International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16066 - 16066
Published: Nov. 8, 2023
Cancer poses a significant global public health challenge [...]
Language: Английский
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 311, P. 123957 - 123957
Published: Jan. 26, 2024
Language: Английский
Citations
6
Chirality, Journal Year: 2025, Volume and Issue: 37(2)
Published: Jan. 23, 2025
Chirality plays a crucial role in the pharmacological activity of triazoles, key scaffold antifungal agents and various therapeutic applications. This study focuses on optimizing enantiomeric resolution chiral triazoles using supercritical fluid chromatography (SFC) 10 different columns, either immobilized or coated, chlorinated nonchlorinated, cellulose amylose-based stationary phases (CSPs). Four novel two marketed ones (tebuconazole hexaconazole) were separated to determine optimal conditions. The best was achieved CSPs across tested compounds. Optical rotation X-ray crystallography employed absolute configurations purified enantiomers.
Language: Английский
Citations
0
Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 75 - 122
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 147 - 147
Published: Dec. 21, 2023
species are important sources of polycyclic and macrocyclic diterpenes, which have been the focus natural-product-based drug research due to their relevant biological properties, including anticancer, multidrug resistance reversal, antiviral, anti-inflammatory activities. Premyrsinane, cyclomyrsinane, myrsinane diterpenes generally collectively designated as myrsinane-type diterpenes. These compounds derived from lathyrane structure characterized by having highly oxygenated rearranged systems. This review aims describe summarize distribution diversity 220 isolated in last four decades about 20
Language: Английский
Citations
9
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118999 - 118999
Published: Oct. 28, 2024
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2121 - 2121
Published: Feb. 9, 2024
Cancer is a complex disease characterized by several alterations, which confer, to the cells, capacity proliferate uncontrollably and resist cellular death. Multiresistance conventional chemotherapy drugs often cause of treatment failure; thus, search for natural products or their derivatives with therapeutic action essential. Chiral xanthones (CDXs) have shown potential inhibitory activity against growth some human tumor cell lines. This work reports screening library CDXs, through viability assays, in different cancer lines: A375-C5, MCF-7, NCI-H460, HCT-15. CDXs’ effect was analyzed based on parameters it also verified if these compounds were substrates glycoprotein-P (Pgp), one main mechanisms resistance therapy. Pgp expression evaluated all lines, but no observed, except Also, when humanized yeast expressing gene MDR1 used, conclusions could be drawn about CDXs as substrates. The selected did not induce significant differences metabolic analyzed. These results show that present promising antitumor activity, other should triggered compounds.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(3), P. 364 - 364
Published: March 5, 2024
The determination of natural product stereochemistry plays a significant role in drug discovery and development. Understanding the products is essential for predicting optimizing their interactions with biological targets, which, turn, influences therapeutic efficacy, safety, overall impact on living organisms. Here, we present first application competitive enantioselective acylation (CEA) reactions conjunction LC/MS analysis determining absolute configuration secondary alcohols which were purified as mixture. This approach utilizes enantiomeric pair HBTM (homobenzotetramisole) catalysts, demonstrating sufficient kinetic resolution alcohols. rapid reaction kinetics quantitatively estimated characterization technique transformations. Our study has expanded CEA coupled to mixtures. Utilizing analysis, offers sensitive simple method determination. Additionally, cost/time-effective since only small quantities substrates short time are required characterizing compared other conventional methods.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Language: Английский
Citations
0
Published: Jan. 1, 2024
The recognition and separation of stereoselective molecules with similar chemical properties structures are great biological significance. Developing a highly effective chiral platform is crucial for further research on molecules. Herein, aptamer-modified gold nanoclusters functionalized electrochemical device that exhibits an ideal enantioselective reported. Its current restriction amplification strategy enables signal electrode. It found introducing aptamers into the would result in nice tyrosinamide recognition. This work has liner range ranging from 1 nM to 10 μM. Furthermore, ratio peak change was 4. study might provide useful designing sensitive devices materials restricting their currents.
Language: Английский
Citations
0