Journal of the Serbian Chemical Society,
Journal Year:
2023,
Volume and Issue:
89(7-8), P. 1039 - 1051
Published: Dec. 12, 2023
Inflammation,
a
widespread
biological
process
linked
to
various
diseases,
poses
significant
global
health
challenge.
Recent
research
targeting
the
development
of
new
anti-inflammatory
drugs
has
prioritized
plant-derived
compounds
due
their
cost-effectiveness
and
minimal
side
effects
compared
synthetic
drugs.
Flavonoids,
polyphenolic
in
plants,
show
potential
for
treating
inflammation-related
diseases.
This
study
evaluates
antiinflammatory
activity
flavonoids
from
Knema
genus,
member
Myristicaceae
family.
We
focused
on
inhibiting
two
pro-inflammatory
proteins,
human
murine
interleukin-1B
(IL-1)
interleukin-6
(IL-6).
Molecular
docking
ADMET
prediction
identified
sulfuretin
(?)-catechin
with
high
binding
affinity
IL-6,
whereas
4'-hydroxy-7-methoxyflavanone
7,2'-dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan
stably
bind
IL-6.
interaction
analyses
revealed
that
hydrogen
???
bonds
contribute
interaction.
Notably,
these
exhibited
affinities
comparable
celecoxib.
Our
computational
predictions
support
suitability
as
drug
candidates,
indicating
promise
natural
agents
capable
modulating
signaling
pathways.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 393 - 393
Published: March 25, 2024
The
aging
of
the
global
population
has
increased
prevalence
neurodegenerative
conditions.
Bacopa
monnieri
(BM),
an
herb
with
active
compounds,
such
as
bacosides
A
and
B,
betulinic
acid,
loliolide,
asiatic
quercetin,
demonstrates
potential
for
brain
health.
Limited
research
been
conducted
on
therapeutic
applications
BM
in
This
systematic
review
aims
to
project
BM’s
beneficial
role
disorders.
anti-apoptotic
antioxidant
actions
can
repair
damaged
neurons,
stimulate
kinase
activity,
restore
synaptic
function,
improve
nerve
transmission,
increase
neuroprotection.
included
twenty-two
clinical
trials
demonstrated
that
reduce
Nuclear
Factor-κB
phosphorylation,
emotional
cognitive
functions,
anhedonia,
hyperactivity,
sleep
routine,
depression,
attention
deficit,
learning
problems,
memory
retention,
impulsivity,
psychiatric
problems.
Moreover,
levels
pro-inflammatory
biomarkers
oxidative
stress.
Here,
we
highlight
provides
notable
benefits
serve
a
complementary
approach
care
patients
conditions
associated
adds
growing
interest
natural
products
their
by
improving
our
understanding
mechanisms
underlying
function
neurodegeneration
informing
development
new
strategies
diseases.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116023 - 116023
Published: Jan. 30, 2024
An
in
vivo
model
is
necessary
for
toxicology.
This
review
analyzed
the
uses
of
zebrafish
(Danio
rerio)
toxicology
based
on
bibliometrics.
Totally
56,816
publications
about
from
2002
to
2023
were
found
Web
Science
Core
Collection,
with
Toxicology
as
top
6
among
all
disciplines.
Accordingly,
bibliometric
map
reveals
that
"toxicity"
has
become
a
hot
keyword.
It
further
most
common
exposure
types
include
acute,
chronic,
and
combined
exposure.
The
toxicological
effects
behavioral,
intestinal,
cardiovascular,
hepatic,
endocrine
toxicity,
neurotoxicity,
immunotoxicity,
genotoxicity,
reproductive
transgenerational
toxicity.
mechanisms
oxidative
stress,
inflammation,
autophagy,
dysbiosis
gut
microbiota.
toxicants
commonly
evaluated
by
using
nanomaterials,
arsenic,
metals,
bisphenol,
dioxin.
Overall,
provide
unique
well-accepted
investigate
mechanisms.
We
also
discussed
possible
ways
address
some
limitations
model,
such
combination
human
organoids
avoid
species
differences.
Diabetes Obesity and Metabolism,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Aims
Obesity
is
a
global
public
health
challenge,
and
the
traditional
WHO‐proposed
diagnostic
criteria
based
on
body
mass
index
(BMI)
often
fail
to
fully
assess
related
risks.
The
European
Association
for
Study
of
(EASO)
has
proposed
new
that
combine
BMI,
waist‐to‐height
ratio
(WtHR)
complications
more
accurately
evaluate
obesity‐related
Materials
Methods
This
study
utilized
data
from
National
Health
Nutrition
Examination
Survey
database,
covering
years
1999–2018.
validated
EASO
diagnosing
obesity,
defined
as
BMI
≥25
kg/m
2
,
WtHR
≥0.5
presence
12
complications.
associations
between
obesity
mortality
were
assessed
using
Kaplan–Meier
survival
curves
Cox
proportional
hazards
regression
analyses.
Mediation
analysis
was
conducted
explore
potential
mechanisms
by
which
impacts
patient
prognosis.
Results
A
total
39
066
participants
included,
with
mean
age
43.6
years;
51.3%
male.
Over
median
follow‐up
period
141
months,
3708
deaths
recorded.
prevalence
63.04%
according
criteria.
rate
≥30
only
35.55%.
achieved
C‐index
0.5549,
surpasses
predictive
accuracy
criterion,
0.5265.
indicated
when
criterion
diagnose
it
associated
all‐cause
cardiovascular
disease
(CVD)‐related
mortality,
but
did
not
predict
cancer‐related
mortality.
diagnosed
significantly
an
increased
risk
(hazard
[HR]
95%
confidence
interval
[CI]:
1.13
[1.02,
1.24]),
CVD
(HR
CI:
1.48
[1.20,
1.83])
cancer
1.26
[1.03,
1.54]).
When
simplified
any
top
five
(diabetes
mellitus,
hypertension,
CVD,
metabolic
syndrome
ageing)
criteria,
had
highest
(0.612),
remained
independent
prognostic
factor
poor
overall
CI
mortality:
1.41
[1.26,
1.58],
HR
2.08
[1.61,
2.68]
1.32
[1.06,
1.65]).
Conclusions
confirms
value
EASO,
suggesting
these
offer
accurate
assessment
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(2), P. 259 - 259
Published: Jan. 15, 2024
Chronic
inflammation
is
the
result
of
an
acute
inflammatory
response
that
fails
to
eliminate
pathogenic
agent
or
heal
tissue
injury.
The
consequence
this
failure
lays
foundations
onset
several
chronic
ailments,
including
skin
disorders,
respiratory
and
neurodegenerative
diseases,
metabolic
syndrome,
and,
eventually,
cancer.
In
context,
long-term
use
synthetic
anti-inflammatory
drugs
treat
illnesses
cannot
be
tolerated
by
patients
owing
severe
side
effects.
Based
on
this,
need
for
novel
agents
endowed
with
effects
prompted
search
potential
candidates
also
within
plant
kingdom,
being
recognized
as
a
source
molecules
currently
employed
in
therapeutical
areas.
Indeed,
ever-growing
evidence
properties
dietary
polyphenols
traced
route
towards
study
flavonoid-rich
sources,
such
Citrus
bergamia
(bergamot)
its
derivatives.
Interestingly,
recent
paradigm
circular
economy
has
promoted
valorization
fruit
waste
regard
bergamot,
it
brought
light
new
corroborating
bergamot
byproducts,
thus
increasing
scientific
knowledge
field.
Therefore,
review
aims
gather
latest
literature
supporting
beneficial
role
both
derivatives
products
different
models
inflammatory-based
highlighting
great
potentiality
re-evaluation
perspective.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e31862 - e31862
Published: May 24, 2024
Chronic
inflammatory
diseases
are
caused
due
to
prolonged
inflammation
at
a
specific
site
of
the
body.
Among
other
diseases,
bacterial
meningitis,
chronic
obstructive
pulmonary
disease
(COPD),
atherosclerosis
and
bowel
(IBD)
primarily
focused
on
because
their
adverse
effects
fatality
rates
around
globe
in
recent
times.
In
order
come
up
with
novel
strategies
eradicate
these
clear
understanding
mechanisms
is
needed.
Similarly,
detailed
insight
into
commercially
available
drugs
potent
lead
compounds
from
natural
sources
also
important
establish
efficient
therapeutic
effects.
Zebrafish
widely
accepted
as
model
study
drug
toxicity
pharmacokinetic
drug.
Moreover,
researchers
use
various
inducers
trigger
cascades
stimulate
physiological
changes
zebrafish.
The
effect
contrasts
type
zebrafish
used
investigation.
Hence,
thorough
analysis
required
current
advancements
for
suppression.
This
review
presents
most
common
drugs,
therapeutics,
action
provides
description
models
diseases.
Finally,
future
prospects
challenges
same
described,
which
can
help
understand
potency
its
further
exploration
attenuation.
Journal of the American Nutrition Association,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 14
Published: Jan. 9, 2025
Objective
Obesity
has
become
one
of
the
major
public
health
issues
and
is
associated
with
various
comorbidities,
including
type
2
diabetes
mellitus,
dyslipidemia,
hypertension.
Lychee
seeds
are
considered
promising
ingredients
for
developing
functional
foods
owing
to
their
nutraceutical
properties
phytochemical
composition.
This
study
aimed
induce
obesity
in
zebrafish
(Danio
rerio)
through
a
hyperlipidic
diet
supplemented
different
concentrations
lychee
seed
flour
evaluate
its
effects
on
adipose
tissue,
biochemical
parameters,
oxidative
stress,
caudal
fin
regeneration.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(5), P. 2077 - 2077
Published: Feb. 27, 2025
Plant
secondary
metabolites
are
known
to
be
valuable
agents
hamper
inflammation
owing
their
multiple
mechanisms
of
action.
This
study
investigates
the
molecular
underlying
anti-inflammatory
effects
vicenin-2
in
lipopolysaccharide
(LPS)-stressed
THP-1
cells.
After
ascertaining
safety
our
vitro
model,
we
assessed
potential
this
flavonoid.
Indeed,
it
counteracted
increase
tumor
necrosis
factor
(TNF)-α,
interleukin
(IL)-1β,
and
IL-6
levels,
as
well
overexpression
both
inducible
nitric
oxide
synthase
(iNOS)
cyclooxygenase
(COX)-2
caused
by
exposure
cells
LPS.
Acknowledged
role
SIRT1
inflammatory
process,
focused
attention
on
enzyme.
Our
results
showed
that
LPS
dramatically
decreased
expression
SIRT1,
whereas
restored
levels
enzyme
those
unexposed
These
were
also
observed
terms
acetylated
p53,
a
substrate.
Notably,
did
not
act
direct
activator
SIRT1.
Therefore,
investigated
involvement
AMP-activated
protein
kinase
(AMPK),
an
upstream
Of
note,
blocking
AMPK
dorsomorphin,
protective
activity
lost,
suggesting
engagement
kinase.
Consequently,
blockage
downstream
loss
effect
vicenin-2,
which
was
no
longer
able
decrease
activation
nuclear
(NF)-κB
production
cytokines
induced
Finally,
docking
simulation
suggested
might
Ca2+/calmodulin-dependent
β
(CaMKKβ),
one
regulators
AMPK.
Overall,
suggest
may
due
interaction
with
CaMKKβ-AMPK-SIRT1
axis.
