International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8813 - 8813
Published: Aug. 13, 2024
Keratinocytes
are
major
cellular
components
of
the
skin
and
strongly
involved
in
its
homeostasis.
Oncogenic
events,
starting
mainly
from
excessive
sun
exposure,
lead
to
dysregulation
their
proliferation
differentiation
programs
promote
initiation
progression
non-melanoma
cancers
(NMSCs).
Primary
melanomas,
which
originate
melanocytes,
initiate
develop
close
interaction
with
keratinocytes,
whose
role
melanoma
initiation,
progression,
immune
escape
is
currently
being
explored.
Recent
studies
highlighted,
particular,
unexpected
modes
communication
between
melanocytic
cells
may
be
interest
as
sources
new
biomarkers
melanomagenesis
or
potential
therapeutic
targets.
This
review
aims
at
reporting
various
contributions
keratinocytes
basal
cell
carcinoma
(BCC),
cutaneous
squamous
(cSCC),
melanoma,
a
greater
focus
on
latter
order
highlight
some
recent
breakthrough
findings.
The
readers
referred
reviews
when
contextual
information
needed.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 3790 - 3790
Published: March 28, 2024
Cutaneous
wound
healing
is
a
complex
biological
process
involving
series
of
well-coordinated
events
aimed
at
restoring
skin
integrity
and
function.
Various
experimental
models
have
been
developed
to
study
the
mechanisms
underlying
repair
evaluate
potential
therapeutic
interventions.
This
review
explores
diverse
array
utilized
in
research,
ranging
from
rodent
excisional
wounds
advanced
tissue
engineering
constructs
microfluidic
platforms.
More
importantly,
influence
lipids
on
examined,
emphasizing
their
role
enhancing
barrier
function
restoration,
modulating
inflammation,
promoting
cell
proliferation,
remodeling.
Lipids,
such
as
phospholipids,
sphingolipids,
ceramides,
play
crucial
roles
membrane
structure,
signaling,
repair.
Understanding
interplay
between
microenvironment
provides
valuable
insights
into
development
novel
strategies
for
efficient
regeneration.
highlights
significance
investigating
elucidating
intricate
involvement
process,
offering
avenues
improving
clinical
outcomes
management.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(15), P. 5014 - 5014
Published: July 30, 2023
Ulcerative
colitis
(UC)
is
a
chronic
inflammatory
bowel
disease
(IBD)
that
negatively
impacts
patients’
quality
of
life.
In
the
last
decades,
therapeutic
options
available
for
management
patients
with
moderate
to
severe
UC
have
increased
significantly,
including
not
only
biological
drugs
but
also
small
molecules.
However,
there
persistent
need
develop
new
act
on
targets
while
minimizing
risk
adverse
events.
Sphingosine-1-phosphate
(S1P)
membrane-derived
lysophospholipid.
The
S1P
gradient
between
tissues
and
circulatory
system
has
key
role
in
regulating
trafficking
immune
cells
as
autoreactive
B
T
lymphocytes.
receptor
modulators
could
be
safe
efficacious
alternative
mechanism
reducing
inflammation
immune-mediated
disorders,
UC,
by
lymphocyte
egress
from
lymph
nodes
bloodstream.
Several
been
developed
tested
UC.
Ozanimod
already
approved
Food
Drug
Administration
(FDA)
European
Medical
Agency
(EMA),
etrasimod
VTX002
are
still
under
approval.
Oral
administration
route,
rapidity
reliable
safety
profile
main
advantages
this
class
drugs.
aim
review
summarize
evidence
efficacy,
safety,
pharmacokinetics
ozanimod,
etrasimod,
Physiological Reviews,
Journal Year:
2024,
Volume and Issue:
104(3), P. 1061 - 1119
Published: Feb. 1, 2024
Ceramides
are
signals
of
fatty
acid
excess
that
accumulate
when
a
cell's
energetic
needs
have
been
met
and
its
nutrient
storage
has
reached
capacity.
As
these
sphingolipids
accrue,
they
alter
the
metabolism
survival
cells
throughout
body
including
in
heart,
liver,
blood
vessels,
skeletal
muscle,
brain,
kidney.
These
ceramide
actions
elicit
tissue
dysfunction
underlies
cardiometabolic
diseases
such
as
diabetes,
coronary
artery
disease,
metabolic-associated
steatohepatitis,
heart
failure.
Here,
we
review
biosynthesis
degradation
pathways
maintain
levels
normal
physiology
discuss
how
loss
homeostasis
drives
pathologies.
We
highlight
signaling
nodes
sense
small
changes
ceramides
turn
reprogram
cellular
stimulate
apoptosis.
Finally,
evaluate
emerging
therapeutic
utility
unique
lipids
biomarkers
forecast
disease
risk
targets
ceramide-lowering
interventions
ameliorate
disease.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Oct. 18, 2023
S1P,
also
referred
to
as
sphingosine-1-phosphate,
is
a
lipid
molecule
with
bioactive
properties
involved
in
numerous
cellular
processes
such
cell
growth,
movement,
programmed
death,
self-degradation,
specialization,
aging,
and
immune
system
reactions.
Autophagy
meticulously
controlled
mechanism
which
cells
repurpose
their
elements
maintain
balance.
There
are
five
stages
autophagy:
initiation,
nucleation,
elongation
maturation,
fusion,
degradation.
New
research
has
provided
insight
into
the
complex
connection
between
S1P
autophagy,
uncovering
interaction
both
normal
abnormal
circumstances.
Gaining
knowledge
about
regulatory
of
signaling
on
autophagy
can
offer
valuable
understanding
its
function
well-being
illness,
potentially
leading
innovative
therapeutic
concepts
for
diverse
ailments.
Hence,
this
review
analyzes
essential
mammalian
specific
emphasis
recent
exploring
control
each
stage
by
S1P.
Additionally,
it
sheds
light
roles
S1P-induced
various
disorders.
Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
260, P. 108681 - 108681
Published: June 17, 2024
Our
skin
protects
us
from
external
threats
including
ultraviolet
radiation,
pathogens
and
chemicals,
prevents
excessive
trans-epidermal
water
loss.
These
varied
activities
are
reliant
on
a
vast
array
of
lipids,
many
which
unique
to
skin,
that
support
physical,
microbiological
immunological
barriers.
The
cutaneous
physical
barrier
is
dependent
specific
lipid
matrix
surrounds
terminally-differentiated
keratinocytes
in
the
stratum
corneum.
Sebum-
keratinocyte-derived
lipids
cover
skin's
surface
regulate
microbiota.
Meanwhile,
signal
between
resident
infiltrating
immune
cells,
driving
inflammation
its
resolution
response
other
threats.
Lipids
particular
importance
include
ceramides,
crucial
for
corneum
formation
therefore
functionality,
fatty
acids,
contribute
acidic
pH
microbiota,
as
well
matrix,
bioactive
metabolites
these
involved
cell
signalling,
inflammation,
numerous
processes.
diverse
complex
maintain
homeostasis
healthy
implicated
diseases,
unrelated
systemic
conditions
with
manifestations,
processes
such
ageing.
also
gut-skin
axis,
signalling
two
sites.
Therefore,
provide
valuable
resource
exploration
processes,
local
disease
development
progression,
accessible
biomarker
discovery
disease,
an
opportunity
fully
understand
relationship
host
Investigation
could
diagnostic
prognostic
biomarkers,
help
identify
new
targets
interventions.
Development
improvement
existing
vitro
silico
approaches
explore
lipidome,
advances
lipidomics
technologies,
will
facilitate
ongoing
progress
research.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 6913 - 6913
Published: June 24, 2024
Chronic
exposure
to
harmful
pollutants,
chemicals,
and
pathogens
from
the
environment
can
lead
pathological
changes
in
epithelial
barrier,
which
increase
risk
of
developing
an
allergy.
During
allergic
inflammation,
cells
send
proinflammatory
signals
group
2
innate
lymphoid
cell
(ILC2s)
eosinophils,
require
energy
resources
mediate
their
activation,
cytokine/chemokine
secretion,
mobilization
other
cells.
This
review
aims
provide
overview
metabolic
regulation
asthma,
atopic
dermatitis
(AD),
rhinitis
(AR),
highlighting
its
underlying
mechanisms
phenotypes,
potential
regulatory
roles
eosinophils
ILC2s.
Eosinophils
ILC2s
regulate
inflammation
through
lipid
mediators,
particularly
cysteinyl
leukotrienes
(CysLTs)
prostaglandins
(PGs).
Arachidonic
acid
(AA)-derived
metabolites
Sphinosine-1-phosphate
(S1P)
are
significant
markers
that
indicate
immune
dysfunction
barrier
Notably,
promoters
symptoms
exhibit
greater
plasticity
compared
ILC2s,
directly
involved
promoting
symptoms.
Our
findings
suggest
metabolomic
analysis
provides
insights
into
complex
interactions
between
cells,
environmental
factors.
Potential
therapeutic
targets
have
been
highlighted
further
understand
Future
research
metabolomics
facilitate
development
novel
diagnostics
therapeutics
for
future
application.
Lipids in Health and Disease,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: April 18, 2023
Abstract
Sphingosine-1-phosphate
(S1P)
is
a
sphingolipid
mediator
that
exerts
variety
of
biological
functions,
including
immune,
cardiovascular,
and
neurological
regulation
as
well
tumor
promotion,
through
high-affinity
G
protein-coupled
receptors
(S1P
1-5
).
It
has
been
reported
circulating
S1P
levels
remain
higher
in
patients
with
psoriasis
than
healthy
individuals
do
not
decrease
after
anti-TNF-α
treatment
those
patients.
The
S1P-S1PR
signaling
system
plays
an
important
role
inhibiting
keratinocyte
proliferation,
regulating
lymphocyte
migration,
promoting
angiogenesis,
thus
contributing
to
the
pathogenesis.
Here,
we
review
mechanisms
by
which
affects
development
available
clinical/preclinical
evidence
for
targeting
psoriasis.
may
partially
explain
link
between
its
comorbidities.
Although
detailed
be
elucidated,
new
target
future
remission.
