Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 5, 2025
Language: Английский
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121537 - 121537
Published: Nov. 2, 2023
Language: Английский
Citations
57
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154855 - 154855
Published: Aug. 14, 2024
Language: Английский
Citations
27
Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)
Published: Jan. 24, 2025
Abstract Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, well exogenous sources, including radiation, pollution, smoking. While free radicals essential for certain physiological signaling defense, their overproduction disrupt delicate balance between oxidants antioxidants, leading to oxidative stress. Oxidative stress results damage critical biomolecules like DNA, proteins, lipids, contributing pathogenesis diseases. Chronic conditions cancer, cardiovascular diseases, neurodegenerative disorders, inflammatory diseases have been strongly associated with harmful effects radicals. This review provides comprehensive overview characteristics types mechanisms formation, biological impacts. Additionally, we explore natural compounds extracts studied antioxidant properties, offering potential therapeutic avenues managing radical-induced damage. Future research directions also discussed advance our understanding treatment radical-associated
Language: Английский
Citations
17
Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 72 - 72
Published: Jan. 9, 2025
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes
Language: Английский
Citations
8
Obesity Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100579 - 100579
Published: Jan. 1, 2025
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 450 - 450
Published: Jan. 7, 2025
Taraxacum officinale (dandelion) is a perennial flowering plant of the Asteraceae family that has spread globally and well-known for its traditional uses. The aim this work to provide detailed review scientific literature on genus from last two decades, with particular emphasis biological pharmacological characteristics dandelions. use species their potential in medicine are assessed. In addition, individual papers describing principal pathways molecules modulated by antitumoral, anti-inflammatory, antidiabetic, hepatoprotective, immunomodulatory, antimicrobial, antioxidant activities presented. This phytochemical studies reveals dandelions contain wide range bioactive compounds, such as polyphenols, phytosterols, flavonoids, carotenoids, terpene, coumarins, whose actively explored various areas human health, some constituents having synergistic activities, including antioxidant, anti-inflammatory anticancer activities. study provides screening sp. chemical composition, an assessment main properties, description relevant supporting dandelion particularly valuable diversified therapeutic different diseases.
Language: Английский
Citations
3
European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)
Published: Jan. 7, 2025
Diabetic foot infections (DFIs) are a significant complication in diabetes mellitus, leading to increased morbidity, hospitalizations, and healthcare burdens. The growing prevalence of antibiotic-resistant pathogens has reduced the efficacy conventional treatments, highlighting need for alternative therapeutic strategies. Natural products, known their antimicrobial, anti-inflammatory, wound-healing properties, have garnered attention as potential treatments DFIs. This review examines key natural compounds, including eugenol, thymol, carvacrol, curcumin, Aloe vera, mechanisms action combating diabetic infections. We analyze antimicrobial these ability inhibit biofilm formation, role wound healing. also explores challenges integrating products into clinical practice use alongside or place traditional antibiotic therapies. Our findings suggest that could play crucial developing sustainable effective treatment strategies DFIs, especially face rising resistance.
Language: Английский
Citations
2
Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
Diabetes-related cognitive impairment is increasingly recognized as a significant complication, profoundly impacting patients' quality of life. This review aims to examine the pathophysiological mechanisms, clinical manifestations, risk factors, assessment and diagnosis, management strategies, future research directions in diabetes. A comprehensive literature search was conducted using PubMed, Medline, other medical databases identify, review, evaluate published articles on The focused studies examining pathophysiology, presentations, diagnostic approaches, strategies. current revealed that chronic hyperglycemia, insulin resistance, vascular factors are major contributing deficits Clinical manifestations include impairments attention, memory, executive function, visuospatial abilities, language. Risk encompass disease duration, glycemic control, presence complications, age, education level, comorbidities. Assessment tools screening instruments, neuropsychological testing, neuroimaging techniques. Management strategies involve control optimization, lifestyle modifications, training, pharmacological interventions. highlights prevalence impact diabetes, resulting from complex metabolic disturbances. Early detection multifaceted interventions crucial for preserving function improving patient outcomes. Future should focus neuroprotective biomarker identification, personalized approaches. Collaborative efforts between clinicians researchers essential effectively address this growing healthcare challenge enhance life individuals with diabetes-related impairment.
Language: Английский
Citations
2
Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107610 - 107610
Published: Jan. 17, 2025
Language: Английский
Citations
2
Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 727 - 727
Published: Jan. 23, 2025
Diabetic Kidney Disease (DKD) is the leading cause of end-stage renal disease (ESRD) worldwide. Among individuals with type 1 diabetes mellitus (T1DM), 30–40% are at risk developing DKD. This review focuses on mechanistic processes, available and emerging biomarkers for diagnosing, monitoring, preventing DKD, as well treatment options targeted DKD patients. A literature search was conducted PubMed Scopus using specific keywords. Inclusion exclusion criteria were applied to select articles used this review. The highlights various mechanisms involved in progression more severe stages. Additionally, several have been identified, which aid diagnosing monitoring disease. Furthermore, numerous approaches being explored address underlying causes Advanced research exploring new medications remission; sodium-glucose cotransport (SGLT2) inhibitors finerenone, particular, gaining attention their novel renoprotective effects. a major complication diabetes, marked by complex multifactorial mechanisms. Thus, understanding these processes essential therapies potentially reverse progression. Biomarkers show promise early diagnosis progression, while current strategies underscore importance multifaceted approach.
Language: Английский
Citations
2