Autism
spectrum
disorder
(ASD)
is
a
neurodevelopment
mainly
arises
due
to
the
abnormalities
in
different
brain
regions,
resulting
behavioral
deficits.
Besides
its
diverse
phenotypical
features,
ASD
associated
with
complex
and
varied
etiology,
presenting
challenges
understanding
precise
neuro-pathophysiology.
Pioglitazone
was
reported
have
fundamental
role
neuroprotection
various
other
neurological
disorders.
The
aim
of
present
study
investigate
therapeutic
potential
pioglitazone
prenatal
valproic
acid
(VPA)
model
Wistar
rats.
Pregnant
female
rats
received
VPA
on
embryonic
day
(E.D12.5)
induce
autistic-like-behavioral
neurobiological
alterations
their
offspring.
VPA-exposed
presented
core
symptoms
such
as
deficits
social
interaction,
poor
spatial
learning
behavior,
increased
anxiety,
locomotors
repetitive
activity,
decreased
exploratory
activity.
Apart
from
these,
exposure
also
stimulated
neurochemical
histopathological
neurodegeneration
regions.
We
administered
three
doses
i.e.,
2.5,
5,
10
mg/kg
for
assessing
parameters.
Of
all
doses,
our
highlighted
that
efficiently
attenuated
autistic
along
oxidative
stress,
neuroinflammation,
apoptosis.
Moreover,
significantly
by
restoring
neuronal
loss
hippocampus
cerebellum.
Taken
together,
ameliorating
effect
rat
can
be
linked
further
treating
disease.
Journal of Cerebral Blood Flow & Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Photobiomodulation
(PBM)
therapy
stands
as
an
innovative
neurostimulation
modality
that
has
demonstrated
both
efficacy
and
safety
in
improving
brain
function.
This
exerts
multifaceted
influences
on
neurons,
blood
vessels,
their
intricate
interplay
known
neurovascular
coupling
(NVC).
Growing
evidence
indicates
NVC
may
present
a
promising
target
for
PBM
intervention.
However,
the
detailed
mechanisms
underlying
its
therapeutic
benefits
remain
to
be
fully
understood.
review
aims
elucidate
potential
metabolic
pathways
signaling
cascades
involved
modulatory
effects
of
PBM,
while
also
exploring
extensive
repertoire
applications
neurologic
psychiatric
conditions.
The
prospects
within
realm
investigation
are
intensively
considered,
providing
deeper
insights
into
powerful
capabilities
revolutionize
treatments.
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 26, 2024
Small
pilot
studies
have
suggested
that
transcranial
photobiomodulation
(tPBM)
could
help
reduce
symptoms
of
neurological
conditions,
such
as
depression,
traumatic
brain
injury,
and
autism
spectrum
disorder
(ASD).
Journal of Affective Disorders,
Journal Year:
2024,
Volume and Issue:
354, P. 574 - 588
Published: March 14, 2024
Chronic
stress
is
an
important
risk
factor
for
the
development
of
major
depressive
disorder
(MDD).
Recent
studies
have
shown
microbiome
dysbiosis
as
one
pathogenic
mechanisms
associated
with
MDD.
Thus,
it
to
find
novel
non-pharmacological
therapeutic
strategies
that
can
modulate
gut
microbiota
and
brain
activity.
One
such
strategy
photobiomodulation
(PBM),
which
involves
non-invasive
use
light.
Acta Pharmacologica Sinica,
Journal Year:
2024,
Volume and Issue:
45(8), P. 1591 - 1603
Published: April 8, 2024
Autism
spectrum
disorder
(ASD)
is
a
cluster
of
neurodevelopmental
disorders
characterized
by
deficits
in
communication
and
behavior.
Increasing
evidence
suggests
that
the
microbiota-gut-brain
axis
likely
related
immune
imbalance
may
play
role
development
this
disorder.
Gastrointestinal
gut
microbiota
dysfunction
have
been
linked
to
or
severity
autistic
Therefore,
treatments
focus
on
specific
diets
improve
gastrointestinal
function
aberrant
behavior
individuals
with
ASD.
In
study,
we
investigated
whether
diet
containing
prebiotic
fibers,
namely,
3%
galacto-oligosaccharide/fructo-oligosaccharide
(GOS/FOS;
9:1),
can
mitigate
adverse
effects
utero
exposure
valproic
acid
(VPA)
mice.
Pregnant
BALB/cByJ
dams
were
injected
VPA
(600
mg/kg,
sc.)
phosphate-buffered
saline
(PBS)
gestational
day
11
(G11).
Male
offspring
divided
into
four
groups:
(1)
PBS-exposed
control
diet,
(2)
GOS/FOS
(3)
VPA-exposed
(4)
diet.
Dietary
intervention
started
from
birth
continued
throughout
duration
experiment.
We
showed
normalized
VPA-induced
alterations
male
offspring,
including
restoration
key
microbial
taxa,
intestinal
permeability,
peripheral
homeostasis,
reduction
neuroinflammation
cerebellum,
impairments
social
cognition
Overall,
our
research
provides
valuable
insights
gut-brain
involvement
ASD
development.
addition,
dietary
interventions
might
correct
disbalance
responses
and,
ultimately,
detrimental
behavioral
outcomes
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(24), P. 17394 - 17394
Published: Dec. 12, 2023
Age-related
macular
degeneration
(AMD)
is
a
global
health
challenge.
AMD
causes
visual
impairment
and
blindness,
particularly
in
older
individuals.
This
multifaceted
disease
progresses
through
various
stages,
from
asymptomatic
dry
to
advanced
wet
AMD,
driven
by
factors
including
inflammation
oxidative
stress.
Current
treatments
are
effective
mainly
for
AMD;
the
therapeutic
options
limited.
Photobiomodulation
(PBM)
using
low-energy
light
red-to-near-infrared
range
promising
treatment
retinal
diseases.
study
investigated
effects
of
multi-wavelength
PBM
(680,
780,
830
nm)
on
sodium
iodate-induced
oxidatively
damaged
tissue.
In
an
vivo
rat
model
induced
iodate,
effectively
protected
layers,
reduced
apoptosis,
prevented
rod
bipolar
cell
depletion.
Furthermore,
inhibited
photoreceptor
pigment
epithelium
toxicity.
These
results
suggest
that
may
be
useful
strategy
mitigating
stress,
preserving
integrity,
preventing
apoptosis.
