International Journal of Genomics,
Journal Year:
2023,
Volume and Issue:
2023, P. 1 - 22
Published: Dec. 16, 2023
Breast
cancer
(BC)
has
emerged
as
an
extremely
destructive
malignancy,
causing
significant
harm
to
female
patients
and
society
at
large.
Proteomic
research
holds
great
promise
for
early
diagnosis
treatment
of
diseases,
the
integration
proteomics
with
genomics
can
offer
valuable
assistance
in
diagnosis,
treatment,
improved
prognosis
BC
patients.
In
this
study,
we
downloaded
breast
protein
expression
data
from
The
Cancer
Genome
Atlas
(TCGA)
combined
construct
a
proteomic-based
prognostic
model
BC.
This
consists
nine
proteins
(HEREGULIN,
IDO,
PEA15,
MERIT40_pS29,
CIITA,
AKT2,
CD171
DVL3,
CABL9).
accuracy
predicting
survival
was
further
validated
through
risk
curve
analysis,
independent
analysis.
We
confirmed
impact
differential
these
key
on
overall
patients,
their
encoding
genes
using
immunohistochemical
staining.
Enrichment
analysis
revealed
functional
associations
primarily
related
PPAR
signaling
pathway,
steroid
hormone
metabolism,
chemokine
DNA
conformation
changes,
immunoglobulin
production,
complex
high-
low-risk
groups.
Immune
infiltration
immune
cells
between
groups,
providing
theoretical
basis
subsequent
immunotherapy.
constructed
study
predict
identified
may
serve
biomarkers
aid
provide
necessary
exploration
molecular
mechanisms
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(12), P. e22595 - e22595
Published: Nov. 23, 2023
Hepatocellular
carcinoma
(HCC)
is
a
highly
prevalent
malignancy
and
the
third
highest
contributor
to
cancer-associated
deaths
globally.
Research
has
increasingly
demonstrated
strong
correlation
between
long
noncoding
RNAs
(lncRNAs)
incidence
progression
of
HCC.
Nonetheless,
exact
mechanism
whereby
function
lncRNAs
in
HCC
not
been
elucidated.
This
study
explored
pathological
role
LINC00294
HCC,
as
well
modulatory
involved.
Based
on
"The
Cancer
Genome
Atlas
(TCGA)"
database
validation
cell
lines
tissues,
expression
was
discovered
be
upregulated
tissues
correlated
with
tumor
grade
prognosis
patients
Functionally,
stimulated
proliferation
cells
Warburg
effect
(aerobic
glycolysis)
enhance
vivo.
Mechanistically,
METTL3/YTHDC1-mediated
N6-methyladenosine
(m6A)
modification
underwent
significant
enrichment
within
shown
its
RNA
stability.
Moreover,
promoted
interaction
YTHDC1
HK2
GLUT1
mRNA.
Overall,
our
illustrates
m6A
modification-mediated
epigenetic
regulatory
HK2and
mRNA
indicate
potential
biomarker
panel
for
prognostic
prediction
treatment
Non-Coding RNA,
Journal Year:
2023,
Volume and Issue:
9(4), P. 44 - 44
Published: Aug. 1, 2023
Lymphoid
cells
play
a
critical
role
in
the
immune
system,
which
includes
three
subgroups
of
T,
B,
and
NK
cells.
Recognition
complexity
human
genetics
transcriptome
lymphopoiesis
has
revolutionized
our
understanding
regulatory
potential
RNA
normal
lymphoid
malignancies.
Long
non-coding
RNAs
(lncRNAs)
are
class
molecules
greater
than
200
nucleotides
length.
LncRNAs
have
recently
attracted
much
attention
due
to
their
roles
various
biological
processes,
including
gene
regulation,
chromatin
organization,
cell
cycle
control.
can
also
be
used
for
differentiation
fate,
as
expression
patterns
often
specific
particular
types
or
developmental
stages.
Additionally,
lncRNAs
been
implicated
differentiation,
such
regulating
T-cell
B-cell
development,
linked
immune-associated
diseases
leukemia
lymphoma.
In
addition,
investigated
biomarkers
diagnosis,
prognosis,
therapeutic
response
disease
management.
this
review,
we
provide
an
overview
current
knowledge
about
physiopathology
processes
during
leukemia.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: Oct. 16, 2024
The
p53
is
a
crucial
tumor
suppressor
and
transcription
factor
that
participates
in
apoptosis
senescence.
It
can
be
activated
upon
DNA
damage
to
regulate
the
expression
of
series
genes.
Previous
studies
have
demonstrated
some
specific
lncRNAs
are
part
TP53
regulatory
network.
To
enhance
our
understanding
relationship
between
P53
cancers,
we
review
localization,
structure,
function
related
mechanisms
pathway
or
serve
as
transcriptional
targets.
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Oct. 24, 2024
Hepatocellular
carcinoma
(HCC)
remains
a
significant
global
health
challenge
with
few
effective
treatment
options.
The
dysregulation
of
endoplasmic
reticulum
(ER)
stress
responses
has
emerged
as
pivotal
factor
in
HCC
progression
and
therapy
resistance.
Long
non-coding
RNAs
(lncRNAs)
play
crucial
role
key
epigenetic
modifiers
this
process.
Recent
research
explored
how
lncRNAs
influence
ER
which
turn
affects
activity
HCC.
We
systematically
analyze
the
current
literature
to
highlight
regulatory
roles
modulating
vice
versa
Our
scrutinization
highlights
dysregulated
contribute
various
facets
HCC,
including
apoptosis
resistance,
enhanced
proliferation,
invasion,
metastasis,
all
driven
by
stress.
Moreover,
we
delve
into
emerging
paradigm
lncRNA-miRNA-mRNA
axis,
elucidating
it
promising
avenue
for
developing
novel
biomarkers
paving
way
more
personalized
options
Nevertheless,
acknowledge
challenges
future
directions
translating
these
insights
clinical
practice.
In
conclusion,
our
review
provides
complex
mechanisms
governing
modulation
