The impact of vitamin D on cancer: A mini review

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2023, Volume and Issue: 231, P. 106308 - 106308

Published: April 11, 2023

In this review, we summarize the most recent advances in vitamin D cancer research to provide molecular clarity, as well its translational trajectory across landscape. Vitamin is known for role regulating mineral homeostasis; however, deficiency has also been linked development and progression of a number types. Recent epigenomic, transcriptomic, proteomic studies have revealed novel D-mediated biological mechanisms that regulate cell self-renewal, differentiation, proliferation, transformation, death. Tumor microenvironmental dynamic relationships between immune system D's anti-neoplastic properties. These findings help explain large population-based show clinicopathological correlations circulating levels risk The majority evidence suggests low are associated with an increased cancers, whereas supplementation alone or combination other chemo/immunotherapeutic drugs may improve clinical outcomes even further. promising results still necessitate further into approaches target signaling metabolic systems outcomes.

Language: Английский

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Advances in biomedical applications of vitamin D for VDR targeted management of obesity and cancer

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117001 - 117001

Published: June 26, 2024

1,25(OH)2D3 is a fat-soluble vitamin, involved in regulating Ca2+ homeostasis the body. Its storage adipose tissue depends on fat content of Obesity result abnormal lipid deposition due to prolonged positive energy balance and increases risk several cancer types. Furthermore, it has been associated with vitamin D deficiency defined as low 25(OH)2D3 blood level. In addition, plays vital roles Ca2+-Pi glucose metabolism adipocytes obese individuals regulates expressions adipogenesis-associated genes mature adipocytes. The present contribution focused VDR mediated mechanisms interconnecting condition proliferation 1,25(OH)2D3-deficiency humans. This also summarizes identification development molecular targets for VDR-targeted drug discovery. Several studies have revealed that background deficient obesity involves gene. Moreover, known influence cellular processes, including differentiation, proliferation, adhesion. multifaceted physiology improved our understanding therapeutic targets. However, currently available anti-cancer drugs are notorious their side effects, which raised safety issues. Thus, there interest developing 1,25(OH)2D3-based therapies without any effects.

Language: Английский

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Melatonin and vitamin D as potential synergistic adjuvants for cancer therapy (Review)

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(6)

Published: Oct. 22, 2024

Significant advancements have been made in cancer therapy; however, limitations remain with some conventional approaches. Adjuvants are agents used alongside primary treatments to enhance their efficacy and the treatment outcomes of patients. Modern lifestyles contribute deficiencies melatonin vitamin D. Limited sun exposure affects D synthesis, artificial light at night suppresses production. Both possess anti‑inflammatory, immune‑boosting anticancer properties, rendering them potential adjuvants interest. Studies suggest supplementation may address antioxidant imbalances lip, oral pharyngeal cancers. Moreover, promising results from breast, head neck, brain, osteosarcoma research indicate for tumor growth inhibition, improved survival, a better quality life patients cancer. The radioprotective properties another exciting area exploration, potentially enhancing radiotherapy effectiveness while reducing side effects. For its part, sleep‑promoting effects indirectly benefit by influencing immune system. Thus, prevalence highlights importance supplementation, as lower levels can worsen side‑effects treatments. present review explores combining synergistic therapy. These shown promise individually prevention treatment, combined warrant investigation. Therefore, large‑scale controlled trials crucial definitively determine optimal dosage, safety this combination improving lives

Language: Английский

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A novel LC-MS/MS analysis of vitamin D metabolites in mice serum and hair: impact of diet and light exposure

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Numerous physiological systems, such as the functioning of immune system, bone health, and regulation expression genes, depend critically on vitamin D. Considering significance D for it is critical to understand how metabolized factors that affect its levels. The objective this study was develop validate an LC-MS/MS method examine effects light exposure dietary consumption levels metabolites in a mouse model under consistent growth conditions throughout year. Serum hair samples from mice were analyzed various experimental using liquid chromatography-tandem mass spectrometry (LC-MS/MS). included D-deficient diet, D-standard changes ambient ranging complete darkness regular light-dark cycle. Mice fed standard diet exposed cycle exhibited significantly higher 25OHD3 both serum hair, indicating synergistic effect intake exposure. but kept continuous showed moderately elevated levels, demonstrating efficacy maintaining adequate despite absence light. Conversely, housed displayed below limit quantification, highlighting combined detrimental deficiency lack This provides valuable insights into complex interplay between intake, exposure, metabolism mice. Moreover, our results underscore potential implications human suggesting importance sunlight optimal Further research area has unveil additional influencing metabolism, offering strategies optimizing animal models subjects.

Language: Английский

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Vitamin D and Clinical Outcomes in Head and Neck Cancer: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1100 - 1100

Published: March 21, 2025

Background/Objectives: Vitamin D is classically associated with calcium and phosphate homeostasis, but recent research has expanded its role to include several new roles such as immune regulation, inflammation, potential anti-cancer properties. The vitamin receptor (VDR) expressed in over 400 tissues, including those of the head neck, implying a link between neck cancers (HNCs). Given need for newer better therapeutic approaches, this systematic review aims synthesize existing clinical evidence on relationship status outcomes HNC patients. Methods Results: A comprehensive literature search, across multiple databases PubMed, Google Scholar Science Direct, identified 187,642 studies related cancer, from which 16 met inclusion criteria. criteria were English-language, full-text original (2015-2025) D's progression treatment, focusing human studies. findings indicate that deficiency highly prevalent among patients, rates ranging 47% 95%, particularly advanced-stage undergoing intensive treatment. Inverse association levels risk was reported, higher serum 25(OH)D linked 30-32% reduction cancer risk. Additionally, correlated improved survival reduced recurrence, though some lacked statistical significance. Deficiencies malnutrition postoperative complications, reinforcing nutritional stability surgical recovery. Conclusions: This highlights how common significant (HNC) exploring possible risk, prognosis, survival, treatment-related side effects, malnutrition, post-surgical complications. suggests while are fewer issues, benefits seem level off beyond certain point, indicating more complex relationship. supplementation appears help reduce chemoradiation effects like mucositis, skin toxicity, dysphagia, pain, ultimately improving patients' quality life during

Language: Английский

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The impact of genetic variations in retinoid X receptor alpha on the risk and prognosis of HPV‐negative oral carcinoma

European Journal Of Oral Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Abstract Oral squamous cell carcinoma (OSCC) is characterized by a high recurrence rate and poor survival. The retinoid X receptor (RXR) nuclear that modulates variety of biological processes related to cancer, including apoptosis, cellular adhesion, immune function. A number cancers exhibit aberrant expression altered function the RXR isoform alpha (RXRA), but polymorphisms in RXRA gene have not been investigated previously patients with oral cancer. current study examined rs7864987 rs3118523 genetic variants, assessed real‐time PCR Taq‐Man method, 95 HPV‐negative OSCC 101 age‐ sex‐matched healthy controls. Kaplan‐Meier analysis revealed was significantly associated worse overall survival showed tendency toward lower recurrence‐free when compared wild‐type allele carriers (combined TC+TT genotypes) mutant genotype CC. rs7864987, however, did independently predict C variant reduced risk OSCC. Our indicates may be prognostic disease‐predisposing factors for Additionally, might influence potential profile‐based approach therapy

Language: Английский

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Advantages of the Combinatorial Molecular Targeted Therapy of Head and Neck Cancer—A Step before Anakoinosis-Based Personalized Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(17), P. 4247 - 4247

Published: Aug. 24, 2023

The molecular initiators of Head and Heck Squamous Cell Carcinoma (HNSCC) are complex. Human Papillomavirus (HPV) infection is linked to an increasing number HNSCC cases, but HPV-positive tumors generally have a good prognosis. External factors that promote the development HPV-negative include tobacco use, excessive alcohol consumption, proinflammatory poor oral hygiene. On level, several events, including well-known overexpression epidermal growth factor receptors (EGFR) related downstream signaling pathways, contribute HNSCC. Conventional chemotherapy insufficient for many patients. Thus, molecular-based therapy offers patients better chance at cure. first target was EGFR, inhibited by monoclonal antibody cetuximab, its use in monotherapy induces resistance. This article describes attempts combinatorial targeted based on targets exemplary drugs/drug candidates. new concept anakoinosis-based therapy, which means treatment intercellular intracellular communication cancer cells, thought be way improve clinical outcome identification link between anakoinosis raises potential further progress therapy.

Language: Английский

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Potential treatment of squamous cell carcinoma by targeting heparin-binding protein 17/fibroblast growth factor-binding protein 1 with vitamin D3 or eldecalcitol

In Vitro Cellular & Developmental Biology - Animal, Journal Year: 2024, Volume and Issue: 60(6), P. 583 - 589

Published: May 7, 2024

Heparin-binding protein 17 (HBp17), first purified in 1991 from the conditioned medium of human A431 squamous cell carcinoma (SCC) line, was later renamed fibroblast growth factor-binding 1 (FGFBP-1). HBp17/FGFBP-1 is specifically expressed and secreted by epithelial cells, it reversibly binds to factor (FGF)-1 FGF-2, as well FGFs-7, -10, -22, indicating a crucial involvement transportation function these FGFs. Our laboratory has investigated reported several studies elucidate SCC cells its potential molecular therapeutic target. transgene exoression A431-4 clonal subline that lacks tumorigenicity does not express HBp17/FGFBP-1, demonstrated significantly enhanced proliferation vitro compared with acquired subcutis nude mice. Knockout (KO) genome editing suppressed tumor growth, motility, control cells. A comprehensive analysis molecules both types revealed promote differentiation were highly KO Additionally, we 1α,25(OH)

Language: Английский

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Exploring the tumor-suppressive role of miRNA-200c in head and neck squamous cell carcinoma: Potential and mechanisms of exosome-mediated delivery for therapeutic applications

Translational Oncology, Journal Year: 2024, Volume and Issue: 51, P. 102216 - 102216

Published: Nov. 29, 2024

Language: Английский

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Different impact of vitamin D on mitochondrial activity and morphology in normal and malignant keratinocytes, the role of genomic pathway

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 210, P. 286 - 303

Published: Nov. 30, 2023

Deregulation of mitochondria activity is one the hallmarks cancerogenesis and an important target for cancer therapy. Therefore, we compared impact active form vitamin D3 (1,25(OH)2D3) on mitochondrial morphology bioenergetics in human squamous cell carcinoma (A431) immortalized HaCaT keratinocytes. It was shown that cancerous A431 cells differ from observed keratinocytes terms network, morphology, bioenergetics, glycolysis, DNA copy number, while treatment with 1,25(OH)2D3 partially eliminates these differences. Furthermore, membrane potential, basal respiration, reactive oxygen species production were decreased treated 1,25(OH)2D3. Additionally, expression protein level mitophagy marker PINK1 significantly increased cells, but not cells. Knockout VDR (vitamin D receptor) or RXRA (binding partner retinoid X altered function as well response to Transcriptomic analysis revealed modulation several mitochondrial-related genes involved depolarization, translation (i.e. LYRM9, MARS2), fusion-fission (OPA1, FIS1, MFN1 2), however, none coded by affected. Interestingly, silico analyses nuclear-encoded they are rather activated secondary genomic Taken together, remodels architecture through VDR-dependent only RXRA-dependent activation pathway, thus outlining a new perspective anticancer properties relation carcinoma.

Language: Английский

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