hautnah dermatologie, Journal Year: 2024, Volume and Issue: 40(S1), P. 20 - 25
Published: Feb. 1, 2024
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10152 - 10152
Published: Sept. 21, 2024
Many skin diseases begin with inflammatory changes on a molecular level. To develop more thorough understanding of pathology and to identify new targets for therapeutic advancements, mechanisms inflammation in the context disease should be studied. Current research efforts better understand have focused examining role processes at several stages response such as dysregulation innate immunity sensors, disruption both transcriptional post-transcriptional regulation, crosstalk between immune neuronal (neuro-immune crosstalk). This review seeks summarize recent developments our highlight opportunities advancements. With focus publications within past 5 years (2019–2024), databases PubMed EBSCOhost were used search peer-reviewed papers regarding disease. Several themes interest determined through extensive included based their relative representation current potential. psoriasis, atopic dermatitis, hidradenitis suppurativa, scleroderma described paper demonstrate widespread influence
Language: Английский
Citations
9
Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101518 - 101518
Published: Jan. 1, 2025
Language: Английский
Citations
0
Allergies, Journal Year: 2025, Volume and Issue: 5(2), P. 9 - 9
Published: March 27, 2025
Background: Atopic dermatitis (AD), allergic rhinitis (AR), and chronic rhinosinusitis with nasal polyps (CRSwNP) represent interconnected conditions within the spectrum of type 2 inflammatory diseases. While these share common genetic epigenetic pathways, precise molecular mechanisms remain underexplored. Methods: This review integrates latest insights on factors linking AD, AR, CRSwNP, focusing genome-wide association studies, DNA methylation patterns, histone modifications, microRNA regulation. Results: In all three conditions, including (Me) acetylation (Ac) methylation, regulate barrier-related genes, influencing disease severity. Notably, miRNAs such as miR-146a miR-155 play pivotal roles in modulating inflammation across diseases, while disease-specific contribute to airway remodeling (miR-125b miR-21 AR CRSwNP). Emerging evidence underscores role microbiome-driven inflammasome activation matrix metalloproteinases (MMP-2, MMP-9, MMP-12) perpetuating remodeling. Conclusions: The interplay between predispositions, exposomal systemic nature inflammation. A deeper understanding could lead transformative, personalized diagnostic therapeutic advancements.
Language: Английский
Citations
0
Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)
Published: April 9, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4287 - 4287
Published: May 1, 2025
Psoriasis and atopic dermatitis (AD) are both chronic inflammatory skin diseases. Their pathogenesis remains incompletely understood. The polarization states of macrophages, as a crucial part the innate immune system, influenced by various factors such cytokines, mediators, epigenetics. Research has demonstrated that macrophages play "double-edged sword" role in pathological process diseases: they drive inflammation progression participate tissue repair. This article summarizes roles development homeostasis psoriasis dermatitis. It explores impact different on In conclusion, understanding classification plasticity is for deeper AD personalized treatments.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11679 - 11679
Published: July 20, 2023
Non-coding RNAs (ncRNAs) are a family of RNA molecules that, unlike messenger RNAs, not templates for protein synthesis but have an essential or regulatory role in this process [...].
Language: Английский
Citations
9
Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 147, P. 103255 - 103255
Published: May 25, 2024
To investigate the epigenetic footprint of idiopathic inflammatory myopathies (IIM) through characterization circulating extracellular vesicles (EVs) and expression EV-derived small non-coding RNAs (sncRNAs). In this cross-sectional study, EVs were isolated by size-exclusion chromatography from plasma patients with IIM age- sex-matched healthy donors (HD). sncRNAs sequenced quantified using Next-Generation Sequencing (NGS). Following quality control normalization, filtered count reads used for differential microRNA (miRNA) piwi-interacting RNA (piRNA) analyses. Putative gene targets enriched pathways implicated in analyzed. Patients' clinical laboratory characteristics at time sampling recorded. Forty-seven 45 HD enrolled. MiR-486-5p (p < 0.01), miR-122-5p, miR-192-5p, miR-32-5p significantly upregulated 0.05 all), while miR-142-3p 0.001), miR-141-3p let-7a-5p 0.05) miR-3613-5p downregulated versus HD. was associated raised muscle enzymes levels. Several target genes up/downregulated miRNAs participate inflammation, necroptosis, interferon immune signaling. Six piRNAs dysregulated 0.05). Within IIM, miR-335-5p selectively miR-27a-5p dermatomyositis (n = 21, p 0.01). Finally, EV levels increased cancer-associated myositis (CAM, n 12) non-CAM 35, 0.02) cargo CAM let-7f-5p depleted miR-143-3p. Through an unbiased screening sncRNAs, we characterize as potential biomarkers modifiers diverse phenotypes.
Language: Английский
Citations
3
Trends in cancer, Journal Year: 2024, Volume and Issue: 10(9), P. 809 - 824
Published: Aug. 5, 2024
Language: Английский
Citations
3
International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 54(5)
Published: Aug. 21, 2024
Psoriasis is a chronic inflammatory skin condition with numerous causes, including genetic, immunological and infectious factors. The course of psoriasis long recurrence common; pathogenesis not completely understood. However, there an association between advancement aberrant microRNA (miR or miRNA)‑155 expression. Through bioinformatics, the present study aimed to analyze differentially expressed genes miRNAs in its biological mechanism function psoriatic inflammation. First all, (DEGs) (DEMs) patients were identified using GEO2R interactive web application. A model was established lipopolysaccharide (LPS)‑treated HaCaT keratinocytes, which transfected miR‑155 mimic inhibitor. Cell Counting Kit‑8 used for assessment cell viability proliferation, changes cycle examined flow cytometry. ELISA reverse transcription‑quantitative PCR (RT‑qPCR) detect expression levels factors IL‑1β IL‑6. dual‑luciferase reporter assay verify targeting miR‑155‑5p IFN regulatory factor 2 binding protein (IRF2BP2). To IRF2BP2/kruppel‑like (KLF2)/NF‑κB signaling pathway, IRF2BP2, KLF2 p65 by RT‑qPCR western blotting. IRF2BP2 also confirmed immunofluorescence, conjunction bioinformatics database analysis. Overexpression inhibited proliferation cells increased number S phase decreasing G1 G2 phase. In LPS‑induced state, overexpression heightened response while inhibition lessened it. Suppression cytokine inhibitor reversed knockdown IRF2BP2. shown interact negatively regulate expression, leading decreased secretion factors, intensifying cells. Therefore, may contribute development inducing tissue damage increasing via IRF2BP2/KLF2/NF‑κB pathway. conclusion, results offer novel perspectives on role onset progression psoriasis.
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114606 - 114606
Published: April 6, 2025
Language: Английский
Citations
0