Association between composite dietary antioxidant index and cognitive function impairment among the US older adults: a cross-sectional study based on the NHANES 2011–2014 DOI Creative Commons
Cong Zhao, Meng Pu,

Chengji Wu

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 22, 2024

Background Cognitive function impairment (CFI) and the Composite Dietary Antioxidant Index (CDAI) were investigated in this study. Methods Participants from 2011–2014 cycles of National Health Nutrition Examination Survey chosen to assess cognitive using Consortium Establish a Registry for Alzheimer’s Disease Word Learning Test, Animal Fluency Digit Symbol Substitution Test. scored below 25% percentile any three tests defined as having impairment. 24-h recalls diet collected calculate CDAI. Results 2,424 participants included. The fully adjusted multivariate logistic regression model showed an increase one CDAI unit reduced CFI risk by 5% (95% CI: 0.92 ~ 0.98, p = 0.004). When comparing individuals with lowest first quartile (<−2.42), odds ratio 0.81 0.61 1.06, 0.125) second quartile, 0.69 0.51 0.92, 0.012) third 0.59 0.43 0.82, 0.002) fourth respectively. Restricted cubic spline analysis revealed steady negative linear correlation between CFI, -value non-linearity 0.122. Subgroup did not reveal significant interactions based on age, education level, family income, history diabetes, hypertension, stroke, depression. Conclusion was inversely associated large representative American population. Further longitudinal studies are needed causal inference.

Language: Английский

A review on the influence of nutraceuticals and functional foods on health DOI Creative Commons
Arumugam Vignesh,

Thomas Cheeran Amal,

Ariyan Sarvalingam

et al.

Food Chemistry Advances, Journal Year: 2024, Volume and Issue: 5, P. 100749 - 100749

Published: June 10, 2024

In recent years, functional foods have gained attention for their potential health benefits beyond basic nutrition, serving as rich sources of proteins, carbohydrates, vitamins, and dietary fiber. Enriched with bioactive compounds such polyphenols, tannins, flavonoids, alkaloids, these shown promise in inhibiting cell signaling pathways related to proliferation, communication, apoptosis. Key components offer benefits. Omega-3 fatty acids scavenge free radicals, reducing the risk chronic diseases like heart disease cancer. Antioxidants sesame seed oil promote cardiovascular anti-inflammatory effects. Curcumin inhibits cancer by suppressing inflammatory cytokines. Understanding mechanisms action is crucial realizing therapeutic However, identifying suitable substances comprehending role prevention are challenging. As we enter food era, this review aims present current state nutraceuticals, exploring applications human wellness. Recognizing nutrition's individualized nature nutrition a central theme, emphasizing importance tailored recommendations based on diverse responses elements, ensuring that personalized approaches aligned individual goals.

Language: Английский

Citations

28
Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics DOI Open Access
Mónika Fekete,

Andrea Lehoczki,

Dávid Major

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(6), P. 789 - 789

Published: March 10, 2024

Recent research exploring the relationship between gut and brain suggests that condition of microbiota can influence cognitive health. A well-balanced may help reduce inflammation, which is linked to neurodegenerative conditions. Prebiotics, probiotics, symbiotics are nutritional supplements functional food components associated with gastrointestinal well-being. The bidirectional communication gut–brain axis essential for maintaining homeostasis, pre-, pro-, potentially affecting various functions such as attention, perception, memory. Numerous studies have consistently shown incorporating into a healthy diet lead improvements in mood. Maintaining support optimal function, crucial disease prevention our fast-paced, Westernized society. Our results indicate benefits older individuals probiotic supplementation but not who good adequate levels physical activity. Additionally, it appears there patients mild impairment Alzheimer’s disease, while mixed seem arise younger healthier individuals. However, important acknowledge individual responses vary, use these dietary should be tailored each individual’s unique health circumstances needs.

Language: Английский

Citations

21
The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis DOI Creative Commons
Mónika Fekete, Péter Varga, Zoltán Ungvári

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Language: Английский

Citations

4
Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

Citations

3
Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis DOI Creative Commons
Zoltán Ungvári, Mónika Fekete,

Andrea Lehoczki

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Abstract Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, neurodegenerative diseases such Alzheimer’s disease (AD) vascular impairment dementia (VCID). However, the extent specificity of these associations remain uncertain. This meta-analysis evaluates impact common disorders on risk developing decline. A comprehensive search literature was conducted identify prospective cohort studies assessing risk. Studies reporting estimates for AD, or decline associated with insomnia, other (e.g., restless legs syndrome, circadian rhythm excessive daytime sleepiness) were included. Meta-analyses performed using a random-effects model calculate pooled hazard ratios (HRs) 95% confidence intervals (CIs). Thirty-nine included, subgroup analyses showing between all-cause apnea (HR 1.33, CI 1.09–1.61), 1.36, 1.19–1.55), 1.24–1.43). Obstructive increased AD 1.45, 1.24–1.69), though its association did not reach statistical significance 1.35, 0.99–1.84). Insomnia significantly both 1.59, 1.01–2.51) 1.49, 1.27–1.74). highlights critical role in risk, emphasizing need early detection management disturbances. Targeted interventions could play pivotal reducing among high-risk populations.

Language: Английский

Citations

1
The Role of Dietary Antioxidants, Food Supplements and Functional Foods for Energy Enhancement in Healthcare Professionals DOI Creative Commons

Theodora Kalogerakou,

Μαρία Αντωνιάδου

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1508 - 1508

Published: Dec. 10, 2024

Healthcare professionals frequently experience significant work overload, which often leads to substantial physical and psychological stress. This stress is closely linked increased oxidative a corresponding decline in energy levels. scoping review investigates the potential impact of dietary antioxidants food supplements conjunction with diet controlling these negative effects. Through an analysis biochemical pathways involved metabolism, paper emphasizes effectiveness targeted interventions. Key antioxidants, such as vitamins C E, polyphenols, carotenoids, are evaluated for their ability counteract enhance Additionally, assesses various supplements, including omega-3 fatty acids, coenzyme Q10, ginseng, mechanisms action enhancement. Practical guidelines incorporating energy-boost strategies into routine healthcare provided, emphasizing importance modifications reducing improving overall well-being performance high-stress environments. The concludes by suggesting directions future research validate findings explore new interventions that may further support under overload.

Language: Английский

Citations

5
Association Between Composite Dietary Antioxidant Index and Cognitive Function Among Aging Americans from NHANES 2011–2014 DOI

Jiesheng Mao,

Haoxiang Hu,

Yunhan Zhao

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 98(4), P. 1377 - 1389

Published: April 2, 2024

Antioxidant diets are considered to be protective factors for cognitive function. However, comprehensive measures of antioxidant lacking.

Language: Английский

Citations

4
Preliminary Effects of American Elderberry Juice on Cognitive Functioning in Mild Cognitive Impairment Patients: A Secondary Analysis of Cognitive Composite Scores in a Randomized Clinical Trial DOI Creative Commons
Madison Musich, Ashley Curtis, Bradley J. Ferguson

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 131 - 131

Published: Jan. 23, 2025

Previous work examining dietary interventions high in polyphenols (i.e., antioxidant/anti-inflammatory properties) has shown cognitive benefits. In a prior investigation American elderberry juice consumption with inflammation and cognition mild impairment (MCI), we found trend toward better visuospatial construct flexibility MCI patients who consumed relative to the placebo control. This study aims further examine preliminary effects of on domains using composite scores. (N = 24; Mage 76.33 ± 6.95) received (n 11) or 13) for 6 months completed tasks targeting memory, ability, at baseline, 3 months, months. For z-scores calculated global each domain, multilevel models Kenward–Roger post hoc tests examined interaction between condition (elderberry/placebo) time (baseline/3 months/6 months). The findings showed significant (p 0.049) (not placebo) trending decrease (better) latency scores from baseline (M 29.89, SE 18.12) 18.57, 9.68). Preliminary suggest may provide overall benefits MCI. These promising results support prospective investigations potential underlying mechanisms elderberries that MCI, possibly due anti-inflammatory effects.

Language: Английский

Citations

0
Introductory Chapter: Vitaminology as a Nutritional Supplement to Maintain a Healthy Lifestyle DOI Creative Commons

Abdalbasit Mariod

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels DOI Creative Commons

Zhikui Zhou,

Binke Fan,

Qiang Chen

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 29, 2025

Background Vitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives present study were to evaluate association between dietary vitamin intake cognitive function in elderly adults explore potential impact serum neurofilament light chain (NfL) concentration. Methods Data from 468 individuals, including information on consumption 10 vitamins, used. Cognitive performance was assessed according a composite Z-score Animal Fluency Test (AFT), Consortium Establish Registry Alzheimer’s Disease (CERAD), Digit Symbol Substitution (DSST). Serum NfL levels measured using highly sensitive immunoassay. Bayesian kernel machine regression (BKMR) models used estimate combined effects mixtures function. Results In both single- multiple-vitamin models, individuals with higher K exhibited greater global function, compared those lower intake. BKMR revealed positive associations AFT Z-scores, DSST Z-scores. Individuals third tertile than first (regression coefficient, β = −0.16 [95% confidence interval −0.29 −0.02]; p 0.023). mediated (8.73%). Conclusion Vitamin positively associated participants. may be by

Language: Английский

Citations

0