The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

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Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1525 - 1525

Published: Jan. 26, 2024

Platelet concentrates such as platelet-rich plasma, fibrin or concentrated growth factors are cost-effective autologous preparations containing various factors, including platelet-derived factor, transforming factor β, insulin-like 1 and vascular endothelial factor. For this reason, they often used in regenerative medicine to treat wounds, nerve damage well cartilage bone defects. Unfortunately, after administration, these release very quickly, which lose their activity rapidly. As a consequence, results the need repeat therapy, is associated with additional pain discomfort for patient. Recent research shows that combining platelet biomaterials overcomes problem because released more sustainable manner. Moreover, concept fits into latest trends tissue engineering, include biomaterials, bioactive cells. Therefore, review presents literature reports on properties of enriched applications skin, nerve, engineering.

Language: Английский

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How to explain the beneficial effects of platelet‐rich plasma

Periodontology 2000, Journal Year: 2024, Volume and Issue: unknown

Published: April 10, 2024

Abstract Platelet‐rich plasma (PRP) is the platelet and leukocyte‐containing plasmatic fraction of anticoagulated autologous blood. While evidence supporting clinical use PRP in dentistry low, widely used sports medicine, orthopedics, dermatology. Its beneficial activity commonly attributed to growth factors released from platelets accumulating PRP; however, indirect not comprehensive. There thus a demand revisit with respect basic translational science. This review (i) recapitulate protocols tools prepare (ii) discuss cellular molecular composition focus on platelets, leukocytes, fibrin‐rich extracellular matrix coagulated plasma; finally (iii) potential effects level an outlook its current other medical fields.

Language: Английский

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Anti-Aging Potential of Platelet Rich Plasma (PRP): Evidence from Osteoarthritis (OA) and Applications in Senescence and Inflammaging

Bioengineering, Journal Year: 2023, Volume and Issue: 10(8), P. 987 - 987

Published: Aug. 21, 2023

Aging and age-related changes impact the quality of life (QOL) in elderly with a decline movement, cognitive abilities increased vulnerability towards diseases (ARDs). One key contributing factors is cellular senescence, which triggered majorly by DNA damage response (DDR). Accumulated senescent cells (SCs) release senescence-associated secretory phenotype (SASP), includes pro-inflammatory cytokines, matrix metalloproteinases (MMPs), lipids chemokines that are detrimental to surrounding tissues. Chronic low-grade inflammation or inflammaging also associated senescence contributes ARDs. The literature from last decade has recorded use platelet rich plasma (PRP) combat inflammation, alleviate pain as an analgesic, promote tissue regeneration repair via angiogenesis—all essential anti-aging strategies. In few decades, platelet-rich been used treatment option for dermatological applications great interest orthopaedic applications, especially osteoarthritis (OA). this exploration, we connect intricate relationship between aging, ARDs, delve into PRP’s properties potential benefits. We conduct comparative review current on PRP strategies, paying particular attention instances strongly linked Finally, upon careful consideration interconnected information context suggest prospective role developing therapeutic

Language: Английский

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Prospective study on a new combination of pulsed radiofrequency and platelet-rich plasma injections for managing grade I lumbosacral spondylolisthesis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 9, 2025

Language: Английский

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Platelet-Rich Plasma in Spine Disease

Contemporary Spine Surgery, Journal Year: 2025, Volume and Issue: 26(2), P. 1 - 6

Published: Jan. 10, 2025

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Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials

Experimental Biology and Medicine, Journal Year: 2025, Volume and Issue: 250

Published: Feb. 4, 2025

The current meta-analysis was performed to analyze the efficacy and safety of platelet-rich plasma (PRP) as an epidural injectate, in comparison with steroids management radiculopathy due lumbar disc disease (LDD). We conducted independent duplicate searches electronic databases (PubMed, Embase Cochrane Library) March 2024 identify randomized controlled trials (RCTs) analyzing PRP for pain relief LDD. Animal or vitro studies, clinical studies without a comparator group, retrospective non-randomised were excluded. Diverse post-intervention scores [visual analog score (VAS)] functional [Oswestry Disability Index (ODI), SF-36], reported reviewed evaluated. Statistical analysis using STATA 17 software. 5 RCTs including 310 patients (PRP/Steroids = 153/157) included analysis. compared at various time-points 1, 3, 6, 12, 24, 48 weeks. Epidural injection found offer comparable (VAS; WMD −0.09, 95% CI [−0.66, 0.47], p 0.641; I 2 96.72%, < 0.001), improvement (ODI; 0.72, [-6.81, 8.25], 0.524; 98.73%, overall health (SF-36; 1.01, [−1.14, 3.17], 0.224; 0.0%, 0.36) steroid (ESI) all observed time points any increase adverse events complications. administration offers benefit profile is also similar ESI.

Language: Английский

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Role of Platelet-Rich Plasma (PRP) in the Management of Stage III and IV Degenerative Disc Disease

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Degenerative disc disease is a common disorder that can significantly impact patients' quality of life, leading to chronic pain and disability. Platelet-rich plasma (PRP) therapy emerging as potential treatment for degenerative disease. The purpose this review summarize the role PRP in management types III IV. This scoping literature review. online database PUBMED was used, papers were searched using keywords: ("PRP" OR "platelet-rich plasma") AND ("degenerative disk disease" "disk degeneration" "intradiscal injection" "discogenic pain" "intervertebral "degenerative disease"). Clinical studies evaluating stage IV included study. Systematic reviews, animal studies, vitro case reports, study designs, languages other than English excluded. present includes 14 studies. has been found promote tissue regeneration modulate inflammatory response degenerated discs. be administered mostly intradiscally but also epidurally. benefits use include reduction, improvement functionality, low risk adverse events. effect intradiscal injections similar steroid injections. A higher concentration platelets associated with enhanced clinical outcomes. represents promising avenue healing across While evidence supporting its efficacy encouraging, further research needed elucidate mechanisms action, optimize protocols, expand applications.

Language: Английский

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A Systematic Review of Sacroiliac Joint Injections of Platelet-Rich Plasma (Prp) and Stem Cells

Current Pain and Headache Reports, Journal Year: 2025, Volume and Issue: 29(1)

Published: March 17, 2025

Language: Английский

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Therapeutic interventions of platelet-rich plasma versus corticosteroid injections for lumbar radicular pain: a systematic review and meta-analysis

Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 25, 2025

Although epidural corticosteroid injections (ESIs) provide short-term relief for lumbar radicular pain caused by disc herniation, concerns remain regarding their long-term efficacy and complications. Platelet-rich plasma (PRP), with its dual anti-inflammatory regenerative properties, is a promising alternative, but the comparative evidence between two treatments remains inconclusive. A systematic search was conducted in PubMed, Embase, Web of Science, Cochrane Library, cutoff date January 10, 2025. The primary outcomes were Visual Analog Scale (VAS) Oswestry Disability Index (ODI) scores. risk bias included studies assessed using ROB ROBINS-I. outcome measures analyzed evaluating standardized mean differences (SMDs). total seven (four randomized controlled trials three prospective studies) meta-analysis, comprising 416 patients. results indicated that corticosteroids significantly reduced ODI scores at initial follow-up (4 weeks) (SMD = 0.48, 95% CI: 0.20 to 0.75, p 0.0008, I² 15%), no significant observed VAS groups other time points. complication rates PRP reported, severe adverse events reported. Compared PRP, showed early functional improvements points, future are needed assess safety versus treating standardizing preparation, extending durations, increasing sample sizes.

Language: Английский

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