Human‐based new approach methodologies to accelerate advances in nutrition research DOI Creative Commons
Manuela Cassotta, Danila Cianciosi, María Zabaleta

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: 5(3), P. 1031 - 1062

Published: March 5, 2024

Abstract Much of nutrition research has been conventionally based on the use simplistic in vitro systems or animal models, which have extensively employed an effort to better understand relationships between diet and complex diseases as well evaluate food safety. Although these models undeniably contributed increase our mechanistic understanding basic biological processes, they do not adequately model human physiopathological phenomena, creating concerns about translatability humans. During last decade, extraordinary advancement stem cell culturing, three‐dimensional cultures, sequencing technologies, computer science occurred, originated a wealth novel human‐based more physiologically relevant tools. These tools, also known “new approach methodologies,” comprise patient‐derived organoids, organs‐on‐chip, multi‐omics approach, along with computational analysis, represent innovative exciting tools forward from human‐biology‐oriented perspective. After considering some shortcomings conventional vivo approaches, here we describe main available emerging that are appropriate for designing human‐relevant research. Our aim is encourage discussion opportunity explore paths promote paradigm‐change toward biology‐focused nutritional pathophysiology, products, develop effective targeted preventive therapeutic strategies while helping reducing number replacing animals

Language: Английский

Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications DOI Creative Commons
Mohammad Harun‐Ur‐Rashid, Israt Jahan, Tahmina Foyez

et al.

Micromachines, Journal Year: 2023, Volume and Issue: 14(9), P. 1786 - 1786

Published: Sept. 18, 2023

Exploring bio-inspired nanomaterials (BINMs) and incorporating them into micro/nanodevices represent a significant development in biomedical applications. Nanomaterials, engineered to imitate biological structures processes, exhibit distinctive attributes such as exceptional biocompatibility, multifunctionality, unparalleled versatility. The utilization of BINMs demonstrates potential diverse domains micro/nanodevices, encompassing biosensors, targeted drug delivery systems, advanced tissue engineering constructs. This article thoroughly examines the various BINMs, including those originating from proteins, DNA, biomimetic polymers. Significant attention is directed toward these entities subsequent ramifications that arise. review explores biomimicry’s structure–function correlations. Synthesis mosaics include bioprocesses, biomolecules, natural structures. These nanomaterials’ interfaces use functionalization geometric adaptations, transforming delivery, nanobiosensing, organ-on-chip cancer-on-chip models, wound healing dressing mats, antimicrobial surfaces. It provides an in-depth analysis existing challenges proposes prospective strategies improve efficiency, performance, reliability devices. Furthermore, this study offers forward-thinking viewpoint highlighting avenues for future exploration advancement. objective effectively utilize maximize application progression thereby propelling rapidly developing field its promising future.

Language: Английский

Citations

55
The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders DOI Creative Commons
Adrian Boicean, Cristian Ichim, Samuel Bogdan Todor

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(9), P. 861 - 861

Published: April 23, 2024

The role of the intestinal microbiota in diagnosis and treatment pancreatic diseases is increasingly significant. Consequently, fecal transplantation (FMT) emerging as a promising therapeutic avenue for various disorders, including cancer, pancreatitis, type 1 diabetes (T1D). This innovative procedure entails transferring gut from healthy donors to individuals affected by ailments with potential restore balance alleviate associated symptoms. FMT represents pioneering approach improve patient outcomes diseases, offering tailored treatments customized individual microbiomes specific conditions. Recent research highlights benefits targeting personalized interventions disorders. However, comprehensive understanding intricate interplay between physiology warrants further investigation. necessity additional studies endeavors remains crucial, especially elucidating both adult pediatric cases pathological

Language: Английский

Citations

26
Potential inhibitory effect of Auricularia auricula polysaccharide on advanced glycation end-products (AGEs) DOI
Pin Gong,

Shuya Pei,

Hui Long

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129856 - 129856

Published: Feb. 29, 2024

Language: Английский

Citations

20
Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress DOI
Pin Gong, Hui Long, Yuxi Guo

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 318, P. 116927 - 116927

Published: July 31, 2023

Language: Английский

Citations

32
The Gut–Organ Axis within the Human Body: Gut Dysbiosis and the Role of Prebiotics DOI Creative Commons

Georgia Saxami,

Evangelia N. Kerezoudi, Christos Eliopoulos

et al.

Life, Journal Year: 2023, Volume and Issue: 13(10), P. 2023 - 2023

Published: Oct. 8, 2023

The human gut microbiota (GM) is a complex microbial ecosystem that colonises the gastrointestinal tract (GIT) and comprised of bacteria, viruses, fungi, protozoa. GM has symbiotic relationship with its host fundamental for body homeostasis. not limited to scope GIT, but there are bidirectional interactions between other organs, highlighting concept "gut-organ axis". Any deviation from normal composition GM, termed "microbial dysbiosis", implicated in pathogenesis various diseases. Only few studies have demonstrated modifications disease phenotypes, it still unknown whether an altered contributes or simply reflects status. Restoration probiotics prebiotics been postulated, evidence effects limited. Prebiotics substrates "selectively utilized by microorganisms, conferring health benefit". This study highlights vital organs demonstrates dysbiosis emergence certain representative Finally, this article focuses on potential as target therapy manipulate presents gaps literature research.

Language: Английский

Citations

27
Siraitia grosvenorii As a Homologue of Food and Medicine: A Review of Biological Activity, Mechanisms of Action, Synthetic Biology, and Applications in Future Food DOI
Yuxi Guo, Xuefeng Chen, Pin Gong

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(13), P. 6850 - 6870

Published: March 21, 2024

Siraitia grosvenorii (SG), also known as Luo Han Guo or Monk fruit, boasts a significant history in food and medicine. This review delves into SG's historical role varied applications traditional Chinese culture, examining its phytochemical composition the health benefits of bioactive compounds. It further explores biological activities, including antioxidant, anti-inflammatory, antidiabetic properties elucidates mechanisms behind these effects. The highlights recent synthetic biology advances enhancing production compounds, presenting new opportunities for broadening their availability. Ultimately, this emphasizes value medicine, showcasing cultural importance, phytochemistry, functions, action mechanisms, sustainable use.

Language: Английский

Citations

15
Lab-on-chip technologies for exploring the gut–immune axis in metabolic disease DOI Creative Commons
Alexandra Wheeler, Verena Stoeger, Róisı́n M. Owens

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1266 - 1292

Published: Jan. 1, 2024

Further development of lab-on-chip platforms is required to create an environment capable hosting more complex microbiota and immune cells.

Language: Английский

Citations

8
Role of the microbiome in regulation of the immune system DOI Creative Commons
Songhui Kim,

Cebile Ndwandwe,

Hannah Devotta

et al.

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Language: Английский

Citations

1
Effect of in vitro digestion and fermentation of kiwifruit pomace polysaccharides on structural characteristics and human gut microbiota DOI Creative Commons

Mengyin Chen,

Xuefeng Chen, Yuxi Guo

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127141 - 127141

Published: Sept. 28, 2023

Language: Английский

Citations

22
Gut microbiota in health and disease: advances and future prospects DOI Creative Commons
Y J Zhang, Hong Wang, Yingpeng Sang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Nov. 20, 2024

Abstract The gut microbiota plays a critical role in maintaining human health, influencing wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances composition can contribute to the onset progression various diseases, such as metabolic disorders (e.g., obesity diabetes) neurodegenerative conditions Alzheimer's Parkinson's). These are often accompanied by chronic inflammation dysregulated responses, which closely linked specific forms cell death, pyroptosis ferroptosis. Pathogenic bacteria trigger these death pathways through toxin release, while probiotics been found mitigate effects modulating responses. Despite insights, precise mechanisms influences diseases remain insufficiently understood. This review consolidates recent findings on impact immune‐mediated inflammation‐associated conditions. It also identifies gaps current research explores potential advanced technologies, organ‐on‐chip models microbiome–gut–organ axis, for deepening our understanding. Emerging tools, single‐bacterium omics spatial metabolomics, discussed their promise elucidating microbiota's disease development.

Language: Английский

Citations

8