Eucommiae cortex polysaccharides ameliorates learning and memory deficits in Alzheimer's disease mice by modulating gut microbiota and glutamate metabolism DOI Creative Commons

Yongkang Zhao,

Wenxing Zhao,

Xuejun Chai

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 21, 2023

Abstract Alzheimer's disease (AD) is a chronic neurodegenerative disorder that distinguished by impairments in learning and memory. The microbiota-gut-brain axis has emerged as significant factor the pathogenesis of disease. Eucommiae cortex polysaccharides (EPs), one most abundant substances , exhibit potential immunomodulatory neuroprotective effects. In our study, we discovered long-term intervention with EPs (0.25%, w/w food) significantly improved memory 5×FAD mice, well recognized mouse model for Additionally, substantially reduce generation deposition amyloid-beta (Aβ) plaques AD Mice. reshaped composition gut microbiota, increased abundance Erysipelotrichaceae Allobaculum Bacteroidota Muribaculaceae which are related to immunity short-chain fatty acids(SCFs) production exert effects through gut-brain axis. Furthermore, administration was able correct metabolic disorders particularly glutamate metabolism disturbances. Correlation analysis demonstrates robust association between restructuring microbiota alterations metabolism. Importantly, inhibited neuroinflammation restored oxidative-antioxidative balance brains factors contributing impairments. Interestingly, activated autophagy. Our results demonstrate corrected disturbances, alleviated 5xFAD mice natural extract holds promising therapeutic management disorders.

Language: Английский

Polysaccharide from Panax japonicus C.A. Mey prevents non-alcoholic fatty liver disease development based on regulating liver metabolism and gut microbiota in mice DOI
Yi Wu, Wen Yin,

Ping Hao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129430 - 129430

Published: Jan. 18, 2024

Language: Английский

Citations

11
Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice DOI Creative Commons

Tianchan Peng,

Jian Xiang, Yun Tian

et al.

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 200, P. 112686 - 112686

Published: Jan. 18, 2025

Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking. To investigate geroprotective effects Lycium barbarum glycopeptide (LbGp) its potential mechanisms in D-galactose-induced accelerated aging mouse model. Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks induce aging, while LbGp was orally administered (100 throughout study. The assessed by behavioral tests, cardiac echocardiography, pathohistological transcriptomic analyses. Transmission electron microscopy used observe ultrastructure mitochondria. Mitochondrial stress assays JC-1 fluorescent probe conducted evaluate mitochondrial function. Flow cytometer western blot performed assess mitophagy flux. improved phenotypes mice, pronounced enhancement function compared neurocognitive skeletal muscle functions. Transcriptome analysis indicated ameliorated energy metabolism heart. revealed preserved structural integrity inner membrane. attenuated fission restored impaired PINK1/Parkin-mediated pathway caused cardiomyocytes. can ameliorate enhance activating mice. These findings underscore therapeutic agent aging-related diseases.

Language: Английский

Citations

0
Effects of Silibinin on Delaying Aging in Drosophila melanogaster DOI Creative Commons
Kai Zhu,

Hang Ni,

Eqra Hafeez

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 147 - 147

Published: Jan. 27, 2025

Aging is an inevitable physiological process, but delaying aging has always been enduring human pursuit. Silibinin (SIL), derived from the seeds of milk thistle plant, exhibits a broad spectrum pharmacological properties, including anti-tumor effects, liver protection, inhibition apoptosis, and alleviation inflammation. However, whether it anti-aging effects remains unclear. The SIL dietary supplement to Drosophila melanogaster prolonged lifespan, improved climbing ability, ameliorated age-associated intestinal barrier disruption, enhanced resistance oxidative stress, increased enzyme activities superoxide dismutase (SOD) catalase (CAT). Furthermore, RNA-seq results showed that addition significantly upregulated 74 genes downregulated 50 compared with control. KEGG (Kyoto Encyclopedia genomes) analysis demonstrated these differentially expressed were primarily involved in Toll signaling pathway endoplasmic reticulum proteins processing, six among which, IM2, IM3, Drsl3, CG7556, GCS1, TRAM, particularly regulation by supplementation. indicate enhancing antioxidant capacity regulating aging-related pathways. Therefore, shows potential application regimens.

Language: Английский

Citations

0
Human Milk Oligosaccharides Ameliorate Intestinal Barrier in Aging Honey Bee by Regulating Gut Microbiota DOI
Xiaodong Lin, Yingying Lin, Yueyi Wang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105954 - 105954

Published: Jan. 1, 2025

Language: Английский

Citations

0
Reshaping the gut microbiota: A novel oppinion of Eucommiae cortex polysaccharide alleviate learning and memory impairments in Alzheimer’s disease DOI Creative Commons

Yongkang Zhao,

Wenxing Zhao,

Xuejun Chai

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Alzheimer's disease (AD), which is a chronic neurodegenerative disorder, marked by the progressive deteriorations in learning and memory capabilities. The microbiota-gut-brain axis has come to be regarded as crucial element relation pathogenesis well treatment of AD. Eucommiae cortex polysaccharides (EPs), being among most plentiful substances present cortex, show potential exert immunomodulatory neuroprotective function. However, whether EPs are protective against AD their mechanism action remain investigated OBJECTIVES: We hypothesize that can regulate brain glutamine metabolism through gut microbiota butyric acid metabolized them, improve oxidative stress autophagy brain, thus alleviate In study, we used (0.25 % w/w food) fecal transplantation, butyrate supplementation (0.1 M water), intervene mice. Multi-omics were determine AD-related impairments. Our results suggest EPs, functioning prebiotic, alleviated impairments Mechanistically, able reshape microbiota, promote growth involved short-chain fatty metabolism, particularly butyrate-producing microbes. produced these microbes improves microenvironment modulating mediated glutamate improving mice, inhibiting formation deposition beta-amyloid proteins. Fecal transplantation (FMT) further confirm this conclusion. highlighted with microbiota-dependent manner acid-metabolizing bacteria plays central role regulating microenvironmental homeostasis. Meanwhile, study provides new insights into natural products.

Language: Английский

Citations

0
Extraction, Characterization, and Antioxidant Activity of Eucommia ulmoides Polysaccharides DOI Creative Commons
Yuqing Peng,

Yang Yulin,

Yitong Tian

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4793 - 4793

Published: Oct. 10, 2024

Herein, the ultrasound-assisted extraction conditions affecting yield of EUPS (

Language: Английский

Citations

3
Assessment of the risk of imidaclothiz to the dominant aphid parasitoid Binodoxys communis (Hymenoptera: Braconidae) DOI

Lingen Du,

Xueke Gao,

Likang Zhao

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117165 - 117165

Published: Sept. 20, 2023

Language: Английский

Citations

5
Chlorella pyrenoidosa polysaccharides supplementation increases Drosophila melanogaster longevity at high temperature DOI
Yuanyuan Chang,

Feng Zheng,

Chen Miao

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133844 - 133844

Published: July 14, 2024

Language: Английский

Citations

1
Eucommiae cortex polysaccharides ameliorates learning and memory deficits in Alzheimer's disease mice by modulating gut microbiota and glutamate metabolism DOI Creative Commons

Yongkang Zhao,

Wenxing Zhao,

Xuejun Chai

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 21, 2023

Abstract Alzheimer's disease (AD) is a chronic neurodegenerative disorder that distinguished by impairments in learning and memory. The microbiota-gut-brain axis has emerged as significant factor the pathogenesis of disease. Eucommiae cortex polysaccharides (EPs), one most abundant substances , exhibit potential immunomodulatory neuroprotective effects. In our study, we discovered long-term intervention with EPs (0.25%, w/w food) significantly improved memory 5×FAD mice, well recognized mouse model for Additionally, substantially reduce generation deposition amyloid-beta (Aβ) plaques AD Mice. reshaped composition gut microbiota, increased abundance Erysipelotrichaceae Allobaculum Bacteroidota Muribaculaceae which are related to immunity short-chain fatty acids(SCFs) production exert effects through gut-brain axis. Furthermore, administration was able correct metabolic disorders particularly glutamate metabolism disturbances. Correlation analysis demonstrates robust association between restructuring microbiota alterations metabolism. Importantly, inhibited neuroinflammation restored oxidative-antioxidative balance brains factors contributing impairments. Interestingly, activated autophagy. Our results demonstrate corrected disturbances, alleviated 5xFAD mice natural extract holds promising therapeutic management disorders.

Language: Английский

Citations

0