Maternal hyperglycemia and postnatal high-fat diet impair metabolic regulation and autophagy response in the liver of adult female rats DOI
Larissa Lopes da Cruz, Yuri Karen Sinzato, Verônyca Gonçalves Paula

et al.

Journal of Developmental Origins of Health and Disease, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 1, 2025

Abstract This study aimed to investigate the mechanisms by which association between maternal hyperglycemia and postnatal high-fat diet (HFD) exposure compromises metabolic parameters hepatic autophagy in adult female pups. For this, Sprague Dawley rats, pups from nondiabetic (control = FC) or diabetic (FD) mothers, were fed a standard (SD) HFD weaning until adulthood ( n minimum 5 rats/group): FC/SD, FC/HFD, FD/SD, FD/HFD. In adulthood, these rats tested with oral glucose tolerance test, euthanized, serum biochemistry analyzed. Liver samples collected evaluate cytokines, redox status, protein expression apoptosis markers. Histomorphometric analyses an assessment of lipofuscin accumulation also performed reflect incomplete autolysosomal digestion. The FD/HFD groups showed intolerance increased number hepatocytes. Furthermore, FD/SD hyperlipidemia insulin resistance. Adaptations pathways observed group antioxidant defense marker activity. exhibited expression, such as p-AMPK, LC3-II/LC3-I, p62/SQSTM1, accumulation, caspase-3 activation. After HFD, had reduced p-AMPK LC3-II/LC3-I ratio, presence steatosis, oxidative stress, inflammation. reduction autophagy, stimulated may be vital importance for susceptibility dysfunction-associated fatty liver disease induced diabetes.

Language: Английский

Stimuli-responsive polysaccharide-based smart hydrogels for diabetic wound healing: Design aspects, preparation methods and regulatory perspectives DOI

Tejaswini Kolipaka,

Giriraj Pandey,

Noella Abraham

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537

Published: Nov. 2, 2023

Language: Английский

Citations

54
Multi-Functional hydrogels to promote diabetic wound Healing: A review DOI

Yongyan Yang,

Shuangling Zhong,

Fanyu Meng

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154855 - 154855

Published: Aug. 14, 2024

Language: Английский

Citations

21
Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects DOI Creative Commons
Francesco Buonfiglio, Joanna Wasielica‐Poslednik, Norbert Pfeiffer

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(1), P. 120 - 120

Published: Jan. 18, 2024

Diabetes mellitus, the most prevalent endocrine disorder, not only impacts retina but also significantly involves ocular surface. contributes to development of dry eye disease and induces morphological functional corneal alterations, particularly affecting nerves epithelial cells. These changes manifest as defects, reduced sensitivity, delayed wound healing, collectively encapsulated in context diabetic keratopathy. In advanced stages this condition, progression ulcers scarring further unfolds, eventually leading opacities. This critical complication hampers vision carries potential for irreversible visual loss. The primary objective review article is offer a comprehensive overview pathomechanisms underlying Emphasis placed on exploring redox molecular pathways responsible aberrant structural observed cornea tear film during diabetes. Additionally, we provide insights into latest experimental findings concerning treatments targeting oxidative stress. endeavor aims enhance our understanding intricate interplay between diabetes complications, offering valuable perspectives future therapeutic interventions.

Language: Английский

Citations

16
Free radicals and their impact on health and antioxidant defenses: a review DOI Creative Commons

Nisansala Chandimali,

Seon Gyeong Bak,

Eun Hyun Park

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated

Language: Английский

Citations

12
Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications DOI Creative Commons
Alfredo Caturano,

Maria Rocco,

Giuseppina Tagliaferri

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 72 - 72

Published: Jan. 9, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes

Language: Английский

Citations

7
Therapeutic Efficacy of Hydroalcoholic Extract of Euphorbia prostrata Aiton in NAD-STZ-Induced Diabetic Nephropathy: A Multifaceted Intervention Targeting Oxidative Stress and Inflammation DOI
Nikhil Garg, Ashi Mannan, Maneesh Mohan

et al.

Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100579 - 100579

Published: Jan. 1, 2025

Language: Английский

Citations

4
Natural products in the treatment of diabetic foot infection DOI Creative Commons
Mohsen Nazari, Leili Shokoohizadeh, Mohammad Taheri‬

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: Jan. 7, 2025

Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy conventional treatments, highlighting need for alternative therapeutic strategies. Natural products, known their antimicrobial, anti-inflammatory, wound-healing properties, have garnered attention as potential treatments DFIs. This review examines key natural compounds, including eugenol, thymol, carvacrol, curcumin, Aloe vera, mechanisms action combating diabetic infections. We analyze antimicrobial these ability inhibit biofilm formation, role wound healing. also explores challenges integrating products into clinical practice use alongside or place traditional antibiotic therapies. Our findings suggest that could play crucial developing sustainable effective treatment strategies DFIs, especially face rising resistance.

Language: Английский

Citations

2
Bioactive Compounds from Vegetal Organs of Taraxacum Species (Dandelion) with Biomedical Applications: A Review DOI Open Access

Maria-Virginia Tanasa,

Ticuţa Negreanu–Pîrjol,

Laura Olariu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 450 - 450

Published: Jan. 7, 2025

Taraxacum officinale (dandelion) is a perennial flowering plant of the Asteraceae family that has spread globally and well-known for its traditional uses. The aim this work to provide detailed review scientific literature on genus from last two decades, with particular emphasis biological pharmacological characteristics dandelions. use species their potential in medicine are assessed. In addition, individual papers describing principal pathways molecules modulated by antitumoral, anti-inflammatory, antidiabetic, hepatoprotective, immunomodulatory, antimicrobial, antioxidant activities presented. This phytochemical studies reveals dandelions contain wide range bioactive compounds, such as polyphenols, phytosterols, flavonoids, carotenoids, terpene, coumarins, whose actively explored various areas human health, some constituents having synergistic activities, including antioxidant, anti-inflammatory anticancer activities. study provides screening sp. chemical composition, an assessment main properties, description relevant supporting dandelion particularly valuable diversified therapeutic different diseases.

Language: Английский

Citations

2
Mitochondrial Insights on Antidiabetic Therapies: Differential Impacts of SGLT2i, GLP-1, and Insulin DOI Creative Commons
Yu‐Hsiang Lin, Kuo‐Hsuan Chang, Yu‐Jen Lu

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107610 - 107610

Published: Jan. 17, 2025

Language: Английский

Citations

2
Mechanisms, Biomarkers, and Treatment Approaches for Diabetic Kidney Disease: Current Insights and Future Perspectives DOI Open Access
Jean Paule Joumaa,

Angela Raffoul,

Claudia Sarkis

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 727 - 727

Published: Jan. 23, 2025

Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Among individuals with type 1 diabetes mellitus (T1DM), 30–40% are at risk developing DKD. This review focuses on mechanistic processes, available and emerging biomarkers for diagnosing, monitoring, preventing DKD, as well treatment options targeted DKD patients. A literature search was conducted PubMed Scopus using specific keywords. Inclusion exclusion criteria were applied to select articles used this review. The highlights various mechanisms involved in progression more severe stages. Additionally, several have been identified, which aid diagnosing monitoring disease. Furthermore, numerous approaches being explored address underlying causes Advanced research exploring new medications remission; sodium-glucose cotransport (SGLT2) inhibitors finerenone, particular, gaining attention their novel renoprotective effects. a major complication diabetes, marked by complex multifactorial mechanisms. Thus, understanding these processes essential therapies potentially reverse progression. Biomarkers show promise early diagnosis progression, while current strategies underscore importance multifaceted approach.

Language: Английский

Citations

2