Application of novel strategies in chronic wound management with focusing on pressure ulcers: new perspective

Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)

Published: Jan. 31, 2025

Language: Английский

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New Perspectives of Hydrogels in Chronic Wound Management

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 686 - 686

Published: Feb. 4, 2025

Chronic wounds pose a substantial healthcare concern due to their prevalence and cost burden. This paper presents detailed overview of chronic emphasizes the critical need for novel therapeutic solutions. The pathophysiology wound healing is discussed, including stages factors contributing chronicity. focus on diverse types wounds, such as diabetic foot necrosis, pressure ulcers, venous leg highlighting etiology, consequences, issues they provide. Further, modern care solutions, particularly hydrogels, are highlighted tackling challenges management. Hydrogels characterized multipurpose materials that possess vital characteristics like capacity retain moisture, biocompatibility, incorporation active drugs. Hydrogels’ effectiveness in applications demonstrated by how support healing, preserving ideal moisture levels, promoting cellular migration, possessing antibacterial properties. Thus, this hydrogel technology’s latest developments, emphasizing drug-loaded stimuli-responsive underscoring these advanced formulations greatly improve therapy outcomes enabling dynamic focused reactions environment. Future directions research promote development customized treatments digital health tools treatment wounds.

Language: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

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Simultaneous Biofilm Disruption, Bacterial Killing, and Inflammation Elimination for Wound Treatment Using Silver Embellished Polydopamine Nanoplatform

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 10, 2024

Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, reduce for wound treatment is presented. These findings reveal Ag/PDAs exhibit broad‐spectrum antimicrobial activity through direct membrane structure. Additionally, demonstrate potent conversion efficiency. When combined with near‐infrared (NIR) irradiation, disrupt structure biofilms synergistically eradicate resident bacteria. Furthermore, show remarkable anti‐inflammatory properties counteracting bacterium‐induced macrophage polarization. The vivo results confirm topical application significantly suppress Staphylococcus aureus wounds murine models, concurrently facilitating healing. This research provides promising avenue eradication wounds.

Language: Английский

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The role of graphene quantum dots in cutting‐edge medical therapies

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(9)

Published: Sept. 1, 2024

Abstract Graphene quantum dots (GQDs), owing to their unique optical, electrical, and chemical properties, have emerged as promising nanomaterials for various biomedical applications. This review provides a comprehensive overview of the latest advancements in utilization GQDs tissue engineering, wound healing, drug delivery systems, other therapies. The inherent properties GQDs, including high biocompatibility, tunable photoluminescence, significant surface area, make them ideal candidates enhancing medical treatments diagnostics. In improve mechanical biological performance scaffolds, promoting cell proliferation differentiation. For enhance antimicrobial activity facilitate faster regeneration. Their potential DDS is highlighted by ability deliver therapeutic agents efficiently, ensuring targeted controlled release. Additionally, play crucial role therapies, particularly cancer treatment, efficacy reducing side effects. While offer diagnostics, challenges such understanding long‐term cytotoxicity at higher concentrations, need standardized synthesis methods remain critical areas further research. also discusses future directions opportunities emphasizing transformative advancing modern healthcare solutions. insights presented here contribute expanding field GQD research, highlighting significantly patient outcomes drive innovations.

Language: Английский

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Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

A significant global health crisis is predicted to emerge due antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic necessitates continuous therapeutic innovation as conventional treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative synthetic antibiotics. This review presents bacterial mechanisms, nanocarriers for drug delivery, plant-based nanoformulations, particularly nanoantibiotics (nAbts). Green synthesis of nanoparticles has emerged revolutionary approach, it enhances the effectiveness, specificity, transport encapsulated antimicrobials. In addition minimizing systemic side effects, these can maximize impact delivering antimicrobials directly infection site. Furthermore, combining two or more antibiotics within often exhibits synergistic enhancing effectiveness against drug-resistant bacteria. Antimicrobial agents are routinely obtained from secondary metabolites plants, including essential oils, phenols, polyphenols, alkaloids, others. Integrating antibacterial antibiotics, assisted suitable codelivery, potential solution addressing resistance. increasing their boosting immune system, this approach provides safer effective method tackling future infections.

Language: Английский

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Advancing chronic and acute wound healing with cold atmospheric plasma: cellular and molecular mechanisms, benefits, risks, and future directions

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Chronic and acute wounds represent significant challenges in healthcare, often leading to prolonged recovery times increased complications. While chronic wounds, such as diabetic foot ulcers venous leg ulcers, persist due underlying conditions biofilm formation, including surgical incisions burns, can also benefit from innovative therapeutic approaches. Cold atmospheric plasma (CAP) has emerged a promising non-invasive therapy capable of enhancing wound healing outcomes across both types. This review examines the cellular molecular mechanisms by which CAP promotes repair, focusing on its modulation inflammation, stimulation angiogenesis, facilitation tissue remodeling, antimicrobial effects, potentially be used regenerative medicine. generates reactive oxygen nitrogen species that influence key processes, accelerating regeneration while reducing bacterial load preventing formation. Clinical applications have demonstrated efficacy improving metrics for wounds. Despite results, translating into routine clinical practice requires addressing standardizing treatment protocols, assessing long-term safety, developing portable devices. Future research should prioritize optimizing parameters exploring combination therapies maximize potential. Overall, represents safe, effective, versatile modality management, with potential significantly improve patient care.

Language: Английский

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Schiff Base-Based Hydrogel Embedded with In Situ Generated Silver Nanoparticles Capped by a Hyaluronic Acid–Diethylenetriamine Derivative for Wound Healing Application

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: April 11, 2024

In this study, hydrogels were produced using a Schiff base reaction between two hyaluronic acid derivatives: one containing aldehyde groups (HA-Ald) and the other holding diethylenetriamine with terminal amino (HA-DETA). The DETA portion promotes in situ growth, complexation, stabilization of silver nanoparticles (AgNPs), eliminating need for external reducing agents. HA-DETA HA-Ald leads to formation imine bonds, which results dynamically pH-responsive cross-linking. While capping ability helped embedding AgNPs, on/off pH environmental responsivity hydrogel allows controlled on-demand release drug, mainly when bacterial infections cause variation wound bed. injectable resulted being highly compatible contact blood red cells, fibroblasts, keratinocytes capable having proliferative effect on an vitro scratch model. showed proper antibacterial activity againstPseudomonas aeruginosaandStaphylococcus aureus, common strains presented infections. Finally, vivo model studies demonstrated overall speeding up healing rate advanced conditions experimental group treated compared control samples.

Language: Английский

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Direct metagenomics investigation of non-surgical hard-to-heal wounds: a review

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 3, 2024

Abstract Background Non-surgical chronic wounds, including diabetes-related foot diseases (DRFD), pressure injuries (PIs) and venous leg ulcers (VLU), are common hard-to-heal wounds. Wound evolution partly depends on microbial colonisation or infection, which is often confused by clinicians, thereby hampering proper management. Current routine microbiology investigation of these wounds based in vitro culture, focusing only a limited panel the most frequently isolated bacteria, leaving large part wound microbiome undocumented. Methods A literature search was conducted original studies published through October 2022 reporting metagenomic next generation sequencing (mNGS) samples. Studies were eligible for inclusion if they applied 16 S rRNA metagenomics shotgun analysis diagnosis. Case reports, prospective, retrospective included. However, review articles, animal studies, model optimisation, benchmarking, treatment optimisation non-clinical excluded. Articles identified PubMed, Google Scholar, Web Science, Microsoft Academic, Crossref Semantic Scholar databases. Results Of 3,202 articles found initial search, 2,336 removed after deduplication 834 following title abstract screening. further 14 full text reading, with 18 finally Data provided 3,628 patients, 1,535 DRFDs, 956 VLUs, 791 PIs, 164 genera 116 species using mNGS approaches. high diversity observed depending geographical location evolution. Clinically infected diverse, possibly due to widespread pathogenic bacteria from body environmental microbiota. data presence virus (EBV) fungi ( Candida Aspergillus species), as well Staphylococcus Pseudomonas bacteriophages. Conclusion This study highlighted benefit time-effective pathogen genome detection. Despite majority included investigating rDNA, ignoring viral, fungal parasite colonisation, detected number studies. Such technology could be implemented microbiota post-treatment surveillance.

Language: Английский

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Effect of Topical Silver Nanoparticle Formulation on Wound Bacteria Clearance and Healing in Patients With Infected Wounds Compared to Standard Topical Antibiotic Application: A Randomized Open-Label Parallel Clinical Trial

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: May 18, 2024

Background: Infected wounds pose a special challenge for management, with an increased risk of wound chronicity, systemic infection, and the emergence antibiotic resistance. Silver nanoparticles have multimodal effects on bacteria clearance healing. This study aimed to document efficacy topical silver nanoparticle-based cream healing in infected compared Mupirocin. Methods: open-label parallel randomized clinical trial allocated 86 participants (culture-positive) into Kadermin, arm (n=43) Mupirocin documented swab culture day 5 at 28, along periodic status using Bates-Jensen Wound Assessment Tool. Patients received oral/systemic antibiotics other medications underlying diseases. The intention-to-treat principle was adopted data analysis chi-square Student t tests differences between groups according variable characteristics. Results: All completed follow-up. On 5, observed 86% 65.1% Kadermin arms, respectively (p=0.023). At complete 81.4% 37.2% (p≤0.001). No local or adverse event reaction any participants. Conclusion: cream, has better achieving faster may relevance its use as antibiotic-sparing agent management.

Language: Английский

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