STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 13, 2025

Obstructive sleep apnea (OSA) is frequently associated with increased incidence and mortality of pulmonary hypertension (PH). The immune response contributes to artery remodeling OSA-related diseases. immunologic factors linked OSA-induced PH are not well understood. STAT6 crucial in the signaling pathway that modulates response. However, status phosphorylated (p-STAT6) an mouse model remains largely unexplored. Chronic intermittent hypoxia (CIH) plays a role progression OSA. This study utilized vivo CIH examine CIH-induced PH. mice exhibited hypertension, indicated by right ventricular systolic pressure (RVSP), higher left plus septum (RV/LV + S) ratios, significant morphological alterations compared normoxic (Nor) mice. Increased p-STAT6 lungs elevated IL-4 producing T cells deficiency (STAT6-/-) improved PA models.STAT6 impaired helper 2 (Th2) response, affecting IL-13 secretion. IL-4, rather than IL-13, activated human smooth muscle (hPASMCs). knockdown decreased proliferation treated hPASMCs. These findings exhibit critical pathogenesis induced regulating Th2 response.STAT6 could be therapeutic target for

Language: Английский

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Gender Differences in Insulin Resistance: New Knowledge and Perspectives

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(10), P. 7845 - 7861

Published: Sept. 27, 2023

Insulin resistance is the main mechanism in a whole series of pathological conditions, which are not only metabolic interest but also systemic type. This phenomenon means that body’s cells become less sensitive to hormone insulin, leading higher levels insulin blood. can be found both men and women particular, latter, it mainly after menopause. Premenopause, hormonal fluctuations during menstrual cycle, presence estrogen affect sensitivity. Androgens, such as testosterone, typically contribute resistance. In sexes, different human body types distribution location fat, influencing development diabetes cardiovascular disease. associated with some neurological neurogenerative disorders, polycystic ovary syndrome, atherosclerosis, neoplastic pathologies. A healthy lifestyle, including regular physical activity, balanced diet, self-maintenance, help prevent onset resistance, regardless gender, although habits between greatly implementation preventative guidelines fighting manifestations this disorder. review may shed light on gender differences diseases by placing necessary focus personalized medical management inspiring differentiated therapeutic approaches.

Language: Английский

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Exploring the therapeutic potential of GLP-1 receptor agonists in the management of obstructive sleep apnea: a comprehensive review

Journal of Basic and Clinical Physiology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder marked by repeated episodes of partial or complete upper airway obstruction during sleep, which leads to intermittent hypoxia and fragmented sleep. These disruptions negatively impact cardiovascular health, metabolic function, overall quality life. Obesity major modifiable risk factor for OSA, as it contributes both anatomical physiological mechanisms that increase the likelihood collapse While continuous positive pressure (CPAP) therapy remains gold standard OSA treatment, its limitations - particularly issues with patient adherence underscore need alternative adjunct therapeutic options. One such option use glucagon-like peptide-1 receptor agonists (GLP-1 RAs), are widely recognized their ability reduce body weight improve health. Emerging evidence suggests GLP-1 RAs may offer benefits in managing addressing obesity, key contributor condition. This narrative review seeks explore role treatment evaluating efficacy reducing severity discussing broader clinical implications future research practice.

Language: Английский

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Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus: Complex Interactions and Clinical Implications

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1809 - 1809

Published: March 7, 2025

Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) are highly prevalent chronic conditions, frequently coexisting due to their shared pathophysiological mechanisms risk factors. Epidemiological studies estimate that up 30% of COPD patients have comorbid T2DM, contributing worsened progression, more hospitalizations, higher mortality rates. Systemic inflammation in contributes insulin resistance by increasing pro-inflammatory cytokines (TNF-α, IL-6, CRP), which impair glucose metabolism beta-cell function. Conversely, hyperglycemia T2DM exacerbates oxidative stress, leading endothelial dysfunction, reduced lung function, impaired repair mechanisms. A comprehensive narrative review was conducted evaluate the interplay between examining mechanisms, clinical consequences, management strategies. The co-occurrence accelerates development, elevates hospitalization rates, deteriorates overall prognosis. Pharmacological interactions complicate illness treatment, requiring a multidisciplinary therapy strategy. Recent data underscore need integrate palliative care, facilitate decision-making, provide psychological support enhance patient outcomes. Efficient COPD-T2DM comorbidity necessitates customized, interdisciplinary strategy targets both respiratory metabolic health. Preliminary prognostic dialogues, holistic lifestyle modifications can improve quality life results.

Language: Английский

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Approach the Patient With Obstructive Sleep Apnea and Obesity

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2023, Volume and Issue: 109(3), P. e1267 - e1279

Published: Sept. 27, 2023

Abstract Obstructive sleep apnea (OSA) and obesity are highly prevalent bidirectionally associated. OSA is underrecognized, however, particularly in women. By mechanisms that overlap with those of obesity, increases the risk developing, or having poor outcomes from, comorbid chronic disorders impairs quality life. Using 2 illustrative cases, we discuss relationships between type diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, reproductive disorders. The differences men women, phenotypic variability OSA, highlighted. When probability high due to consistent comorbidities, both, a diagnostic study advisable. Continuous positive airway pressure mandibular advancement splints improve symptoms. Benefits for comorbidities variable depending on nightly duration use. contrast, weight loss optimization lifestyle behaviors consistently beneficial.

Language: Английский

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Effects of Metabolic Factors on Left Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea

Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 43 - 53

Published: Jan. 1, 2025

Purpose: The effect of metabolic factors on cardiovascular risk in obstructive sleep apnea (OSA) is unclear. This study aimed to investigate the left ventricular diastolic function patients with OSA. Patients and Methods: cross-sectional included a total 478 OSA from September 2018 2023. After propensity score matching, wherein 193 syndrome (MS) were 1:1 matched without MS by sex age, data 386 ultimately analyzed. Furthermore, all divided into mild, moderate, severe groups according their apnea-hypopnea index (AHI). Measurements nocturnal polysomnography, biochemical testing, transthoracic echocardiography data. Results: AHI group was higher (30.24± 21.69 vs 23.19± 17.65, p< 0.001) lowest oxygen saturation at night lower (77.67± 9.23 80.59± 9.26, than those non-MS group. Additionally, end-diastolic diameter (LVEDD), end-systolic (LVESD), septal thickness (IVST), posterior wall (LVPWT), atrial internal (LAD), E peak A velocity ratio (E/A) (P< 0.05). e' (E/e') that (12.02± 3.68 11.13± 3.12, P=0.011) positively correlated diagnosis ( r =0.115, p=0.024; =0.131, p=0.010, respectively). five had significantly E/e' elevation (odds ratio=4.238, p=0.007). Conclusion: may be related severity dysfunction. An increase Among factors, blood pressure most important. Keywords: syndrome, apnea, dysfunction

Language: Английский

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Circadian biology in obstructive sleep apnea associated cardiovascular disease

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Occupational but not leisure-time physical activity associated with high-risk of obstructive sleep apnea status: a population-based study

BMC Pulmonary Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Despite the well-documented benefits of physical activity, distinct impacts occupational activity (OPA) and leisure-time (LTPA) on risk obstructive sleep apnea (OSA) remain poorly understood. The objective this study was to examine relationship between OPA/LTPA developing OSA within a nationally representative sample. We hypothesized that high-intensity OPA could potentially elevate OSA, whereas effect LTPA might be different. cross-sectional utilized data from Korean National Health Nutritional Examination Survey database (2019-2020), encompassing total 8093 participants. assessed using STOP-BANG questionnaire, where score ≥ 3 signified high risk. Physical levels were evaluated questions adapted version Global Activity Questionnaire. Participants allocated based their or low OPA. Logistic regression analyses conducted unveil associations LTPA/OPA. multivariate analysis revealed posed factor for (odds ratio [OR] = 1.738, 95% confidence interval [CI]: 1.134, 2.666), particularly among individuals with age 60 years old (OR 1.321, CI: 1.036, 1.682), those BMI 25 1.967, 1.027, 3.767), hypertension 3.729, 1.586, 8.768). Furthermore, visible association observed increased tiredness 1.447, 1.107, 1.891). However, no notable correlation detected prevalence in both overall subgroup (all P > 0.5). supported link an elevated suggesting need manage duration intensity

Language: Английский

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Association Between Preoperative COVID-19 Infection and Postoperative Outcomes in Patients with Obstructive Sleep Apnea Undergoing Metabolic Surgery: A Retrospective Analysis

Obesity Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Language: Английский

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Association between visceral adiposity index and sleep disorders among the U.S. adults: a cross-sectional study

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Background The visceral adiposity index (VAI) reliably measures body fat distribution and related dysfunctions. However, its association with sleep disorders among US adults remains unclear. Methods This study analyzed cross-sectional data from the 2005 to 2018 National Health Nutrition Examination Survey (NHANES) for aged 18 older. We used multivariable logistic regression evaluate between VAI applied restricted cubic splines assess potential non-linear relationships. Additionally, subgroup analyses by gender, age, race were conducted explore VAI-sleep disorder across different populations. Results included 14,021 +. In Model 1, adjusted gender each unit increase in was associated a 5% higher risk of (OR = 1.05; 95% CI 1.02–1.07). 2, which all confounders, linked 3% 1.03; 1.00–1.05). When treating as categorical variable, those highest quartile (Q4) had 21% compared lowest (Q1) 1.21; 1.03–1.41). Restricted spline analysis revealed positive linear relationship prevalence. Subgroup found stronger associations males non-Hispanic white individuals. Conclusion While causality cannot be confirmed, this shows significant U.S. adults.

Language: Английский

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