Molecular Mechanisms for Changing Brain Connectivity in Mice and Humans DOI Open Access
Pascale Voelker, Aldis P. Weible, Cristopher M. Niell

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15840 - 15840

Published: Oct. 31, 2023

The goal of this study was to examine commonalities in the molecular basis learning mice and humans. In previous work we have demonstrated that anterior cingulate cortex (ACC) hippocampus (HC) are involved a two-choice visuospatial discrimination task. Here, began by looking for candidate genes upregulated mouse ACC HC with learning. We then determined which these were also blood. Finally, used RT-PCR compare gene expression blood from humans following one two forms learning: working memory task (network training) or meditation (a generalized training shown change many networks). Two caspase recruitment domain-containing protein 6 (Card6) inosine monophosphate dehydrogenase 2 (Impdh2). Impdh2 product catalyzes first committed step guanine nucleotide synthesis is tightly linked cell proliferation. Card6 positively modulates signal transduction. humans, significantly upregulated, trended toward upregulation training. These been regulate pathways influence nuclear factor kappa B (NF-κB), previously found be related enhanced synaptic function

Language: Английский

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis? DOI Creative Commons
Long Yan, Hong Li,

Yulin Qian

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Feb. 27, 2024

Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the distributed over body surface. Studies suggest a correlation between brain-gut-microbiota (BGM) axis and pathogenesis Alzheimer’s disease (AD). The BGM represents complex bidirectional communication system, with being crucial component. Therefore, electrical might have potential modify—most time probably in non-physiological way—the signal transmission within axis, potentially influencing progression or symptoms AD. This review explores interaction percutaneous emphasizing its effects on It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance intestinal environmental homeostasis, inflammatory responses, plasticity, hypothalamic–pituitary–adrenal (HPA) regulation. suggests that tVNS could serve effective strategy modulate intervene treatment future.

Language: Английский

Citations

13
Activation of σ-1 receptor mitigates estrogen withdrawal-induced anxiety/depressive-like behavior in mice via restoration of GABA/glutamate signaling and neuroplasticity in the hippocampus DOI Creative Commons
Peng Ren, Jingya Wang, Honglei Chen

et al.

Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 154(4), P. 236 - 245

Published: Feb. 9, 2024

Postpartum depression (PPD) is a significant contributor to maternal morbidity and mortality. The Sigma-1 (σ-1) receptor has received increasing attention in recent years because of its ability link different signaling systems exert function the brain through chaperone actions, especially neuropsychiatric disorders. YL-0919, novel σ-1 agonist developed by our institute, shown antidepressive anxiolytic effects variety animal models, but on PPD have not been revealed. In present study, excitatory/inhibitory hippocampus was reflected GABA glutamate their associated excitatory-inhibitory proteins, HPA axis hormones were assessed ELISA. Finally, immunofluorescence for markers newborn neuron undertaken dentate gyri, along with dendritic spine staining arborization tracing. YL-0919 rapidly improves anxiety depressive-like behavior PPD-like mice within one week, normalizing excitation/inhibition as well activity. rescued decrease hippocampal complexity density induced estrogen withdrawal. study results suggest that elicits therapeutic effect mice; therefore, may be promising target treatment future.

Language: Английский

Citations

9
Do the therapeutic effects of psilocybin involve actions in the gut? DOI

Felicia Reed,

Claire J. Foldi

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(2), P. 107 - 117

Published: Jan. 11, 2024

Language: Английский

Citations

8
Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients DOI Creative Commons
Ziyi Guo,

Tianjian Long,

Jianping Yao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: April 2, 2024

Background: Depression is a severe mental disorder that poses significant threat to both the physical and wellbeing of individuals. Currently, there are various methods for treating depression, including traditional Chinese herbal formulations like Chaihu-Shugan-San (CSS), which have shown effective antidepressant effects in clinical animal research. Objective: This review aims provide comprehensive synthesis evidence related CSS, considering preclinical studies, uncover its potential multi-level, multi-pathway, multi-target mechanisms depression identify active ingredients. Methods: A thorough search was conducted electronic databases, PubMed, MEDLINE, Web Science, Google Scholar, CNKI, Wanfang, using keywords such as “Chaihu Shugan” “depression” retrieve relevant literature on CSS The process adhered PRISMA guidelines. Results: consolidates underlying It emphasizes involvement regulation monoaminergic neurotransmitter systems, synaptic plasticity, hypothalamic-pituitary-adrenal axis, among other aspects. Conclusion: exerts pivotal role through pathways, system, inflammation, brain-derived neurotrophic factor levels, brain-gut axis. facilitates understanding current state research, fostering an in-depth exploration etiological discovery novel drugs.

Language: Английский

Citations

5
Serotonergic psychedelics as potential therapeutics for post-COVID-19 syndrome (or Long COVID): A comprehensive review DOI
Zhen Xuen Brandon Low, Shin Jie Yong, Hayam Ali AlRasheed

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111279 - 111279

Published: Feb. 1, 2025

Language: Английский

Citations

0
Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome DOI
Erin E. Mauney, Franklin King, Helen Burton Murray

et al.

Journal of Clinical Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Irritable bowel syndrome (IBS) is prevalent and can be disabling. Many patients remain symptomatic despite behavioral medical therapies. Psychedelic-assisted therapy (PAT), in which serotonergic agents like psilocybin are administered a psychotherapeutic context, has shown promise for refractory psychiatric disorders, including major depressive disorder post-traumatic stress disorder. Emerging evidence suggests PAT may also beneficial chronic pain conditions, fibromyalgia, low back pain, migraines. IBS highly comorbid with depression, anxiety, other suggesting shared cognitive neurological roots potentially therapeutic targets. In this editorial, we discuss 3 lines of as treatment IBS, under the overarching themes (1) psychological mechanisms (the findings from historic studies psychedelics elements psychobiological dysfunction targeted by PAT), (2) central nervous system (default mode network modulation induction neuroplasticity), (3) neurointestinal pathophysiology that modified PAT. We argue worthy study new disorders gut-brain interaction (DGBI). Successful application to gastrointestinal disease would represent step beyond mind-body dualism, potential implications functional somatic disorders.

Language: Английский

Citations

0
Vagus nerve stimulation (VNS) modulates synaptic plasticity in the infralimbic cortex via Trk-B receptor activation to reduce drug-seeking in male rats DOI
Christopher Driskill, Jessica E. Childs, Aarron Phensy

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(23), P. e0107242024 - e0107242024

Published: May 7, 2024

Drugs of abuse cause changes in the prefrontal cortex (PFC) and associated regions that impair inhibitory control over drug-seeking. Breaking contingencies between drug-associated cues delivery reward during extinction learning reduces relapse. Vagus nerve stimulation (VNS) has previously been shown to enhance reduce Here we determined effects VNS-mediated release brain-derived neurotrophic factor (BDNF) on cue-induced reinstatement male rats trained self-administer cocaine. Pairing 10 d training with VNS facilitated reduced drug-seeking behavior reinstatement. Rats received a single session showed elevated BDNF levels medial PFC as via an enzyme-linked immunosorbent assay. Systemic blockade tropomyosin receptor kinase B (TrkB) receptors extinction, TrkB antagonist ANA-12, decreased Whole-cell recordings brain slices cocaine self-administration induced alterations ratio AMPA NMDA receptor-mediated currents Layer 5 pyramidal neurons infralimbic (IL). reversed cocaine-induced glutamatergic transmission by enhancing AMPAR currents, this effect was blocked ANA-12. Our study suggests consolidates reversing drug-induced synaptic IL, is abolished blocking highlighting potential mechanism for therapeutic addiction.

Language: Английский

Citations

3
The role of Microbiota in the Pathogenesis of Alzheimer’s Disease DOI Open Access
Aastha Sharma, Ian Martins

Acta Scientifci Nutritional Health, Journal Year: 2023, Volume and Issue: 7(7), P. 108 - 118

Published: June 30, 2023

The World Health Organization has reported that in 2020 approximately 55 million people live with dementia worldwide 10 new cases every year.Alzheimer's disease (AD) is the most common form of and contributes to 60-70% cases.The role gut microbiota host metabolic regulation acts as a bridge between food lipids health AD individuals become major concern.Microbiome composition been linked neurodegenerative plays critical brain axis.Microbial fermentation may release short-chain fatty acids such butyric acid have influence on gut-brain axis effects amyloid beta levels plaque deposition.Butyric involved histone acetylation deacetylation an important regulation, amyloidosis pathogenesis AD.Several mechanistic studies are required determine underlying mechanisms for effective safe probiotic treatment relevance dysbiosis be cause induction AD.The safety therapy patients requires investigation dyslipidemia bacterial lipopolysaccharides from gram-negative bacteria needs controlled these formulations.In this review, we will summarize knowledge characteristics communication pathways microbiota-gut-brain axis, analyse AD, highlight modification preventive or therapeutic approach AD) benefits, limitations probiotics by LPS delay reverse Alzheimer's disease.

Language: Английский

Citations

5
Vagus nerve stimulation for long COVID DOI
Claire-Marie Rangon

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 383 - 392

Published: Nov. 22, 2024

Language: Английский

Citations

1
Exposure to alpha-glycosyl isoquercitrin from gestation to adulthood increases synaptic densities of glutamatergic and GABAergic inputs in the hippocampal dentate gyrus in rats DOI Creative Commons
Qian Tang, Xinyu Zou, Ryota Ojiro

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 112, P. 105990 - 105990

Published: Jan. 1, 2024

Exposure to alpha-glycosyl isoquercitrin (AGIQ) from gestation adulthood has been shown enhance synaptic plasticity in the hippocampal dentate gyrus (DG) and facilitate fear memory extinction rats. Here, we investigated effect of exposure 0.5 % AGIQ diet gestational day 6 postnatal 77 rats on excitatory inhibitory inputs DG. increased VGLUT2 immunoreactivity granule cell layer PSD95 whole structure. also VGAT all DG laminae as well number hilar GABAergic interneurons expressing NMDAR2D subpopulations CB1R, parvalbumin or somatostatin. The input was dominant glutamatergic input. These results suggest that increases densities both may upregulate diverse interneuron subpopulations, thereby enhancing structural cells, which might extinction.

Language: Английский

Citations

0