Inflammasome activity regulation by PUFA metabolites

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 3, 2024

Oxidative stress and the accompanying chronic inflammation constitute an important metabolic problem that may lead to pathology, especially when body is exposed physicochemical biological factors, including UV radiation, pathogens, drugs, as well endogenous disorders. The cellular response associated, among others, with changes in lipid metabolism, mainly due oxidation action of lipolytic enzymes. Products oxidative fragmentation/cyclization polyunsaturated fatty acids (PUFAs) [4-HNE, MDA, 8-isoprostanes, neuroprostanes] eicosanoids generated a result enzymatic metabolism PUFAs significantly modify functioning immune system by interfering intracellular molecular signaling. key regulators inflammation, effectiveness which can be regulated interacting products under stress, are inflammasome complexes. An example both negative or positive regulation NLRP3 activity 4-HNE depending on severity stress. modifies direct interaction alteration NF-κB Furthermore, prostaglandin E2 known positively correlated NLRC4 activity, while its potential interference AIM2 NLRP1 unproven. Therefore, influence PUFA metabolites well-characterized complexes reviewed.

Language: Английский

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Macrophages in the inflammatory response to endotoxic shock

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(10)

Published: Oct. 1, 2024

Abstract Background Endotoxic shock, particularly prevalent in intensive care units, represents a significant medical challenge. Endotoxin, upon invading the host, triggers intricate interactions with innate immune system, macrophages. This activation leads to production of inflammatory mediators such as tumor necrosis factor‐alpha, interleukin‐6, and interleukin‐1‐beta, well aberrant nuclear factor‐kappa‐B mitogen‐activated protein kinase signaling pathways. Objective review delves into cascades underpinning endotoxic particular focus on pivotal role It aims elucidate clinical implications these processes offer insights potential therapeutic strategies. Results Macrophages, central regulation, manifest two distinct subsets: M1 (classically activated subtype) macrophages M2 (alternatively The former exhibit an phenotype, while latter adopt anti‐inflammatory role. By modulating response patients play crucial restoring balance facilitating recovery. Conclusion Macrophages undergo dynamic changes within orchestrating essential for maintaining tissue homeostasis. A deeper comprehension mechanisms governing macrophage‐mediated inflammation lays groundwork anti‐inflammatory, targeted approach treating shock. understanding can significantly contribute development more effective interventions.

Language: Английский

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Potensi Ekstrak Etanol Kulit Batang Jabon (Anthocephalus cadamba (Roxb) Miq.) Sebagai Antiinflamasi

JURNAL BIOLOGI PAPUA, Journal Year: 2024, Volume and Issue: 16(1), P. 20 - 26

Published: April 5, 2024

This study investigates the anti-inflammatory properties of an ethanol extract from Jabon plant stem bark in male mice using Rat Hind Paw Edema method. Twenty-five were divided into five groups: negative control (Na-CMC 1%), positive (mefenamic acid), and three groups receiving at doses 50 mg/kg, 100 200 mg/kg. Measurements taken every 30 minutes for hours a plethysmometer. Analysis with one-way ANOVA Duncan's test revealed significant effects all doses, most effective being showing 93.42% inhibition. The results suggest as promising agent.

Language: Английский

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Comparison of Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(11), P. 509 - 509

Published: Nov. 10, 2024

Lipid extracts from the microalgae

Language: Английский

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