Levantamento epidemiológico de CPO-D e Xerostomia em estudantes universitários brasileiros: relações com a saúde bucal DOI Open Access
Felipe Ferreira de Sousa, Ianny Maria Meira Araújo, Bianca Hozana Bezerra Cavalcanti

et al.

Research Society and Development, Journal Year: 2023, Volume and Issue: 12(4), P. e21812441299 - e21812441299

Published: April 15, 2023

O CPO-D, é a soma dos elementos dentários cariados (C), perdidos (P) e índices de dentes obturados (O). Xerostomia forma mais prevalente ressecamento bucal. Este artigo tem como objetivo descrever os CPO-D xerostomia estudantes Odontologia brasileiros. do tipo descritivo, relacionado aos objetivos campo, que utilizou abordagem quantitativa, adotando as orientações da pesquisa com corte transversal observação direta extensiva utilização questionário amostragem não probabilística. Para coleta dados foi utilizado o procedimento divulgação em cadeia intitulado bola neve. Dados referentes também foram investigados, obtidos através um questionário, consistia 4 perguntas. Os analisados utilizando Statistical Package for Social Science (SPSS 21). Não encontradas diferenças significativas entre participantes.

Sentinel and networked symptoms in patients with breast cancer undergoing chemotherapy DOI
Minyu Liang,

Tong Zhong,

M. Tish Knobf

et al.

European Journal of Oncology Nursing, Journal Year: 2024, Volume and Issue: 70, P. 102566 - 102566

Published: March 13, 2024

Language: Английский

Citations

12
A multi-center study of symptoms in patients with esophageal cancer postoperatively: A networking analysis DOI
Fu‐Rong Chen, Ziyun Shen, Ying Xiong

et al.

European Journal of Oncology Nursing, Journal Year: 2025, Volume and Issue: 74, P. 102784 - 102784

Published: Jan. 8, 2025

Language: Английский

Citations

1
Severe Xerostomia Induced by Multiple Systemic Diseases in a Patient with Psoriasis Vulgaris: A Case Report and Literature Review DOI Creative Commons
Yessy Novianti, Wahyu Hidayat, D. A. O. Rosa

et al.

International Medical Case Reports Journal, Journal Year: 2024, Volume and Issue: Volume 17, P. 77 - 88

Published: Jan. 1, 2024

Introduction: Psoriasis is a complex autoimmune disease associated with chronic systemic keratinization and inflammation, which can affect the skin, joints, oral cavity. Xerostomia subjective feeling of dryness that impairs patient comfort lowers quality life. The aim this case report to describe clinical mechanism xerostomia in psoriasis multiple diseases. Case Report: A 51-year-old inpatient man vulgaris was referred Oral Medicine Department complaints difficulty swallowing due sore throat dry tongue since last week. had 15 years ago, adrenal insufficiency, psoriatic arthritis, acute circulatory collapse, anemia kidney injury, dehydration, gastritis, urinary tract infections, malnutrition. complete anamnesis examination were done. diagnosed severe xerostomia, fissured tongue, exfoliative cheilitis, angular gingivitis by Department. Management: treated petroleum jelly, chlorine dioxide mouthwash, miconazole cream, benzydamine HCl lozenges. Conclusion: Based on reports reviews, diseases may not only increase risk but also aggravate its severity. Keywords: nitrogen oxide, SXI-ID

Language: Английский

Citations

4
Oral Lubrication, Xerostomia, and Advanced Macromolecular Lubricants for Treatment of Dry Mouth DOI Creative Commons

William Austin,

Maryam Hdeib,

Paige Fraser

et al.

Lubricants, Journal Year: 2024, Volume and Issue: 12(4), P. 126 - 126

Published: April 12, 2024

Dry mouth, also known as xerostomia, is a condition in which insufficient or ineffective saliva does not provide sufficient oral lubrication. The severity of this can vary from mild discomfort to debilitating that greatly impairs patients’ lives. Xerostomia arises side effect various medications, diseases, radiation therapy, chemotherapy, nerve damage. Various aqueous dispersions macromolecules have been proposed assist replace the these patients. It vital ample lubricity and water retention properties while showing long-lasting efficacy. emphasis review general overview on lubricating clinically used reported literature potential replacements for saliva. These include natural synthetic polymers, proteins, peptides, lipids are form solutions, gels, emulsions, colloids. Perspectives into future macromolecular lubricants treatment xerostomia provided.

Language: Английский

Citations

4
BuZhong YiQi Formula Alleviates Diabetes-Caused Hyposalivation by Activating Salivary Secretion Pathway in the Parotid and Submandibular Glands of Rats DOI Creative Commons
Mingyu Wang, Z.-Y. Hu, Liang Wang

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 377 - 377

Published: March 6, 2025

Background/Objectives: BuZhong Yiqi Formula (BZYQF) has significant ameliorative effects on type 2 diabetes mellitus (T2DM). However, its efficacy in alleviating the hyposalivation caused by T2DM needs to be confirmed, and mechanism is unclear. Methods: Network pharmacology molecular docking were combined analyze which BZYQF alleviates T2DM-caused hyposalivation. A rat model was induced evaluate of BZYQF. The total saliva before after acid stimulation collected determine salivary flow rate alpha-amylase (sAA) activity. parotid (PG) submandibular glands (SMG) experimental rats removed perform histopathology observation, biochemical indicator determination, expression detection signaling molecules secretion pathway. Results: present study screened out 1014 potential targets regarding treatment T2DM. These mainly involved formation receptor complex, exercising neurotransmitter activity regulating secretion. They significantly enriched pathway β1-AR/PKA/AMY1 CHRM3/IP3R/AQP5. Furthermore, BZYQF, nine validated compounds able dock into active site β1-AR, three CHRM3. Animal experiments confirmed that reduces fasting blood glucose, cholesterol triglyceride levels; enhances insulin level HOMA-IS (p < 0.05); increases (Basal: increase from 21.04 ± 14.31 42.65 8.84 μL/min, effect size Cohen’s d = 6.80, p 0.0078; Stimulated: 36.88 17.48 72.63 17.67 7.61, 0.0025) sAA 0.68 0.32 2.17 0.77 U/mL, 9.49, 0.0027; 1.15 4.80 1.26 13.10, 0.0001) basal stimulated rats. Further mechanistic studies revealed glucose lipid accumulation, acetylcholine content, improves pathological lesions inflammation, molecules, including PKA, IP3R, AQP5, CHRM3, AMY1 PG SMG 0.05). Conclusions: demonstrated alleviate improving metabolism activating This might provide a novel rationale strategy for diabetes-induced clinical setting.

Language: Английский

Citations

0
Impact of Dry Mouth and Factors Associated with Sarcopenia on Oral Health-Related Quality of Life in Peritoneal Dialysis Patients DOI Creative Commons

Natcha Boonyapratheeprat,

Kununya Pimolbutr, Dulyapong Rungraungrayabkul

et al.

European Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract Objectives This cross-sectional study aimed to investigate the oral health-related quality of life (OHRQoL), its associated factors, and prevalence possible sarcopenia in Thai well-maintained patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD). Materials Methods Data were collected from 63 participants PD at Banphaeo-Charoenkrung Hemodialysis Center. Dry mouth was evaluated through unstimulated salivary flow rate measurement self-reported xerostomia questionnaires. OHRQoL assessed using version Oral Health Impact Profile (OHIP-14). Statistical Analysis analyses conducted IBM SPSS Statistics 21.0. Descriptive statistics summarized participant characteristics, normality tested Kolmogorov–Smirnov test. Continuous variables expressed as medians interquartile ranges, while categorical presented frequencies percentages. The Mann–Whitney U test Fisher's exact used assess differences between groups. Partial Spearman's rank correlation examined variable relationships, logistic regression identified factors linked a higher negative impact on OHRQoL, adjusting for age, sex, body mass index, chair stand test, rate. A p-value < 0.05 considered significant. Results median age 59 years (range 27–79), 52.4%. OHIP-14 scores ranged 0 32, 4 13 lower (n = 31) 32) respectively. Those exhibited significantly proportion (p 0.01), longer 5-time 0.04) compared individuals OHRQoL. Correlation time handgrip strength (r –0.439, p 0.001) sex –0.351, 0.006) revealed. Multivariate showed significant association (odds ratio 0.018; 95% confidence interval: 0.001, 0.545; 0.02). Conclusion finding suggests that reduced affected ESRD PD, highlighting importance managing dry alleviate their

Language: Английский

Citations

0
Exploring the impact of advanced glycation end products on diabetic salivary gland dysfunctions DOI
Heba Hassan

Glycoconjugate Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Does COVID-19 cause xerostomia? A systematic review DOI Creative Commons
Zahra Khoshkalam, Sepideh Soheilifar,

Mohammad Hossein Khoshkalam

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 1, 2025

Language: Английский

Citations

0
From scent to saliva: The saliva-stimulating effect of terpenes in dry mouth DOI Creative Commons
Wiktoria Potocka, Z. Assy,

Annina P. van Splunter

et al.

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: 175, P. 106282 - 106282

Published: May 1, 2025

There is an increasing trend towards the use of bioactive compounds in oral healthcare. Some have been identified as sialagogues, such mastic resin and its main isolate, α-pinene. These act acetylcholinesterase inhibitors (AChEIs), consequently salivary flow. With up to half global population experiencing dry mouth symptoms, there a clear need for new interventions. An vitro screening 148-compound library was conducted identify novel AChEIs. Following this, four were chosen vivo validation administered through nasal spray pumps olfactory stimulus healthy individuals (n = 12) evaluate their sialagogic effects. Saliva quantity, rheology, composition (total protein concentration MUC5B concentration) analysed before after compounds. This study confirmed α-pinene, basil, eugenol guaiacol AChEIs vitro. Basil significantly increased flow, while simultaneously basil preserved spinnbarkeit levels. α-Pinene, subjective feeling moistness mouth. Total not affected by scent these compounds, however, output. Furthermore, found most pleasant out In conclusion, this showed potency sialagogues. However, further research necessary assess long-term effects efficacy patients diagnosed with

Language: Английский

Citations

0
Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sjögren’s Sicca Syndrome DOI Open Access
Joanna Papinska, Justyna Durślewicz,

Harini Bagavant

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5983 - 5983

Published: May 30, 2024

Elevated oxidative stress can play a pivotal role in autoimmune diseases by exacerbating inflammatory responses and tissue damage. In Sjögren’s disease (SjD), the contribution of pathogenesis remains unclear. To address this question, we created mice with tamoxifen-inducible conditional knockout (KO) critical antioxidant enzyme, superoxide dismutase 2 (Sod2), salivary glands (i-sg-Sod2 KO mice). Following tamoxifen treatment, Sod2 deletion occurred primarily ductal epithelium, showed significant downregulation expression. At twelve weeks post-treatment, from i-sg-Sod2 exhibited increased 3-Nitrotyrosine staining. Bulk RNA-seq revealed alterations gene expression pathways related to ribosome biogenesis, mitochondrial function, phosphorylation. Significant changes were noted genes characteristic gland ionocytes. The developed reversible glandular hypofunction. However, functional loss was not accompanied lymphocytic foci or circulating anti-nuclear antibodies. These data demonstrate that although localized cells insufficient for SjD development, it induced dysfunction. mouse resembles patients classified as non-Sjögren’s sicca will be valuable model deciphering oxidative-stress-mediated dysfunction recovery mechanisms.

Language: Английский

Citations

3