A Review of the Use of Extracellular Vesicles in the Treatment of Neonatal Diseases: Current State and Problems with Translation to the Clinic

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2879 - 2879

Published: March 1, 2024

Neonatal disorders, particularly those resulting from prematurity, pose a major challenge in health care and have significant impact on infant mortality long-term child health. The limitations of current therapeutic strategies emphasize the need for innovative treatments. New cell-free technologies utilizing extracellular vesicles (EVs) offer compelling opportunity neonatal therapy by harnessing inherent regenerative capabilities EVs. These nanoscale particles, secreted variety organisms including animals, bacteria, fungi plants, contain repertoire bioactive molecules with potential. This review aims to provide comprehensive assessment effects EVs mechanistic insights into stem cells, biological fluids non-animal sources, focus common conditions such as hypoxic–ischemic encephalopathy, respiratory distress syndrome, bronchopulmonary dysplasia necrotizing enterocolitis. summarizes evidence potential EVs, analyzes their mechanisms action discusses challenges associated implementation EV-based therapies clinical practice.

Language: Английский

Integrating engineered nanomaterials with extracellular vesicles: advancing targeted drug delivery and biomedical applications

Frontiers in Nanotechnology, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 22, 2025

Extracellular vesicles (EVs), natural membrane-bound structures released by cells, offer a promising platform for precise and targeted delivery of therapeutic payloads, including drugs nanoparticles. This comprehensive review explores the integration engineered nanomaterials with EVs to advance drug systems. It covers various aspects this integration, techniques synthesizing, loading, characterizing, applying within EVs. Methodologies integrating diverse nanocarriers like nanoparticles, liposomes, quantum dots into are discussed, along characterization methods such as electron microscopy light scattering. Attention is also given considerations biological compatibility, safety assessments, strategies surface modification enhance targeting precision. Highlighting applications, delivery, cancer therapy, vaccine development, underscores potential EV-nanomaterial hybrids leverage EVs’ innate capabilities versatility nanomaterials. However, it addresses challenges scalability, standardization, that must be overcome facilitate clinical translation these biomedical solutions.

Language: Английский