Role of Bioelectrical Signaling Networks in Tumor Growth DOI Open Access

Taleh Yusifov,

Fidan Qudretova,

Aysel Aliyeva

et al.

American Journal of Biomedical and Life Sciences, Journal Year: 2024, Volume and Issue: 12(5), P. 83 - 92

Published: Nov. 28, 2024

The ion channels are distributed in all cells and promote the rapid influx of ions that underlie formation cellular bioelectrical signals. Bioelectrical signals coupled with other regulator mechanisms provide fundamental physiological processes, such as differentiation, proliferation, apoptosis, which strongly associated manifestation cancer hallmarks. Alterations signaling mechanism unusual features cells. Investigating role tumor growth provides insights into diagnosis tumor-targeted treatment. Hence, this field research is becoming one frontrunners medicine, advances biophysical tools enabling progress understanding biological phenomenon. Recent studies have revealed represent a promising target therapy. It increasingly convincing conditions can be reversed to normal by regulating Herein, we brief review pathophysiology data on manipulation novel approach preventing malignant growth.

Language: Английский

Targeting ion channels with ultra-large library screening for hit discovery DOI Creative Commons
Kortney M. Melançon, Palina Pliushcheuskaya, Jens Meiler

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Jan. 5, 2024

Ion channels play a crucial role in variety of physiological and pathological processes, making them attractive targets for drug development diseases such as diabetes, epilepsy, hypertension, cancer, chronic pain. Despite the importance ion discovery, vastness chemical space complexity pose significant challenges identifying candidates. The use silico methods discovery has dramatically reduced time cost potential to revolutionize field medicine. Recent advances computer hardware software have enabled screening ultra-large compound libraries. Integration different at various scales dimensions is becoming an inevitable trend development. In this review, we provide overview current state-of-the-art computational chemistry methodologies library their application channel research. We discuss advantages limitations techniques, including virtual screening, molecular mechanics/dynamics simulations, machine learning-based approaches. also highlight several successful applications insights into future directions field.

Language: Английский

Citations

4
TRP Channels in Cancer: Therapeutic Opportunities and Research Strategies DOI Creative Commons
Jiahui Xu, Ziming Wang, Yuqing Niu

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107412 - 107412

Published: Sept. 19, 2024

Language: Английский

Citations

4
Caffeic acid activates Nrf2 enzymes, providing protection against oxidative damage induced by ionizing radiation DOI Creative Commons
Juan Yao, Yuanyuan Liu, Hang Lin

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111325 - 111325

Published: March 1, 2025

Caffeic acid (CA) is a prevalent polyphenolic compound commonly found in various plant-derived foods. Due to its diverse pharmacological properties, including antioxidant activity, cardiovascular protection, and immune regulation, CA has garnered significant attention. Ionizing radiation (IR) extensively utilized across industrial sectors, agriculture, defense applications, scientific research, clinical medicine; however, the detrimental effects of on human health cannot be ignored. IR can directly damage DNA, proteins, lipids within macromolecules or ionize water molecules generate substantial quantities free radicals that indirectly harm cells, especially those brain which are highly susceptible exposure. Consequently, effective strategies for preventing treating IR-induced neurological represent an urgent medical challenge necessitates resolution. Our study aims investigate protective against neuronal cell along with elucidating potential mechanisms action. The results indicate covalently modify active cysteine residues Keap1 protein altering conformation; this modification disrupts interaction between Nrf2 while facilitating Nrf2's translocation into nucleus where it activates downstream expression cellular factors such as heme oxygenase-1 (HO-1), NAD(P)H: quinone oxidoreductase 1 (NQO1), Thioredoxin Reductase-1 (TrxR1) other play role countering radiation-induced damage. In conclusion, emerges radioprotective agent capable exerting antiradiation effects. findings provide valuable insights developing novel therapeutic agents aimed at impairment.

Language: Английский

Citations

0
Beyond hydrodynamics: The role of ion channels in dentine hypersensitivity DOI

Yutong Sun,

Andrea Sanders,

David H. Pashley

et al.

Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown, P. 105745 - 105745

Published: April 1, 2025

Language: Английский

Citations

0
Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradine DOI Creative Commons

Tong Che,

Wei Zhang, Xinyu Cheng

et al.

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 107798 - 107798

Published: Sept. 1, 2024

Language: Английский

Citations

3
Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges DOI Open Access

Tongtong Song,

Wenting Hui,

Min Huang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6467 - 6467

Published: June 12, 2024

In different areas of the heart, action potential waveforms differ due to differences in expressions sodium, calcium, and potassium channels. One characteristics myocardial infarction (MI) is an imbalance oxygen supply demand, leading ion imbalance. After MI, regulation expression levels K

Language: Английский

Citations

1
Cell Surface Receptors DOI
Nataša Popović, Emily Wilson

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Citations

1
Ion Channels as Targets in Drug Discovery: Outlook and Perspectives DOI
Edward B. Stevens, Gary J. Stephens

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 34

Published: Jan. 1, 2024

Language: Английский

Citations

1
Rationally Designed Novel Antimicrobial Peptides Targeting Chitin Synthase for Combating Soybean Phytophthora Blight DOI Open Access

Yue Ran,

Kiran Shehzadi,

Jianhua Liang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3512 - 3512

Published: March 20, 2024

Soybean phytophthora blight is a severe menace to global agriculture, causing annual losses surpassing USD 1 billion. Present crop loss mitigation strategies primarily rely on chemical pesticides and disease-resistant breeding, frequently surpassed by the pathogens' quick adaptive evolution. In this urgent scenario, our research delves into innovative antimicrobial peptides characterized low drug resistance environmental friendliness. Inhibiting chitin synthase gene activity in Phytophthora sojae impairs vital functions such as growth sporulation, presenting an effective method reduce its pathogenic impact. study, we screened 16 previously tested evaluate their effects against using structure-guided design, which involves molecular docking, saturation mutagenesis, dynamics, toxicity prediction. The silico analysis identified AMP_04 with potential inhibitory sojae's synthase. Through three rounds of pin-pointed most triple mutant, TP (D10K, G11I, S14L). Molecular dynamic simulations revealed TP's stability synthase-TP complex transmembrane mechanism, employing all-atom force field. Our findings demonstrate efficacy occupying substrate-binding pocket translocation catalytic channel. Effective inhibition enzyme can be achieved. Specifically, mutant demonstrates enhanced potency decreased relative wild-type AMP_04, utilizing mechanism akin barrel-stave model during membrane translocation. Collectively, study provides new strategy that could used potent agent combatting soybean blight, contributing sustainable agricultural practices.

Language: Английский

Citations

0
STRUCTURAL MODEL COMPARISON OF HISTIDINE DECARBOXYLASE (HDC) OF HISTAMINE-PRODUCING BACTERIA MORGANELLA MORGANII CONSTRUCTED BY ALPHAFOLD2 AND SWISSMODEL DOI Creative Commons
Heru Pramono,

Aulia Dista Mahrunisa,

Aghnina Elvia Fauziah

et al.

Jurnal Perikanan Unram, Journal Year: 2024, Volume and Issue: 14(2), P. 611 - 619

Published: June 18, 2024

Morganella morganii is one of bacteria that capable converting histidine to histamine in fishery products, particularly the histidine-rich species Scobridae family.The enzyme responsible for conversion decarboxylase (HDC), however crystal structure HDC has not been reported.The aim this study was compare models constructed de novo with AlphaFold2 and by homologous modeling SwissModel.The overall both showed a high similarity superposition α-backbone (R.M.S.D.) being 0.522 Å.The active site analysis shows position Lys233, which can form an internal aldimine (Lys-pyridoxal-5'-phosphate) conservation Lys233 from Photobacterium phosphoreum (PDB 7ERV).The main difference between two lies Asp252-Val256 residues, α-helix model, while these residues loop SwissModel model P. structure.Nevertheless, putative Tetragenococcus halophilus low level amino acid sequence homology different R.M.S.D reaching 1.103 Å.This research proteins be performed using methods.

Language: Английский

Citations

0