP2, IQGAP2, VAV3) form robust signature. This stratified into high- low-risk groups, high-risk demonstrating significantly worse outcomes. exhibited excellent predictive accuracy (AUC > 0.7 training validation cohorts). High-risk characterized an immunosuppressive microenvironment reduced sensitivity immunotherapy. Drug analysis revealed 107 agents correlated score, underscoring relevance. Mechanistically, showed distinct expression patterns, cellular distribution, positive correlation VHL mutations, highlighting as actionable drug targets. study established novel predicting prognosis, responses ccRCC, which offers improving patient guiding personalized treatment strategies.
Language: Английский
Citations
0