In-utero exposure to estrogen-mimicking bisphenols alters bone mineralization in the offspring DOI Creative Commons

Saikanth Varma,

Archana Molangiri,

Sreedhar Mudavath

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

Abstract Exposure to plastic-derived estrogen-mimicking endocrine-disrupting bisphenols can have a long-lasting effect on bone health. However, gestational exposure below tolerable daily intake (TDI) of bisphenol A (BPA) and its substitute, S (BPS), offspring’s mineralization is unclear. This study examined the effects in-utero growth density offspring rats. Pregnant Wistar rats were exposed BPA BPS (0.0, 0.4 μg/kg bw) via oral gavage from day 4 21. The density, IGF-1, osteocalcin, calcium levels measured by DEXA, ELISA AAS, respectively. bisphenol’s action canonical BMP signaling was in osteoblast SaOS-2 cells. Maternal (BPA BPS) increased body weight, mineral content, aged 30 90 days (p<0.05). Plasma calcium, alkaline phosphatase activities altered BPA-exposed cells decreased viability dose-dependent manner promoted cell cycle progression S/G2-M phase expression BMP1, BMP4, intracellular signalling mediators SMAD1, SMAD5, RUNX2 mRNAs upon these index extracellular matrix proteins such as ALPL, COL1A1, DMP1, FN1 downregulated Bisphenol co-incubation with noggin TGF-β1 expression, indicating involvement mineralization. Overall, during gestation modulating BMP/ mediators. Highlights Gestational low doses increases whole-body BMC BMD offspring. In-utero plasma IGF-1 gla-type marker activity modulates Smad-dependent

Language: Английский

Strontium-calcium doped titanium dioxide nanotubes loaded with GL13K for promotion of antibacterial activity, anti-Inflammation, and vascularized bone regeneration DOI

Fenghuan Jia,

Danyang Xu,

Yuxuan Sun

et al.

Ceramics International, Journal Year: 2023, Volume and Issue: 49(22), P. 35703 - 35721

Published: Aug. 22, 2023

Language: Английский

Citations

44
A comprehensive review on environmental pollutants and osteoporosis: Insights into molecular pathways DOI

P. Snega Priya,

P. Pratiksha Nandhini,

Jesu Arockiaraj

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 117103 - 117103

Published: Sept. 7, 2023

Language: Английский

Citations

16
Per- and Poly-fluoroalkyl Substances as Forever Chemicals in Drinking Water: Unraveling the Nexus with Obesity and Endocrine Disruption – A Mini Review DOI Creative Commons

Hoda Pezeshki,

Saeed Rajabi, Majid Hashemi

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42782 - e42782

Published: Feb. 1, 2025

Per- and Poly-fluoroalkyl substances (PFASs) are among the that have been widely employed across world due to their distinct features. These chemicals' great stability in environment capacity be released from consumer goods demonstrated existence all matrices. Additionally, world's attention has drawn these substances' direct relation human health recent years. This research aimed unravel nexus of PFASs with obesity endocrine disruption as a comprehensive review. Studies shown drinking water is primary way which humans exposed PFASs. As result, it become difficult determine how contaminated compounds impacts affect health. Through various routes, metabolic processes, possible effects on hypothalamus-pituitary-thyroid axis, chemicals increase incidence obesity, particularly during crucial growth phases. Another negative impact glands' function, for controlling body's physiological functions. leads alterations hormone production. The exposure include secondary hyperparathyroidism, non-alcoholic fatty liver, diabetes, cardiovascular illnesses, reproductive abnormalities, infertility. Because characteristics, including propensity propagate through food chain, accumulate biomagnify, ultimately pose threat life, replace remove chemicals.

Language: Английский

Citations

0
Machine learning-optimized trimetallic MOF integrated nanofibers for precise detection of p-Nitrophenol in agricultural soil DOI

Ayesha Yousaf,

Zhihua Zhao,

Naeem Akhtar

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161299 - 161299

Published: March 1, 2025

Language: Английский

Citations

0
From repellent to risk: DEET’s adverse effects on hormones and bone health in kids DOI Creative Commons
Xinyu Zhu, Wanlu Liu,

Baihao Lin

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Early life bone accumulation, which predicts future fragility fracture risk, is intimately associated with sex hormones. N, N-diethyl-3-methylbenzamide (DEET) the primary and most effective active ingredient widely used globally, especially among children adolescents. However, effects of DEET on hormones mass remain unclear. We aimed to explore adverse exposure elucidate potential mediating roles in This cross-sectional study analyzed 864 adolescents from NHANES 2013-2016. Urinary 3-diethyl-carbamoyl benzoic acid (DCBA) was employed as a biomarker for exposure. The examined relationships between DCBA, hormones, mass, particular focus evaluating independent serial mediation DEET-bone associations. Increased DCBA decreased testosterone (TT), estrogen (E2), free androgen index (FAI), alongside an increase hormone-binding globulin (SHBG) levels, particularly pronounced subjects < 12 years [β% (95 % CI) = -0.081 (-0.144, -0.017), -0.064 (-0.114, -0.013), -0.101 (-0.177, -0.024), 0.020 (-0.009, 0.048), respectively] non-overweight -0.160 (-0.234, -0.086), -0.103 (-0.158, -0.048), -0.195 (-0.282, -0.107), 0.035 (0.012, 0.058), respectively]. Negative dose-response were observed participants -0.011 (-0.018, -0.005) -0.027 (-0.041, -0.013) total mineral density (BMD) content (BMC), respectively], BMC -0.012 (-0.024, 0.000)]. Additionally, TT, E2, SHBG found significantly independently mediate 15.41 79.84 relationship mass. Furthermore, detected SHBG. exerts detrimental effect health by interfering adolescents, warranting heightened public concern.

Language: Английский

Citations

0
Callus organoids reveal distinct cartilage to bone transition mechanisms across donors and a role for biological sex DOI Creative Commons
Isaak Decoene, Hanna Svitina, Mohamed Belal Hamed

et al.

Bone Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 26, 2025

Language: Английский

Citations

0
Exposure to BPA and BPS during pregnancy disrupts the bone mineralization in the offspring DOI

Saikanth Varma,

Archana Molangiri,

Sreedhar Mudavath

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 189, P. 114772 - 114772

Published: May 29, 2024

Language: Английский

Citations

2
Effects of Endocrine-Disrupting Chemicals on Bone Health DOI Creative Commons
So Young Park, Sung Hye Kong, Kyoung Jin Kim

et al.

Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 39(4), P. 539 - 551

Published: July 17, 2024

This comprehensive review critically examines the detrimental impacts of endocrine-disrupting chemicals (EDCs) on bone health, with a specific focus substances such as bisphenol A (BPA), per- and polyfluoroalkyl (PFASs), phthalates, dioxins. These EDCs, by interfering endocrine system’s normal functioning, pose significant risk to metabolism, potentially leading heightened susceptibility bone-related disorders diseases. Notably, BPA has been shown inhibit differentiation osteoblasts promote apoptosis osteoblasts, which results in altered turnover status. PFASs, known for their environmental persistence ability bioaccumulate human body, have linked an increased osteoporosis risk. Similarly, are widely used production plastics, associated adverse health outcomes, showing inverse relationship between phthalate exposure mineral density. Dioxins present more complex picture, research findings suggesting both potential benefits effects structure density, depending factors timing level exposure. underscores urgent need further better understand pathways through EDCs affect develop targeted strategies mitigating harmful impacts.

Language: Английский

Citations

2
From gut to bone: deciphering the impact of gut microbiota on osteoporosis pathogenesis and management DOI Creative Commons

Linjie Hao,

Yuzhu Yan, Guilin Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 25, 2024

Osteoporosis (OP) is characterized by decreased bone mineral density (BMD) and increased fracture risk, poses a significant global health burden. Recent research has shed light on the bidirectional relationship between gut microbiota (GM) health, presenting novel avenue for understanding OP pathogenesis developing targeted therapeutic interventions. This review provides comprehensive overview of GM-bone axis, exploring impact GM development management. We elucidate established risk factors OP, delve into diversity functional changes in OP. Furthermore, we examine experimental evidence clinical observations linking alterations composition or function with variations BMD risk. Mechanistic insights microbial mediators such as metabolites products, are discussed. Therapeutic implications, including GM-targeted interventions dietary strategies, also explored. Finally, identify future directions challenges translating these findings practice.

Language: Английский

Citations

2
Imprinting and Reproductive Health: A Toxicological Perspective DOI Open Access

Ritu Chauhan,

Anthony E. Archibong,

Aramandla Ramesh

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16559 - 16559

Published: Nov. 21, 2023

This overview discusses the role of imprinting in development an organism, and how exposure to environmental chemicals during fetal leads physiological biochemical changes that can have adverse lifelong effects on health offspring. There has been a recent upsurge use chemical products everyday life. These include industrial byproducts, pesticides, dietary supplements, pharmaceutical products. They mimic natural estrogens bind estradiol receptors. Consequently, they reduce number receptors available for ligand binding. faulty signaling neuroendocrine system critical developmental process 'imprinting'. Imprinting causes structural organizational differentiation male female reproductive organs, sexual behavior, bone mineral density, metabolism exogenous endogenous substances. Several studies conducted animal models epidemiological provide profound evidence altered various abnormalities other diseases humans. Altered be measured by endpoints such as profile cytochrome P-450 enzymes (CYP450's), xenobiotic metabolite levels, DNA adducts. The importance potentiation or attenuation toxic is discussed.

Language: Английский

Citations

4