Atopic dermatitis: a comprehensive updated review of this intriguing disease with futuristic insights

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

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Comparative Real-World Analysis of Baseline Demographic Characteristics and Comorbidities in Atopic Dermatitis Patients Initiating Biologics Versus JAK Inhibitors

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1291 - 1291

Published: Feb. 15, 2025

Background: Systemic advanced therapies, including biologic drugs and Janus kinase (JAK) inhibitors, have revolutionized atopic dermatitis management. The increasing number of available options for such complex diseases demands careful treatment selection each patient, considering numerous variables. Comparative analyses these modalities in the real world are still limited. Only a faithful basal characterization would enable posterior meaningful accurate comparisons efficacy safety profiles groups drugs. This communication focuses on describing comparing baseline demographics comorbidities patients with currently treated therapies versus JAK inhibitors our setting. Methods: We conducted an observational, descriptive, ambispective study across three hospitals covering population over 500,000 inhabitants from January 2019 to December 2024. Baseline demographic data, anthropometric measures, lifestyle factors, cardiovascular risk were analyzed using descriptive inferential statistics. Additionally, severity effectivity time also been compared. Results: A total 150 analyzed. 102 had received biological (dupilumab or tralokinumab), whereas 48 (upadacitinib, baricitinib, abrocitinib). Ages ranged 11 76 years. overall cohort mean age 35.87 ± 14.37 years male predominance (male-to-female ratio 1.63:1). Hypertension was more prevalent group (p = 0.0175), yet other body measurements, non-atopic comorbidities, disease comparable both groups. Conclusions: helped characterize characteristics systemic real-world clinical It pointed just slight differences between biologics inhibitors. homogeneity sets ground further future outcomes this as potential confounding factors related imbalances minimized.

Language: Английский

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The role of LINC00114 in atopic dermatitis: modulating inflammation and epidermal barrier dysfunction

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: April 1, 2025

Language: Английский

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Cure for the itch: current clinical standards and therapies in allergic eczema

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 6

Published: April 3, 2025

Allergic Eczema (AE) is a chronic, relapsing skin condition that significantly affects the quality of life AE patients and their caretakers. Decades scientific clinical research has helped understand highly complex underpinnings presentation wherein multitude variables, including conspicuous variables such as environmental allergens, immunological triggers, genetic predisposition individuals, to more nuanced socio-economic status, play an important part. Given complexity disease, it imperative develop biomarkers enabling early reliable identifications help in active management thereby minimizing impact burden disease on patients. In this mini review, we provide brief overview AE, affected demographics, trigger its onset, summarize discovery various total specific serum IgE levels, Th2 cytokine filaggrin (FLG) mutations, periostin levels skin, etc. have been developed over years further improve state monitoring progression. Lastly, also interventions therapies, topical agents, phototherapy, biologics, are available manage AE-related complications. While vastly improved standard care diagnosis for patients, there still many unmet needs developing non-invasive, effective, predictors which can usher better personalized treatments demographics.

Language: Английский

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Head and neck dermatitis: a variant of atopic dermatitis

Italian Journal of Dermatology and Venereology, Journal Year: 2025, Volume and Issue: 160(2)

Published: April 1, 2025

Atopic dermatitis involves the head and neck area across all age groups. This manifestation is frequently referred to as "the dermatitis." Aside from a considerable deterioration of quality life, it poses significant diagnostic therapeutic challenge. The may be mimicked by other inflammatory conditions such seborrheic or contact dermatitis. Furthermore, can associated with wide range infectious, ocular, psychiatric hair disorders, which should raise clinical alertness encourage multidisciplinary management affected individuals. Skin lesions in are often difficult treat, particularly because exposure this region exacerbating factors limitations regarding use some pharmaceuticals. Although several hypotheses explaining recalcitrant course have been proposed, none them provide successful solutions applicable daily practice. comprehensive review comprises current insights on pathogenesis, presentation, comorbidities Recommendations possible treatments condition antifungals, well special considerations for choice biologics JAK inhibitors candidates systemic treatment outlined.

Language: Английский

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Study of the immunomodulatory activity of cryopreserved and lyophilised human cord blood leukoconcentrate in experimental model of atopic dermatitis

One Health Journal, Journal Year: 2025, Volume and Issue: 3(3), P. 32 - 47

Published: April 29, 2025

Atopic dermatitis (AD) is a chronic autoimmune disease characterized by rashes, itching, and dryness of the skin. The drugs choice for treatment AD are steroidal anti-inflammatory drugs, disadvantage which development undesirable side effects. Based on this, search effective at same time safe methods treating an urgent task medicine. use cell tissue therapy promising, have proven themselves as correctors immune system, acting various pathogenetic links this type disease. aim study was didacated to evaluation immunomodulatory activity lyophilized (lHCBL) cryopreserved human cord blood leukoconcentrate (cHCBL) in comparative aspect model. experiments were conducted 6-month-old Wistar Albino rats. When induced, focus inflammation back rats (3–4 cm^2) formed daily rubbing 5% alcohol-acetone solution 2,4-dinitrochlorobenzene (DNCB) 21 days. suspensions lHCBL cHCBL administered intraperitoneally dose 0.5 ml 5 × 10^6 cells one day after end DNCB administration. On 3rd 7th treatment, certain subpopulations lymphocytes (CD3+, CD4+, CD8+, CD16+, CD4+CD25+), level circulating complexes, serum concentrations immunoglobulin A E, adhesive phagocytic peritoneal cavity determined. For induced DNCB, characteristic systemic changes status expressed indicators cellular humoral immunity. Thus, with AD, immunity spleen detected: namely, decrease number total T-lymphocytes their (CD4+ CD8+ cells). Against background, monocyte-phagocytic noted. work proved immunocorrective DNCB-induced AD. In addition, features effect each preparations, i.e. lHCBL, experimental model atopic dermatitis, therapeutic has been proven, namely ability correct state impaired system animals. At time, higher noted compared cHCBL, opens up prospects clinical practice.

Language: Английский

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Coffea arabica Extract Attenuates Atopic Dermatitis-like Skin Lesions by Regulating NLRP3 Inflammasome Expression and Skin Barrier Functions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12367 - 12367

Published: Aug. 2, 2023

Atopic dermatitis (AD) is a common skin disease worldwide. The major causes of AD are barrier defects, immune dysfunction, and oxidative stress. In this study, we investigated the anti-oxidation anti-inflammation effects Coffea arabica extract (CAE) its regulation functions in AD. vitro experiments revealed that CAE decreased reactive oxygen species levels inhibited translocation nuclear factor-κB (NF-κB), further reducing secretion interleukin (IL)-1β IL-6 induced by interferon-γ (IFN-γ)/tumor necrosis factor-α (TNF-α). Moreover, IFN-γ/TNF-α-induced NLR family pyrin domain-containing 3 (NLRP3), caspase-1, high-mobility group box 1 (HMGB1), receptor for advanced glycation end products (RAGE) expression levels. It also restored protein function-related markers including filaggrin claudin-1. vivo not only reduced redness backs mice caused 2,4-dinitrochlorobenzene (DNCB) but pro-inflammatory factors their skin. transepidermal water loss (TEWL) cell infiltration DNCB-treated mice. Overall, exerted ameliorated suggesting potential as an active ingredient treatment.

Language: Английский

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Interleukin antagonists for atopic dermatitis: a new era of therapy

Expert Opinion on Investigational Drugs, Journal Year: 2024, Volume and Issue: 33(6), P. 549 - 559

Published: April 24, 2024

Introduction Over the last decade, increasing understanding of immunopathogenesis atopic dermatitis (AD) enabled recognition multiple therapeutic targets and subsequently development novel, highly effective systemic treatments, including interleukin (IL)-antagonists. To date, IL-4Ra-inhibitor dupilumab, IL-13 inhibitor tralokinumab, have gained regulatory approval in Europe for treatment moderate-to-severe AD, while more than 70 new therapeutics are currently development.

Language: Английский

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Role of interleukins in dermatology: Exploring the immune mechanisms in skin diseases

JEADV Clinical Practice, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Abstract Interleukins are central in the modulation of immune responses. This narrative review aims to summarize growing evidence on their significance as key drivers numerous cutaneous diseases with a special focus some more prevalent chronic inflammatory dermatologic such psoriasis, atopic dermatitis, allergic contact urticaria, and hidradenitis suppurativa. Additionally, we discuss relevance recent developments targeted therapies that have significantly transformed management these skin conditions. To this end, conducted comprehensive search through Cochrane Library Database Systematic Reviews MEDLINE engine, summarized available clinical considering up 466 records including meta‐analyses, systematic reviews, reviews trials. Ultimately, intents foster both dermatologist non‐dermatologist physicians' understanding immunology behind manifestations most common engage novel therapeutic approaches by providing accessible insights into implications interleukin pathways dysregulation.

Language: Английский

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Investigation of immunomodulatory and cytotoxic effects of shed snake skin (Elaphe sauromates) extract

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 12, 2024

Introduction Shed snake skin (SSS) is commonly used empirically in ethnomedicine to treat psoriasis, acne, warts, eczema, scabies, open wounds, hemorrhoids, and glaucoma. Although a few studies exist, SSS extracts’ vitro immunological effects have yet be well described. Therefore, we aimed investigate the immunomodulatory of extract on murine lymphocytes T cells. Methods Hexane, methanol, chloroform extractions were conducted collected samples. Protein concentrations measured. The cytotoxic anticancer activities measured using L929 Fibroblast SK MEL 30 Cell Lines via MTT assay as described TS EN ISO 10993-5. Immunomodulatory total or enriched CD4 + cell cultures, their cell-specific pro-inflammatory cytokines ( IL-6 , IL-1β . IL-12p40 IL-23p19 TNF- α, IL-17A IFN-γ IL-10 TGFβ1 ) levels FACS ARIA III analysis related gene expression with Real-Time Quantitative Polymerase Chain Reaction (Rt-qPCR). Results chloroform-extracted tested SK-MEL-30 cells revealed superior anti-proliferative effect for hexane at low concentrations. treatment augmented Tnf-α produced by CD3 when activated anti-CD3/CD28 LPS stimulation. This required presence non-T cells, possibly antigen-presenting was not observed purified Additionally, significantly blocked suppressive cytokine Tgfb (but Il10 without altering Treg generation/or expansion. Discussion first study investigating SSS’s anti-tumor effects. Our data provide evidence activity its role lymphocytes, which warrants further investigation potential use vivo disease models.

Language: Английский

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