Integrative Roles of Pro‐Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma

Immunological Reviews, Journal Year: 2025, Volume and Issue: 330(1)

Published: Feb. 24, 2025

ABSTRACT Asthma has become more appreciated for its heterogeneity with studies identifying type 2 and non‐type phenotypes/endotypes that ultimately lead to airflow obstruction, airway hyperresponsiveness, remodeling. The pro‐inflammatory environment in asthma influences smooth muscle (ASM) structure function. ASM a vast repertoire of inflammatory receptors that, upon activation, contribute prominent features asthma, notably immune cell recruitment hypercontractility, proliferation, migration, extracellular matrix protein deposition. These responses can be mediated by both (e.g., IL‐4, IL‐13, TSLP) TNFα, IFNγ, IL‐17A, TGFβ) cytokines, highlighting roles phenotypes/endotypes. In recent years, there been considerable advances understanding how cytokines promote dysfunction impair responsiveness therapy, corticosteroids long‐acting β2‐adrenergic receptor agonists (LABAs). Transcriptomic analyses on human cells tissues have expanded our knowledge this area but also raised new questions regarding role asthma. review, we discuss corticosteroids, LABAs affect function, particular focus changes gene expression transcriptional programs

Language: Английский

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Long-term trends in the burden of asthma in China: a joinpoint regression and age-period-cohort analysis based on the GBD 2021

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 15, 2025

To develop effective strategies for controlling asthma, a thorough assessment of its disease burden is essential. In this study, we examined long-term trends in the asthma China over past three decades and analyzed epidemiological features. We assessed via global (GBD) 2021 database, focusing on prevalence, incidence, mortality, years life lost (YLLs), lived with disability (YLDs), disability-adjusted (DALYs). Additionally, employed joinpoint analysis age-period-cohort (apc) methods to interpret characteristics asthma. Finally, attributable gain comprehensive understanding impact. The age-standardized incidence rate (ASIR) mortality (ASMR) both sexes shifted from 524.81 (95% UI: 421.31, 672.76) 314.17 283.22, 494.10) 5.82 4.46, 8.50) 1.47 1.15, 1.79) per 100,000 population between 1990 2021. According analysis, average annual percentage change (AAPC) was – 1.2 CI: 1.4, 1.1), indicating gradual but fluctuating decline (with significant turning points 2005 2014). apc fitting results suggest that prevalence now lower than it relative risk high among adolescents middle-aged elderly individuals, possibly due different pathophysiological mechanisms. 2021, primary asthma-related burdens were metabolic risks, especially obesity. conclusion, found has significantly decreased. However, remains major concern individuals. Metabolic factors, particularly obesity, are main contributors burden. It essential address specific factors targeted public health age groups.

Language: Английский

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Association between low serum testosterone level and severe asthma among elderly women

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Asthma Phenotypes in the Era of Personalized Medicine

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(19), P. 6207 - 6207

Published: Sept. 26, 2023

Asthma is a widespread disease affecting approximately 300-million people globally. This condition leads to significant morbidity, mortality, and economic strain worldwide. Recent clinical laboratory research advancements have illuminated the immunological factors contributing asthma. As of now, asthma understood be heterogeneous disease. Personalized medicine involves categorizing by its endotypes, linking observable characteristics specific mechanisms. Identifying these endotypic mechanisms paramount in accurately profiling patients tailoring therapeutic approaches using innovative biological agents targeting distinct immune pathways. article presents synopsis key implicated pathogenesis manifestation disease’s phenotypic traits individualized treatments for severe subtypes.

Language: Английский

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Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 459 - 459

Published: Dec. 29, 2023

Bronchial asthma is an extremely heterogenous chronic respiratory disorder with several distinct endotypes and phenotypes. These subtypes differ not only in the pathophysiological changes and/or clinical features but also their response to treatment. Therefore, precise diagnostics represent a fundamental condition for effective therapy. In diagnostic process, metabolomic approaches have been increasingly used, providing detailed information on metabolic alterations associated human asthma. Further brought by analysis of samples obtained from animal models. This article summarizes current knowledge studies reveals that lipid metabolism, amino acid purine glycolysis tricarboxylic cycle found resemble, large extent, patients The findings indicate that, despite limitations modeling asthma, pre-clinical testing may, together samples, contribute novel way personalized treatment patients.

Language: Английский

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Asthma Phenotypes in the Era of Personalized Medicine

Published: July 24, 2023

Asthma is a prevalent disease that around 300 million worldwide, resulting in substantial morbidity, mortality, and economic burden on global scale. New clinical laboratory research has shed light the immunology causing asthma. now recognized as heterogeneous disease. A personalized medicine based classification of asthma by endotype linking observable characteristics to immunological mechanisms. Identifying mechanisms essential for better characterizing patients personalizing therapeutic approaches with novel biological agents target specific immune pathways. This article provides summary major involved pathogenesis emergence disease's phenotypic features, well individualized treatment severe subtypes

Language: Английский

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Tripterygium Glycosides in the Treatment of Asthma: Integrating Network Pharmacology, Molecular Docking and In Vitro Preliminary Pharmacological Evaluation

Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(3)

Published: March 1, 2024

Objectives The mechanism of tripterygium glycosides (TG) in the treatment asthma was explored by utilizing network pharmacology, molecular docking, and vitro preliminary pharmacological tests. Methods An analysis bioactive ingredients TG conducted using Traditional Chinese Medicine Systems Pharmacology Database database or predicted FAFdrugs4, with relevant targets gathered from HERB, Swiss Target Prediction, STITCH, SEA databases, for were collected Drugbank, DisGeNET, GeneCards databases. Compound-target-pathway interactions function putative annotated Cytoscape 3.6.0 Visualization Integrated Discovery, respectively. affinity key ingredient hub assessed docking AutoDock Vina software. Real-time quantitative polymerase chain reaction, cell-secreted cytokine assay, ELISA used to explore effect its triptolide (TP) asthma. Results There 12 335 corresponding targets, 2672 asthma-associated 204 anti-asthma targets. TP Tripterine identified as two ingredients. RELA TP53 exhibited best topological index protein-protein interaction regarded might play a role biological processes such lipopolysaccharide-mediated signaling pathway, regulation nitric oxide biosynthetic process mainly related toll-like receptor, TNF apoptosis pathways. Molecular revealed that effectively bound In experiments demonstrated reversed RNA expression airway remodeling marker CDH1 FN. Moreover, reduced secretion vascular endothelial growth factor, implicating remodeling. Conclusion act on target genes TP53, active TP, regulate pathways TNF, apoptosis, thereby playing improving

Language: Английский

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Effects of Obesity and Depression on the Incidence of Asthma in Korean Older Adults: A Secondary Analysis of the Korea National Health and Nutrition Examination Survey 2020

Journal of Korean Academy of Fundamentals of Nursing, Journal Year: 2023, Volume and Issue: 30(3), P. 335 - 344

Published: Aug. 31, 2023

Purpose: This study investigated the effects of body mass index (BMI), waist circumference (WC), and depression on asthma in older adults Koreans.Methods: Data for 1,388 individuals (≥65 years) were extracted from Korea National Health Nutrition Examination Survey (KNHANES Ⅷ-2, 2020). Complex sampling design data analyzed using stratification, clustering, weights. unweighted frequencies, weighted percentages, estimated means standard errors, Rao-Scott x² test, multiple logistic regression analysis, which was performed to identify variables that influenced after adjusting confounding factors.Results: The factors influencing a diagnosis, age at onset depression, current status, gender. In contrast, BMI WC did not affect asthma. A diagnosis had an odds ratio 3.07 adults. Furthermore, ratios 5.08 <49 years 3.37 compared no diagnosis. female 1.35.Conclusion: results this suggest could be detected early through symptoms. also provides evidence depression-related interventions should included prevention management programs Korea.

Language: Английский

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