Advances in Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(12), P. 19352 - 19359
Published: Jan. 1, 2023
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2179 - 2179
Published: June 8, 2024
Pancreatic cancer is a prevalent lethal gastrointestinal that generally does not show any symptoms until it reaches advanced stages, resulting in high mortality rate. People at risk, such as those with family history or chronic pancreatitis, do have universally accepted screening protocol. Chemotherapy and radiotherapy demonstrate limited effectiveness the management of pancreatic cancer, emphasizing urgent need for innovative therapeutic strategies. Recent studies indicated complex interaction among cells within dynamic microenvironment, comprising extracellular matrix, cancer-associated cells, diverse immune intricately regulates biological characteristics disease. Additionally, mounting evidence suggests EVs play crucial role mediators intercellular communication by transportation different biomolecules, miRNA, proteins, DNA, mRNA, lipids, between heterogeneous cell subpopulations. This mediated significantly impacts multiple aspects pathogenesis, including proliferation, angiogenesis, metastasis, resistance to therapy. In this review, we delve into pivotal EV-associated miRNAs progression, development drug well their potential biomarkers drug-delivery mechanisms cancer.
Language: Английский
Citations
8
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 567 - 567
Published: April 21, 2024
Extracellular vesicles (EVs), acting as inherent nanocarriers adept at transporting a range of different biological molecules such proteins, lipids, and genetic material, exhibit diverse functions within the gastroenteric tract. In states normal health, they participate in upkeep systemic organ homeostasis. Conversely, pathological conditions, significantly contribute to pathogenesis gastrointestinal diseases (GIDs). Isolating EVs from patients' biofluids facilitates discovery new biomarkers that have potential offer rapid, cost-effective, non-invasive method for diagnosing prognosing specific GIDs. Furthermore, demonstrate considerable therapeutic naturally targeted physiological carriers intercellular delivery cargo or nanoscale tools engineered specifically regulate physio-pathological conditions disease progression. Their attributes including safety, high permeability, stability, biocompatibility, low immunogenicity, homing/tropism capabilities their promising clinical applications. This review will delve into various examples serving context GIDs, highlighting both functional structural conditions. The versatile advantageous properties position them candidates innovative strategies advancing personalized medicine approaches tailored tract, addressing
Language: Английский
Citations
5
Cancers, Journal Year: 2023, Volume and Issue: 15(13), P. 3434 - 3434
Published: June 30, 2023
Liver cancer is a complex and challenging disease with limited treatment options dismal prognosis. Understanding the underlying molecular mechanisms driving liver progression metastasis crucial for developing effective therapeutic strategies. The EPH/ephrin system, which comprises family of cell surface receptors their corresponding ligands, has been implicated in pathogenesis HCC. This review paper aims to provide an overview current understanding role system Specifically, we discuss dysregulation signaling HCC its impact on various cellular processes, including proliferation, migration, invasion. Overall, emerges as compelling multifaceted player biology. Elucidating precise implications responses may pave way novel targeted therapies personalized approaches patients. Further research warranted unravel full potential clinical translation.
Language: Английский
Citations
10
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 27, 2025
Scutellarin (SC), a natural flavonoid, has been expansively employed in treating innumerable inflammation-related diseases due to its antitumor, antiinflammatory, anticancer, and antioxidant potential. can inhibit significant inflammatory cell signaling pathways, comprisingPI3K/Akt, NF-κB, MAPK, while activating antioxidant-related pathways such as Nrf2 ARE. Numerous reviews have outlined scutellarin’s pharmacological effects associated mechanisms diseases. Several studies elucidated the of anticancer activity by inhibiting various pathways; however, our knowledge, none distinguished potential scutellarin based on different human cancer types. Our review detailed insights about type body. Furthermore, we also formulations, combinatorial therapies, comprehensive mechanistic research deliver enhanced effective treatment options for patients. This study will provide thorough into scutellarin, supporting development promising candidate treatment.
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(51), P. 20453 - 20478
Published: Dec. 12, 2023
Food-derived peptides, as dietary supplements, have significant effects on promoting brain health and relieving central nervous system (CNS) diseases. However, the blood–brain barrier (BBB) greatly limits their in-brain bioavailability. Thus, overcoming BBB to target CNS is a major challenge for bioactive peptides in prevention treatment of This review discusses improvement neuroprotective function food-derived active diseases, well source penetrating (BBB-shuttles) mechanism transmembrane transport. Notably, this also various peptide modification methods overcome low permeability stability BBB. Lipification, glycosylation, introduction disulfide bonds, cyclization are effective strategies improving penetration efficiency through provides new prospective developing treatments delay or even prevent
Language: Английский
Citations
9
Cell Cycle, Journal Year: 2023, Volume and Issue: 22(12), P. 1514 - 1527
Published: May 28, 2023
Background Long non-coding RNAs (lncRNAs) have been proved to play a vital role in pancreatic cancer (PC). However, the of lncRNA FAM83A-AS1 PC remains unclear. In this study, we explored biological function and underlying mechanism cells.
Language: Английский
Citations
6
Cancers, Journal Year: 2023, Volume and Issue: 15(15), P. 3963 - 3963
Published: Aug. 4, 2023
Erythropoietin-producing hepatocellular carcinoma receptors (EPHs) represent the largest family of receptor tyrosine kinases (RTKs). EPH interaction with ephrins, their membrane-bound ligands, holds a pivotal role in embryonic development, while, though less active, it is also implicated various physiological functions during adult life. In normal hematopoiesis, different patterns EPH/ephrin expression have been correlated hematopoietic stem cell (HSC) maintenance and lineage-committed progenitor (HPC) differentiation, as well functional properties mature offspring. Research field hematologic malignancies has unveiled rather complex involvement EPH/ephrinsignaling pathway pathophysiology these neoplasms. Aberrations genetic, epigenetic, protein levels identified possible players both tumor progression suppression, while correlations highlighted regarding prognosis response to treatment. Initial efforts therapeutically target axis undertaken setting neoplasia but are mainly confined preclinical level. To this end, deciphering complexity signaling malignant hematopoiesis necessary.
Language: Английский
Citations
4
Medical Diagnosis, Journal Year: 2023, Volume and Issue: 13(04), P. 478 - 486
Published: Jan. 1, 2023
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6619 - 6619
Published: June 16, 2024
Diagnostic markers are desperately needed for the early detection of pancreatic ductal adenocarcinoma (PDA). We describe sets expressed in temporal order mouse models during pancreatitis, PDA initiation and progression. Cell type specificity differential expression were identified by screening single cell (sc) RNAseq from tumor samples a model (KIC) at late stages progression compared to that normal pancreas. Candidate genes three sources: (1) an unsupervised preferentially tumors; (2) signaling pathways drive PDA, including Ras pathway, calcium signaling, known cancer genes, or encoding proteins mass spectrometry (MS) tumors conditioned media human lines; (3) whose is associated with poor better prognoses (PAAD, oncolnc.org). The developmental was detected gene cells KIC mice. earliest diagnostic epithelial early-stage, but not late-stage, tumors. Other epithelium both early- late-state Markers somewhat later first elevated late-stage tumors, then mesenchymal cells, only cells. Stromal differentially and/or neoplasia fibroblast hematopoietic (lymphocytes macrophages) broadly many stromal types. Pancreatitis risk factor humans. Mouse caerulein treatment acinar-specific homozygous deletion differentiation transcription factors (dTFs), screened all neoplasia. Prognostic more rapid decline showed cell-type-specific predominately Select validated immunohistochemistry pancreas those PDA. In total, we present 2165 individual prognostic disease be tested humans pancreatitis
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 31, 2024
Pancreatic cancer (PC) is one of the most common malignant tumors digestive tract and has a very high mortality rate worldwide. Different PC patients may respond differently to therapy develop therapeutic resistance due complexity variety tumor microenvironment. The Eph/ephrin signaling pathway extensively involved in tumor-related biological functions. However, key function not been fully elucidated. We first explored pan-cancer overview genes (EPGs). Then we grouped into 3 subgroups based on EPG expression levels. Significantly different prognoses immune microenvironments between subtypes further validate Eph/ephrin's important role pathophysiology PC. Additionally, estimated IC50 values for several commonly used molecularly targeted drugs treat three clusters, which could help receive more personalized treatment plan. Following progressive screening optimal genes, established prognostic signature validated it internal external test sets. receiver operating characteristic (ROC) curves our model exhibited great predictive performance. Meanwhile, results through qRT-PCR immunohistochemistry. Overall, this research provides fresh clues prognosis as well theoretical groundwork future research.
Language: Английский
Citations
0