Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function DOI Creative Commons
Hao Han, Lei Tian,

YaJing Dong

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Alcoholic liver disease (ALD) is one of the major global public health problems. Yeast extract (YE), a product prepared from yeast, has been proven to have antioxidant and anti-inflammatory properties. However, potential role YE in prevention ALD remains unclear. The present study aimed investigate protective effects on explore underlying mechanism based gut microbiota.  The  result  showed  that  YE  supplementation  significantly  ameliorated chronic alcohol exposure-induced injury mice. In addition, counteracted alcohol-induced dysbiosis, intestinal barrier dysfunction, lipopolysaccharide (LPS) leakage-induced inflammatory response liver. Moreover, microbiota depletion by broad-spectrum antibiotic was sufficient block effect ALD, indicating contribution dysbiosis modulation hepatoprotective YE. Furthermore, we demonstrated causal relationship between with fecal transplantation (FMT) experiment. Compared ALD-FMT mice, LPS/TLR4 signaling pathway activation, were significantly improved YE-FMT Together, our findings highlight that dietary protects against through correction.

Language: Английский

Probiotics: Shaping the gut immunological responses DOI Creative Commons
Eirini Filidou, Leonidas Kandilogiannakis, Anne Shrewsbury

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(15), P. 2096 - 2108

Published: April 19, 2024

Probiotics are live microorganisms exerting beneficial effects on the host's health when administered in adequate amounts. Among most popular and adequately studied probiotics bacteria from families

Language: Английский

Citations

11
Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids DOI
Jia Wang, Yuying Shi,

Bei Mao

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 36, P. 102078 - 102078

Published: Jan. 20, 2024

Language: Английский

Citations

9
Preparation of Selenium in Kluyveromyces Marxianus YG-4 and its Protective effects in mice with patulin-induced Jejunal injury DOI

Mengge Ning,

Peng Guo,

Yuanyuan Cui

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106033 - 106033

Published: Jan. 1, 2025

Language: Английский

Citations

1
The Role of Intestinal Fungi in the Pathogenesis and Treatment of Ulcerative Colitis DOI Creative Commons
Yujing Zhang,

Lin Wang,

Lihua Peng

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 794 - 794

Published: March 31, 2025

Ulcerative colitis (UC) is a chronic inflammatory bowel disease closely associated with dysbiosis of the gut microbiome, encompassing not only bacterial communities but also fungal populations. Despite growing recognition microbiome’s role in UC pathogenesis, contribution intestinal fungi has recently garnered significant attention. In this review, we comprehensively examine characteristics both healthy individuals and patients, elucidating their pathogenesis interactions communities. Additionally, explore impact on severity therapeutic responses UC. Furthermore, evaluate potential antifungal agents, probiotics, fecal microbiota transplantation (FMT) management, emphasizing critical these treatment modalities. Future research should prioritize multifunctional roles implications for strategies. Moreover, identification biomarkers FMT efficacy could pave way precision medicine approaches FMT, offering novel insights into personalized interventions

Language: Английский

Citations

0
Lactobacillus helveticus HY7804 Modulates the Gut–Liver Axis to Improve Metabolic Dysfunction-Associated Steatotic Liver Disease in a Mouse Model DOI Open Access
Hyeonji Kim, Hyejin Jeon,

Ji-Woong Jeong

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3557 - 3557

Published: April 10, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common type of worldwide. In a previous study, we confirmed that Lactobacillus helveticus HY7804 (HY7804) improves MASLD by suppressing expression mRNAs encoding genes related to hepatic lipogenesis, inflammation, and fibrosis in model mice. Here, evaluated ability restore intestinal barrier function modulate gut microbiota, as well improve symptoms. Mice fed an MASLD-inducing diet for 7 weeks received (109 CFU/kg/day), Type strain, or positive control (Pioglitazone) during same period. alleviated physiological (p < 0.001) blood biochemical indicators reduced activity scores 0.05) on histological analysis. addition, increased fatty acid oxidation 0.001); decreased apoptosis-related rescued tight junction (TJ)-related 0.05); suppressed pro-inflammatory cytokines TLR4/MyD88/NF-κB signaling 0.01) intestine. Finally, modulated composition microbiota MASLD-induced abundance MASLD-suppressive Bacteroidaceae Bacteroides, which positively correlated with TJ- oxidation-related genes. By contrast, bacteria progression MASLD, including Cloastridaceae, Clostridium, Streptococcaceae, Lactococcus, Lachnospiraceae, immune responses conclusion, L. may be suitable functional supplement alleviates symptoms health.

Language: Английский

Citations

0
Versatile inulin/trans-ferulic acid/silk sericin nanoparticles-nourished probiotic complex with prolonged intestinal retention for synergistic therapy of inflammatory bowel disease DOI
Yujie Zhang, Xiaojiang Zhang, Ling Lv

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 350, P. 123063 - 123063

Published: Nov. 26, 2024

Language: Английский

Citations

2
Early-Life Supplementation Enhances Gastrointestinal Immunity and Microbiota in Young Rats DOI Creative Commons
Laura Sáez‐Fuertes, Garyfallia Kapravelou, Blanca Grases-Pintó

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(13), P. 2058 - 2058

Published: June 28, 2024

Immunonutrition, which focuses on specific nutrients in breast milk and post-weaning diets, plays a crucial role supporting infants' immune system development. This study explored the impact of maternal supplementation with

Language: Английский

Citations

1
Study on the Anti-Ulcerative Colitis Effect of Pseudo-Ginsenoside RT4 Based on Gut Microbiota, Pharmacokinetics, and Tissue Distribution DOI Open Access
Hui Yu, Caixia Wang,

Junzhe Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 835 - 835

Published: Jan. 9, 2024

The purpose of this study was to explore the therapeutic effect oral administration pseudo-ginsenoside RT4 (RT4) on ulcerative colitis (UC), and determine rate absorption distribution in mice with UC. Balb/c were induced using dextran sulfate sodium salts (DSS) establish UC model, 10, 20, or 40 mg/kg subsequently administered via gavage. clinical symptoms, inflammatory response, intestinal barrier, content total short-chain fatty acids (SCFAs), gut microbiota investigated. Caco-2 cells epithelial barrier damage model LPS, an intervention performed 4, 8, 16 µg/mL RT4. factors, transient electrical resistance (TEER), tight-junction protein expression determined. Finally, pharmacokinetic tissue studies following intragastric performed. According results mice, decreased disease activity index (DAI) score, restored colon length, reduced levels pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), boosted immunosuppressive cytokine IL-10, increased SCFAs, improved colonic histopathology, maintained ultrastructure mucosal cells, corrected disturbances microbiota. Based caco-2 TNF-α, IL-1β; protected integrity monolayers; expression. Additionally, main parameters (Cmax, Tmax, t1/2, Vd, CL, AUC) obtained, absolute bioavailability calculated as 18.90% ± 2.70%, tissues small intestine colon. In conclusion, RT4, features slow elimination directional distribution, could alleviate by inhibiting repairing boosting dominant microflora, modulating SCFAs.

Language: Английский

Citations

1
Yeast supplementation potentiates fluoxetine’s anti-depressant effect in mice via modulation of oxido-inflammatory, CREB, and MAPK signaling pathways DOI Creative Commons

Augustina Potokiri,

Noah A. Omeiza, Abayomi M. Ajayi

et al.

Current Research in Physiology, Journal Year: 2024, Volume and Issue: 7, P. 100132 - 100132

Published: Jan. 1, 2024

Language: Английский

Citations

1
Huangqin Tea Total Flavonoids–Gut Microbiota Interactions: Based on Metabolome and Microbiome Analysis DOI Creative Commons
Yaping Zheng, Kailin Yang, Jie Shen

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(24), P. 4410 - 4410

Published: Dec. 7, 2023

Huangqin tea (HQT), a Non-Camellia Tea derived from the aerial parts of Scutellaria baicalensis, is widely used in north China. The intervention effects HQT on intestinal inflammation and tumors have been found recently, but active ingredient mechanism action remain unclear. This study aimed to investigate interactions between potential flavonoid components gut microbiota through culture experiments vitro combined with HPLC-UV, UPLC-QTOF-MS, 16S rDNA sequencing technology. results showed that total flavonoids were mainly composed isocarthamidin-7-O-β-D-glucuronide, carthamidin-7-O-β-D-glucuronide, scutellarin, others, which interact closely microbiota. After 48 h, primary glycosides transformed into corresponding aglycones varying degrees deglycosylation. composition was changed significantly. beneficial bacteria, such as Enterococcus Parabacteroides, promoted, while harmful Shigella, inhibited. functional prediction indicated notable regulatory exerted by scutellarin various pathways, including purine metabolism aminoacyl-tRNA biosynthesis, among play role tumor-related diseases. These findings provided valuable insights for further in-depth research investigation ingredients, metabolic processes, mechanisms HQT.

Language: Английский

Citations

3