Exercise-induced adaptations in the kynurenine pathway: implications for health and disease management DOI Creative Commons
Marcus Vinícius dos Santos Rangel, Karynne Grutter Lopes, Xuebin Qin

et al.

Frontiers in Sports and Active Living, Journal Year: 2025, Volume and Issue: 7

Published: March 6, 2025

Background Tryptophan (TRP) metabolism through the kynurenine (KYN) pathway is influenced by inflammatory mediators, generating metabolites that regulate immune and responses. Exercise has been proposed as a modulator of this pathway, but its role in health benefits chronic disease management remains unclear. Objective This systematic review examines exercise-induced adaptations KYN their potential implications for management. Additionally, we identify key methodological considerations future research. Methods A structured search PubMed/Medline, Web Science, Scopus was conducted up to October 2024 clinical trials investigating effects exercise training on pathway. Results Of 2,795 articles initially found, 13 involving 592 participants met inclusion criteria. Most studies reported particularly cancer survivors. These appeared be intensity duration. However, several limitations were noted, no included patients with metabolic or cardiovascular diseases. Conclusions Here, show modulates both healthy diseased populations, highlighting prevention further randomized-controlled are needed clarify mechanisms applications, Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42022351481 , PROSPERO (CRD42022351481).

Language: Английский

Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

Citations

3
Tryptophan degradation as a systems phenomenon in inflammation – an analysis across 13 chronic inflammatory diseases DOI
Danielle M M Harris, Silke Szymczak, Sven Schuchardt

et al.

EBioMedicine, Journal Year: 2024, Volume and Issue: 102, P. 105056 - 105056

Published: March 11, 2024

Language: Английский

Citations

15
The role of the kynurenine pathway in cardiovascular disease DOI Creative Commons

Yuehang Yang,

Xing Liu, Xinyi Liu

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: May 31, 2024

The kynurenine pathway (KP) serves as the primary route for tryptophan metabolism in most mammalian organisms, with its downstream metabolites actively involved various physiological and pathological processes. Indoleamine 2,3-dioxygenase (IDO) (TDO) serve initial pivotal enzymes of KP, IDO playing important intricate roles cardiovascular diseases. Multiple KP have been observed to exhibit elevated concentrations plasma across diseases, such atherosclerosis, hypertension, acute myocardial infarction. studies indicated that (KYN) may a potential biomarker several adverse events. Furthermore, Kynurenine complex inflammation, exhibiting both inhibitory stimulatory effects on inflammatory responses under different conditions. In upregulation stimulates KYN production, mediating aromatic hydrocarbon receptor (AhR)-induced exacerbation vascular inflammation promotion foam cell formation. Conversely, arterial calcification, this mediation alleviates osteogenic differentiation smooth muscle cells. Additionally, cardiac remodeling, KYN-mediated AhR activation exacerbates left ventricular hypertrophy fibrosis. Interventions targeting components inhibitors, 3-hydroxyanthranilic acid, anthranilic demonstrate protective effects. This review outlines mechanistic coronary highlighting diagnostic, prognostic, therapeutic value thus providing novel insights development application related drugs future research.

Language: Английский

Citations

15
“Inflamed” depression: A review of the interactions between depression and inflammation and current anti-inflammatory strategies for depression DOI Creative Commons

Yishu Yin,

Ting Ju,

Deyong Zeng

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 207, P. 107322 - 107322

Published: July 20, 2024

Depression is a common mental disorder, the effective treatment of which remains challenging issue worldwide. The clinical pathogenesis depression has been deeply explored, leading to formulation various pathogenic hypotheses. Among these, monoamine neurotransmitter hypothesis holds prominent position, yet it significant limitations as more than one-third patients do not respond conventional treatments targeting transmission disturbances. Over past few decades, growing body research highlighted link between inflammation and potential key factor in pathophysiology depression. In this review, we first summarize relationship depression, with focus on pathophysiological changes mediated by mechanisms linking well multiple anti-inflammatory strategies are also discussed, their efficacy safety assessed. This review broadens perspective specific aspects using for treating laying groundwork advancing precision medicine individuals suffering from "inflamed"

Language: Английский

Citations

15
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer DOI Creative Commons
Jing Yan, Di Chen, Zi Ye

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 30, 2024

Language: Английский

Citations

11
Tobacco induces abnormal metabolism of tryptophan via the kynurenine pathway DOI Creative Commons
Mustafa Onmaz, Duygu Eryavuz Onmaz, Nur Demirbaş

et al.

Turkish Journal of Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract Objectives This study aims to investigate the effect of smoking on metabolism kynurenine and thus contribute elucidation potential mechanism cigarette smoking. Methods The included 82 smokers 63 nonsmokers who applied Family Medicine Polyclinic for routine check-ups. Sociodemographic data, laboratory results, Framingham risk scores (FRS), Fagerström Nicotine Dependence Test (FTND) were recorded. Serum tryptophan, kynurenine, kynurenic acid, 3-hydroxyanthranilic 3-hydroxykynurenine, quinolinic acid concentrations measured with tandem mass spectrometry. Results tryptophan levels (p=0.040) statistically significantly lower in smokers, kynurenine/tryptophan ratio serum higher (p<0.001). correlation analysis smoker group showed a positive between FTDN. positively correlated total cholesterol, triglyceride, low-density lipoprotein FRS. There was participants’ systolic diastolic blood pressures. Conclusions Our findings that via pathway induced smokers.

Language: Английский

Citations

1
Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis DOI Open Access
Erika Meléndez‐Oliva, Oliver Martínez‐Pozas, Pierluigi Sinatti

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 264 - 264

Published: Jan. 12, 2025

Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, synovial inflammation, leading to chronic pain, stiffness, impaired function. Initially regarded as a “wear tear” condition associated with aging mechanical stress, OA now recognized multifaceted influenced by systemic factors such metabolic syndrome, obesity, low-grade inflammation. Recent studies have focused on gut-joint axis investigate how gut microbiome modulates inflammation pain in OA. Materials Methods: A systematic review was conducted following PRISMA guidelines registered PROSPERO (CRD42024556265). This included involving adults symptomatic analyzed relationship between OA-related pain. Randomized non-randomized clinical trials, case reports, editorials, pilot were excluded. Searches performed PubMed, Cochrane Library, Web Science without publication date restrictions, filtered for “observational studies”. The study selection data extraction two independent researchers, risk bias assessed using appropriate tools. Results: Five observational review, three meta-analysis. Two reported an association different tryptophan metabolites levels patients other demonstrated correlation lipopolysaccharide fifth confirmed Streptococcus relative abundance spp. knee These results not supported meta-analysis, which found no significant presence bacilli genus or plasma markers pathway. Conclusions: Current evidence indicates potential link dysbiosis However, methodological limitations preclude definitive conclusions. Further research advanced techniques larger cohorts needed validate extend these findings elucidate underlying mechanisms. Targeted manipulation may be valuable strategy management patients.

Language: Английский

Citations

1
Gut microbiota-derived metabolites and chronic inflammatory diseases DOI Creative Commons
Alejandra Vargas, Benjamin L. Robinson, Kevin Houston

et al.

Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

The gut microbiota, a complex ecosystem of microorganisms, plays an essential role in maintaining immune and metabolic homeostasis. Disruption this microbial balance, known as dysbiosis, has been increasingly implicated the pathogenesis chronic inflammatory conditions, including cardiovascular, gastrointestinal, autoimmune diseases, well disorders such diabetes obesity. A crucial mechanism through which microbiota exerts its effects on host physiology is via production bioactive metabolites. These metabolites, short-chain fatty acids, bile tryptophan derivatives, are key modulating responses regulating functions. Dysbiosis disrupts function these thereby contributing to dysregulation, inflammation, disease progression. This review examines microbiota-derived metabolites with focus their immunomodulatory effects. deeper understanding mechanisms may open way for novel therapeutic strategies aimed at restoring homeostasis mitigating global burden diseases.

Language: Английский

Citations

1
One step synthesis of tryptophan-isatin carbon nano dots and bio-applications as multifunctional nanoplatforms DOI
Kerem Tok, Fırat Barış Barlas, Ece Bayır

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114533 - 114533

Published: Jan. 21, 2025

Language: Английский

Citations

1
Aqueous humor metabolomic profiling identifies a distinct signature in pseudoexfoliation syndrome DOI Creative Commons
Arturs Zemitis, Juris Vanags, Theresa Schiemer

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 23, 2025

Purpose PEXS was first described in 1917, yet its etiology still needs clarification. An imbalance between oxidants and antioxidants plays a significant role. leads to various ocular complications, including increased risk during cataract surgery due weak zonules, lens dislocation, reduced visual outcomes. Our study investigates whether metabolomics can provide insights into this pathology. Methods The included 183 patients undergoing at Pauls Stradins Clinical University Hospital. 104 did not have PEXS, while 79 were diagnosed with the condition. Intraocular fluid samples from these analyzed using targeted metabolite analysis, performed through HILIC liquid chromatography coupled mass spectrometry detection. Results aqueous humor of contains statistically higher levels cystine ( p &lt; 0.001), citrulline phenylalanine = 0.041), tyrosine 0.025), serine 0.030), arginine 0.017), lactic acid 0.055), tryptophan creatinine 0.022). These results suggest potential link ferroptosis. Conclusion Ferroptosis is form programmed cell death characterized by iron-dependent LPO. inhibition antiporter system X c − oxidative stress, suggesting that changes seen could be linked findings indicate cysteine synthesis occurs via transsulfation pathway, attributable inhibiting . Treatment pseudoexfoliation should lower stress inside anterior chamber reducing uptake PUFAs, iron levels, supplementation.

Language: Английский

Citations

1