Maternal gut microbiome and its impact on developing idiopathic late fetal growth retardation

Obstetrics Gynecology and Reproduction, Journal Year: 2025, Volume and Issue: 18(6), P. 788 - 799

Published: Jan. 10, 2025

Aim: to analyze a rectal microbiome composition in pregnant women and assess its potential impact on developing of idiopathic late fetal growth retardation (FGR) syndrome. Materials Methods. We analyzed course pregnancy labour 80 women: main group consisted 40 with FGR, control – healthy women. The analysis the intestinal microbiota 53 (25 FGR 28 women) was carried out by using nitrogenous base sequencing 16S ribosomal RNA (rRNA) genes. Results. Analyses gut study groups revealed significant differences particularly showing 1.0 % increase proportion Clostridiales Ruminococcaceae Oscillospira that correlated 331.7 g neonatal weight gain; level Coriobacteriales Coriobacteriaceae Collinsella associated 476.2 decrease gain. Firmicutes/Bacteroides ratio 2,0 3.6 (p = 0.02), respectively, which may suggest about microbiological dysbiosis putative pathophysiological outcomes. A association between elevated leucocyte counts (in absence other manifestations inflammatory processes) probability development found. white blood cell count ≥ 11.05×10 9 /L predicted risk sensitivity 60.6 specificity 79.2 %. Also, erythrocyte sedimentation rate 41.5 mm/hour increased risk, demonstrating 85.7 70.6 Conclusion. It can be concluded play role FGR. negative correlation decreased as well higher Actinobacteria birth

Language: Английский

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Gut microbiome derived short chain fatty acids: Promising strategies in necrotising enterocolitis

Current Research in Microbial Sciences, Journal Year: 2024, Volume and Issue: 6, P. 100219 - 100219

Published: Jan. 1, 2024

Necrotising enterocolitis (NEC) is a devastating condition that poses significant risk of morbidity and mortality, particularly among preterm babies. Extensive research efforts have been directed at identifying optimal treatment diagnostic strategies but results from such studies remain unclear controversial. Among the most promising candidates are prebiotics, probiotics their metabolites, including short chain fatty acids (SCFAs). Such metabolites widely explored as possible biomarkers gut health for different clinical conditions, with overall positive effects on host observed. This review aims to describe role microbiome derived SCFAs in necrotising enterocolitis. Until now, information has conflicting, primary focus main three (acetic acid, propionic butyric acid). While numerous indicated relationship between NEC, current evidence insufficient draw definitive conclusions about use these NEC or potential strategies. Ongoing this area will help enhance both our understanding valuable indicators practical application settings.

Language: Английский

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Effect of gestational age on clinical features in necrotizing enterocolitis-associated intestinal perforation

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 6, 2025

To investigate the clinical features of necrotizing enterocolitis-associated intestinal perforation (NEC-IP) in neonates with different gestational ages (GAs). Furthermore, we also want to identify risk factors poor prognosis for these patients. The retrospective study patients NEC-IP was conducted basic information, comorbidity, intraoperative findings, related treatment, and prognosis. According GA, were divided into three groups: early (GA: 28-<32 weeks, Group 1), mid-term 32-<34 2), late 34-<37 3). groups analyzed, identified. Of 113 cases, number cases Groups 1 3 36 (31.9%), 44 (38.9%), 33 (29.2%), respectively; overall proportion 19.4% (22/113). For birth weight lower than that 2 3, while postnatal day at time surgery NEC onset age higher (onset age: G1 12.0[7.00;20.5], G2 9.00[4.00;13.0]; surgery: 22.0[13.8;27.2], 13.0[8.00;21.0]) (P < 0.016). incidence sepsis, coagulopathy, type (congenital heart disease) CHD, hypoproteinemia (all P 0.016), respiratory failure, usage rate vasoactive substances mechanical ventilation By Lasso Logistic regression analysis, found GA (OR: 0.274, 95%CI: 0.078-0.796), sepsis 7.955, 1.424-65.21), coagulopathy 19.51, 3.393-179.1), CHD 6.99, 1.418-54.83) diseased bowel segment 2.804, 1.301-7.316) independent 0.05). differ based on particularly terms type, surgery, utilization substances, are NEC-IP.

Language: Английский

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Necrotizing Enterocolitis: Pathogenetic Features and Differential Diagnosis with Inflammatory Bowel Disease in Newborns

Вопросы современной педиатрии, Journal Year: 2025, Volume and Issue: 23(6), P. 438 - 446

Published: Jan. 2, 2025

Necrotizing enterocolitis (NEC) is a disease primarily affecting premature infants. NEC pathogenesis based on the development of inflammation damaging mucous membranes associated with bacterial colonization, intestinal epithelium immaturity, blood flow regulation, and excessive inflammatory response activation. Inflammatory bowel (IBD) very early onset (VEO-IBD) can also manifest in neonatal period. They are characterized by severe course, often resistant to traditional immunosuppressive therapy. This article discusses features differential diagnosis VEO-IBD. Despite certain similarities pathogenesis, IBD different diseases. Infantile more monogenic diseases primary immunodeficiency. VEO-IBD chronic damage all layers has lower incidence compared NEC. Its clinical manifestations may include diarrhea, stool, delayed physical development, perianal diseases, ulcerations oral cavity. usually affects colon, while ileum The microbiome specific features. It been reported that cases Crohn’s patients who had period surgery. crucial consider perinatal when assessing risk (prenatal effects antibacterial therapy smoking, several courses during first year life, formula feeding).

Language: Английский

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Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 18, 2025

Necrotizing Enterocolitis (NEC) is a severe, life-threatening inflammatory condition of the gastrointestinal tract, especially affecting preterm infants. This review consolidates evidence from various biomedical disciplines to elucidate complex pathogenesis NEC, integrating insights clinical, microbial, and molecular perspectives. It emphasizes modulation NEC-associated pathways by probiotics novel biologics, highlighting their therapeutic potential. We further critically examine dysbiotic alterations within gut microbiota, with particular focus on imbalances in bacterial viral communities, which may contribute onset NEC. The intricate interactions among toll-like receptor 4 (TLR4), microvascular integrity, immune activation, milieu are meticulously summarized, offering sophisticated understanding NEC pathophysiology. academic aims enhance etiological comprehension promote development targeted interventions, impart significant impact perinatal factors formulation preventive curative strategies for disease.

Language: Английский

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Spatial Transcriptomics Delineates Potential Differences in Intestinal Phenotypes of Cardiac and Classical Necrotizing Enterocolitis

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112166 - 112166

Published: March 7, 2025

Necrotizing enterocolitis (NEC) is a devastating neonatal gastrointestinal disease, often resulting in multi-organ failure and death. While classical NEC strictly associated with prematurity, cardiac subset of the disease occurring infants comorbid congenital heart disease. Despite similar symptomatology, subtypes vary slightly presentation may represent etiologically distinct diseases. We compared ileal spatial transcriptomes patients NEC. Epithelial immune cells cluster well by cell-type segment subtype. Differences metabolism cell activation functionally differentiate makeup subtypes. The phenotype defined dysbiosis-induced inflammatory signaling metabolic acidosis, while that involves reduced angiogenesis endoplasmic reticulum stress-induced apoptosis. subtype-associated clinical demographic variability, transcriptomics has substantiated pathway network differences within epithelial segments between

Language: Английский

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Clinical characterization of necrotizing enterocolitis in neonates with or without congenital heart disease: a case–control study

˜The œItalian Journal of Pediatrics/Italian journal of pediatrics, Journal Year: 2025, Volume and Issue: 51(1)

Published: March 24, 2025

Abstract Background This study aimed to analyze the clinical characteristics and differences between neonates with congenital heart disease (CHD)–related neonatal necrotizing enterocolitis (NEC) those non-CHD–related NEC. Method retrospective included patients CHD who met Bell’s staging diagnostic criteria were hospitalized 2014 2023 in Cardiac Intensive Care Unit of Cardiothoracic Surgery, Shanghai Children’s Medical Center affiliated Jiao Tong University School Medicine. These comprised CHD-related NEC group (CHD-NEC group). Meanwhile, control randomly matched children (nCHD-NEC group) admitted department Second People’s Hospital Kashi Prefecture according 1:2 matching principle. Patients’ basic information, adverse events before onset as well severity treatment recorded. Results The CHD-NEC 60 cases, whereas nCHD-NEC 120 cases. Compared group, had an older gestational age (38.71 [37.89, 39.67] weeks vs. 30.65 [29.68, 32.29] weeks, p < 0.001); a heavier birth weight (3.2 [2.69, 3.67] kg 1.39 [1.1, 1.59] kg, higher proportions patent ductus arteriosus (73.3% 26.7%, 0.001), shock (81.7% 36.7%, mechanical ventilation requirement (91.7% 51.7%, 0.001). At onset, vasoactive drug score (16.75 [7.26, 23.63] 0 [0, 10], 0.001) but lower values for proportion infants small (15% 33.3%, = 0.045), incidence premature rupture membranes (3.3% 0.002), early sepsis (6.7% 23.3%, 0.038), late (46.7% 70%, 0.036) than group. Among required abdominal surgery, tended have more colon involvement (6.6% 0.8%, 0.063), no significant difference mortality was noted two groups. Conclusion Children significantly different characteristics. is mainly observed full-term appropriate age, perioperative intestinal ischemia may be main pathophysiology. Conversely, preterm infants, possibly related immature development infection. Large prospective research warranted explore pathogenesis, pathophysiology, indicator monitoring, plan

Language: Английский

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Refining Surgical Risk Assessment in Necrotising Enterocolitis– A Nomogram-Based Approach

The Indian Journal of Pediatrics, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Probiotic-Derived Ecto-5'-Nucleotidase Produces Anti-Inflammatory Adenosine Metabolites in Treg-Deficient Scurfy Mice

Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 15(4), P. 1001 - 1013

Published: May 13, 2023

Language: Английский

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The Effect of Oral Iron Supplementation/Fortification on the Gut Microbiota in Infancy: A Systematic Review and Meta-Analysis

Children, Journal Year: 2024, Volume and Issue: 11(2), P. 231 - 231

Published: Feb. 10, 2024

(1) Background: Iron is an essential metal for the proper growth and neurodevelopment of infants. To prevent treat iron deficiency, supplementation or fortification often required. It has been shown, though, that it affects synthesis gut microbiota. (2) Methods: This paper a systematic review meta-analysis effect oral supplementation/fortification on microbiota in infancy. Studies healthy neonates infants who received per os with existing data were included. Three databases searched: PUBMED, Scopus, Google Scholar. Randomized controlled trials (RCTs) Quality appraisal was assessed using ROB2Tool. (3) Results: A total six RCTs met inclusion criteria review, four them included both fixed random effects methods. Our results showed there very good heterogeneity group (I

Language: Английский

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